James Eshleman

Professor

1988 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

1988

A gene amplified in a transformed mouse cell line undergoes complex transcriptional processing and encodes a nuclear protein

Snyder, L. C., Trusko, S. P., Freeman, N., Eshleman, J. R., Fakharzadeh, S. S. & George, D. L., Jan 1 1988, In : Journal of Biological Chemistry. 263, 32, p. 17150-17158 9 p.

Research output: Contribution to journalArticle

1989

Differential response of myofibrillar and cytoskeletal proteins in cells treated with phorbol myristate acetate

Lin, Z., Eshleman, J., Grund, C., Fischman, D. A., Masaki, T., Franke, W. W. & Holtzer, H., Jan 1 1989, In : Journal of Cell Biology. 108, 3, p. 1079-1091 13 p.

Research output: Contribution to journalArticle

Open Access
1991

The development of selective plasmapheresis as a means for specific therapeutic intervention

Eshleman, J. R. & Silberstein, L. E., Feb 1991, In : Transfusion. 31, 2, p. 96-98 3 p.

Research output: Contribution to journalEditorial

1992

N-linked glycosylation of rabies virus glycoprotein. Individual sequons differ in their glycosylation efficiencies and influence on cell surface expression

Shakin-Eshleman, S. H., Remaley, A. T., Eshleman, J. R., Wunner, W. H. & Spitalnik, S. L., Jan 1 1992, In : Journal of Biological Chemistry. 267, 15, p. 10690-10698 9 p.

Research output: Contribution to journalArticle

1995

Both Transforming Growth Factor-β and Substrate Release Are Inducers of Apoptosis in a Human Colon Adenoma Cell Line

Wang, C. Y., Eshleman, J. R., Willson, J. K. V., Markowitz, S., Wang, C. Y., Willson, J. K. V., Markowitz, S. & Eshleman, J. R., Nov 1 1995, In : Cancer Research. 55, 21, p. 5101-5105 5 p.

Research output: Contribution to journalArticle

DNA typing of the human MN and Ss blood group antigens in amniotic fluid and following massive transfusion

Eshleman, J. R., Shakin-Eshleman, S. H., Church, A., Kant, J. A. & Spitalnik, S. L., Jan 1 1995, In : American journal of clinical pathology. 103, 3, p. 353-357 5 p.

Research output: Contribution to journalArticle

Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer

Eshleman, J. R., Lang, E. Z., Bowerfind, G. K., Parsons, R., Vogelstein, B., Willson, J. K. V., Veigl, M. L., Sedwick, W. D. & Markowitz, S. D., Jan 1 1995, In : Oncogene. 10, 1, p. 33-37 5 p.

Research output: Contribution to journalArticle

Microsatellite instability in inherited and sporadic neoplasms

Eshleman, J. R. & Markowitz, S. D., Jan 1 1995, In : Current opinion in oncology. 7, 1, p. 83-89 7 p.

Research output: Contribution to journalReview article

1996

Diverse hypermutability of multiple expressed sequence motifs present in a cancer with microsatellite instability

Eshleman, J. R., Markowitz, S. D., Donover, P. S., Lang, E. Z., Lutterbaugh, J. D., Li, G. M., Longley, M., Modrich, P., Veigl, M. L. & Sedwick, W. D., May 13 1996, In : Oncogene. 12, 7, p. 1425-1432 8 p.

Research output: Contribution to journalArticle

Mismatch repair defects in human carcinogenesis

Eshleman, J. R. & Markowitz, S. D., Jan 1 1996, In : Human molecular genetics. 5, REVIEW, p. 1489-1494 6 p.

Research output: Contribution to journalShort survey

Open Access

Spontaneous apoptosis in human colon tumor cell lines and the relation of wt p53 to apoptosis

Chengya, W., Eshleman, J., Lutterbaugh, J., Willson, B. Y. J. & Markowitz, S., Dec 1 1996, In : Chinese medical journal. 109, 7, p. 537-541 5 p.

Research output: Contribution to journalArticle

Wild-type p53 protein potentiates cytotoxicity of therapeutic agents in human colon cancer cells

Yang, B., Eshleman, J. R., Berger, N. A. & Markowitz, S. D., Oct 1 1996, In : Clinical Cancer Research. 2, 10, p. 1649-1657 9 p.

Research output: Contribution to journalArticle

1998

Accumulated clonal genetic alterations in familial and sporadic colorectal carcinomas with widespread instability in microsatellite sequences

Fujiwara, T., Stolker, J. M., Watanabe, T., Rashid, A., Longo, P., Eshleman, J. R., Booker, S., Lynch, H. T., Jass, J. R., Green, J. S., Kim, H., Jen, J., Vogelstein, B. & Hamilton, S. R., Oct 1998, In : American Journal of Pathology. 153, 4, p. 1063-1078 16 p.

Research output: Contribution to journalArticle

A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer

Boland, C. R., Thibodeau, S. N., Hamilton, S. R., Sidransky, D., Eshleman, J. R., Burt, R. W., Meltzer, S. J., Rodriguez-Bigas, M. A., Fodde, R., Ranzani, G. N. & Srivastava, S., Nov 15 1998, In : Cancer Research. 58, 22, p. 5248-5257 10 p.

Research output: Contribution to journalArticle

Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53

Eshleman, J. R., Casey, G., Kochera, M. E., Sedwick, W. D., Swinler, S. E., Veigl, M. L., Willson, J. K. V., Schwartz, S. & Markowitz, S. D., Aug 13 1998, In : Oncogene. 17, 6, p. 719-725 7 p.

Research output: Contribution to journalArticle

Open Access

Increased transversions in a novel mutator colon cancer cell line

Eshleman, J. R., Donover, P. S., Littman, S. J., Swinler, S. E., Li, G. M., Lutterbaugh, J. D., Willson, J. K. V., Modrich, P., Sedwick, W. D., Markowitz, S. D. & Veigl, M. L., Mar 5 1998, In : Oncogene. 16, 9, p. 1125-1130 6 p.

Research output: Contribution to journalArticle

Open Access
1999

Leukemia arising out of paroxysmal nocturnal hemoglobinuria

Harris, J. W., Koscick, R., Lazarus, H. M., Eshleman, J. R. & Medof, M. E., Jan 1 1999, In : Leukemia and Lymphoma. 32, 5-6, p. 401-426 26 p.

Research output: Contribution to journalArticle

2000

Conversion of diploidy to haploidy

Yan, H., Papadopoulos, N., Marra, G., Perrera, C., Jiricny, J., Boland, C. R., Lynch, H. T., Chadwick, R. B., De La Chapelle, A., Berg, K., Eshleman, J. R., Yuan, W., Markowitz, S., Laken, S. J., Lengauer, C., Kinzler, K. W. & Vogelstein, B., Feb 17 2000, In : Nature. 403, 6771, p. 723-724 2 p.

Research output: Contribution to journalArticle

Cytotoxicity and mutagenicity of frameshift-inducing agent ICR191 in mismatch repair-deficient colon cancer cells

Chen, W. D., Eshleman, J. R., Aminoshariae, M. R., Ma, A. H., Veloso, N., Markowitz, S. D., Sedwick, W. D. & Veigl, M. L., Mar 15 2000, In : Journal of the National Cancer Institute. 92, 6, p. 480-485 6 p.

Research output: Contribution to journalArticle

Open Access

Detection of microsatellite instability by fluorescence multiplex polymerase chain reaction

Berg, K. D., Glaser, C. L., Thompson, R. E., Hamilton, S. R., Griffin, C. A. & Eshleman, J. R., Jan 1 2000, In : Journal of Molecular Diagnostics. 2, 1, p. 20-28 9 p.

Research output: Contribution to journalArticle

Pseudo-spikes are common in histologically benign lymphoid tissues

Lee, S. C., Berg, K. D., Racke, F. K., Griffin, C. A. & Eshleman, J. R., Aug 2000, In : Journal of Molecular Diagnostics. 2, 3, p. 145-152 8 p.

Research output: Contribution to journalArticle

Use of single nucleotide polymorphisms (SNP) and real-time polymerase chain reaction for bone marrow engraftment analysis

Oliver, D. H., Thompson, R. E., Griffin, C. A. & Eshleman, J. R., Nov 2000, In : Journal of Molecular Diagnostics. 2, 4, p. 202-208 7 p.

Research output: Contribution to journalArticle

2001

An early lesion in hepatic carcinogenesis: Loss of heterozygosity in human cirrhotic livers and dysplastic nodules at the 1p36-p34 region

Sun, M., Eshleman, J. R., Ferrell, L. D., Jacobs, G., Sudilovsky, E. C., Tuthill, R., Hussein, M. R. & Sudilovsky, O., Jan 1 2001, In : Hepatology. 33, 6, p. 1415-1424 10 p.

Research output: Contribution to journalArticle

Brief report: Transmission of a T-cell lymphoma by allogeneic bone marrow transplantation

Berg, K. D., Brinster, N. K., Huhn, K. M., Goggins, M. G., Jones, R. J., Makary, A., Murphy, K. M., Griffin, C. A., Rosenblum-Vos, L. S., Borowitz, M. J., Nousari, H. C. & Eshleman, J. R., Nov 15 2001, In : New England Journal of Medicine. 345, 20, p. 1458-1463 6 p.

Research output: Contribution to journalArticle

Glycophosphatidylinositol-anchored protein deficiency as a marker of Mutator phenotypes in cancer

Chen, R., Eshleman, J. R., Brodsky, R. A. & Medof, M. E., Jan 15 2001, In : Cancer Research. 61, 2, p. 654-658 5 p.

Research output: Contribution to journalArticle

Microsatellite instability is infrequent in medullary breast cancer

Lee, S. C., Berg, K. D., Sherman, M. E., Griffin, C. A. & Eshleman, J. R., Jan 1 2001, In : American journal of clinical pathology. 115, 6, p. 823-827 5 p.

Research output: Contribution to journalArticle

Open Access
2002

8-Hydroxyguanosine repair is defective in some microsatellite stable colorectal cancer cells

Parker, A. R., O'Meally, R. N., Oliver, D. H., Hua, L., Nelson, W. G., DeWeese, T. L. & Eshleman, J. R., Dec 15 2002, In : Cancer Research. 62, 24, p. 7230-7233 4 p.

Research output: Contribution to journalArticle

2003

A single nucleotide primer extension assay to detect the APC I1307K gene variant

Murphy, K. M., Geiger, T., Hafez, M. J., Eshleman, J. R., Griffin, C. A. & Berg, K. D., Nov 2003, In : Journal of Molecular Diagnostics. 5, 4, p. 222-226 5 p.

Research output: Contribution to journalArticle

Defective Human MutY Phosphorylation Exists in Colorectal Cancer Cell Lines with Wild-type MutY Alleles

Parker, A. R., O'Meally, R. N., Sahin, F., Su, G. H., Racke, F. K., Nelson, W. G., DeWeese, T. L. & Eshleman, J. R., Nov 28 2003, In : Journal of Biological Chemistry. 278, 48, p. 47937-47945 9 p.

Research output: Contribution to journalArticle

Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays

Iacobuzio-Donahue, C. A., Maitra, A., Olsen, M., Lowe, A. W., Van Heek, N. T., Rosty, C., Walter, K., Sato, N., Parker, A., Ashfaq, R., Jaffee, E., Ryu, B., Jones, J., Eshleman, J. R., Yeo, C. J., Cameron, J. L., Kern, S. E., Hruban, R. H., Brown, P. O. & Goggins, M., Apr 1 2003, In : American Journal of Pathology. 162, 4, p. 1151-1162 12 p.

Research output: Contribution to journalArticle

Human MutY: Gene structure, protein functions and interactions, and role in carcinogenesis

Parker, A. R. & Eshleman, J. R., Oct 1 2003, In : Cellular and Molecular Life Sciences. 60, 10, p. 2064-2083 20 p.

Research output: Contribution to journalReview article

Molecular diagnosis of oligodendroglioma in paraffin sections

Hatanpaa, K. J., Burger, P. C., Eshleman, J. R., Murphy, K. M. & Berg, K. D., Mar 1 2003, In : Laboratory Investigation. 83, 3, p. 419-428 10 p.

Research output: Contribution to journalArticle

Open Access

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

Berman, D. M., Karhadkar, S. S., Maitra, A., De Oca, R. M., Gerstenblith, M. R., Briggs, K., Parker, A. R., Shimada, Y., Eshleman, J. R., Watkins, D. N. & Beachy, P. A., Oct 23 2003, In : Nature. 425, 6960, p. 846-851 6 p.

Research output: Contribution to journalArticle

2004

A subgroup of microsatellite stable colorectal cancers has elevated mutation rates and different responses to alkylating and oxidising agents

Parker, A. R., Leonard, C. P., Hua, L., Francis, R. O., Dhara, S., Maitra, A. & Eshleman, J. R., Apr 19 2004, In : British journal of cancer. 90, 8, p. 1666-1671 6 p.

Research output: Contribution to journalArticle

LigAmp for sensitive detection of single-nucleotide differences

Shi, C., Eshleman, S. H., Jones, D., Fukushima, N., Hua, L., Parker, A. R., Yeo, C. J., Hruban, R. H., Goggins, M. G. & Eshleman, J. R., Nov 2004, In : Nature Methods. 1, 2, p. 141-147 7 p.

Research output: Contribution to journalArticle

2005

A novel functionally deficient MYH variant in individuals with colorectal adenomatous polyposis.

Alhopuro, P., Parker, A. R., Lehtonen, R., Enholm, S., Järvinen, H. J., Mecklin, J. P., Karhu, A., Eshleman, J. R. & Aaltonen, L. A., Oct 2005, In : Human mutation. 26, 4, 1 p.

Research output: Contribution to journalArticle

Capillary electrophoresis artifact due to eosin: Implications for the interpretation of molecular diagnostic assays

Murphy, K. M., Berg, K. D., Geiger, T., Hafez, M., Flickinger, K. A., Cooper, L., Pearson, P. & Eshleman, J. R., Feb 2005, In : Journal of Molecular Diagnostics. 7, 1, p. 143-148 6 p.

Research output: Contribution to journalArticle

Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair

Parker, A. R., Sieber, O. M., Shi, C., Hua, L., Takao, M., Tomlinson, I. P. & Eshleman, J. R., Nov 1 2005, In : Carcinogenesis. 26, 11, p. 2010-2018 9 p.

Research output: Contribution to journalArticle

Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma

Sato, N., Parker, A. R., Fukushima, N., Miyagi, Y., Iacobuzio-Donahue, C. A., Eshleman, J. R. & Goggins, M., Jan 27 2005, In : Oncogene. 24, 5, p. 850-858 9 p.

Research output: Contribution to journalArticle

Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita

Armanios, M., Chen, J. L., Chang, Y. P. C., Brodsky, R. A., Hawkins, A., Griffin, C. A., Eshleman, J. R., Cohen, A. R., Chakravarti, A., Hamosh, A. & Greider, C. W., Nov 1 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 44, p. 15960-15964 5 p.

Research output: Contribution to journalArticle

Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers

Karikari, C. A., Mullendore, M., Eshleman, J. R., Argani, P., Leoni, L. M., Chattopadhyay, S., Hidalgo, M. & Maitra, A., Dec 1 2005, In : Molecular cancer therapeutics. 4, 12, p. 1860-1866 7 p.

Research output: Contribution to journalArticle

Sensitive drug-resistance assays reveal long-term persistence of HIV-1 variants with the K103N nevirapine (NVP) resistance mutation in some women and infants after the administration of single-dose NVP: HIVNET 012

Flys, T., Nissley, D. V., Claasen, C. W., Jones, D., Shi, C., Guay, L. A., Musoke, P., Mmiro, F., Strathern, J. N., Jackson, J. B., Eshleman, J. R. & Eshleman, S. H., Jul 1 2005, In : Journal of Infectious Diseases. 192, 1, p. 24-29 6 p.

Research output: Contribution to journalArticle

Sequencing of genomic DNA by combined amplification and cycle sequencing reaction

Murphy, K. M., Berg, K. D. & Eshleman, J. R., Jan 1 2005, In : Clinical chemistry. 51, 1, p. 35-39 5 p.

Research output: Contribution to journalArticle

Xenografting and harvesting human ductal pancreatic adenocarcinomas for DNA analysis.

Walter, K., Eshleman, J. & Goggins, M., 2005, In : Methods in Molecular Medicine. 103, p. 103-111 9 p.

Research output: Contribution to journalArticle

2006

An in vivo platform for translational drug development in pancreatic cancer

Rubio-Viqueira, B., Jimeno, A., Cusatis, G., Zhang, X., Iacobuzio-Donahue, C., Karikari, C., Shi, C., Danenberg, K., Danenberg, P. V., Kuramochi, H., Tanaka, K., Singh, S., Salimi-Moosavi, H., Bouraoud, N., Amador, M. L., Altiok, S., Kulesza, P., Yeo, C., Messersmith, W., Eshleman, J. & 3 others, Hruban, R. H., Maitra, A. & Hidalgo, M., Aug 1 2006, In : Clinical Cancer Research. 12, 15, p. 4652-4661 10 p.

Research output: Contribution to journalArticle

Comparison of the microsatellite instability analysis system and the Bethesda panel for the determination of microsatellite instability in colorectal cancers

Murphy, K. M., Zhang, S., Geiger, T., Hafez, M. J., Bacher, J., Berg, K. D. & Eshleman, J. R., Jul 2006, In : Journal of Molecular Diagnostics. 8, 3, p. 305-311 7 p.

Research output: Contribution to journalArticle