James Barrow

Associate Professor

19942018
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Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

T-Type Calcium Channels Medicine & Life Sciences
Calcium Channel Blockers Medicine & Life Sciences
Thrombin Medicine & Life Sciences
Pharmacokinetics Chemical Compounds
Assays Chemical Compounds
Catechol O-Methyltransferase Medicine & Life Sciences
Amides Medicine & Life Sciences
Rats Chemical Compounds

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Research Output 1994 2018

Novel inhibitors of As(III) S-adenosylmethionine methyltransferase (AS3MT) identified by virtual screening

Bürli, R. W., Wei, H., Ernst, G., Mariga, A., Hardern, I. M., Herlihy, K., Cross, A. J., Wesolowski, S. S., Chen, H., McKay, R. D. G., Weinberger, D., Brandon, N. J. & Barrow, J., Oct 15 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 19, p. 3231-3235 5 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Methyltransferases
Screening
Enzyme Assays
Scaffolds

Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase

Buchler, I., Akuma, D., Au, V., Carr, G., De León, P., Depasquale, M., Ernst, G., Huang, Y., Kimos, M., Kolobova, A., Poslusney, M., Wei, H., Swinnen, D., Montel, F., Moureau, F., Jigorel, E., Schulze, M. S. E. D., Wood, M. & Barrow, J., Nov 8 2018, In : Journal of medicinal chemistry. 61, 21, p. 9647-9665 19 p.

Research output: Contribution to journalArticle

Oxyquinoline
Dopamine
Catalytic Domain
Quinolines
Catechol O-Methyltransferase

Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity

Wormald, M., Liao, G., Kimos, M., Barrow, J. & Wei, H., Nov 1 2017, In : PLoS One. 12, 11, e0188852.

Research output: Contribution to journalArticle

Assays
phosphotransferases (kinases)
Throughput
Inositol
assays

Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis

Zhu, Q., Ghoshal, S., Rodrigues, A., Gao, S., Asterian, A., Kamenecka, T. M., Barrow, J. & Chakraborty, A., Nov 1 2016, In : Journal of Clinical Investigation. 126, 11, p. 4273-4288 16 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Thermogenesis
Adipocytes
Energy Metabolism
Obesity

Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function

Scherer, P. C., Ding, Y., Liu, Z., Xu, J., Mao, H., Barrow, J., Wei, N., Zheng, N., Snyder, S. H. & Rao, F., Mar 29 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 13, p. 3503-3508 6 p.

Research output: Contribution to journalArticle

Cullin Proteins
Phytic Acid
Ubiquitin-Protein Ligases
Polyphosphates
Ubiquitination