James Barrow

Associate Professor

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T-Type Calcium Channels Medicine & Life Sciences
Calcium Channel Blockers Medicine & Life Sciences
Assays Chemical Compounds
Thrombin Medicine & Life Sciences
Pharmacokinetics Chemical Compounds
Catechol O-Methyltransferase Medicine & Life Sciences
Rats Chemical Compounds
Drug Discovery Medicine & Life Sciences

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Research Output 1994 2019

A Medicinal Chemist's Perspective on Transitioning from Industry to Academic Drug Discovery

Barrow, J., May 9 2019, In : ACS Medicinal Chemistry Letters. 10, 5, p. 687-689 3 p.

Research output: Contribution to journalReview article

Translational Medical Research
Drug Industry
Drug Discovery
Pharmaceutical Preparations

Synthesis and characterization of novel isoform-selective IP6K1 inhibitors

Wormald, M. M., Ernst, G., Wei, H. & Barrow, J., Oct 1 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 19, 126628.

Research output: Contribution to journalArticle

Protein Isoforms
Lead compounds

Novel inhibitors of As(III) S-adenosylmethionine methyltransferase (AS3MT) identified by virtual screening

Bürli, R. W., Wei, H., Ernst, G., Mariga, A., Hardern, I. M., Herlihy, K., Cross, A. J., Wesolowski, S. S., Chen, H., McKay, R. D. G., Weinberger, D., Brandon, N. J. & Barrow, J., Oct 15 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 19, p. 3231-3235 5 p.

Research output: Contribution to journalArticle

Enzyme Assays

Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase

Buchler, I., Akuma, D., Au, V., Carr, G., De León, P., Depasquale, M., Ernst, G., Huang, Y., Kimos, M., Kolobova, A., Poslusney, M., Wei, H., Swinnen, D., Montel, F., Moureau, F., Jigorel, E., Schulze, M. S. E. D., Wood, M. & Barrow, J., Nov 8 2018, In : Journal of Medicinal Chemistry. 61, 21, p. 9647-9665 19 p.

Research output: Contribution to journalArticle

Catalytic Domain
Catechol O-Methyltransferase

Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity

Wormald, M., Liao, G., Kimos, M., Barrow, J. & Wei, H., Nov 1 2017, In : PLoS One. 12, 11, e0188852.

Research output: Contribution to journalArticle

phosphotransferases (kinases)