James Barrow

Associate Professor

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T-Type Calcium Channels Medicine & Life Sciences
Calcium Channel Blockers Medicine & Life Sciences
Catechol O-Methyltransferase Medicine & Life Sciences
Assays Chemical Compounds
Pharmacokinetics Chemical Compounds
Thrombin Medicine & Life Sciences
Rats Chemical Compounds
Ligands Medicine & Life Sciences

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Research Output 1994 2019

A Medicinal Chemist's Perspective on Transitioning from Industry to Academic Drug Discovery

Barrow, J., May 9 2019, In : ACS Medicinal Chemistry Letters. 10, 5, p. 687-689 3 p.

Research output: Contribution to journalReview article

Translational Medical Research
Drug Industry
Drug Discovery
Pharmaceutical Preparations

Development of a PC12 Cell Based Assay for Screening Catechol- O-methyltransferase Inhibitors

Zhang, G., Buchler, I. P., Depasquale, M., Wormald, M., Liao, G., Wei, H., Barrow, J. & Carr, G., Oct 16 2019, In : ACS Chemical Neuroscience. 10, 10, p. 4221-4226 6 p.

Research output: Contribution to journalArticle

PC12 Cells
Catechol O-Methyltransferase

Synthesis and characterization of novel isoform-selective IP6K1 inhibitors

Wormald, M. M., Ernst, G., Wei, H. & Barrow, J., Oct 1 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 19, 126628.

Research output: Contribution to journalArticle

Protein Isoforms
Lead compounds

Synthesis and Evaluation of Bicyclic Hydroxypyridones as Inhibitors of Catechol O-Methyltransferase

Ernst, G., Akuma, D., Au, V., Buchler, I. P., Byers, S., Carr, G. V., Defays, S., De León, P., Demaude, T., Depasquale, M., Durieu, V., Huang, Y., Jigorel, E., Kimos, M., Kolobova, A., Montel, F., Moureau, F., Poslusney, M., Swinnen, D., Vandergeten, M. C. & 5 others, Van Houtvin, N., Wei, H., White, N., Wood, M. & Barrow, J. C., Jan 1 2019, (Accepted/In press) In : ACS Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

Catechol O-Methyltransferase

Novel inhibitors of As(III) S-adenosylmethionine methyltransferase (AS3MT) identified by virtual screening

Bürli, R. W., Wei, H., Ernst, G., Mariga, A., Hardern, I. M., Herlihy, K., Cross, A. J., Wesolowski, S. S., Chen, H., McKay, R. D. G., Weinberger, D., Brandon, N. J. & Barrow, J., Oct 15 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 19, p. 3231-3235 5 p.

Research output: Contribution to journalArticle

Enzyme Assays