James Barrow

Associate Professor

19942019
If you made any changes in Pure, your changes will be visible here soon.

Fingerprint Dive into the research topics where James Barrow is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

T-Type Calcium Channels Medicine & Life Sciences
Calcium Channel Blockers Medicine & Life Sciences
Assays Chemical Compounds
Thrombin Medicine & Life Sciences
Pharmacokinetics Chemical Compounds
Catechol O-Methyltransferase Medicine & Life Sciences
Rats Chemical Compounds
Drug Discovery Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1994 2019

A Medicinal Chemist's Perspective on Transitioning from Industry to Academic Drug Discovery

Barrow, J., May 9 2019, In : ACS Medicinal Chemistry Letters. 10, 5, p. 687-689 3 p.

Research output: Contribution to journalReview article

Translational Medical Research
Drug Industry
Drug Discovery
Industry
Pharmaceutical Preparations

Synthesis and characterization of novel isoform-selective IP6K1 inhibitors

Wormald, M. M., Ernst, G., Wei, H. & Barrow, J., Oct 1 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 19, 126628.

Research output: Contribution to journalArticle

Protein Isoforms
Solubility
Lead compounds
Phenotype
Physiology

Novel inhibitors of As(III) S-adenosylmethionine methyltransferase (AS3MT) identified by virtual screening

Bürli, R. W., Wei, H., Ernst, G., Mariga, A., Hardern, I. M., Herlihy, K., Cross, A. J., Wesolowski, S. S., Chen, H., McKay, R. D. G., Weinberger, D., Brandon, N. J. & Barrow, J., Oct 15 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 19, p. 3231-3235 5 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Methyltransferases
Screening
Enzyme Assays
Scaffolds

Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase

Buchler, I., Akuma, D., Au, V., Carr, G., De León, P., Depasquale, M., Ernst, G., Huang, Y., Kimos, M., Kolobova, A., Poslusney, M., Wei, H., Swinnen, D., Montel, F., Moureau, F., Jigorel, E., Schulze, M. S. E. D., Wood, M. & Barrow, J., Nov 8 2018, In : Journal of Medicinal Chemistry. 61, 21, p. 9647-9665 19 p.

Research output: Contribution to journalArticle

Oxyquinoline
Dopamine
Catalytic Domain
Quinolines
Catechol O-Methyltransferase

Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity

Wormald, M., Liao, G., Kimos, M., Barrow, J. & Wei, H., Nov 1 2017, In : PLoS One. 12, 11, e0188852.

Research output: Contribution to journalArticle

Assays
phosphotransferases (kinases)
Throughput
Inositol
assays