1971 …2019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1971 2019

2019

Abdominal Pain in Patients with Gastroparesis: Associations with Gastroparesis Symptoms, Etiology of Gastroparesis, Gastric Emptying, Somatization, and Quality of Life

Parkman, H. P., Wilson, L., Hasler, W. L., McCallum, R. W., Sarosiek, I., Koch, K. L., Abell, T. L., Schey, R., Kuo, B., Snape, W. J., Nguyen, L., Farrugia, G., Grover, M., Clarke, J., Miriel, L., Tonascia, J. A., Hamilton, F. & Pasricha, P. J., Jan 1 2019, In : Digestive Diseases and Sciences.

Research output: Contribution to journalArticle

Gastroparesis
Gastric Emptying
Abdominal Pain
Quality of Life
Opiate Alkaloids

Association of Histologic Disease Activity With Progression of Nonalcoholic Fatty Liver Disease

Nonalcoholic Steatohepatitis Clinical Research Network, Oct 2 2019, In : JAMA Network Open. 2, 10, p. e1912565

Research output: Contribution to journalArticle

Open Access
Aspartate Aminotransferases
Fibrosis
Odds Ratio
Aspartic Acid
Fatty Liver
Chronic Obstructive Pulmonary Disease
Oxygen
Odds Ratio
Confidence Intervals
Therapeutics

Delayed Gastric Emptying Associates With Diabetic Complications in Diabetic Patients With Symptoms of Gastroparesis

NIDDK Gastroparesis Clinical Research Consortium (GpCRC), Nov 1 2019, In : The American Journal of Gastroenterology. 114, 11, p. 1778-1794 17 p.

Research output: Contribution to journalArticle

Gastroparesis
Gastric Emptying
Diabetes Complications
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus

Diagnostic Accuracy of Noninvasive Fibrosis Models to Detect Change in Fibrosis Stage

NASH CLINICAL RESEARCH NETWORK, Jan 1 2019, In : Clinical Gastroenterology and Hepatology.

Research output: Contribution to journalArticle

Fibrosis
Blood Platelets
Aspartate Aminotransferases
Biopsy
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)

Effectiveness of gastric electrical stimulation in gastroparesis: Results from a large prospectively collected database of national gastroparesis registries

Abell, T. L., Yamada, G., McCallum, R. W., Van Natta, M. L., Tonascia, J., Parkman, H. P., Koch, K. L., Sarosiek, I., Farrugia, G., Grover, M., Hasler, W., Nguyen, L., Snape, W., Kuo, B., Shulman, R., Hamilton, F. A. & Pasricha, P. J., Jan 1 2019, (Accepted/In press) In : Neurogastroenterology and Motility. e13714.

Research output: Contribution to journalArticle

Gastroparesis
Electric Stimulation
Registries
Stomach
Databases

Ethnic, Racial, and Sex Differences in Etiology, Symptoms, Treatment, and Symptom Outcomes of Patients With Gastroparesis

Parkman, H. P., Yamada, G., Van Natta, M. L., Yates, K., Hasler, W. L., Sarosiek, I., Grover, M., Schey, R., Abell, T. L., Koch, K. L., Kuo, B., Clarke, J., Farrugia, G., Nguyen, L., Snape, W. J., Miriel, L., Tonascia, J., Hamilton, F., Pasricha, P. J. & McCallum, R. W., Jan 1 2019, In : Clinical Gastroenterology and Hepatology.

Research output: Contribution to journalArticle

Gastroparesis
Sex Characteristics
Hispanic Americans
Stomach
Nausea

Frailty and clinical outcomes in chronic obstructive pulmonary disease

NETT Research Group, Feb 1 2019, In : Annals of the American Thoracic Society. 16, 2, p. 217-224 8 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Confidence Intervals
Emphysema
Forced Expiratory Volume
Phenotype

Histologic Findings of Advanced Fibrosis and Cirrhosis in Patients With Nonalcoholic Fatty Liver Disease Who Have Normal Aminotransferase Levels

and the NASH Clinical Research Network, Oct 1 2019, In : The American Journal of Gastroenterology. 114, 10, p. 1626-1635 10 p.

Research output: Contribution to journalArticle

Transaminases
Fibrosis
Aspartate Aminotransferases
Alanine Transaminase
Histology

Impact of obeticholic acid on the lipoprotein profile in patients with non-alcoholic steatohepatitis

for the NASH CRN, Jan 1 2019, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

Open Access
Fatty Liver
Lipoproteins
LDL Lipoproteins
VLDL Lipoproteins
Placebos

Marijuana Use in Patients with Symptoms of Gastroparesis: Prevalence, Patient Characteristics, and Perceived Benefit

Frank A. Hamilton for the NIH Gastroparesis Consortium, Jan 1 2019, (Accepted/In press) In : Digestive Diseases and Sciences.

Research output: Contribution to journalArticle

Gastroparesis
Cannabis
Gastric Emptying
Nausea
Abdominal Pain
Gastroparesis
Opioid Analgesics
Quality of Life
Abdominal Pain
Gastric Emptying

Patient safety outcomes under flexible and standard resident duty-hour rules

iCOMPARE Research Group, Mar 7 2019, In : New England Journal of Medicine. 380, 10, p. 905-914 10 p.

Research output: Contribution to journalArticle

Patient Safety
Mortality
Internship and Residency
Medicare
Length of Stay

Patient Safety under Flexible and Standard Duty-Hour Rules. Reply

Silber, J. H., Tonascia, J. A. & Asch, D. A., Jun 13 2019, In : The New England journal of medicine. 380, 24, 1 p.

Research output: Contribution to journalLetter

Personnel Staffing and Scheduling
Patient Safety
Workload

Penicillin Allergy Evaluation: A Prospective, Multicenter, Open-Label Evaluation of a Comprehensive Penicillin Skin Test Kit

Solensky, R., Jacobs, J., Lester, M., Lieberman, P., McCafferty, F., Nilsson, T., Park, M., Schwarz, G., Soong, W., Wagelie-Steffen, A., Wedner, H. J., Weiss, M., Windom, H., Tonascia, J. A., Yates, K., Mendelson, L. M., Wolfe, J. & Adkinson, N. F., Jan 1 2019, In : Journal of Allergy and Clinical Immunology: In Practice.

Research output: Contribution to journalArticle

Skin Tests
Penicillins
Hypersensitivity
Amoxicillin
Skin

Proteomics in gastroparesis: unique and overlapping protein signatures in diabetic and idiopathic gastroparesis

Grover, M., Dasari, S., Bernard, C. E., Chikkamenahalli, L. L., Yates, K. P., Pasricha, P. J., Sarosiek, I., McCallum, R., Koch, K. L., Abell, T. L., Kuo, B., Shulman, R. J., Gibbons, S. J., McKenzie, T. J., Kellogg, T. A., Kendrick, M. L., Tonascia, J., Hamilton, F. A., Parkman, H. P. & Farrugia, G., Nov 1 2019, In : American journal of physiology. Gastrointestinal and liver physiology. 317, 5, p. G716-G726

Research output: Contribution to journalArticle

Open Access
Gastroparesis
Proteomics
Proteins
Gastric Emptying
Macrophages

Recruitment of trial participants through electronic medical record patient portal messaging: A pilot study

Plante, T. B., Gleason, K. T., Miller, H. N., Charleston, J., McArthur, K., Himmelfarb, C. D., Lazo, M., Ford, D. E., Miller, E. R., Appel, L. J., Juraschek, S. P., Cronin, N., McClure, S., Miskimon, J., Mitchell, C. M., Kalyani, R. R., Roth, D. L., Schrack, J. A., Szanton, S. L., Urbanek, J. & 73 others, Walston, J., Wanigatunga, A., Baksh, S. N., Blackford, A. L., Chattopadhyay, S., Drye, L. T., Dodge, J., Ewing, C., Haider, S., Holland, S. C., Jackson, R., Lears, A., Meinert, C., Shade, D., Smith, M., Sternberg, A. L., Tonascia, J., Van Natta, M. L., Wagoner, A., Comstock, G. W., Michos, E. D., Bennett, J. D., Bowers, P., Coresh, J., Crowley, P., Crunkleton, T., Dick, B., Evans, R., Godwin, M., Hammann, L., Hawks, D., Horning, K., Hull, E., Mills, B., Minotti, M., Raley, L., Reed, A., Reeder, R., Reid, C., Shuda, M., Spikes, A., Stouffer, R., Weicht, K., Abbas, C., Carey, B., Davis, S., DeRoche-Brown, N., Gayles, D., Holland, S., Glenn-Smith, I., Johnson, D., Johnson, M., Keyes, E., Santiago, D., Sapun, C., Sneed, V., Swartz, L., Thomas, L., Christenson, R. H., Duh, S. H., Rebuck, H., Rosen, C., Cook, T., Duncan, P., Hansen, K., Kenny, A., Shapses, S., Hannah, J., Romashkan, S., Davis, C. D., Sempos, C. T., Guralnik, J. M. & Gallagher, J. C., Jan 1 2019, (Accepted/In press) In : Clinical Trials.

Research output: Contribution to journalArticle

Electronic Health Records
Vitamin D
Patient Selection
Clinical Trials
Research Ethics Committees

Relationship between resolution of non-alcoholic steatohepatitis and changes in lipoprotein sub-fractions: a post-hoc analysis of the PIVENS trial

the NASH Clinical Research Network, May 1 2019, In : Alimentary Pharmacology and Therapeutics. 49, 9, p. 1205-1213 9 p.

Research output: Contribution to journalArticle

Fatty Liver
Lipoproteins
pioglitazone
E-Selectin
Vitamin E

Satiety testing in diabetic gastroparesis: Effects of insulin pump therapy with continuous glucose monitoring on upper gastrointestinal symptoms and gastric myoelectrical activity

the NIDDK Gastroparesis Clinical Research Consortium, Jan 1 2019, (Accepted/In press) In : Neurogastroenterology and Motility. e13720.

Research output: Contribution to journalArticle

Gastroparesis
Meals
Stomach
Insulin
Glucose

Sleep and alertness in a duty-hour flexibility trial in internal medicine

iCOMPARE Research Group, Mar 7 2019, In : New England Journal of Medicine. 380, 10, p. 915-923 9 p.

Research output: Contribution to journalArticle

Internal Medicine
Sleep
Confidence Intervals
Actigraphy
Sleep Deprivation

Vibration-Controlled Transient Elastography to Assess Fibrosis and Steatosis in Patients With Nonalcoholic Fatty Liver Disease

NASH CLINICAL RESEARCH NETWORK, Jan 1 2019, In : Clinical Gastroenterology and Hepatology. 17, 1, p. 156-163.e2

Research output: Contribution to journalArticle

Elasticity Imaging Techniques
Vibration
Fibrosis
Liver
ROC Curve
2018

Aprepitant Has Mixed Effects on Nausea and Reduces Other Symptoms in Patients With Gastroparesis and Related Disorders

for the, NIDDK Gastroparesis Clinical Research Consortium (GpCRC) & NIDDK Gastroparesis Clinical Research Consortium (GpCRC), Jan 1 2018, In : Gastroenterology. 154, 1, p. 65-76.e11

Research output: Contribution to journalArticle

aprepitant
Gastroparesis
Nausea
Vomiting
Visual Analog Scale

Clinical and metabolic effects associated with weight changes and obeticholic acid in non-alcoholic steatohepatitis

for the NASH CRN, Mar 1 2018, In : Alimentary Pharmacology and Therapeutics. 47, 5, p. 645-656 12 p.

Research output: Contribution to journalArticle

Fatty Liver
Weight Loss
Weights and Measures
Placebos
Histology

Clinical differences in COPD patients with variable patterns of hypoxemia

For the Long-Term Oxygen Treatment Trial Research Group, Jan 1 2018, In : Chronic Obstructive Pulmonary Diseases. 5, 3, p. 167-178 12 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Oxygen
Hypoxia
Oximetry
Body Mass Index

Clinically Actionable Hypercholesterolemia and Hypertriglyceridemia in Children with Nonalcoholic Fatty Liver Disease

Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), Jan 1 2018, (Accepted/In press) In : Journal of Pediatrics.

Research output: Contribution to journalArticle

Hypertriglyceridemia
Hypercholesterolemia
Lipids
Dyslipidemias
LDL Cholesterol

Developing a risk-based composite neurologic outcome for a trial of hydroxyurea in young children with sickle cell disease

Casella, J. F., Adams, R. J., Brambilla, D. J., Strouse, J., Maier, P., Dlugash, R., Avadhani, R., Vermillion, K., Tonascia, J. A., Voeks, J. H., Hanley, D. F., Thompson, R. & Lehmann, H. P., Jan 1 2018, (Accepted/In press) In : Clinical Trials.

Research output: Contribution to journalArticle

Hydroxyurea
Sickle Cell Anemia
Nervous System
Stroke
Research Personnel
Patient Safety
Internal Medicine
Clinical Protocols
Research Ethics Committees
Medicare

Diagnostic accuracy of magnetic resonance imaging hepatic proton density fat fraction in pediatric nonalcoholic fatty liver disease

for the NASH Clinical Research Network, Mar 1 2018, In : Hepatology. 67, 3, p. 858-872 15 p.

Research output: Contribution to journalArticle

Protons
Fats
Magnetic Resonance Imaging
Pediatrics
Liver

Education outcomes in a duty-hour flexibility trial in internal medicine

iCOMPARE Research Group, Apr 19 2018, In : New England Journal of Medicine. 378, 16, p. 1494-1508 15 p.

Research output: Contribution to journalArticle

Internal Medicine
Confidence Intervals
Education
Odds Ratio
Patient Education

Effects of deep brain stimulation on rest tremor progression in early stage Parkinson disease

Hacker, M. L., DeLong, M. R., Turchan, M., Heusinkveld, L. E., Ostrem, J. L., Molinari, A. L., Currie, A. D., Konrad, P. E., Davis, T. L., Phibbs, F. T., Hedera, P., Cannard, K. R., Drye, L. T., Sternberg, A. L., Shade, D., Tonascia, J. A. & Charles, D., Jul 31 2018, In : Neurology. 91, 5, p. e463-e471

Research output: Contribution to journalArticle

Deep Brain Stimulation
Tremor
Parkinson Disease
Drug Therapy
Dyskinesias

Glucose sensor-augmented continuous subcutaneous insulin infusion in patients with diabetic gastroparesis: An open-label pilot prospective study

Calles-Escandón, J., Koch, K. L., Hasler, W. L., Van Natta, M. L., Pasricha, P. J., Tonascia, J. A., Parkman, H. P., Hamilton, F., Herman, W. H., Basina, M., Buckingham, B., Earle, K., Kirkeby, K., Hairston, K., Bright, T., Rothberg, A. E., Kraftson, A. T., Siraj, E. S., Subauste, A., Lee, L. A. & 9 others, Abell, T. L., McCallum, R. W., Sarosiek, I., Nguyen, L., Fass, R., Snape, W. J., Vaughn, I. A., Miriel, L. A. & Farrugia, G., Apr 1 2018, In : PLoS One. 13, 4, e0194759.

Research output: Contribution to journalArticle

Gastroparesis
Glucose sensors
Subcutaneous Infusions
prospective studies
Labels

Haptoglobin 2 Allele is Associated With Histologic Response to Vitamin E in Subjects With Nonalcoholic Steatohepatitis

for the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), Jan 1 2018, (Accepted/In press) In : Journal of Clinical Gastroenterology.

Research output: Contribution to journalArticle

Haptoglobins
Vitamin E
Alleles
Genotype
Placebos

Hepatic R2* is more strongly associated with proton density fat fraction than histologic liver iron scores in patients with nonalcoholic fatty liver disease

on behalf of the NASH Clinical Research Network (NASH CRN), Jan 1 2018, (Accepted/In press) In : Journal of Magnetic Resonance Imaging.

Research output: Contribution to journalArticle

Protons
Iron
Fats
Liver
Non-alcoholic Fatty Liver Disease

Intragastric meal distribution during gastric emptying scintigraphy for assessment of fundic accommodation: Correlation with symptoms of gastroparesis

NIH Gastroparesis Consortium, Apr 1 2018, In : Journal of Nuclear Medicine. 59, 4, p. 691-697 7 p.

Research output: Contribution to journalArticle

Gastroparesis
Gastric Emptying
Radionuclide Imaging
Meals
Stomach

Islet cell associated autoantibodies and C-peptide levels in patients with diabetes and symptoms of gastroparesis

Siraj, E. S., Homko, C., Wilson, L., May, P., Rao, A. D., Calles, J., Farrugia, G., Hasler, W. L., Koch, K. L., Nguyen, L., Snape, W. J., Abell, T. L., Sarosiek, I., McCallum, R. W., Pasricha, P. J., Clarke, J., Tonascia, J. A., Hamilton, F. & Parkman, H. P., Feb 13 2018, In : Frontiers in Endocrinology. 9, FEB, 32.

Research output: Contribution to journalArticle

Gastroparesis
C-Peptide
Islets of Langerhans
Glutamate Decarboxylase
Autoantibodies

Performance characteristics of vibration-controlled transient elastography for evaluation of nonalcoholic fatty liver disease

for the NASH Clinical Research Network, Jan 1 2018, In : Hepatology. 67, 1, p. 134-144 11 p.

Research output: Contribution to journalArticle

Elasticity Imaging Techniques
Vibration
Liver
Reading
Touch

Racial differences in completion of the living kidney donor evaluation process

Kumar, K., Tonascia, J. A., Muzaale, A., Purnell, T., Ottmann, S., Al Ammary, F., Bowring, M. G., Poon, A., King, E., Massie, A. B., Chow, E. K. H., Thomas, A. G., Ying, H., Borja, M., Konel, J. M., Henderson, M., Cameron, A. M., Garonzik, J. & Segev, D., Jul 1 2018, In : Clinical Transplantation. 32, 7, e13291.

Research output: Contribution to journalArticle

Living Donors
Kidney
African Americans
Kidney Transplantation
Referral and Consultation
Cholecalciferol
Vitamin D
Randomized Controlled Trials
Outcome Assessment (Health Care)
Accelerometry

The long-term oxygen treatment trial for chronic obstructive pulmonary disease: Rationale, design, and lessons learned

for the LOTT Research Group, Jan 1 2018, In : Annals of the American Thoracic Society. 15, 1, p. 89-101 13 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Oxygen
Sample Size
Research Personnel
Therapeutics

Transcriptomic signatures reveal immune dysregulation in human diabetic and idiopathic gastroparesis

Grover, M., Gibbons, S. J., Nair, A. A., Bernard, C. E., Zubair, A. S., Eisenman, S. T., Wilson, L., Miriel, L., Pasricha, P. J., Parkman, H. P., Sarosiek, I., McCallum, R. W., Koch, K. L., Abell, T. L., Snape, W. J., Kuo, B., Shulman, R. J., McKenzie, T. J., Kellogg, T. A., Kendrick, M. L. & 3 others, Tonascia, J. A., Hamilton, F. A. & Farrugia, G., Aug 7 2018, In : BMC Medical Genomics. 11, 1, 62.

Research output: Contribution to journalArticle

Gastroparesis
Genes
Macrophages
Transendothelial and Transepithelial Migration
Interleukin-17
2017

Genome-Wide Associations Related to Hepatic Histology in Nonalcoholic Fatty Liver Disease in Hispanic Boys

Wattacheril, J., Lavine, J. E., Chalasani, N. P., Guo, X., Kwon, S., Schwimmer, J., Molleston, J. P., Loomba, R., Brunt, E. M., Chen, Y. D. I., Goodarzi, M. O., Taylor, K. D., Yates, K., Tonascia, J. A. & Rotter, J. I., 2017, (Accepted/In press) In : Journal of Pediatrics.

Research output: Contribution to journalArticle

Hispanic Americans
Histology
Genome
Liver
Single Nucleotide Polymorphism

Persistent regional and racial disparities in nondirected living kidney donation

Kumar, K., Holscher, C. M., Luo, X., Garonzik, J., Anjum, S., King, E., Massie, A. B., Tonascia, J. A., Purnell, T. & Segev, D., 2017, (Accepted/In press) In : Clinical Transplantation.

Research output: Contribution to journalArticle

Living Donors
Kidney
Transplants
African Americans
Cluster Analysis

Relating gastric scintigraphy and symptoms to motility capsule transit and pressure findings in suspected gastroparesis

Hasler, W. L., May, K. P., Wilson, L., Van Natta, M. L., Parkman, H. P., Pasricha, P. J., Koch, K. L., Abell, T. L., Mccallum, R. W., Nguyen, L. A., Snape, W. J., Sarosiek, I., Clarke, J. O., Farrugia, G., Calles-Escandon, J., Grover, M., Tonascia, J. A., Lee, L. A., Miriel, L. & Yates, K., 2017, (Accepted/In press) In : Neurogastroenterology and Motility.

Research output: Contribution to journalArticle

Gastroparesis
Radionuclide Imaging
Gastric Emptying
Capsules
Stomach

Repeat polymorphisms in the Homo sapiens heme oxygenase-1 gene in diabetic and idiopathic gastroparesis

Gibbons, S. J., Grover, M., Choi, K. M., Wadhwa, A., Zubair, A., Wilson, L., Wu, Y., Abell, T. L., Hasler, W. L., Koch, K. L., McCallum, R. W., Nguyen, L. A. B., Parkman, H. P., Sarosiek, I., Snape, W. J., Tonascia, J. A., Hamilton, F. A., Pasricha, P. J. & Farrugia, G., Nov 1 2017, In : PLoS One. 12, 11, e0187772.

Research output: Contribution to journalArticle

heme oxygenase (biliverdin-producing)
Gastroparesis
Heme Oxygenase-1
Polymorphism
Genes
HMGB1 Protein
fatty liver
Liver
pioglitazone
Serum
2016

A randomized trial of long-term oxygen for COPD with moderate desaturation

The Long-Term Oxygen Treatment Trial Research Group, Oct 27 2016, In : New England Journal of Medicine. 375, 17, p. 1617-1627 11 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Oxygen
Hospitalization
Exercise
Confidence Intervals

Baseline features and differences in 48 week clinical outcomes in patients with gastroparesis and type 1 vs type 2 diabetes

the NIDDK Gastroparesis Clinical Research Consortium (GpCRC), 2016, (Accepted/In press) In : Neurogastroenterology and Motility.

Research output: Contribution to journalArticle

Gastroparesis
Type 2 Diabetes Mellitus
Hemoglobins
Gastric Emptying
Peripheral Nervous System Diseases

Diabetic and idiopathic gastroparesis is associated with loss of CD206-positive macrophages in the gastric antrum

Grover, M., Bernard, C. E., Pasricha, P. J., Parkman, H. P., Gibbons, S. J., Tonascia, J. A., Koch, K. L., Mccallum, R. W., Sarosiek, I., Hasler, W. L., Nguyen, L. A. B., Abell, T. L., Snape, W. J., Kendrick, M. L., Kellogg, T. A., Mckenzie, T. J., Hamilton, F. A. & Farrugia, G., 2016, (Accepted/In press) In : Neurogastroenterology and Motility.

Research output: Contribution to journalArticle

Gastroparesis
Pyloric Antrum
Interstitial Cells of Cajal
Macrophages
Anti-Inflammatory Agents

Early satiety and postprandial fullness in gastroparesis correlate with gastroparesis severity, gastric emptying, and water load testing

Parkman, H. P., Hallinan, E. K., Hasler, W. L., Farrugia, G., Koch, K. L., Nguyen, L., Snape, W. J., Abell, T. L., Mccallum, R. W., Sarosiek, I., Pasricha, P. J., Clarke, J., Miriel, L., Tonascia, J. A. & Hamilton, F., 2016, (Accepted/In press) In : Neurogastroenterology and Motility.

Research output: Contribution to journalArticle

Gastroparesis
Gastric Emptying
Water
Quality of Life
Body Weight

End Points Must Be Clinically Meaningful for Drug Development in Nonalcoholic Fatty Liver Disease

Sanyal, A. J., Neuschwander-Tetri, B. A. & Tonascia, J. A., Jan 1 2016, In : Gastroenterology. 150, 1, p. 11-13 3 p.

Research output: Contribution to journalArticle

Severity of Illness Index
Investigational Drugs
Needs Assessment
Needle Biopsy
Drug Discovery