Ivan M Borrello

Associate Professor

1988 …2019

Research output per year

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Research Output

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2011

Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model

Meyera, C., Sevko, A., Ramacher, M., Bazhin, A. V., Falk, C. S., Osena, W., Borrello, I., Kato, M., Schadendorf, D., Baniyash, M. & Umanskya, V., Oct 11 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 41, p. 17111-17116 6 p.

Research output: Contribution to journalArticle

2010

A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma

Noonan, K., Marchionni, L., Anderson, J., Pardoll, D., Roodman, G. D. & Borrello, I., Nov 4 2010, In : Blood. 116, 18, p. 3554-3563 10 p.

Research output: Contribution to journalArticle

High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease

Luznik, L., Bolaños-Meade, J., Zahurak, M., Chen, A. R., Smith, B. D., Brodsky, R., Huff, C. A., Borrello, I., Matsui, W., Powell, J. D., Kasamon, Y., Goodman, S. N., Hess, A., Levitsky, H. I., Ambinder, R. F., Jones, R. J. & Fuchs, E. J., Apr 22 2010, In : Blood. 115, 16, p. 3224-3230 7 p.

Research output: Contribution to journalArticle

Nonmyeloablative HLA-Haploidentical Bone Marrow Transplantation with High-Dose Posttransplantation Cyclophosphamide: Effect of HLA Disparity on Outcome

Kasamon, Y. L., Luznik, L., Leffell, M. S., Kowalski, J., Tsai, H. L., Bolaños-Meade, J., Morris, L. E., Crilley, P. A., O'Donnell, P. V., Rossiter, N., Huff, C. A., Brodsky, R. A., Matsui, W. H., Swinnen, L. J., Borrello, I., Powell, J. D., Ambinder, R. F., Jones, R. J. & Fuchs, E. J., Apr 1 2010, In : Biology of Blood and Marrow Transplantation. 16, 4, p. 482-489 8 p.

Research output: Contribution to journalArticle

2009

Granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting cellular immunotherapy in combination with autologous stem cell transplantation (ASCT) as postremission therapy for acute myeloid leukemia (AML)

Borrello, I. M., Levitsky, H. I., Stock, W., Sher, D., Qin, L., DeAngelo, D. J., Alyea, E. P., Stone, R. M., Damon, L. E., Linker, C. A., Maslyar, D. J. & Hege, K. M., Nov 20 2009, In : Blood. 114, 9, p. 1736-1745 10 p.

Research output: Contribution to journalArticle

2008

Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance

Matsui, W., Wang, Q., Barber, J. P., Brennan, S., Smith, B. D., Borrello, I., McNiece, I., Lin, L., Ambinder, R. F., Peacock, C., Watkins, D. N., Huff, C. A. & Jones, R. J., Jan 1 2008, In : Cancer Research. 68, 1, p. 190-197 8 p.

Research output: Contribution to journalArticle

Escape from suppression: Tumor-specific effector cells outcompete regulatory T cells following stem-cell transplantation

Mirmonsef, P., Tan, G., Zhou, G., Morino, T., Noonan, K., Borrello, I. & Levitsky, H. I., Feb 15 2008, In : Blood. 111, 4, p. 2112-2121 10 p.

Research output: Contribution to journalArticle

HLA-Haploidentical Bone Marrow Transplantation for Hematologic Malignancies Using Nonmyeloablative Conditioning and High-Dose, Posttransplantation Cyclophosphamide

Luznik, L., O'Donnell, P. V., Symons, H. J., Chen, A. R., Leffell, M. S., Zahurak, M., Gooley, T. A., Piantadosi, S., Kaup, M., Ambinder, R. F., Huff, C. A., Matsui, W., Bolaños-Meade, J., Borrello, I., Powell, J. D., Harrington, E., Warnock, S., Flowers, M., Brodsky, R. A., Sandmaier, B. M. & 3 others, Storb, R. F., Jones, R. J. & Fuchs, E. J., Jun 1 2008, In : Biology of Blood and Marrow Transplantation. 14, 6, p. 641-650 10 p.

Research output: Contribution to journalArticle

Myeloablative allogeneic bone marrow transplant using T cell depleted allografts followed by post-transplant GM-CSF in high-risk myelodysplastic syndromes

Warlick, E. D., O'Donnell, P. V., Borowitz, M., Grupka, N., Decloe, L., Garrett-Mayer, E., Borrello, I., Brodsky, R., Fuchs, E., Huff, C. A., Luznik, L., Matsui, W., Ambinder, R., Jones, R. J. & Douglas Smith, B., Sep 1 2008, In : Leukemia Research. 32, 9, p. 1439-1447 9 p.

Research output: Contribution to journalArticle

Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells

Serafini, P., Mgebroff, S., Noonan, K. & Borrello, I., Jul 1 2008, In : Cancer Research. 68, 13, p. 5439-5449 11 p.

Research output: Contribution to journalArticle

2007

Induction of Autologous Graft-versus-Host Disease: Results of a Randomized Prospective Clinical Trial in Patients with Poor Risk Lymphoma

Bolaños-Meade, J., Garrett-Mayer, E., Luznik, L., Anders, V., Webb, J., Fuchs, E. J., Huff, C. A., Matsui, W., Borrello, I. M., Brodsky, R., Kasamon, Y. L., Swinnen, L. J., Flinn, I. W., Ambinder, R. F., Jones, R. J., Hess, A. D. & Vogelsang, G. B., Oct 1 2007, In : Biology of Blood and Marrow Transplantation. 13, 10, p. 1185-1191 7 p.

Research output: Contribution to journalArticle

Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America

Weber, D. M., Chen, C., Niesvizky, R., Wang, M., Belch, A., Stadtmauer, E. A., Siegel, D., Borrello, I., Rajkumar, S. V., Chanan-Khan, A. A., Lonial, S., Yu, Z., Patin, J., Olesnyckyj, M., Zeldis, J. B. & Knight, R. D., Nov 22 2007, In : New England Journal of Medicine. 357, 21, p. 2133-2142 10 p.

Research output: Contribution to journalArticle

2006

Graft-versus-host reactions and the effectiveness of donor lymphocyte infusions

Huff, C. A., Fuchs, E. J., Smith, B. D., Blackford, A., Garrett-Mayer, E., Brodsky, R. A., Flinn, I. W., Ambinder, R. F., Borrello, I. M., Matsui, W. H., Vogelsang, G. B., Griffin, C. A., Luznik, L. & Jones, R. J., Apr 1 2006, In : Biology of Blood and Marrow Transplantation. 12, 4, p. 414-421 8 p.

Research output: Contribution to journalArticle

In vivo disruption of tolerogenic cross-presentation mechanisms uncovers an effective T-cell activation by B-cell lymphomas leading to antitumor immunity

Horna, P., Cuenca, A., Cheng, F., Brayer, J., Wang, H. W., Borrello, I., Levitsky, H. & Sotomayor, E. M., Apr 1 2006, In : Blood. 107, 7, p. 2871-2878 8 p.

Research output: Contribution to journalArticle

Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function

Serafini, P., Meckel, K., Kelso, M., Noonan, K., Califano, J., Koch, W., Dolcetti, L., Bronte, V. & Borrello, I., Nov 1 2006, In : Journal of Experimental Medicine. 203, 12, p. 2691-2702 12 p.

Research output: Contribution to journalArticle

Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells

Gallina, G., Dolcetti, L., Serafini, P., De Santo, C., Marigo, I., Colombo, M. P., Basso, G., Brombacher, F., Borrello, I., Zanovello, P., Bicciato, S. & Bronte, V., Oct 2 2006, In : Journal of Clinical Investigation. 116, 10, p. 2777-2790 14 p.

Research output: Contribution to journalArticle

2005

Activated marrow-infiltrating lymphocytes effectively target plasma cells and their clonogenic precursors

Noonan, K., Matsui, W., Serafini, P., Carbley, R., Tan, G., Khalili, J., Bonyhadi, M., Levitsky, H., Whartenby, K. & Borrello, I., Mar 1 2005, In : Cancer Research. 65, 5, p. 2026-2034 9 p.

Research output: Contribution to journalArticle

2004

High-dose granulocyte-macrophage colony-stimulating factor-producing vaccines impair the immune response through the recruitment of myeloid suppressor cells

Serafini, P., Carbley, R., Noonan, K. A., Tan, G., Bronte, V. & Borrello, I., Sep 1 2004, In : Cancer Research. 64, 17, p. 6337-6343 7 p.

Research output: Contribution to journalArticle

2003

Extra-Lymphatic Solid Tumor Growth Is Not Immunologically Ignored and Results in Early Induction of Antigen-Specific T-Cell Anergy: Dominant Role of Cross-Tolerance to Tumor Antigens

Cuenca, A., Cheng, F., Wang, H., Brayer, J., Horna, P., Gu, L., Bien, H., Borrello, I. M., Levitsky, H. I. & Sotomayor, E. M., Dec 15 2003, In : Cancer Research. 63, 24, p. 9007-9015 9 p.

Research output: Contribution to journalArticle

Immunotherapy of established tumors using bone marrow transplantation with antigen gene-modified hematopoietic stem cells

Cui, Y., Kelleher, E., Straley, E., Fuchs, E., Gorski, K., Levitsky, H., Borrello, I., Civin, C. I., Schoenberger, S. P., Cheng, L., Pardoll, D. M. & Whartenby, K. A., Jul 1 2003, In : Nature medicine. 9, 7, p. 952-958 7 p.

Research output: Contribution to journalArticle

Long-term follow-up of T cell-depleted allogeneic bone marrow transplantation in refractory multiple myeloma: Importance of allogeneic T cells

Huff, C. A., Fuchs, E. J., Noga, S. J., O'Donnell, P. V., Ambinder, R. F., Diehl, L., Borrello, I., Vogelsang, G. B., Miller, C. B., Flinn, I. A., Brodsky, R. A., Marcellus, D. & Jones, R. J., May 1 2003, In : Biology of Blood and Marrow Transplantation. 9, 5, p. 312-319 8 p.

Research output: Contribution to journalArticle

Successful therapy of metastatic cancer using tumor vaccines in mixed allogeneic bone marrow chimeras

Luznik, L., Slansky, J. E., Jalla, S., Borrello, I., Levitsky, H. I., Pardoll, D. M. & Fuchs, E. J., Feb 15 2003, In : Blood. 101, 4, p. 1645-1652 8 p.

Research output: Contribution to journalArticle

2002

Cancer vaccines for hematologic malignancies

Borrello, I. M. & Sotomayor, E. M., Jan 1 2002, In : Cancer Control. 9, 2, p. 138-151 14 p.

Research output: Contribution to journalArticle

2001

Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression

Sotomayor, E. M., Borrello, I., Rattis, F. M., Cuenca, A. G., Abrams, J., Staveley-O'Carroll, K. & Levitsky, H. I., Aug 15 2001, In : Blood. 98, 4, p. 1070-1077 8 p.

Research output: Contribution to journalArticle

2000

New approaches to treating malignances with stem cell transplantation

Margolis, J., Borrello, I. & Flinn, I. W., Jan 1 2000, In : Seminars in oncology. 27, 5, p. 524-530 7 p.

Research output: Contribution to journalArticle

Sustaining the graft-versus-tumor effect through posttransplant immunization with granulocyte-macrophage colony-stimulating factor (GM-CSF)- producing tumor vaccines

Borrello, I., Sotomayor, E. M., Rattis, F. M., Cooke, S. K., Gu, L. & Levitsky, H. I., May 15 2000, In : Blood. 95, 10, p. 3011-3019 9 p.

Research output: Contribution to journalArticle

1999

A universal granulocyte-macrophage colony-stimulating factor-producing bystander cell line for use in the formulation of autologous tumor cell- based vaccines

Borrello, I., Sotomayor, E. M., Cooke, S. & Levitsky, H. I., Aug 10 1999, In : Human gene therapy. 10, 12, p. 1983-1991 9 p.

Research output: Contribution to journalArticle

Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of cd40

Sotomayor, E. M., Borrello, I., Tubb, E., Rattis, F. M., Bien, H., Lu, Z., Fein, S., Schoenberger, S. & Levitsky, H. I., Jul 1 1999, In : Nature medicine. 5, 7, p. 780-787 8 p.

Research output: Contribution to journalArticle

In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance

Sotomayor, E. M., Borrello, I., Tubb, E., Allison, J. P. & Levitsky, H. I., Sep 28 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 20, p. 11476-11481 6 p.

Research output: Contribution to journalArticle

1998

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

Staveley-O'Carroll, K., Sotomayor, E., Montgomery, J., Borrello, I., Hwang, L., Fein, S., Pardoll, D. & Levitsky, H., Feb 3 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 3, p. 1178-1183 6 p.

Research output: Contribution to journalArticle

1996

Tolerance and Cancer: A Critical Issue in Tumor Immunology

Sotomayor, E. M., Borrello, I. & Levitsky, H. I., Jan 1 1996, In : Critical reviews in oncogenesis. 7, 5-6, p. 433-456 24 p.

Research output: Contribution to journalArticle

1988

The calcium signal for BALB/MK keratinocyte terminal differentiation counteracts epidermal growth factor (EGF) very early in the EGF-induced proliferative pathway

Di Fiore, P. P., Falco, J., Borrello, I., Weissman, B. & Aaronson, S. A., Jan 1 1988, In : Molecular and cellular biology. 8, 2, p. 557-563 7 p.

Research output: Contribution to journalArticle

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