Ivan M Borrello

Associate Professor

1988 …2020

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Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells

Gallina, G., Dolcetti, L., Serafini, P., De Santo, C., Marigo, I., Colombo, M. P., Basso, G., Brombacher, F., Borrello, I., Zanovello, P., Bicciato, S. & Bronte, V., Oct 2 2006, In : Journal of Clinical Investigation. 116, 10, p. 2777-2790 14 p.

Research output: Contribution to journalArticle

Total cost comparison in relapsed/refractory multiple myeloma

Durie, B., Binder, G., Pashos, C., Khan, Z., Hussein, M. & Borrello, I., Apr 24 2013, In : Journal of Medical Economics. 16, 5, p. 614-622 9 p.

Research output: Contribution to journalArticle

Tolerance and Cancer: A Critical Issue in Tumor Immunology

Sotomayor, E. M., Borrello, I. & Levitsky, H. I., Jan 1 1996, In : Critical reviews in oncogenesis. 7, 5-6, p. 433-456 24 p.

Research output: Contribution to journalArticle

The society for immunotherapy of cancer consensus statement on immunotherapy for the treatment of hematologic malignancies: Multiple myeloma, lymphoma, and acute leukemia

Boyiadzis, M., Bishop, M. R., Abonour, R., Anderson, K. C., Ansell, S. M., Avigan, D., Barbarotta, L., Barrett, A. J., Besien, K., Bergsagel, P. L., Borrello, I. M., Brody, J., Brufsky, J., Cairo, M., Chari, A., Cohen, A., Cortes, J., Forman, S. J., Friedberg, J. W., Fuchs, E. J. & 28 others, Gore, S. D., Jagannath, S., Kahl, B. S., Kline, J., Kochenderfer, J. N., Kwak, L. W., Levy, R., Lima, M., Litzow, M. R., Mahindra, A., Miller, J., Munshi, N. C., Orlowski, R. Z., Pagel, J. M., Porter, D. L., Russell, S. J., Schwartz, K., Shipp, M. A., Siegel, D., Stone, R. M., Tallman, M. S., Timmerman, J. M., Rhee, F., Waller, E. K., Welsh, A., Werner, M., Wiernik, P. H. & Dhodapkar, M. V., Dec 20 2016, In : Journal for ImmunoTherapy of Cancer. 4, 1, 90.

Research output: Contribution to journalArticle

Therapeutic drug monitoring for either oral or intravenous busulfan when combined with pre-and post-transplantation cyclophosphamide

Lombardi, L. R., Kanakry, C. G., Zahurak, M., Durakovic, N., Bolaños-Meade, J., Kasamon, Y. L., Gladstone, D. E., Matsui, W., Borrello, I., Huff, C. A., Swinnen, L. J., Brodsky, R. A., Ambinder, R. F., Fuchs, E. J., Rosner, G. L., Jones, R. J. & Luznik, L., Mar 3 2016, In : Leukemia and Lymphoma. 57, 3, p. 666-675 10 p.

Research output: Contribution to journalArticle

The calcium signal for BALB/MK keratinocyte terminal differentiation counteracts epidermal growth factor (EGF) very early in the EGF-induced proliferative pathway

Di Fiore, P. P., Falco, J., Borrello, I., Weissman, B. & Aaronson, S. A., Jan 1 1988, In : Molecular and cellular biology. 8, 2, p. 557-563 7 p.

Research output: Contribution to journalArticle

Open Access

Targeting immune suppression with PDE5 inhibition in end-stage multiple myeloma

Noonan, K. A., Ghosh, N., Rudraraju, L., Bui, M. & Borrello, I., Aug 1 2014, In : Cancer Immunology Research. 2, 8, p. 725-731 7 p.

Research output: Contribution to journalArticle

Tadalafil reduces myeloid-derived suppressor cells and regulatory t cells and promotes tumor immunity in patients with head and neck squamous cell carcinoma

Weed, D. T., Vella, J. L., Reis, I. M., De La Fuente, A. C., Gomez, C., Sargi, Z., Nazarian, R., Califano, J., Borrello, I. & Serafini, P., Jan 1 2015, In : Clinical Cancer Research. 21, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

Tadalafil augments tumor specific immunity in patients with head and neck squamous cell carcinoma

Califano, J. A., Khan, Z., Noonan, K. A., Rudraraju, L., Zhang, Z., Wang, H., Goodman, S., Gourin, C. G., Ha, P., Fakhry, C., Saunders, J., Levine, M., Tang, M., Neuner, G., Richmon, J. D., Blanco, R., Agrawal, N., Koch, W. M., Marur, S., Weed, D. T. & 2 others, Serafini, P. & Borrello, I., Jan 1 2015, In : Clinical Cancer Research. 21, 1, p. 30-38 9 p.

Research output: Contribution to journalArticle

Sustaining the graft-versus-tumor effect through posttransplant immunization with granulocyte-macrophage colony-stimulating factor (GM-CSF)- producing tumor vaccines

Borrello, I., Sotomayor, E. M., Rattis, F. M., Cooke, S. K., Gu, L. & Levitsky, H. I., May 15 2000, In : Blood. 95, 10, p. 3011-3019 9 p.

Research output: Contribution to journalArticle

Successful therapy of metastatic cancer using tumor vaccines in mixed allogeneic bone marrow chimeras

Luznik, L., Slansky, J. E., Jalla, S., Borrello, I., Levitsky, H. I., Pardoll, D. M. & Fuchs, E. J., Feb 15 2003, In : Blood. 101, 4, p. 1645-1652 8 p.

Research output: Contribution to journalArticle

Risk-stratified outcomes of nonmyeloablative HLA-haploidentical BMT with high-dose posttransplantation cyclophosphamide

McCurdy, S. R., Kanakry, J. A., Showel, M. M., Tsai, H. L., Bolaños-Meade, J., Rosner, G. L., Kanakry, C. G., Perica, K., Symons, H. J., Brodsky, R. A., Gladstone, D. E., Huff, C. A., Pratz, K. W., Prince, G. T., Dezern, A. E., Gojo, I., Matsui, W. H., Borrello, I., McDevitt, M. A., Swinnen, L. J. & 7 others, Smith, B. D., Levis, M. J., Ambinder, R. F., Luznik, L., Jones, R. J., Fuchs, E. J. & Kasamon, Y. L., May 7 2015, In : Blood. 125, 19, p. 3024-3031 8 p.

Research output: Contribution to journalArticle

Open Access

Pre-radiation lymphocyte harvesting and post-radiation reinfusion in patients with newly diagnosed high grade gliomas

Campian, J. L., Ye, X., Gladstone, D. E., Ambady, P., Nirschl, T. R., Borrello, I., Golightly, M., King, K. E., Holdhoff, M., Karp, J., Drake, C. G. & Grossman, S. A., Sep 29 2015, In : Journal of neuro-oncology. 124, 2, p. 307-316 10 p.

Research output: Contribution to journalArticle

Pilot trial of K562/GM-CSF whole-cell vaccination in MDS patients

Robinson, T. M., Prince, G. T., Thoburn, C., Warlick, E., Ferguson, A., Kasamon, Y. L., Borrello, I. M., Hess, A. D. & Smith, B. D., Apr 5 2018, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-11 11 p.

Research output: Contribution to journalArticle

Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function

Serafini, P., Meckel, K., Kelso, M., Noonan, K., Califano, J., Koch, W., Dolcetti, L., Bronte, V. & Borrello, I., Nov 1 2006, In : Journal of Experimental Medicine. 203, 12, p. 2691-2702 12 p.

Research output: Contribution to journalArticle

PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma

Ansell, S. M., Lesokhin, A. M., Borrello, I., Halwani, A., Scott, E. C., Gutierrez, M., Schuster, S. J., Millenson, M. M., Cattry, D., Freeman, G. J., Rodig, S. J., Chapuy, B., Ligon, A. H., Zhu, L., Grosso, J. F., Kim, S. Y., Timmerman, J. M., Shipp, M. A. & Armand, P., Jan 22 2015, In : New England Journal of Medicine. 372, 4, p. 311-319 9 p.

Research output: Contribution to journalArticle

Nonmyeloablative HLA-Haploidentical Bone Marrow Transplantation with High-Dose Posttransplantation Cyclophosphamide: Effect of HLA Disparity on Outcome

Kasamon, Y. L., Luznik, L., Leffell, M. S., Kowalski, J., Tsai, H. L., Bolaños-Meade, J., Morris, L. E., Crilley, P. A., O'Donnell, P. V., Rossiter, N., Huff, C. A., Brodsky, R. A., Matsui, W. H., Swinnen, L. J., Borrello, I., Powell, J. D., Ambinder, R. F., Jones, R. J. & Fuchs, E. J., Apr 1 2010, In : Biology of Blood and Marrow Transplantation. 16, 4, p. 482-489 8 p.

Research output: Contribution to journalArticle

Nivolumab in patients with relapsed or refractory hematologic malignancy: Preliminary results of a phase ib study

Lesokhin, A. M., Ansell, S. M., Armand, P., Scott, E. C., Halwani, A., Gutierrez, M., Millenson, M. M., Cohen, A. D., Schuster, S. J., Lebovic, D., Dhodapkar, M., Avigan, D., Chapuy, B., Ligon, A. H., Freeman, G. J., Rodig, S. J., Cattry, D., Zhu, L., Grosso, J. F., Brigid Bradley Garelik, M. & 3 others, Shipp, M. A., Borrello, I. & Timmerman, J., Aug 10 2016, In : Journal of Clinical Oncology. 34, 23, p. 2698-2704 7 p.

Research output: Contribution to journalArticle

New approaches to treating malignances with stem cell transplantation

Margolis, J., Borrello, I. & Flinn, I. W., Jan 1 2000, In : Seminars in oncology. 27, 5, p. 524-530 7 p.

Research output: Contribution to journalArticle

Neutrophil to lymphocyte ratio (NLR) improves the risk assessment of ISS staging in newly diagnosed MM patients treated upfront with novel agents

Romano, A., Parrinello, N. L., Consoli, M. L., Marchionni, L., Forte, S., Conticello, C., Pompa, A., Corso, A., Milone, G., Di Raimondo, F. & Borrello, I., Nov 22 2015, In : Annals of hematology. 94, 11, p. 1875-1883 9 p.

Research output: Contribution to journalArticle

Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells

Serafini, P., Mgebroff, S., Noonan, K. & Borrello, I., Jul 1 2008, In : Cancer Research. 68, 13, p. 5439-5449 11 p.

Research output: Contribution to journalArticle

Myeloablative allogeneic bone marrow transplant using T cell depleted allografts followed by post-transplant GM-CSF in high-risk myelodysplastic syndromes

Warlick, E. D., O'Donnell, P. V., Borowitz, M., Grupka, N., Decloe, L., Garrett-Mayer, E., Borrello, I., Brodsky, R., Fuchs, E., Huff, C. A., Luznik, L., Matsui, W., Ambinder, R., Jones, R. J. & Douglas Smith, B., Sep 1 2008, In : Leukemia Research. 32, 9, p. 1439-1447 9 p.

Research output: Contribution to journalArticle

Marrow-infiltrating lymphocytes - Role in biology and cancer therapy

Borrello, I. & Noonan, K. A., Mar 30 2016, In : Frontiers in immunology. 7, MAR, 112.

Research output: Contribution to journalArticle

Low immunosuppressive burden after HLA-matched related or unrelated BMT using posttransplantation cyclophosphamide

Kanakry, C. G., Bolanos Meade, F. J., Kasamon, Y. L., Zahurak, M., Durakovic, N., Furlong, T., Mielcarek, M., Medeot, M., Gojo, I., Smith, B. D., Kanakry, J. A., Borrello, I. M., Brodsky, R. A., Gladstone, D., Huff, C. A., Matsui, W. H., Swinnen, L., Cooke, K. R., Ambinder, R. F., Fuchs, E. J. & 6 others, De Lima, M. J., Andersson, B. S., Varadhan, R., O'Donnell, P. V., Jones, R. J. & Luznik, L., Mar 9 2017, In : Blood. 129, 10, p. 1389-1393 5 p.

Research output: Contribution to journalArticle

Long-term follow-up of T cell-depleted allogeneic bone marrow transplantation in refractory multiple myeloma: Importance of allogeneic T cells

Huff, C. A., Fuchs, E. J., Noga, S. J., O'Donnell, P. V., Ambinder, R. F., Diehl, L., Borrello, I., Vogelsang, G. B., Miller, C. B., Flinn, I. A., Brodsky, R. A., Marcellus, D. & Jones, R. J., May 1 2003, In : Biology of Blood and Marrow Transplantation. 9, 5, p. 312-319 8 p.

Research output: Contribution to journalArticle

Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America

Weber, D. M., Chen, C., Niesvizky, R., Wang, M., Belch, A., Stadtmauer, E. A., Siegel, D., Borrello, I., Rajkumar, S. V., Chanan-Khan, A. A., Lonial, S., Yu, Z., Patin, J., Olesnyckyj, M., Zeldis, J. B. & Knight, R. D., Nov 22 2007, In : New England Journal of Medicine. 357, 21, p. 2133-2142 10 p.

Research output: Contribution to journalArticle

Lenalidomide-induced immunomodulation in multiple myeloma: Impact on vaccines and antitumor responses

Noonan, K., Rudraraju, L., Ferguson, A., Emerling, A., Pasetti, M. F., Huff, C. A. & Borrello, I., Mar 1 2012, In : Clinical Cancer Research. 18, 5, p. 1426-1434 9 p.

Research output: Contribution to journalArticle

Lenalidomide in combination with dexamethasone improves survival and time-to-progression in patients ≥65 years old with relapsed or refractory multiple myeloma

Chanan-Khan, A. A., Lonial, S., Weber, D., Borrello, I., Foà, R., Hellmann, A., Dimopoulos, M., Swern, A. S. & Knight, R., Aug 2012, In : International journal of hematology. 96, 2, p. 254-262 9 p.

Research output: Contribution to journalArticle

IQGAP1 scaffold-MAP kinase interactions enhance multiple myeloma clonogenic growth and self-renewal

Gocke, C., McMillan, R., Wang, Q., Begum, A., Penchev, V. R., Ali, S. A., Borrello, I. M., Huff, C. A. & Matsui, W., Nov 1 2016, In : Molecular Cancer Therapeutics. 15, 11, p. 2733-27339 24607 p.

Research output: Contribution to journalArticle

In vivo disruption of tolerogenic cross-presentation mechanisms uncovers an effective T-cell activation by B-cell lymphomas leading to antitumor immunity

Horna, P., Cuenca, A., Cheng, F., Brayer, J., Wang, H. W., Borrello, I., Levitsky, H. & Sotomayor, E. M., Apr 1 2006, In : Blood. 107, 7, p. 2871-2878 8 p.

Research output: Contribution to journalArticle

In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance

Sotomayor, E. M., Borrello, I., Tubb, E., Allison, J. P. & Levitsky, H. I., Sep 28 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 20, p. 11476-11481 6 p.

Research output: Contribution to journalArticle

Inhibition of TGF-β enhances the in vivo antitumor efficacy of EGF receptor-targeted therapy

Bedi, A., Chang, X., Noonan, K., Pham, V., Bedi, R., Fertig, E. J., Considine, M., Califano, J. A., Borrello, I., Chung, C. H., Sidransky, D. & Ravi, R., Nov 1 2012, In : Molecular cancer therapeutics. 11, 11, p. 2429-2439 11 p.

Research output: Contribution to journalArticle

Induction of Autologous Graft-versus-Host Disease: Results of a Randomized Prospective Clinical Trial in Patients with Poor Risk Lymphoma

Bolaños-Meade, J., Garrett-Mayer, E., Luznik, L., Anders, V., Webb, J., Fuchs, E. J., Huff, C. A., Matsui, W., Borrello, I. M., Brodsky, R., Kasamon, Y. L., Swinnen, L. J., Flinn, I. W., Ambinder, R. F., Jones, R. J., Hess, A. D. & Vogelsang, G. B., Oct 1 2007, In : Biology of Blood and Marrow Transplantation. 13, 10, p. 1185-1191 7 p.

Research output: Contribution to journalArticle

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

Staveley-O'Carroll, K., Sotomayor, E., Montgomery, J., Borrello, I., Hwang, L., Fein, S., Pardoll, D. & Levitsky, H., Feb 3 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 3, p. 1178-1183 6 p.

Research output: Contribution to journalArticle

Impaired B cell immunity in acute myeloid leukemia patients after chemotherapy

Goswami, M., Prince, G., Biancotto, A., Moir, S., Kardava, L., Santich, B. H., Cheung, F., Kotliarov, Y., Chen, J., Shi, R., Zhou, H., Golding, H., Manischewitz, J., King, L., Kunz, L. M., Noonan, K., Borrello, I. M., Smith, B. D. & Hourigan, C., Jul 10 2017, In : Journal of Translational Medicine. 15, 1, 155.

Research output: Contribution to journalArticle

Immunotherapy of established tumors using bone marrow transplantation with antigen gene-modified hematopoietic stem cells

Cui, Y., Kelleher, E., Straley, E., Fuchs, E., Gorski, K., Levitsky, H., Borrello, I., Civin, C. I., Schoenberger, S. P., Cheng, L., Pardoll, D. M. & Whartenby, K. A., Jul 1 2003, In : Nature medicine. 9, 7, p. 952-958 7 p.

Research output: Contribution to journalArticle

HLA-Haploidentical Bone Marrow Transplantation for Hematologic Malignancies Using Nonmyeloablative Conditioning and High-Dose, Posttransplantation Cyclophosphamide

Luznik, L., O'Donnell, P. V., Symons, H. J., Chen, A. R., Leffell, M. S., Zahurak, M., Gooley, T. A., Piantadosi, S., Kaup, M., Ambinder, R. F., Huff, C. A., Matsui, W., Bolaños-Meade, J., Borrello, I., Powell, J. D., Harrington, E., Warnock, S., Flowers, M., Brodsky, R. A., Sandmaier, B. M. & 3 others, Storb, R. F., Jones, R. J. & Fuchs, E. J., Jun 1 2008, In : Biology of Blood and Marrow Transplantation. 14, 6, p. 641-650 10 p.

Research output: Contribution to journalArticle

High-dose granulocyte-macrophage colony-stimulating factor-producing vaccines impair the immune response through the recruitment of myeloid suppressor cells

Serafini, P., Carbley, R., Noonan, K. A., Tan, G., Bronte, V. & Borrello, I., Sep 1 2004, In : Cancer Research. 64, 17, p. 6337-6343 7 p.

Research output: Contribution to journalArticle

High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease

Luznik, L., Bolaños-Meade, J., Zahurak, M., Chen, A. R., Smith, B. D., Brodsky, R., Huff, C. A., Borrello, I., Matsui, W., Powell, J. D., Kasamon, Y., Goodman, S. N., Hess, A., Levitsky, H. I., Ambinder, R. F., Jones, R. J. & Fuchs, E. J., Apr 22 2010, In : Blood. 115, 16, p. 3224-3230 7 p.

Research output: Contribution to journalArticle

Open Access
Open Access