Ivan M Borrello

Associate Professor

1988 …2019

Research output per year

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Activated marrow-infiltrating lymphocytes effectively target plasma cells and their clonogenic precursors

Noonan, K., Matsui, W., Serafini, P., Carbley, R., Tan, G., Khalili, J., Bonyhadi, M., Levitsky, H., Whartenby, K. & Borrello, I., Mar 1 2005, In : Cancer Research. 65, 5, p. 2026-2034 9 p.

Research output: Contribution to journalArticle

Activation of liver X receptors inhibits hedgehog signaling, clonogenic growth, and self-renewal in multiple myeloma

Agarwal, J. R., Wang, Q., Tanno, T., Rasheed, Z., Merchant, A., Ghosh, N., Borrello, I., Huff, C. A., Parhami, F. & Matsui, W., Jul 2014, In : Molecular cancer therapeutics. 13, 7, p. 1873-1881 9 p.

Research output: Contribution to journalArticle

A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma

Noonan, K., Marchionni, L., Anderson, J., Pardoll, D., Roodman, G. D. & Borrello, I., Nov 4 2010, In : Blood. 116, 18, p. 3554-3563 10 p.

Research output: Contribution to journalArticle

A phase 1 study of IPI-504 (retaspimycin hydrochloride) in patients with relapsed or relapsed and refractory multiple myeloma

Siegel, D., Jagannath, S., Vesole, D. H., Borello, I., Mazumder, A., Mitsiades, C., Goddard, J., Dunbar, J., Normant, E., Adams, J., Grayzel, D., Anderson, K. C. & Richardson, P., Dec 1 2011, In : Leukemia and Lymphoma. 52, 12, p. 2308-2315 8 p.

Research output: Contribution to journalArticle

A universal granulocyte-macrophage colony-stimulating factor-producing bystander cell line for use in the formulation of autologous tumor cell- based vaccines

Borrello, I., Sotomayor, E. M., Cooke, S. & Levitsky, H. I., Aug 10 1999, In : Human gene therapy. 10, 12, p. 1983-1991 9 p.

Research output: Contribution to journalArticle

Autologous mesenchymal stem cells produce concordant improvements in regional function, tissue perfusion, and fibrotic burden when administered to patients undergoing coronary artery bypass grafting: The prospective randomized study of mesenchymal stem cell therapy in patients undergoing cardiac surgery (PROMETHEUS) trial

Karantalis, V., Difede, D. L., Gerstenblith, G., Pham, S., Symes, J., Zambrano, J. P., Fishman, J., Pattany, P., McNiece, I., Conte, J., Schulman, S., Wu, K., Shah, A., Breton, E., Davis-Sproul, J., Schwarz, R., Feigenbaum, G., Mushtaq, M., Suncion, V. Y., Lardo, A. C. & 7 others, Borrello, I., Mendizabal, A., Karas, T. Z., Byrnes, J., Lowery, M., Heldman, A. W. & Hare, J. M., Jan 1 2014, In : Circulation research. 114, 8, p. 1302-1310 9 p.

Research output: Contribution to journalArticle

Autologous Stem Cell Transplantation and Multiple Myeloma Cancer Stem Cells

Matsui, W., Borrello, I. & Mitsiades, C., Jan 1 2012, In : Biology of Blood and Marrow Transplantation. 18, 1 SUPPL., p. S27-S32

Research output: Contribution to journalArticle

Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy

Ravi, R., Noonan, K., Pham, V., Bedi, R., Zhavoronkov, A., Ozerov, I. V., Makarev, E., Artemov, A. V., Wysocki, P. T., Mehra, R., Nimmagadda, S., Marchionni, L., Sidransky, D., Borrello, I. M., Izumchenko, E. & Bedi, A., Dec 1 2018, In : Nature Communications. 9, 1, 741.

Research output: Contribution to journalArticle

Biological effects and clinical significance of lenalidomide-induced tumour flare reaction in patients with chronic lymphocytic leukaemia: In vivo evidence of immune activation and antitumour response

Chanan-Khan, A. A., Chitta, K., Ersing, N., Paulus, A., Masood, A., Sher, T., Swaika, A., Wallace, P. K., Mashtare, T. L., Wilding, G., Lee, K., Czuczman, M. S., Borrello, I. & Bangia, N., Nov 1 2011, In : British journal of haematology. 155, 4, p. 457-467 11 p.

Research output: Contribution to journalArticle

Bortezomib and thalidomide, a steroid free regimen in newly diagnosed patients with multiple myeloma

Ghosh, N., Ye, X., Ferguson, A., Huff, C. A. & Borrello, I., Mar 1 2011, In : British journal of haematology. 152, 5, p. 593-599 7 p.

Research output: Contribution to journalArticle

Cancer vaccines for hematologic malignancies

Borrello, I. M. & Sotomayor, E. M., Jan 1 2002, In : Cancer Control. 9, 2, p. 138-151 14 p.

Research output: Contribution to journalArticle

Can we change the disease biology of multiple myeloma?

Borrello, I., Nov 1 2012, In : Leukemia Research. 36, SUPPL.1, p. S3-S12

Research output: Contribution to journalArticle

Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model

Meyera, C., Sevko, A., Ramacher, M., Bazhin, A. V., Falk, C. S., Osena, W., Borrello, I., Kato, M., Schadendorf, D., Baniyash, M. & Umanskya, V., Oct 11 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 41, p. 17111-17116 6 p.

Research output: Contribution to journalArticle

Clarithromycin overcomes resistance to lenalidomide and dexamethasone in multiple myeloma

Ghosh, N., Tucker, N., Zahurak, M., Wozney, J., Borrello, I. & Huff, C. A., Aug 2014, In : American journal of hematology. 89, 8, p. E116-E120

Research output: Contribution to journalArticle

Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance

Matsui, W., Wang, Q., Barber, J. P., Brennan, S., Smith, B. D., Borrello, I., McNiece, I., Lin, L., Ambinder, R. F., Peacock, C., Watkins, D. N., Huff, C. A. & Jones, R. J., Jan 1 2008, In : Cancer Research. 68, 1, p. 190-197 8 p.

Research output: Contribution to journalArticle

Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of cd40

Sotomayor, E. M., Borrello, I., Tubb, E., Rattis, F. M., Bien, H., Lu, Z., Fein, S., Schoenberger, S. & Levitsky, H. I., Jul 1 1999, In : Nature medicine. 5, 7, p. 780-787 8 p.

Research output: Contribution to journalArticle

Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression

Sotomayor, E. M., Borrello, I., Rattis, F. M., Cuenca, A. G., Abrams, J., Staveley-O'Carroll, K. & Levitsky, H. I., Aug 15 2001, In : Blood. 98, 4, p. 1070-1077 8 p.

Research output: Contribution to journalArticle

Downregulation of BCL2 by AT-101 enhances the antileukaemic effect of lenalidomide both by an immune dependant and independent manner

Masood, A., Chitta, K., Paulus, A., Khan, A. N. H., Sher, T., Ersing, N., Miller, K. C., Manfredi, D., Ailawadhi, S., Borrelo, I., Lee, K. P. & Chanan-Khan, A. A., Apr 1 2012, In : British journal of haematology. 157, 1, p. 59-66 8 p.

Research output: Contribution to journalArticle

Efficacy and toxicity of therapy immediately after treatment with nivolumab in relapsed multiple myeloma

Pianko, M. J., Funt, S. A., Page, D. B., Cattry, D., Scott, E. C., Ansell, S. M., Borrello, I. M., Gutierrez, M., Lendvai, N., Hassoun, H., Landgren, C. O. & Lesokhin, A. M., May 26 2017, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-4 4 p.

Research output: Contribution to journalArticle

Escape from suppression: Tumor-specific effector cells outcompete regulatory T cells following stem-cell transplantation

Mirmonsef, P., Tan, G., Zhou, G., Morino, T., Noonan, K., Borrello, I. & Levitsky, H. I., Feb 15 2008, In : Blood. 111, 4, p. 2112-2121 10 p.

Research output: Contribution to journalArticle

Extra-Lymphatic Solid Tumor Growth Is Not Immunologically Ignored and Results in Early Induction of Antigen-Specific T-Cell Anergy: Dominant Role of Cross-Tolerance to Tumor Antigens

Cuenca, A., Cheng, F., Wang, H., Brayer, J., Horna, P., Gu, L., Bien, H., Borrello, I. M., Levitsky, H. I. & Sotomayor, E. M., Dec 15 2003, In : Cancer Research. 63, 24, p. 9007-9015 9 p.

Research output: Contribution to journalArticle

Flow cytometric discrimination of seven lineage markers by using two fluorochromes

Boin, F., Giardino Torchia, M. L., Borrello, I., Noonan, K. A., Neil, M., Soloski, M. J. & Cimbro, R., Nov 2017, In : PloS one. 12, 11, e0188916.

Research output: Contribution to journalArticle

Graft-versus-host reactions and the effectiveness of donor lymphocyte infusions

Huff, C. A., Fuchs, E. J., Smith, B. D., Blackford, A., Garrett-Mayer, E., Brodsky, R. A., Flinn, I. W., Ambinder, R. F., Borrello, I. M., Matsui, W. H., Vogelsang, G. B., Griffin, C. A., Luznik, L. & Jones, R. J., Apr 1 2006, In : Biology of Blood and Marrow Transplantation. 12, 4, p. 414-421 8 p.

Research output: Contribution to journalArticle

Granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting cellular immunotherapy in combination with autologous stem cell transplantation (ASCT) as postremission therapy for acute myeloid leukemia (AML)

Borrello, I. M., Levitsky, H. I., Stock, W., Sher, D., Qin, L., DeAngelo, D. J., Alyea, E. P., Stone, R. M., Damon, L. E., Linker, C. A., Maslyar, D. J. & Hege, K. M., Nov 20 2009, In : Blood. 114, 9, p. 1736-1745 10 p.

Research output: Contribution to journalArticle

Growth differentiating factor 15 enhances the tumor-initiating and self-renewal potential of multiple myeloma cells

Tanno, T., Lim, Y., Wang, Q., Chesi, M., Bergsagel, P. L., Matthews, G., Johnstone, R. W., Ghosh, N., Borrello, I., Huff, C. A. & Matsui, W., Jan 30 2014, In : Blood. 123, 5, p. 725-733 9 p.

Research output: Contribution to journalArticle

Open Access

High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease

Luznik, L., Bolaños-Meade, J., Zahurak, M., Chen, A. R., Smith, B. D., Brodsky, R., Huff, C. A., Borrello, I., Matsui, W., Powell, J. D., Kasamon, Y., Goodman, S. N., Hess, A., Levitsky, H. I., Ambinder, R. F., Jones, R. J. & Fuchs, E. J., Apr 22 2010, In : Blood. 115, 16, p. 3224-3230 7 p.

Research output: Contribution to journalArticle

High-dose granulocyte-macrophage colony-stimulating factor-producing vaccines impair the immune response through the recruitment of myeloid suppressor cells

Serafini, P., Carbley, R., Noonan, K. A., Tan, G., Bronte, V. & Borrello, I., Sep 1 2004, In : Cancer Research. 64, 17, p. 6337-6343 7 p.

Research output: Contribution to journalArticle

HLA-Haploidentical Bone Marrow Transplantation for Hematologic Malignancies Using Nonmyeloablative Conditioning and High-Dose, Posttransplantation Cyclophosphamide

Luznik, L., O'Donnell, P. V., Symons, H. J., Chen, A. R., Leffell, M. S., Zahurak, M., Gooley, T. A., Piantadosi, S., Kaup, M., Ambinder, R. F., Huff, C. A., Matsui, W., Bolaños-Meade, J., Borrello, I., Powell, J. D., Harrington, E., Warnock, S., Flowers, M., Brodsky, R. A., Sandmaier, B. M. & 3 others, Storb, R. F., Jones, R. J. & Fuchs, E. J., Jun 1 2008, In : Biology of Blood and Marrow Transplantation. 14, 6, p. 641-650 10 p.

Research output: Contribution to journalArticle

Immunotherapy of established tumors using bone marrow transplantation with antigen gene-modified hematopoietic stem cells

Cui, Y., Kelleher, E., Straley, E., Fuchs, E., Gorski, K., Levitsky, H., Borrello, I., Civin, C. I., Schoenberger, S. P., Cheng, L., Pardoll, D. M. & Whartenby, K. A., Jul 1 2003, In : Nature medicine. 9, 7, p. 952-958 7 p.

Research output: Contribution to journalArticle

Impaired B cell immunity in acute myeloid leukemia patients after chemotherapy

Goswami, M., Prince, G., Biancotto, A., Moir, S., Kardava, L., Santich, B. H., Cheung, F., Kotliarov, Y., Chen, J., Shi, R., Zhou, H., Golding, H., Manischewitz, J., King, L., Kunz, L. M., Noonan, K., Borrello, I. M., Smith, B. D. & Hourigan, C., Jul 10 2017, In : Journal of Translational Medicine. 15, 1, 155.

Research output: Contribution to journalArticle

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

Staveley-O'Carroll, K., Sotomayor, E., Montgomery, J., Borrello, I., Hwang, L., Fein, S., Pardoll, D. & Levitsky, H., Feb 3 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 3, p. 1178-1183 6 p.

Research output: Contribution to journalArticle

Induction of Autologous Graft-versus-Host Disease: Results of a Randomized Prospective Clinical Trial in Patients with Poor Risk Lymphoma

Bolaños-Meade, J., Garrett-Mayer, E., Luznik, L., Anders, V., Webb, J., Fuchs, E. J., Huff, C. A., Matsui, W., Borrello, I. M., Brodsky, R., Kasamon, Y. L., Swinnen, L. J., Flinn, I. W., Ambinder, R. F., Jones, R. J., Hess, A. D. & Vogelsang, G. B., Oct 1 2007, In : Biology of Blood and Marrow Transplantation. 13, 10, p. 1185-1191 7 p.

Research output: Contribution to journalArticle

Inhibition of TGF-β enhances the in vivo antitumor efficacy of EGF receptor-targeted therapy

Bedi, A., Chang, X., Noonan, K., Pham, V., Bedi, R., Fertig, E. J., Considine, M., Califano, J. A., Borrello, I., Chung, C. H., Sidransky, D. & Ravi, R., Nov 1 2012, In : Molecular cancer therapeutics. 11, 11, p. 2429-2439 11 p.

Research output: Contribution to journalArticle

In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance

Sotomayor, E. M., Borrello, I., Tubb, E., Allison, J. P. & Levitsky, H. I., Sep 28 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 20, p. 11476-11481 6 p.

Research output: Contribution to journalArticle

In vivo disruption of tolerogenic cross-presentation mechanisms uncovers an effective T-cell activation by B-cell lymphomas leading to antitumor immunity

Horna, P., Cuenca, A., Cheng, F., Brayer, J., Wang, H. W., Borrello, I., Levitsky, H. & Sotomayor, E. M., Apr 1 2006, In : Blood. 107, 7, p. 2871-2878 8 p.

Research output: Contribution to journalArticle

IQGAP1 scaffold-MAP kinase interactions enhance multiple myeloma clonogenic growth and self-renewal

Gocke, C., McMillan, R., Wang, Q., Begum, A., Penchev, V. R., Ali, S. A., Borrello, I. M., Huff, C. A. & Matsui, W., Nov 1 2016, In : Molecular Cancer Therapeutics. 15, 11, p. 2733-27339 24607 p.

Research output: Contribution to journalArticle

Lenalidomide in combination with dexamethasone improves survival and time-to-progression in patients ≥65 years old with relapsed or refractory multiple myeloma

Chanan-Khan, A. A., Lonial, S., Weber, D., Borrello, I., Foà, R., Hellmann, A., Dimopoulos, M., Swern, A. S. & Knight, R., Aug 2012, In : International journal of hematology. 96, 2, p. 254-262 9 p.

Research output: Contribution to journalArticle