Ivan M Borrello

Associate Professor

1988 …2019

Research output per year

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Research Output

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Article
2019
Open Access
2018

Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy

Ravi, R., Noonan, K., Pham, V., Bedi, R., Zhavoronkov, A., Ozerov, I. V., Makarev, E., Artemov, A. V., Wysocki, P. T., Mehra, R., Nimmagadda, S., Marchionni, L., Sidransky, D., Borrello, I. M., Izumchenko, E. & Bedi, A., Dec 1 2018, In : Nature Communications. 9, 1, 741.

Research output: Contribution to journalArticle

Pilot trial of K562/GM-CSF whole-cell vaccination in MDS patients

Robinson, T., Prince, G. T., Thoburn, C., Warlick, E., Ferguson, A., Kasamon, Y. L., Borrello, I. M., Hess, A. & Smith, B. D., Apr 5 2018, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-11 11 p.

Research output: Contribution to journalArticle

Efficacy and toxicity of therapy immediately after treatment with nivolumab in relapsed multiple myeloma

Pianko, M. J., Funt, S. A., Page, D. B., Cattry, D., Scott, E. C., Ansell, S. M., Borrello, I. M., Gutierrez, M., Lendvai, N., Hassoun, H., Landgren, C. O. & Lesokhin, A. M., May 26 2017, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-4 4 p.

Research output: Contribution to journalArticle

Flow cytometric discrimination of seven lineage markers by using two fluorochromes

Boin, F., Giardino Torchia, M. L., Borrello, I. M., Noonan, K., Neil, M., Soloski, M. J. & Cimbro, R., Nov 1 2017, In : PLoS One. 12, 11, e0188916.

Research output: Contribution to journalArticle

Impaired B cell immunity in acute myeloid leukemia patients after chemotherapy

Goswami, M., Prince, G., Biancotto, A., Moir, S., Kardava, L., Santich, B. H., Cheung, F., Kotliarov, Y., Chen, J., Shi, R., Zhou, H., Golding, H., Manischewitz, J., King, L., Kunz, L. M., Noonan, K., Borrello, I. M., Smith, B. D. & Hourigan, C., Jul 10 2017, In : Journal of Translational Medicine. 15, 1, 155.

Research output: Contribution to journalArticle

Low immunosuppressive burden after HLA-matched related or unrelated BMT using posttransplantation cyclophosphamide

Kanakry, C. G., Bolanos Meade, F. J., Kasamon, Y. L., Zahurak, M., Durakovic, N., Furlong, T., Mielcarek, M., Medeot, M., Gojo, I., Smith, B. D., Kanakry, J. A., Borrello, I. M., Brodsky, R. A., Gladstone, D., Huff, C. A., Matsui, W. H., Swinnen, L., Cooke, K. R., Ambinder, R. F., Fuchs, E. J. & 6 others, De Lima, M. J., Andersson, B. S., Varadhan, R., O'Donnell, P. V., Jones, R. J. & Luznik, L., Mar 9 2017, In : Blood. 129, 10, p. 1389-1393 5 p.

Research output: Contribution to journalArticle

Open Access
2016

IQGAP1 scaffold-MAP kinase interactions enhance multiple myeloma clonogenic growth and self-renewal

Gocke, C., McMillan, R., Wang, Q., Begum, A., Penchev, V. R., Ali, S. A., Borrello, I. M., Huff, C. A. & Matsui, W., Nov 1 2016, In : Molecular Cancer Therapeutics. 15, 11, p. 2733-27339 24607 p.

Research output: Contribution to journalArticle

Marrow-infiltrating lymphocytes - Role in biology and cancer therapy

Borrello, I. M. & Noonan, K., Mar 30 2016, In : Frontiers in Immunology. 7, MAR, 112.

Research output: Contribution to journalArticle

Nivolumab in patients with relapsed or refractory hematologic malignancy: Preliminary results of a phase ib study

Lesokhin, A. M., Ansell, S. M., Armand, P., Scott, E. C., Halwani, A., Gutierrez, M., Millenson, M. M., Cohen, A. D., Schuster, S. J., Lebovic, D., Dhodapkar, M., Avigan, D., Chapuy, B., Ligon, A. H., Freeman, G. J., Rodig, S. J., Cattry, D., Zhu, L., Grosso, J. F., Brigid Bradley Garelik, M. & 3 others, Shipp, M. A., Borrello, I. & Timmerman, J., Aug 10 2016, In : Journal of Clinical Oncology. 34, 23, p. 2698-2704 7 p.

Research output: Contribution to journalArticle

Therapeutic drug monitoring for either oral or intravenous busulfan when combined with pre-and post-transplantation cyclophosphamide

Lombardi, L. R., Kanakry, C. G., Zahurak, M., Durakovic, N., Bolaños-Meade, J., Kasamon, Y. L., Gladstone, D. E., Matsui, W., Borrello, I., Huff, C. A., Swinnen, L. J., Brodsky, R. A., Ambinder, R. F., Fuchs, E. J., Rosner, G. L., Jones, R. J. & Luznik, L., Mar 3 2016, In : Leukemia and Lymphoma. 57, 3, p. 666-675 10 p.

Research output: Contribution to journalArticle

The society for immunotherapy of cancer consensus statement on immunotherapy for the treatment of hematologic malignancies: Multiple myeloma, lymphoma, and acute leukemia

Boyiadzis, M., Bishop, M. R., Abonour, R., Anderson, K. C., Ansell, S. M., Avigan, D., Barbarotta, L., Barrett, A. J., Besien, K., Bergsagel, P. L., Borrello, I. M., Brody, J., Brufsky, J., Cairo, M., Chari, A., Cohen, A., Cortes, J., Forman, S. J., Friedberg, J. W., Fuchs, E. J. & 28 others, Gore, S. D., Jagannath, S., Kahl, B. S., Kline, J., Kochenderfer, J. N., Kwak, L. W., Levy, R., Lima, M., Litzow, M. R., Mahindra, A., Miller, J., Munshi, N. C., Orlowski, R. Z., Pagel, J. M., Porter, D. L., Russell, S. J., Schwartz, K., Shipp, M. A., Siegel, D., Stone, R. M., Tallman, M. S., Timmerman, J. M., Rhee, F., Waller, E. K., Welsh, A., Werner, M., Wiernik, P. H. & Dhodapkar, M. V., Dec 20 2016, In : Journal for ImmunoTherapy of Cancer. 4, 1, 90.

Research output: Contribution to journalArticle

2015

Neutrophil to lymphocyte ratio (NLR) improves the risk assessment of ISS staging in newly diagnosed MM patients treated upfront with novel agents

Romano, A., Parrinello, N. L., Consoli, M. L., Marchionni, L., Forte, S., Conticello, C., Pompa, A., Corso, A., Milone, G., Di Raimondo, F. & Borrello, I., Nov 22 2015, In : Annals of hematology. 94, 11, p. 1875-1883 9 p.

Research output: Contribution to journalArticle

PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma

Ansell, S. M., Lesokhin, A. M., Borrello, I., Halwani, A., Scott, E. C., Gutierrez, M., Schuster, S. J., Millenson, M. M., Cattry, D., Freeman, G. J., Rodig, S. J., Chapuy, B., Ligon, A. H., Zhu, L., Grosso, J. F., Kim, S. Y., Timmerman, J. M., Shipp, M. A. & Armand, P., Jan 22 2015, In : New England Journal of Medicine. 372, 4, p. 311-319 9 p.

Research output: Contribution to journalArticle

Pre-radiation lymphocyte harvesting and post-radiation reinfusion in patients with newly diagnosed high grade gliomas

Campian, J. L., Ye, X., Gladstone, D. E., Ambady, P., Nirschl, T. R., Borrello, I., Golightly, M., King, K. E., Holdhoff, M., Karp, J., Drake, C. G. & Grossman, S. A., Sep 29 2015, In : Journal of neuro-oncology. 124, 2, p. 307-316 10 p.

Research output: Contribution to journalArticle

Risk-stratified outcomes of nonmyeloablative HLA-haploidentical BMT with high-dose posttransplantation cyclophosphamide

McCurdy, S. R., Kanakry, J. A., Showel, M. M., Tsai, H. L., Bolaños-Meade, J., Rosner, G. L., Kanakry, C. G., Perica, K., Symons, H. J., Brodsky, R. A., Gladstone, D. E., Huff, C. A., Pratz, K. W., Prince, G. T., Dezern, A. E., Gojo, I., Matsui, W. H., Borrello, I., McDevitt, M. A., Swinnen, L. J. & 7 others, Smith, B. D., Levis, M. J., Ambinder, R. F., Luznik, L., Jones, R. J., Fuchs, E. J. & Kasamon, Y. L., May 7 2015, In : Blood. 125, 19, p. 3024-3031 8 p.

Research output: Contribution to journalArticle

Tadalafil augments tumor specific immunity in patients with head and neck squamous cell carcinoma

Califano, J. A., Khan, Z., Noonan, K. A., Rudraraju, L., Zhang, Z., Wang, H., Goodman, S., Gourin, C. G., Ha, P. K., Fakhry, C., Saunders, J., Levine, M., Tang, M., Neuner, G., Richmon, J. D., Blanco, R., Agrawal, N., Koch, W. M., Marur, S., Weed, D. T. & 2 others, Serafini, P. & Borrello, I., Jan 1 2015, In : Clinical Cancer Research. 21, 1, p. 30-38 9 p.

Research output: Contribution to journalArticle

Tadalafil reduces myeloid-derived suppressor cells and regulatory t cells and promotes tumor immunity in patients with head and neck squamous cell carcinoma

Weed, D. T., Vella, J. L., Reis, I. M., De La Fuente, A. C., Gomez, C., Sargi, Z., Nazarian, R., Califano, J., Borrello, I. & Serafini, P., Jan 1 2015, In : Clinical Cancer Research. 21, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

2014

Activation of liver X receptors inhibits hedgehog signaling, clonogenic growth, and self-renewal in multiple myeloma

Agarwal, J. R., Wang, Q., Tanno, T., Rasheed, Z., Merchant, A., Ghosh, N., Borrello, I., Huff, C. A., Parhami, F. & Matsui, W., Jul 2014, In : Molecular cancer therapeutics. 13, 7, p. 1873-1881 9 p.

Research output: Contribution to journalArticle

Autologous mesenchymal stem cells produce concordant improvements in regional function, tissue perfusion, and fibrotic burden when administered to patients undergoing coronary artery bypass grafting: The prospective randomized study of mesenchymal stem cell therapy in patients undergoing cardiac surgery (PROMETHEUS) trial

Karantalis, V., Difede, D. L., Gerstenblith, G., Pham, S., Symes, J., Zambrano, J. P., Fishman, J., Pattany, P., McNiece, I., Conte, J., Schulman, S., Wu, K., Shah, A., Breton, E., Davis-Sproul, J., Schwarz, R., Feigenbaum, G., Mushtaq, M., Suncion, V. Y., Lardo, A. C. & 7 others, Borrello, I., Mendizabal, A., Karas, T. Z., Byrnes, J., Lowery, M., Heldman, A. W. & Hare, J. M., Jan 1 2014, In : Circulation research. 114, 8, p. 1302-1310 9 p.

Research output: Contribution to journalArticle

Clarithromycin overcomes resistance to lenalidomide and dexamethasone in multiple myeloma

Ghosh, N., Tucker, N., Zahurak, M., Wozney, J., Borrello, I. & Huff, C. A., Aug 2014, In : American journal of hematology. 89, 8, p. E116-E120

Research output: Contribution to journalArticle

Growth differentiating factor 15 enhances the tumor-initiating and self-renewal potential of multiple myeloma cells

Tanno, T., Lim, Y., Wang, Q., Chesi, M., Bergsagel, P. L., Matthews, G., Johnstone, R. W., Ghosh, N., Borrello, I., Huff, C. A. & Matsui, W., Jan 30 2014, In : Blood. 123, 5, p. 725-733 9 p.

Research output: Contribution to journalArticle

Targeting immune suppression with PDE5 inhibition in end-stage multiple myeloma

Noonan, K. A., Ghosh, N., Rudraraju, L., Bui, M. & Borrello, I., Aug 1 2014, In : Cancer Immunology Research. 2, 8, p. 725-731 7 p.

Research output: Contribution to journalArticle

2013

Total cost comparison in relapsed/refractory multiple myeloma

Durie, B., Binder, G., Pashos, C., Khan, Z., Hussein, M. & Borrello, I., Apr 24 2013, In : Journal of Medical Economics. 16, 5, p. 614-622 9 p.

Research output: Contribution to journalArticle

2012

Autologous Stem Cell Transplantation and Multiple Myeloma Cancer Stem Cells

Matsui, W., Borrello, I. & Mitsiades, C., Jan 1 2012, In : Biology of Blood and Marrow Transplantation. 18, 1 SUPPL., p. S27-S32

Research output: Contribution to journalArticle

Can we change the disease biology of multiple myeloma?

Borrello, I., Nov 1 2012, In : Leukemia Research. 36, SUPPL.1, p. S3-S12

Research output: Contribution to journalArticle

Downregulation of BCL2 by AT-101 enhances the antileukaemic effect of lenalidomide both by an immune dependant and independent manner

Masood, A., Chitta, K., Paulus, A., Khan, A. N. H., Sher, T., Ersing, N., Miller, K. C., Manfredi, D., Ailawadhi, S., Borrelo, I., Lee, K. P. & Chanan-Khan, A. A., Apr 1 2012, In : British journal of haematology. 157, 1, p. 59-66 8 p.

Research output: Contribution to journalArticle

Inhibition of TGF-β enhances the in vivo antitumor efficacy of EGF receptor-targeted therapy

Bedi, A., Chang, X., Noonan, K., Pham, V., Bedi, R., Fertig, E. J., Considine, M., Califano, J. A., Borrello, I., Chung, C. H., Sidransky, D. & Ravi, R., Nov 1 2012, In : Molecular cancer therapeutics. 11, 11, p. 2429-2439 11 p.

Research output: Contribution to journalArticle

Lenalidomide in combination with dexamethasone improves survival and time-to-progression in patients ≥65 years old with relapsed or refractory multiple myeloma

Chanan-Khan, A. A., Lonial, S., Weber, D., Borrello, I., Foà, R., Hellmann, A., Dimopoulos, M., Swern, A. S. & Knight, R., Aug 2012, In : International journal of hematology. 96, 2, p. 254-262 9 p.

Research output: Contribution to journalArticle

Lenalidomide-induced immunomodulation in multiple myeloma: Impact on vaccines and antitumor responses

Noonan, K., Rudraraju, L., Ferguson, A., Emerling, A., Pasetti, M. F., Huff, C. A. & Borrello, I., Mar 1 2012, In : Clinical Cancer Research. 18, 5, p. 1426-1434 9 p.

Research output: Contribution to journalArticle

2011

A phase 1 study of IPI-504 (retaspimycin hydrochloride) in patients with relapsed or relapsed and refractory multiple myeloma

Siegel, D., Jagannath, S., Vesole, D. H., Borello, I., Mazumder, A., Mitsiades, C., Goddard, J., Dunbar, J., Normant, E., Adams, J., Grayzel, D., Anderson, K. C. & Richardson, P., Dec 1 2011, In : Leukemia and Lymphoma. 52, 12, p. 2308-2315 8 p.

Research output: Contribution to journalArticle

Biological effects and clinical significance of lenalidomide-induced tumour flare reaction in patients with chronic lymphocytic leukaemia: In vivo evidence of immune activation and antitumour response

Chanan-Khan, A. A., Chitta, K., Ersing, N., Paulus, A., Masood, A., Sher, T., Swaika, A., Wallace, P. K., Mashtare, T. L., Wilding, G., Lee, K., Czuczman, M. S., Borrello, I. & Bangia, N., Nov 1 2011, In : British journal of haematology. 155, 4, p. 457-467 11 p.

Research output: Contribution to journalArticle

Bortezomib and thalidomide, a steroid free regimen in newly diagnosed patients with multiple myeloma

Ghosh, N., Ye, X., Ferguson, A., Huff, C. A. & Borrello, I., Mar 1 2011, In : British journal of haematology. 152, 5, p. 593-599 7 p.

Research output: Contribution to journalArticle