Ivan M Borrello

Associate Professor

1988 …2019

Research output per year

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Research Output

2019

BCMA CAR T cells: The winding path to success

Borrello, I. M. & Imus, P., Jun 3 2019, In : Journal of Clinical Investigation. 129, 6, p. 2175-2177 3 p.

Research output: Contribution to journalReview article

Open Access
2018

Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy

Ravi, R., Noonan, K., Pham, V., Bedi, R., Zhavoronkov, A., Ozerov, I. V., Makarev, E., Artemov, A. V., Wysocki, P. T., Mehra, R., Nimmagadda, S., Marchionni, L., Sidransky, D., Borrello, I. M., Izumchenko, E. & Bedi, A., Dec 1 2018, In : Nature Communications. 9, 1, 741.

Research output: Contribution to journalArticle

Correction: Tadalafil Augments Tumor-specific Immunity in Patients with Head and Neck Squamous Cell Carcinoma(Clin Cancer Res (2015)21(30–8)DOI: 10.1158/1078-0432.CCR-14-1716)

Califano, J. A., Khan, Z., Noonan, K. A., Rudraraju, L., Zhang, Z., Wang, H., Goodman, S., Gourin, C. G., Ha, P. K., Fakhry, C., Saunders, J., Levine, M., Tang, M., Neuner, G., Richmon, J. D., Blanco, R., Agrawal, N., Koch, W. M., Marur, S., Weed, D. T. & 2 others, Serafini, P. & Borrello, I., Dec 1 2018, In : Clinical Cancer Research. 24, 23, 1 p.

Research output: Contribution to journalComment/debate

Pilot trial of K562/GM-CSF whole-cell vaccination in MDS patients

Robinson, T., Prince, G. T., Thoburn, C., Warlick, E., Ferguson, A., Kasamon, Y. L., Borrello, I. M., Hess, A. & Smith, B. D., Apr 5 2018, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-11 11 p.

Research output: Contribution to journalArticle

Efficacy and toxicity of therapy immediately after treatment with nivolumab in relapsed multiple myeloma

Pianko, M. J., Funt, S. A., Page, D. B., Cattry, D., Scott, E. C., Ansell, S. M., Borrello, I. M., Gutierrez, M., Lendvai, N., Hassoun, H., Landgren, C. O. & Lesokhin, A. M., May 26 2017, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-4 4 p.

Research output: Contribution to journalArticle

Flow cytometric discrimination of seven lineage markers by using two fluorochromes

Boin, F., Giardino Torchia, M. L., Borrello, I. M., Noonan, K., Neil, M., Soloski, M. J. & Cimbro, R., Nov 1 2017, In : PLoS One. 12, 11, e0188916.

Research output: Contribution to journalArticle

Hematologic Malignancies: Plasma Cell Disorders

Dhodapkar, M. V., Borrello, I., Cohen, A. D. & Stadtmauer, E. A., Jan 1 2017, In : American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting. 37, p. 561-568 8 p.

Research output: Contribution to journalReview article

Impaired B cell immunity in acute myeloid leukemia patients after chemotherapy

Goswami, M., Prince, G., Biancotto, A., Moir, S., Kardava, L., Santich, B. H., Cheung, F., Kotliarov, Y., Chen, J., Shi, R., Zhou, H., Golding, H., Manischewitz, J., King, L., Kunz, L. M., Noonan, K., Borrello, I. M., Smith, B. D. & Hourigan, C., Jul 10 2017, In : Journal of Translational Medicine. 15, 1, 155.

Research output: Contribution to journalArticle

Low immunosuppressive burden after HLA-matched related or unrelated BMT using posttransplantation cyclophosphamide

Kanakry, C. G., Bolanos Meade, F. J., Kasamon, Y. L., Zahurak, M., Durakovic, N., Furlong, T., Mielcarek, M., Medeot, M., Gojo, I., Smith, B. D., Kanakry, J. A., Borrello, I. M., Brodsky, R. A., Gladstone, D., Huff, C. A., Matsui, W. H., Swinnen, L., Cooke, K. R., Ambinder, R. F., Fuchs, E. J. & 6 others, De Lima, M. J., Andersson, B. S., Varadhan, R., O'Donnell, P. V., Jones, R. J. & Luznik, L., Mar 9 2017, In : Blood. 129, 10, p. 1389-1393 5 p.

Research output: Contribution to journalArticle

Open Access
2016

IQGAP1 scaffold-MAP kinase interactions enhance multiple myeloma clonogenic growth and self-renewal

Gocke, C., McMillan, R., Wang, Q., Begum, A., Penchev, V. R., Ali, S. A., Borrello, I. M., Huff, C. A. & Matsui, W., Nov 1 2016, In : Molecular Cancer Therapeutics. 15, 11, p. 2733-27339 24607 p.

Research output: Contribution to journalArticle

Marrow-infiltrating lymphocytes - Role in biology and cancer therapy

Borrello, I. M. & Noonan, K., Mar 30 2016, In : Frontiers in Immunology. 7, MAR, 112.

Research output: Contribution to journalArticle

Nivolumab in patients with relapsed or refractory hematologic malignancy: Preliminary results of a phase ib study

Lesokhin, A. M., Ansell, S. M., Armand, P., Scott, E. C., Halwani, A., Gutierrez, M., Millenson, M. M., Cohen, A. D., Schuster, S. J., Lebovic, D., Dhodapkar, M., Avigan, D., Chapuy, B., Ligon, A. H., Freeman, G. J., Rodig, S. J., Cattry, D., Zhu, L., Grosso, J. F., Brigid Bradley Garelik, M. & 3 others, Shipp, M. A., Borrello, I. & Timmerman, J., Aug 10 2016, In : Journal of Clinical Oncology. 34, 23, p. 2698-2704 7 p.

Research output: Contribution to journalArticle

Role of the immune response in disease progression and therapy in multiple myeloma

Lee, S. J. & Borrello, I. M., 2016, Cancer Treatment and Research. Kluwer Academic Publishers, Vol. 169. p. 207-225 19 p. (Cancer Treatment and Research; vol. 169).

Research output: Chapter in Book/Report/Conference proceedingChapter

The immunotherapy era of myeloma: Monoclonal antibodies, vaccines, and adoptive T-cell therapies

Hoyos, V. & Borrello, I., Sep 29 2016, In : Blood. 128, 13, p. 1679-1687 9 p.

Research output: Contribution to journalReview article

Therapeutic drug monitoring for either oral or intravenous busulfan when combined with pre-and post-transplantation cyclophosphamide

Lombardi, L. R., Kanakry, C. G., Zahurak, M., Durakovic, N., Bolaños-Meade, J., Kasamon, Y. L., Gladstone, D. E., Matsui, W., Borrello, I., Huff, C. A., Swinnen, L. J., Brodsky, R. A., Ambinder, R. F., Fuchs, E. J., Rosner, G. L., Jones, R. J. & Luznik, L., Mar 3 2016, In : Leukemia and Lymphoma. 57, 3, p. 666-675 10 p.

Research output: Contribution to journalArticle

The society for immunotherapy of cancer consensus statement on immunotherapy for the treatment of hematologic malignancies: Multiple myeloma, lymphoma, and acute leukemia

Boyiadzis, M., Bishop, M. R., Abonour, R., Anderson, K. C., Ansell, S. M., Avigan, D., Barbarotta, L., Barrett, A. J., Besien, K., Bergsagel, P. L., Borrello, I. M., Brody, J., Brufsky, J., Cairo, M., Chari, A., Cohen, A., Cortes, J., Forman, S. J., Friedberg, J. W., Fuchs, E. J. & 28 others, Gore, S. D., Jagannath, S., Kahl, B. S., Kline, J., Kochenderfer, J. N., Kwak, L. W., Levy, R., Lima, M., Litzow, M. R., Mahindra, A., Miller, J., Munshi, N. C., Orlowski, R. Z., Pagel, J. M., Porter, D. L., Russell, S. J., Schwartz, K., Shipp, M. A., Siegel, D., Stone, R. M., Tallman, M. S., Timmerman, J. M., Rhee, F., Waller, E. K., Welsh, A., Werner, M., Wiernik, P. H. & Dhodapkar, M. V., Dec 20 2016, In : Journal for ImmunoTherapy of Cancer. 4, 1, 90.

Research output: Contribution to journalArticle

2015

Marrow infiltrating lymphocytes: Their role in adoptive immunotherapy

Noonan, K. A. & Borrello, I. M., Jan 1 2015, In : Cancer Journal (United States). 21, 6, p. 501-505 5 p.

Research output: Contribution to journalReview article

Neutrophil to lymphocyte ratio (NLR) improves the risk assessment of ISS staging in newly diagnosed MM patients treated upfront with novel agents

Romano, A., Parrinello, N. L., Consoli, M. L., Marchionni, L., Forte, S., Conticello, C., Pompa, A., Corso, A., Milone, G., Di Raimondo, F. & Borrello, I., Nov 22 2015, In : Annals of hematology. 94, 11, p. 1875-1883 9 p.

Research output: Contribution to journalArticle

PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma

Ansell, S. M., Lesokhin, A. M., Borrello, I., Halwani, A., Scott, E. C., Gutierrez, M., Schuster, S. J., Millenson, M. M., Cattry, D., Freeman, G. J., Rodig, S. J., Chapuy, B., Ligon, A. H., Zhu, L., Grosso, J. F., Kim, S. Y., Timmerman, J. M., Shipp, M. A. & Armand, P., Jan 22 2015, In : New England Journal of Medicine. 372, 4, p. 311-319 9 p.

Research output: Contribution to journalArticle

Pre-radiation lymphocyte harvesting and post-radiation reinfusion in patients with newly diagnosed high grade gliomas

Campian, J. L., Ye, X., Gladstone, D. E., Ambady, P., Nirschl, T. R., Borrello, I., Golightly, M., King, K. E., Holdhoff, M., Karp, J., Drake, C. G. & Grossman, S. A., Sep 29 2015, In : Journal of neuro-oncology. 124, 2, p. 307-316 10 p.

Research output: Contribution to journalArticle

Risk-stratified outcomes of nonmyeloablative HLA-haploidentical BMT with high-dose posttransplantation cyclophosphamide

McCurdy, S. R., Kanakry, J. A., Showel, M. M., Tsai, H. L., Bolaños-Meade, J., Rosner, G. L., Kanakry, C. G., Perica, K., Symons, H. J., Brodsky, R. A., Gladstone, D. E., Huff, C. A., Pratz, K. W., Prince, G. T., Dezern, A. E., Gojo, I., Matsui, W. H., Borrello, I., McDevitt, M. A., Swinnen, L. J. & 7 others, Smith, B. D., Levis, M. J., Ambinder, R. F., Luznik, L., Jones, R. J., Fuchs, E. J. & Kasamon, Y. L., May 7 2015, In : Blood. 125, 19, p. 3024-3031 8 p.

Research output: Contribution to journalArticle

Tadalafil augments tumor specific immunity in patients with head and neck squamous cell carcinoma

Califano, J. A., Khan, Z., Noonan, K. A., Rudraraju, L., Zhang, Z., Wang, H., Goodman, S., Gourin, C. G., Ha, P. K., Fakhry, C., Saunders, J., Levine, M., Tang, M., Neuner, G., Richmon, J. D., Blanco, R., Agrawal, N., Koch, W. M., Marur, S., Weed, D. T. & 2 others, Serafini, P. & Borrello, I., Jan 1 2015, In : Clinical Cancer Research. 21, 1, p. 30-38 9 p.

Research output: Contribution to journalArticle

Tadalafil reduces myeloid-derived suppressor cells and regulatory t cells and promotes tumor immunity in patients with head and neck squamous cell carcinoma

Weed, D. T., Vella, J. L., Reis, I. M., De La Fuente, A. C., Gomez, C., Sargi, Z., Nazarian, R., Califano, J., Borrello, I. & Serafini, P., Jan 1 2015, In : Clinical Cancer Research. 21, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

2014

Activation of liver X receptors inhibits hedgehog signaling, clonogenic growth, and self-renewal in multiple myeloma

Agarwal, J. R., Wang, Q., Tanno, T., Rasheed, Z., Merchant, A., Ghosh, N., Borrello, I., Huff, C. A., Parhami, F. & Matsui, W., Jul 2014, In : Molecular cancer therapeutics. 13, 7, p. 1873-1881 9 p.

Research output: Contribution to journalArticle

Autologous mesenchymal stem cells produce concordant improvements in regional function, tissue perfusion, and fibrotic burden when administered to patients undergoing coronary artery bypass grafting: The prospective randomized study of mesenchymal stem cell therapy in patients undergoing cardiac surgery (PROMETHEUS) trial

Karantalis, V., Difede, D. L., Gerstenblith, G., Pham, S., Symes, J., Zambrano, J. P., Fishman, J., Pattany, P., McNiece, I., Conte, J., Schulman, S., Wu, K., Shah, A., Breton, E., Davis-Sproul, J., Schwarz, R., Feigenbaum, G., Mushtaq, M., Suncion, V. Y., Lardo, A. C. & 7 others, Borrello, I., Mendizabal, A., Karas, T. Z., Byrnes, J., Lowery, M., Heldman, A. W. & Hare, J. M., Jan 1 2014, In : Circulation research. 114, 8, p. 1302-1310 9 p.

Research output: Contribution to journalArticle

Clarithromycin overcomes resistance to lenalidomide and dexamethasone in multiple myeloma

Ghosh, N., Tucker, N., Zahurak, M., Wozney, J., Borrello, I. & Huff, C. A., Aug 2014, In : American journal of hematology. 89, 8, p. E116-E120

Research output: Contribution to journalArticle

Growth differentiating factor 15 enhances the tumor-initiating and self-renewal potential of multiple myeloma cells

Tanno, T., Lim, Y., Wang, Q., Chesi, M., Bergsagel, P. L., Matthews, G., Johnstone, R. W., Ghosh, N., Borrello, I., Huff, C. A. & Matsui, W., Jan 30 2014, In : Blood. 123, 5, p. 725-733 9 p.

Research output: Contribution to journalArticle

Infusion of cryopreserved autologous lymphocytes using a standard peripheral i.v. catheter

Gladstone, D. E., Davis-Sproul, J., Campian, J., Lemas, M. V., Malatyali, S., Borrello, I., King, K. & Grossman, S. A., Aug 2014, In : Bone marrow transplantation. 49, 8, p. 1119-1120 2 p.

Research output: Contribution to journalLetter

Targeting immune suppression with PDE5 inhibition in end-stage multiple myeloma

Noonan, K. A., Ghosh, N., Rudraraju, L., Bui, M. & Borrello, I., Aug 1 2014, In : Cancer Immunology Research. 2, 8, p. 725-731 7 p.

Research output: Contribution to journalArticle

2013

Total cost comparison in relapsed/refractory multiple myeloma

Durie, B., Binder, G., Pashos, C., Khan, Z., Hussein, M. & Borrello, I., Apr 24 2013, In : Journal of Medical Economics. 16, 5, p. 614-622 9 p.

Research output: Contribution to journalArticle

2012

Autologous Stem Cell Transplantation and Multiple Myeloma Cancer Stem Cells

Matsui, W., Borrello, I. & Mitsiades, C., Jan 1 2012, In : Biology of Blood and Marrow Transplantation. 18, 1 SUPPL., p. S27-S32

Research output: Contribution to journalArticle

Can we change the disease biology of multiple myeloma?

Borrello, I., Nov 1 2012, In : Leukemia Research. 36, SUPPL.1, p. S3-S12

Research output: Contribution to journalArticle