Research output per year
Research output per year
- 1 - 50 out of 94 results
Search results
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2024
Histologic and Immunohistochemical Characterization of GA-Like Pathology in the Rat Subretinal Sodium Iodate Model
Naik, P., Grebe, R., Bhutto, I. A., Scott Mcleod, D. & Edwards, M., Feb 1 2024, In: Translational Vision Science and Technology. 13, 2, 10.Research output: Contribution to journal › Article › peer-review
Open Access -
Visualization of choroidal vasculature in pigmented mouse eyes from experimental models of AMD
Bhutto, I. A., McLeod, D. S., Thomson, B. R., Lutty, G. A. & Edwards, M. M., Jan 2024, In: Experimental eye research. 238, 109741.Research output: Contribution to journal › Article › peer-review
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2023
Clinicopathologic Findings in Three Siblings With Geographic Atrophy
Edwards, M. M., Scott McLeod, D., Shen, M., Grebe, R., Sunness, J. S., Bhutto, I. A., McDonnell, E., Pado, A. M., Gregori, G., Rosenfeld, P. J. & Lutty, G. A., Mar 2023, In: Investigative Ophthalmology and Visual Science. 64, 3, 2.Research output: Contribution to journal › Article › peer-review
Open Access -
Mitophagy initiates retrograde mitochondrial-nuclear signaling to guide retinal pigment cell heterogeneity
Datta, S., Cano, M., Satyanarayana, G., Liu, T., Wang, L., Wang, J., Cheng, J., Itoh, K., Sharma, A., Bhutto, I., Kannan, R., Qian, J., Sinha, D. & Handa, J. T., 2023, In: Autophagy. 19, 3, p. 966-983 18 p.Research output: Contribution to journal › Article › peer-review
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Pathologic vs. protective roles of hypoxia-inducible factor 1 in RPE and photoreceptors in wet vs. dry age-related macular degeneration
Babapoor-Farrokhran, S., Qina, Y., Flores-Bellver, M., Niu, Y., Bhutto, I. A., Aparicio-Domingo, S., Guoa, C., Rodrigues, M., Domashevich, T., Deshpande, M., Megarity, H., Chopde, R., Eberhart, C. G., Canto-Soler, V., Montaner, S. & Sodhi, A., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 50, e2302845120.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Generation of Pericytic-Vascular Progenitors from Tankyrase/PARP-Inhibitor-Regulated Naïve (TIRN) Human Pluripotent Stem Cells
Zimmerlin, L., Park, T. S., Bhutto, I., Lutty, G. & Zambidis, E. T., 2022, Methods in Molecular Biology. Humana Press Inc., p. 133-156 24 p. (Methods in Molecular Biology; vol. 2416).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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2021
Evolution of oxidative stress, inflammation and neovascularization in the choroid and retina in a subretinal lipid induced age-related macular degeneration model
Kim, S. Y., Kambhampati, S. P., Bhutto, I. A., McLeod, D. S., Lutty, G. A. & Kannan, R. M., Feb 2021, In: Experimental eye research. 203, 108391.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Role of glia in optic nerve
Yazdankhah, M., Shang, P., Ghosh, S., Hose, S., Liu, H., Weiss, J., Fitting, C. S., Bhutto, I. A., Zigler, J. S., Qian, J., Sahel, J. A., Sinha, D. & Stepicheva, N. A., Mar 2021, In: Progress in Retinal and Eye Research. 81, 100886.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
Systemic dendrimer nanotherapies for targeted suppression of choroidal inflammation and neovascularization in age-related macular degeneration
Kambhampati, S. P., Bhutto, I. A., Wu, T., Ho, K., McLeod, D. S., Lutty, G. A. & Kannan, R. M., Jul 10 2021, In: Journal of Controlled Release. 335, p. 527-540 14 p.Research output: Contribution to journal › Article › peer-review
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Topical Ketotifen Fumarate Inhibits Choroidal Mast Cell Degranulation and Loss of Retinal Pigment Epithelial Cells in Rat Model for Geographic Atrophy
Nizawa, T., Bhutto, I. A., Tiwari, A., Grebe, R. R., Alt, J., Rais, R., Edwards, M. M. & Lutty, G. A., Dec 2021, In: Translational Vision Science and Technology. 10, 14, 37.Research output: Contribution to journal › Article › peer-review
Open Access -
βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity
Ghosh, S., Liu, H., Yazdankhah, M., Stepicheva, N., Shang, P., Vaidya, T., Hose, S., Gupta, U., Calderon, M. J., Hu, M. W., Nair, A. P., Weiss, J., Fitting, C. S., Bhutto, I. A., Gadde, S. G. K., Naik, N. K., Jaydev, C., Lutty, G. A., Handa, J. T., Jayagopal, A., & 9 others, Dec 2021, In: Communications biology. 4, 1, 248.Research output: Contribution to journal › Article › peer-review
Open Access -
βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells
Shang, P., Stepicheva, N., Teel, K., McCauley, A., Fitting, C. S., Hose, S., Grebe, R., Yazdankhah, M., Ghosh, S., Liu, H., Strizhakova, A., Weiss, J., Bhutto, I. A., Lutty, G. A., Jayagopal, A., Qian, J., Sahel, J. A., Samuel Zigler, J., Handa, J. T., Sergeev, Y., & 3 others, Dec 2021, In: Communications biology. 4, 1, 850.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
A role for mast cells in geographic atrophy
Ogura, S., Baldeosingh, R., Bhutto, I. A., Kambhampati, S. P., Scott McLeod, D., Edwards, M. M., Rais, R., Schubert, W. & Lutty, G. A., Aug 1 2020, In: FASEB Journal. 34, 8, p. 10117-10131 15 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Choriocapillaris dropout in early age-related macular degeneration
Lutty, G. A., McLeod, D. S., Bhutto, I. A., Edwards, M. M. & Seddon, J. M., Mar 2020, In: Experimental eye research. 192, 107939.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease
Yazdankhah, M., Shang, P., Ghosh, S., Bhutto, I. A., Stepicheva, N., Grebe, R., Hose, S., Weiss, J., Luo, T., Mishra, S., Riazuddin, S. A., Ghosh, A., Handa, J. T., Lutty, G. A., Zigler, J. S. & Sinha, D., Jun 2 2020, In: Autophagy. 16, 6, p. 1130-1142 13 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Retinal glial and choroidal vascular pathology in donors clinically diagnosed with stargardt disease
Edwards, M. M., Bonilha, V. L., Bhutto, I. A., Bell, B. A., McLeod, D. S., Hollyfield, J. G. & Lutty, G. A., Jul 2020, In: Investigative Ophthalmology and Visual Science. 61, 8, 27.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina
Park, T. S., Zimmerlin, L., Evans-Moses, R., Thomas, J., Huo, J. S., Kanherkar, R., He, A., Ruzgar, N., Grebe, R., Bhutto, I., Barbato, M., Koldobskiy, M. A., Lutty, G. & Zambidis, E. T., Dec 1 2020, In: Nature communications. 11, 1, 1195.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
2019
Melatonin as the Possible Link Between Age-Related Retinal Regeneration and the Disrupted Circadian Rhythm in Elderly
Stepicheva, N. A., Weiss, J., Shang, P., Yazdankhah, M., Ghosh, S., Bhutto, I. A., Hose, S., Zigler, J. S. & Sinha, D., 2019, Advances in Experimental Medicine and Biology. Springer, p. 45-49 5 p. (Advances in Experimental Medicine and Biology; vol. 1185).Research output: Chapter in Book/Report/Conference proceeding › Chapter
2 Scopus citations -
Neutrophils homing into the retina trigger pathology in early age-related macular degeneration
Ghosh, S., Padmanabhan, A., Vaidya, T., Watson, A. M., Bhutto, I. A., Hose, S., Shang, P., Stepicheva, N., Yazdankhah, M., Weiss, J., Das, M., Gopikrishna, S., Aishwarya, Yadav, N., Berger, T., Mak, T. W., Xia, S., Qian, J., Lutty, G. A., Jayagopal, A., & 6 others, Dec 1 2019, In: Communications biology. 2, 1, 348.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
2018
An Acute Injury Model for the Phenotypic Characteristics of Geographic Atrophy
Bhutto, I. A., Ogura, S., Baldeosingh, R., McLeod, D. S., Lutty, G. A. & Edwards, M. M., Mar 20 2018, In: Investigative ophthalmology & visual science. 59, 4, p. AMD143-AMD151Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
A role for βA3/A1-crystallin in type 2 EMT of RPE cells occurring in dry age-related Macular degeneration
Ghosh, S., Shang, P., Terasaki, H., Stepicheva, N., Hose, S., Yazdankhah, M., Weiss, J., Sakamoto, T., Bhutto, I. A., Xia, S., Zigler, J. S., Kannan, R., Qian, J., Handa, J. T. & Sinha, D., Mar 2018, In: Investigative Ophthalmology and Visual Science. 59, 4, p. AMD104-AMD113Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
Ocular Histopathology and Immunohistochemical Analysis in the Oldest Known Individual with Autosomal Dominant Vitreoretinochoroidopathy
Goldberg, M. F., McLeod, S., Tso, M., Packo, K., Edwards, M., Bhutto, I. A., Baldeosingh, R., Eberhart, C., Weber, B. H. F. & Lutty, G. A., Apr 2018, In: Ophthalmology Retina. 2, 4, p. 360-378 19 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2017
Activating the AKT2–nuclear factor-κB–lipocalin-2 axis elicits an inflammatory response in age-related macular degeneration
Ghosh, S., Shang, P., Yazdankhah, M., Bhutto, I., Hose, S., Montezuma, S. R., Luo, T., Chattopadhyay, S., Qian, J., Lutty, G. A., Ferrington, D. A., Zigler, J. S. & Sinha, D., Apr 1 2017, In: Journal of Pathology. 241, 5, p. 583-588 6 p.Research output: Contribution to journal › Article › peer-review
22 Scopus citations -
Mast cell-derived tryptase in geographic atrophy
McLeod, D. S., Bhutto, I., Edwards, M. M., Gedam, M., Baldeosingh, R. & Lutty, G. A., Nov 2017, In: Investigative Ophthalmology and Visual Science. 58, 13, p. 5887-5896 10 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Subretinal glial membranes in eyes with geographic atrophy
Edwards, M. M., McLeod, D. S., Bhutto, I. A., Grebe, R., Duffy, M. & Lutty, G. A., Mar 2017, In: Investigative Ophthalmology and Visual Science. 58, 3, p. 1352-1367 16 p.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling
Shang, P., Valapala, M., Grebe, R., Hose, S., Ghosh, S., Bhutto, I. A., Handa, J. T., Lutty, G. A., Lu, L., Wan, J., Qian, J., Sergeev, Y., Puertollano, R., Zigler, J. S., Xu, G. T. & Sinha, D., Apr 1 2017, In: Aging Cell. 16, 2, p. 349-359 11 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
2016
Albumen transport to bruch’s membrane and RPE by choriocapillaris caveolae
Nakanishi, M., Grebe, R., Bhutto, I. A., Edwards, M., Scott Mcleod, D. & Lutty, G. A., Apr 1 2016, In: Investigative Ophthalmology and Visual Science. 57, 4, p. 2213-2224 12 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Distribution and quantification of choroidal macrophages in human eyes with age-related macular degeneration
McLeod, D. S., Bhutto, I., Edwards, M. M., Silver, R. E., Seddon, J. M. & Lutty, G. A., Nov 2016, In: Investigative Ophthalmology and Visual Science. 57, 14, p. 5843-5855 13 p.Research output: Contribution to journal › Article › peer-review
Open Access43 Scopus citations -
Histopathological insights into choroidal vascular loss in clinically documented cases of age-related macular degeneration
Seddon, J. M., McLeod, D. S., Bhutto, I. A., Villalonga, M. B., Silver, R. E., Wenick, A. S., Edwards, M. M. & Lutty, G. A., Nov 1 2016, In: JAMA ophthalmology. 134, 11, p. 1272-1280 9 p.Research output: Contribution to journal › Article › peer-review
Open Access85 Scopus citations -
Idiopathic preretinal glia in aging and age-related macular degeneration
Edwards, M. M., McLeod, D. S., Bhutto, I. A., Villalonga, M. B., Seddon, J. M. & Lutty, G. A., Sep 1 2016, In: Experimental eye research. 150, p. 44-61 18 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Increased choroidal mast cells and their degranulation in age-related macular degeneration
Bhutto, I. A., McLeod, D. S., Jing, T., Sunness, J. S., Seddon, J. M. & Lutty, G. A., May 2016, In: British Journal of Ophthalmology. 100, 5, p. 720-726 7 p.Research output: Contribution to journal › Article › peer-review
Open Access31 Scopus citations -
2015
Small-molecule-directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells
Maruotti, J., Sripathi, S. R., Bharti, K., Fuller, J., Wahlin, K. J., Ranganathan, V., Sluch, V. M., Berlinicke, C. A., Davis, J., Kim, C., Zhao, L., Wan, J., Qian, J., Corneo, B., Temple, S., Dubey, R., Olenyuk, B. Z., Bhutto, I., Lutty, G. A. & Zack, D. J., Sep 1 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 35, p. 10950-10955 6 p.Research output: Contribution to journal › Article › peer-review
Open Access65 Scopus citations -
Systemic and intravitreal delivery of dendrimers to activated microglia/macrophage in ischemia/reperfusion mouse retina
Kambhampati, S. P., Clunies-Ross, A. J. M., Bhutto, I., Mishra, M. K., Edwards, M., McLeod, D. S., Kannan, R. M. & Lutty, G., 2015, In: Investigative Ophthalmology and Visual Science. 56, 8, p. 4413-4424 12 p.Research output: Contribution to journal › Article › peer-review
Open Access44 Scopus citations -
2014
Increased Lipocalin-2 in the retinal pigment epithelium of Cryba1 cKO mice is associated with a chronic inflammatory response
Valapala, M., Edwards, M., Hose, S., Grebe, R., Bhutto, I. A., Cano, M., Berger, T., Mak, T. W., Wawrousek, E., Handa, J. T., Lutty, G. A., Samuel Zigler, J. & Sinha, D., Dec 1 2014, In: Aging Cell. 13, 6, p. 1091-1094 4 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling
Valapala, M., Wilson, C., Hose, S., Bhutto, I. A., Grebe, R., Dong, A., Greenbaum, S., Gu, L., Sengupta, S., Cano, M., Hackett, S., Xu, G., Lutty, G. A., Dong, L., Sergeev, Y., Handa, J. T., Campochiaro, P., Wawrousek, E., Zigler, J. S. & Sinha, D., Mar 2014, In: Autophagy. 10, 3, p. 480-496 17 p.Research output: Contribution to journal › Article › peer-review
Open Access74 Scopus citations -
Response to the letter by Huisingh and McGewin: Cluster of Urrets-Zavalia syndrome: A sequel of toxic anterior segment syndrome
Nizamani, N. B., Bhutto, I. A. & Talpur, K. I., Mar 2014, In: British Journal of Ophthalmology. 98, 3, p. 414 1 p.Research output: Contribution to journal › Letter › peer-review
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Vascular progenitors from cord blood-derived induced pluripotent stem cells possess augmented capacity for regenerating ischemic retinal vasculature
Park, T. S., Bhutto, I., Zimmerlin, L., Huo, J. S., Nagaria, P., Miller, D., Rufaihah, A. J., Talbot, C., Aguilar, J., Grebe, R., Merges, C., Reijo-Pera, R., Feldman, R. A., Rassool, F., Cooke, J., Lutty, G. & Zambidis, E. T., Jan 21 2014, In: Circulation. 129, 3, p. 359-372 14 p.Research output: Contribution to journal › Article › peer-review
Open Access48 Scopus citations -
2013
A simple and scalable process for the differentiation of retinal pigment epithelium from human pluripotent stem cells
Maruotti, J., Wahlin, K., Gorrell, D., Bhutto, I., Lutty, G. & Zack, D. J., 2013, In: Stem Cells Translational Medicine. 2, 5, p. 341-354 14 p.Research output: Contribution to journal › Article › peer-review
Open Access70 Scopus citations -
Cluster of Urrets-Zavalia syndrome: A sequel of toxic anterior segment syndrome
Nizamani, N. B., Bhutto, I. A. & Talpur, K. I., Aug 2013, In: British Journal of Ophthalmology. 97, 8, p. 976-979 4 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Hypoxic retinal Müller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4
Xin, X., Rodrigues, M., Umapathi, M., Kashiwabuchi, F., Ma, T., Babapoor-Farrokhran, S., Wang, S., Hu, J., Bhutto, I., Welsbie, D. S., Duh, E. J., Handa, J. T., Eberhart, C. G., Lutty, G., Semenza, G. L., Montaner, S. & Sodhi, A., Sep 3 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 36, p. E3425-E3434Research output: Contribution to journal › Article › peer-review
Open Access75 Scopus citations -
VEGF secreted by hypoxic Müller cells induces MMP-2 expression and activity in endothelial cells to promote retinal neovascularization in proliferative diabetic retinopathy
Rodrigues, M., Xin, X., Jee, K., Babapoor-Farrokhran, S., Kashiwabuchi, F., Ma, T., Bhutto, I., Hassan, S. J., Daoud, Y., Baranano, D., Solomon, S., Lutty, G., Semenza, G. L., Montaner, S. & Sodhi, A., Nov 2013, In: Diabetes. 62, 11, p. 3863-3873 11 p.Research output: Contribution to journal › Article › peer-review
Open Access86 Scopus citations -
2012
Anatomy: Anatomy of the Ocular Vasculatures
Lutty, G. A., Bhutto, I. & McLeod, D. S., Jan 1 2012, Ocular Blood Flow. Springer Berlin Heidelberg, p. 3-24 22 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
6 Scopus citations -
Co-expression of endothelial and neuronal nitric oxide synthases in the developing vasculatures of the human fetal eye
Scott McLeod, D., Baba, T., Bhutto, I. A. & Lutty, G. A., Jun 2012, In: Graefe's Archive for Clinical and Experimental Ophthalmology. 250, 6, p. 839-848 10 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Poly(β-amino ester)-nanoparticle mediated transfection of retinal pigment epithelial cells in vitro and in vivo
Sunshine, J. C., Sunshine, S. B., Bhutto, I., Handa, J. T. & Green, J. J., May 21 2012, In: PloS one. 7, 5, e37543.Research output: Contribution to journal › Article › peer-review
Open Access63 Scopus citations -
Systematic assessment of microneedle injection into the mouse cornea.
Matthaei, M., Meng, H., Bhutto, I., Xu, Q., Boelke, E., Hanes, J. & Jun, A. S., 2012, In: European journal of medical research. 17, p. 19 1 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
The deletion of Math5 disrupts retinal blood vessel and glial development in mice
Edwards, M. M., McLeod, D. S., Li, R., Grebe, R., Bhutto, I., Mu, X. & Lutty, G. A., Mar 2012, In: Experimental eye research. 96, 1, p. 147-156 10 p.Research output: Contribution to journal › Article › peer-review
Open Access36 Scopus citations -
Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris complex
Bhutto, I. & Lutty, G., Aug 2012, In: Molecular Aspects of Medicine. 33, 4, p. 295-317 23 p.Research output: Contribution to journal › Review article › peer-review
500 Scopus citations -
βA3/A1-crystallin is required for proper astrocyte template formation and vascular remodeling in the retina
Sinha, D., Valapala, M., Bhutto, I., Patek, B., Zhang, C., Hose, S., Yang, F., Cano, M., Stark, W. J., Lutty, G. A., Zigler, J. S. & Wawrousek, E. F., Sep 2012, In: Transgenic Research. 21, 5, p. 1033-1042 10 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
2011
C-reactive protein and complement factor H in aged human eyes and eyes with age-related macular degeneration
Bhutto, I. A., Baba, T., Merges, C., Juriasinghani, V., McLeod, D. S. & Lutty, G. A., Sep 2011, In: British Journal of Ophthalmology. 95, 9, p. 1323-1330 8 p.Research output: Contribution to journal › Article › peer-review
Open Access76 Scopus citations -
Effect of VEGF trap on normal retinal vascular development and oxygen-induced retinopathy in the dog
Lutty, G. A., McLeod, D. S., Bhutto, I. & Wiegand, S. J., Jun 2011, In: Investigative Ophthalmology and Visual Science. 52, 7, p. 4039-4047 9 p.Research output: Contribution to journal › Article › peer-review
Open Access55 Scopus citations