Imran Bhutto

Research Associate

1993 …2019
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Research Output 1993 2019

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A case of orbital injury by bamboo chips

Jinbayashi, H., Bhutto, I. A. & Amemiya, T., 1995, In : Japanese Journal of Clinical Ophthalmology. 49, 4, p. 771-774 4 p.

Research output: Contribution to journalArticle

Foreign Bodies
Tomography
Wounds and Injuries
Magnetic Resonance Imaging
Orbit

Activating the AKT2-nuclear factor-κB-lipocalin-2 axis elicits an inflammatory response in age-related macular degeneration

Ghosh, S., Shang, P., Yazdankhah, M., Bhutto, I., Hose, S., Montezuma, S. R., Luo, T., Chattopadhyay, S., Qian, J., Lutty, G. A., Ferrington, D. A., Zigler, J. S. & Sinha, D., 2017, (Accepted/In press) In : Journal of Pathology.

Research output: Contribution to journalArticle

Macular Degeneration
Lysosomes
Retina
Immune System
Epithelium

Albumen transport to bruch’s membrane and RPE by choriocapillaris caveolae

Nakanishi, M., Grebe, R., Bhutto, I. A., Edwards, M., Scott Mcleod, D. & Lutty, G. A., Apr 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 4, p. 2213-2224 12 p.

Research output: Contribution to journalArticle

Bruch Membrane
Caveolae
Tight Junctions
Bovine Serum Albumin
Gold

An Acute Injury Model for the Phenotypic Characteristics of Geographic Atrophy

Bhutto, I. A., Ogura, S., Baldeosingh, R., McLeod, D. S., Lutty, G. A. & Edwards, M. M., Mar 20 2018, In : Investigative ophthalmology & visual science. 59, 4, p. AMD143-AMD151

Research output: Contribution to journalArticle

Geographic Atrophy
Optical Tomography
Wounds and Injuries
Injections
Neuroglia

Analytical and scanning electron microscopic study of intra-ocular foreign bodies

Bhutto, I. A., Imamura, N., Mishima, K. & Amemiya, T., Dec 1993, In : Medical Electron Microscopy. 26, 3-4, p. 231-235 5 p.

Research output: Contribution to journalArticle

Eye Foreign Bodies
Foreign Bodies
Iron
X-Rays
Electrons

A rat model for choroidal neovascularization using subretinal lipid hydroperoxide injection

Baba, T., Bhutto, I. A., Merges, C., Grebe, R., Emmert, D., McLeod, D. S., Armstrong, D. & Lutty, G. A., 2010, In : American Journal of Pathology. 176, 6, p. 3085-3097 13 p.

Research output: Contribution to journalArticle

Choroidal Neovascularization
Lipid Peroxides
Injections
Macular Degeneration
Bruch Membrane

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration

Ghosh, S., Shang, P., Terasaki, H., Stepicheva, N., Hose, S., Yazdankhah, M., Weiss, J., Sakamoto, T., Bhutto, I. A., Xia, S., Zigler, J. S., Kannan, R., Qian, J., Handa, J. T. & Sinha, D., Mar 20 2018, In : Investigative ophthalmology & visual science. 59, 4, p. AMD104-AMD113

Research output: Contribution to journalArticle

Crystallins
Epithelial-Mesenchymal Transition
Macular Degeneration
Vimentin
Cadherins

A simple and scalable process for the differentiation of retinal pigment epithelium from human pluripotent stem cells

Maruotti, J., Wahlin, K., Gorrell, D., Bhutto, I., Lutty, G. A. & Zack, D. J., 2013, In : Stem cells translational medicine. 2, 5, p. 341-354 14 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Retinal Pigments
Retinal Pigment Epithelium
Epithelial Cells
Macular Degeneration

A study of living response to artificially synthesized hydroxyapatite implant in the rabbit orbit

Saitoh, A., Tsuda, Y., Bhutto, I. A., Kitaoka, T. & Amemiya, T., 1995, In : Journal of Japanese Ophthalmological Society. 99, 4, p. 420-426 7 p.

Research output: Contribution to journalArticle

Orbit
Durapatite
Rabbits
Orbital Implants
Foreign-Body Reaction
Inbred SHR Rats
Transmission Electron Microscopy
Electron Scanning Microscopy
Electrons
Corrosion

Cluster of Urrets-Zavalia syndrome: A sequel of toxic anterior segment syndrome

Nizamani, N. B., Bhutto, I. A. & Talpur, K. I., Aug 2013, In : British Journal of Ophthalmology. 97, 8, p. 976-979 4 p.

Research output: Contribution to journalArticle

Poisons
Visual Acuity
Corneal Edema
Cataract
Steroids
Nitric Oxide Synthase Type I
Nitric Oxide Synthase Type III
Pericytes
Nitric Oxide
Endothelial Cells
Corrosion
Choroid
Inbred WKY Rats
Ciliary Arteries
Blood Vessels

Corrosion cast demonstration of retinal vasculature of normal wistar-kyoto rats

Bhutto, I. A. & Amemiya, T., 1995, In : Cells Tissues Organs. 153, 4, p. 290-300 11 p.

Research output: Contribution to journalArticle

Corrosion
Inbred WKY Rats
Veins
Arteries
Surgical Casts

Corrosion cast demonstration of retinal vasculature of normal Wistar-Kyoto rats

Bhutto, I. A. & Amemiya, T., 1995, In : Acta Anatomica. 153, 4, p. 290-300 11 p.

Research output: Contribution to journalArticle

Corrosion
Inbred WKY Rats
Veins
Arteries
Surgical Casts

Corrosion casts and scanning electron microscopy of choroidal vasculature in rats with inherited hypercholesterolemia

Bhutto, I. A. & Amemiya, T., 2001, In : Current Eye Research. 23, 4, p. 240-247 8 p.

Research output: Contribution to journalArticle

Corrosion
Hypercholesterolemia
Electron Scanning Microscopy
Veins
Arteriovenous Anastomosis

C-reactive protein and complement factor H in aged human eyes and eyes with age-related macular degeneration

Bhutto, I. A., Baba, T., Merges, C., Juriasinghani, V., McLeod, D. S. & Lutty, G. A., Sep 2011, In : British Journal of Ophthalmology. 95, 9, p. 1323-1330 8 p.

Research output: Contribution to journalArticle

Complement Factor H
Macular Degeneration
C-Reactive Protein
Bruch Membrane
Inflammation

Developmental basis of nanophthalmos: MFRP is required for both prenatal ocular growth and postnatal emmetropization

Sundin, O. H., Dharmaraj, S., Bhutto, I. A., Hasegawa, T., McLeod, D. S., Merges, C. A., Silval, E. D., Maumenee, I. H. & Lutty, G. A., Mar 2008, In : Ophthalmic Genetics. 29, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Growth
Refractive Errors
Pregnancy
Pigment Epithelium of Eye

Development of the human choriocapillaris

Lutty, G. A., Hasegawa, T., Baba, T., Grebe, R., Bhutto, I. & McLeod, D. S., Mar 2010, In : Eye (London, England). 24, 3, p. 408-415 8 p.

Research output: Contribution to journalArticle

Human Development
Pregnancy
Vascular Endothelial Growth Factor Receptor-2
Pericytes
Blood Vessels

Distribution and quantification of choroidal macrophages in human eyes with age-related macular degeneration

McLeod, D. S., Bhutto, I., Edwards, M., Silver, R. E., Seddon, J. M. & Lutty, G. A., Nov 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 14, p. 5843-5855 13 p.

Research output: Contribution to journalArticle

Macular Degeneration
Macrophages
HLA-DR Antigens
Choroid
Macrophage Activation

Effect of silicone oil tamponade on the rabbit optic nerve

Saitoh, A., Gong, H. Q., Mishima, K., Bhutto, I. A., Ohira, A. & Amemiya, T., 1997, In : Investigative Ophthalmology and Visual Science. 38, 4

Research output: Contribution to journalArticle

Silicone Oils
Optic Nerve
Rabbits
Vacuoles
Electron Probe Microanalysis

Effect of VEGF trap on normal retinal vascular development and oxygen-induced retinopathy in the dog

Lutty, G. A., McLeod, D. S., Bhutto, I. & Wiegand, S. J., Jun 2011, In : Investigative Ophthalmology and Visual Science. 52, 7, p. 4039-4047 9 p.

Research output: Contribution to journalArticle

Retinal Vessels
Vascular Endothelial Growth Factor A
Dogs
Oxygen
Retinopathy of Prematurity
Cilazapril
Retinal Vessels
Corrosion
Inbred SHR Rats
Rats

Expression of pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in sickle cell retina and choroid

Kim, S. Y., Mocanu, C., Mcleod, D. S., Bhutto, I. A., Merges, C., Eid, M., Tong, P. & Lutty, G. A., Oct 1 2003, In : Experimental Eye Research. 77, 4, p. 433-445 13 p.

Research output: Contribution to journalArticle

Choroid
Vascular Endothelial Growth Factor A
Retina
Oceans and Seas
pigment epithelium-derived factor

Histologic study of living response to artificially synthesized hydroxyapatite implant: 1-Year follow-up

Saitoh, A., Tsuda, Y., Bhutto, I. A., Kitaoka, T. & Amemiya, T., Sep 1996, In : Plastic and Reconstructive Surgery. 98, 4, p. 706-710 5 p.

Research output: Contribution to journalArticle

Durapatite
Foreign-Body Reaction
Orbital Implants
Orbit
Electron Scanning Microscopy

Histopathological insights into choroidal vascular loss in clinically documented cases of age-related macular degeneration

Seddon, J. M., McLeod, D. S., Bhutto, I. A., Villalonga, M. B., Silver, R. E., Wenick, A., Edwards, M. & Lutty, G. A., Nov 1 2016, In : JAMA Ophthalmology. 134, 11, p. 1272-1280 9 p.

Research output: Contribution to journalArticle

Macular Degeneration
Blood Vessels
Retinal Pigments
Geographic Atrophy
Atrophy
Corrosion
Inbred SHR Rats
Blood Vessels
Retina
Blood Pressure

Hypoxic retinal Müller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4

Xin, X., Rodrigues, M., Umapathi, M., Kashiwabuchi, F., Ma, T., Babapoor-Farrokhran, S., Wang, S., Hu, J., Bhutto, I., Welsbie, D. S., Duh, E. J., Handa, J., Eberhart, C. G., Lutty, G. A., Semenza, G. L., Montaner, S. & Sodhi, A., Sep 3 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 36

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Macular Edema
Capillary Permeability
Up-Regulation
Vascular Endothelial Growth Factor A

Idiopathic preretinal glia in aging and age-related macular degeneration

Edwards, M., McLeod, D. S., Bhutto, I. A., Villalonga, M. B., Seddon, J. M. & Lutty, G. A., Mar 19 2015, (Accepted/In press) In : Experimental Eye Research.

Research output: Contribution to journalArticle

Macular Degeneration
Neuroglia
Retina
Membranes
Glial Fibrillary Acidic Protein

Immunohistochemical localization of low density lipoprotein receptor-related protein 1 and α2-Macroglobulin in retinal and choroidal tissue of proliferative retinopathies

Barcelona, P. F., Luna, J. D., Chiabrando, G. A., Juarez, C. P., Bhutto, I. A., Baba, T., McLeod, D. S., Sánchez, M. C. & Lutty, G. A., Aug 2010, In : Experimental Eye Research. 91, 2, p. 264-272 9 p.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-2
Low Density Lipoprotein Receptor-Related Protein-1
Lipoprotein Receptors
Macroglobulins
Retina

Impaired expression of thrombospondin-1 in eyes with age related macular degeneration

Uno, K., Bhutto, I. A., McLeod, D. S., Merges, C. & Lutty, G. A., Jan 2006, In : British Journal of Ophthalmology. 90, 1, p. 48-54 7 p.

Research output: Contribution to journalArticle

Thrombospondin 1
Macular Degeneration
Retinal Pigment Epithelium
Basement Membrane
Blood Vessels

Increased choroidal mast cells and their degranulation in age-related macular degeneration

Bhutto, I. A., McLeod, D. S., Jing, T., Sunness, J. S., Seddon, J. M. & Lutty, G. A., Mar 1 2016, (Accepted/In press) In : British Journal of Ophthalmology.

Research output: Contribution to journalArticle

Cell Degranulation
Macular Degeneration
Mast Cells
Choroid
Choroidal Neovascularization

Increased Lipocalin-2 in the retinal pigment epithelium of Cryba1 cKO mice is associated with a chronic inflammatory response

Valapala, M., Edwards, M., Hose, S., Grebe, R., Bhutto, I. A., Cano, M., Berger, T., Mak, T. W., Wawrousek, E., Handa, J., Lutty, G. A., Samuel Zigler, J. & Sinha, D., Dec 1 2014, In : Aging Cell. 13, 6, p. 1091-1094 4 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Macular Degeneration
Knockout Mice
Retinal Pigments
Inflammation

Localisation of SDF-1 and its receptor CXCR4 in retina and choroid of aged human eyes and in eyes with age related macular degeneration

Bhutto, I. A., McLeod, D. S., Merges, C., Hasegawa, T. & Lutty, G. A., Jul 2006, In : British Journal of Ophthalmology. 90, 7, p. 906-910 5 p.

Research output: Contribution to journalArticle

CXCR4 Receptors
Chemokine CXCL12
Choroid
Macular Degeneration
Retina

Localization of collagen XVIII and the endostatin portion of collagen XVIII in aged human control eyes and eyes with age-related macular degeneration

Bhutto, I. A., Kim, S. Y., McLeod, D. S., Merges, C., Fukai, N., Olsen, B. R. & Lutty, G. A., May 2004, In : Investigative Ophthalmology and Visual Science. 45, 5, p. 1544-1552 9 p.

Research output: Contribution to journalArticle

Collagen Type XVIII
Endostatins
Macular Degeneration
Choroid
Bruch Membrane

Low nitric oxide synthases (NOSs) in eyes with age-related macular degeneration (AMD)

Bhutto, I. A., Baba, T., Merges, C., McLeod, D. S. & Lutty, G. A., Jan 2010, In : Experimental Eye Research. 90, 1, p. 155-167 13 p.

Research output: Contribution to journalArticle

Macular Degeneration
Nitric Oxide Synthase
Choroid
Nitric Oxide
Retina

Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling

Valapala, M., Wilson, C., Hose, S., Bhutto, I. A., Grebe, R., Dong, A., Greenbaum, S., Gu, L., Sengupta, S., Cano, M., Hackett, S., Xu, G., Lutty, G. A., Dong, L., Sergeev, Y., Handa, J., Campochiaro, P. A., Wawrousek, E., Zigler, J. S. & Sinha, D., 2014, In : Autophagy. 10, 3, p. 480-496 17 p.

Research output: Contribution to journalArticle

Crystallins
Retinal Pigments
Retinal Pigment Epithelium
Autophagy
Adenosine Triphosphatases

Mast cell-derived tryptase in geographic atrophy

McLeod, D. S., Bhutto, I., Edwards, M., Gedam, M., Baldeosingh, R. & Lutty, G. A., Nov 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 13, p. 5887-5896 10 p.

Research output: Contribution to journalArticle

Geographic Atrophy
Tryptases
Bruch Membrane
Mast Cells
Atrophy

Maturation of the fetal human choriocapillaris

Baba, T., Grebe, R., Hasegawa, T., Bhutto, I., Merges, C., Scott McLeod, D. & Lutty, G. A., 2009, In : Investigative Ophthalmology and Visual Science. 50, 7, p. 3503-3511 9 p.

Research output: Contribution to journalArticle

Pericytes
Pregnancy
Endothelial Cells
Carbonic Anhydrase IV
Transmission Electron Microscopy

Microvascular architecture of the rat choroid: Corrosion cast study

Bhutto, I. A. & Amemiya, T., Sep 1 2001, In : Anatomical Record. 264, 1, p. 63-71 9 p.

Research output: Contribution to journalArticle

Corrosion
Choroid
corrosion
Blood Vessels
blood vessels

Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease

Yazdankhah, M., Shang, P., Ghosh, S., Bhutto, I. A., Stepicheva, N., Grebe, R., Hose, S., Weiss, J., Luo, T., Mishra, S., Riazuddin, S. A., Ghosh, A., Handa, J. T., Lutty, G. A., Zigler, J. S. & Sinha, D., Jan 1 2019, (Accepted/In press) In : Autophagy.

Research output: Contribution to journalArticle

Fetal Diseases
Autophagy
Epidermal Growth Factor Receptor
Phosphotransferases
Astrocytes

Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat

Samuel Zigler, J., Zhang, C., Grebe, R., Sehrawat, G., Hackler, L., Adhya, S., Hose, S., McLeod, D. S., Bhutto, I., Barbour, W., Parthasarathy, G., Zack, D. J., Sergeev, Y., Lutty, G. A., Handa, J. & Sinha, D., Feb 15 2011, In : Journal of Cell Science. 124, 4, p. 523-531 9 p.

Research output: Contribution to journalArticle

Phagosomes
Crystallins
Epithelium
Mutation
Genes

Nanoparticle-delivered biosensor for reactive oxygen species in diabetes

Prow, T. W., Bhutto, I., Grebe, R., Uno, K., Merges, C., Mcleod, D. S. & Lutty, G. A., Feb 2008, In : Vision Research. 48, 3, p. 478-485 8 p.

Research output: Contribution to journalArticle

Antioxidant Response Elements
Biosensing Techniques
Nanoparticles
Reactive Oxygen Species
Oxidative Stress

Natural course of experimental choroidal neovascularization: Three-dimensional study with corrosion cast and scanning electron microscope

Kuroki, A. M., Bhutto, I. A., Kitaoka, T. & Amemiya, T., 2002, In : Ophthalmic Research. 34, 4, p. 200-205 6 p.

Research output: Contribution to journalArticle

Choroidal Neovascularization
Corrosion
Light Coagulation
Electrons
Lasers

Neutrophils homing into the retina trigger pathology in early age-related macular degeneration

Ghosh, S., Padmanabhan, A., Vaidya, T., Watson, A. M., Bhutto, I. A., Hose, S., Shang, P., Stepicheva, N., Yazdankhah, M., Weiss, J., Das, M., Gopikrishna, S., Aishwarya, Yadav, N., Berger, T., Mak, T. W., Xia, S., Qian, J., Lutty, G. A., Jayagopal, A. & 6 others, Zigler, J. S., Sethu, S., Handa, J. T., Watkins, S. C., Ghosh, A. & Sinha, D., Dec 1 2019, In : Communications Biology. 2, 1, 348.

Research output: Contribution to journalArticle

Open Access
Lipocalins
Macular Degeneration
Pathology
retina
Infiltration

Ocular Histopathology and Immunohistochemical Analysis in the Oldest Known Individual with Autosomal Dominant Vitreoretinochoroidopathy

Goldberg, M. F., McLeod, S., Tso, M., Packo, K., Edwards, M., Bhutto, I. A., Baldeosingh, R., Eberhart, C., Weber, B. H. F. & Lutty, G. A., Apr 1 2018, In : Ophthalmology Retina. 2, 4, p. 360-378 19 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Bruch Membrane
Choroid
Retina
Islands

Ocular nanoparticle toxicity and transfection of the retina and retinal pigment epithelium

Prow, T. W., Bhutto, I., Kim, S. Y., Grebe, R., Merges, C., McLeod, D. S., Uno, K., Mennon, M., Rodriguez, L., Leong, K. & Lutty, G. A., Dec 2008, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 4, 4, p. 340-349 10 p.

Research output: Contribution to journalArticle

Retinal Pigments
Retinal Pigment Epithelium
Pigments
Nanoparticles
Transfection

Paracrine modulation of CXCR4 by IGF-1 and VEGF: Implications for choroidal neovascularization

Sengupta, N., Afzal, A., Caballero, S., Chang, K. H., Shaw, L. C., Pang, J. J., Bond, V. C., Bhutto, I., Baba, T., Lutty, G. A. & Grant, M. B., May 2010, In : Investigative Ophthalmology and Visual Science. 51, 5, p. 2697-2704 8 p.

Research output: Contribution to journalArticle

Choroidal Neovascularization
Vascular Endothelial Growth Factor A
Intercellular Signaling Peptides and Proteins
Lasers
Angiogenesis Modulating Agents

Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration

Bhutto, I. A., McLeod, D. S., Hasegawa, T., Kim, S. Y., Merges, C., Tong, P. & Lutty, G. A., Jan 2006, In : Experimental Eye Research. 82, 1, p. 99-110 12 p.

Research output: Contribution to journalArticle

Choroid
Macular Degeneration
Vascular Endothelial Growth Factor A
Bruch Membrane
Antibodies

Poly(β-amino ester)-nanoparticle mediated transfection of retinal pigment epithelial cells in vitro and in vivo

Sunshine, J. C., Sunshine, S. B., Bhutto, I., Handa, J. & Green, J., May 21 2012, In : PLoS One. 7, 5, e37543.

Research output: Contribution to journalArticle

Retinal Pigments
nanoparticles
transfection
Nanoparticles
Transfection