Imran Bhutto

Research Associate

1993 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article

A case of orbital injury by bamboo chips

Jinbayashi, H., Bhutto, I. A. & Amemiya, T., 1995, In : Japanese Journal of Clinical Ophthalmology. 49, 4, p. 771-774 4 p.

Research output: Contribution to journalArticle

Activating the AKT2-nuclear factor-κB-lipocalin-2 axis elicits an inflammatory response in age-related macular degeneration

Ghosh, S., Shang, P., Yazdankhah, M., Bhutto, I., Hose, S., Montezuma, S. R., Luo, T., Chattopadhyay, S., Qian, J., Lutty, G. A., Ferrington, D. A., Zigler, J. S. & Sinha, D., 2017, (Accepted/In press) In : Journal of Pathology.

Research output: Contribution to journalArticle

Albumen transport to bruch’s membrane and RPE by choriocapillaris caveolae

Nakanishi, M., Grebe, R., Bhutto, I. A., Edwards, M., Scott Mcleod, D. & Lutty, G. A., Apr 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 4, p. 2213-2224 12 p.

Research output: Contribution to journalArticle

An Acute Injury Model for the Phenotypic Characteristics of Geographic Atrophy

Bhutto, I. A., Ogura, S., Baldeosingh, R., McLeod, D. S., Lutty, G. A. & Edwards, M. M., Mar 20 2018, In : Investigative ophthalmology & visual science. 59, 4, p. AMD143-AMD151

Research output: Contribution to journalArticle

Analytical and scanning electron microscopic study of intra-ocular foreign bodies

Bhutto, I. A., Imamura, N., Mishima, K. & Amemiya, T., Dec 1993, In : Medical Electron Microscopy. 26, 3-4, p. 231-235 5 p.

Research output: Contribution to journalArticle

A rat model for choroidal neovascularization using subretinal lipid hydroperoxide injection

Baba, T., Bhutto, I. A., Merges, C., Grebe, R., Emmert, D., McLeod, D. S., Armstrong, D. & Lutty, G. A., 2010, In : American Journal of Pathology. 176, 6, p. 3085-3097 13 p.

Research output: Contribution to journalArticle

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration

Ghosh, S., Shang, P., Terasaki, H., Stepicheva, N., Hose, S., Yazdankhah, M., Weiss, J., Sakamoto, T., Bhutto, I. A., Xia, S., Zigler, J. S., Kannan, R., Qian, J., Handa, J. T. & Sinha, D., Mar 20 2018, In : Investigative ophthalmology & visual science. 59, 4, p. AMD104-AMD113

Research output: Contribution to journalArticle

A simple and scalable process for the differentiation of retinal pigment epithelium from human pluripotent stem cells

Maruotti, J., Wahlin, K., Gorrell, D., Bhutto, I., Lutty, G. A. & Zack, D. J., 2013, In : Stem cells translational medicine. 2, 5, p. 341-354 14 p.

Research output: Contribution to journalArticle

A study of living response to artificially synthesized hydroxyapatite implant in the rabbit orbit

Saitoh, A., Tsuda, Y., Bhutto, I. A., Kitaoka, T. & Amemiya, T., 1995, In : Journal of Japanese Ophthalmological Society. 99, 4, p. 420-426 7 p.

Research output: Contribution to journalArticle

Cluster of Urrets-Zavalia syndrome: A sequel of toxic anterior segment syndrome

Nizamani, N. B., Bhutto, I. A. & Talpur, K. I., Aug 2013, In : British Journal of Ophthalmology. 97, 8, p. 976-979 4 p.

Research output: Contribution to journalArticle

Corrosion cast demonstration of retinal vasculature of normal wistar-kyoto rats

Bhutto, I. A. & Amemiya, T., 1995, In : Cells Tissues Organs. 153, 4, p. 290-300 11 p.

Research output: Contribution to journalArticle

Corrosion casts and scanning electron microscopy of choroidal vasculature in rats with inherited hypercholesterolemia

Bhutto, I. A. & Amemiya, T., 2001, In : Current Eye Research. 23, 4, p. 240-247 8 p.

Research output: Contribution to journalArticle

C-reactive protein and complement factor H in aged human eyes and eyes with age-related macular degeneration

Bhutto, I. A., Baba, T., Merges, C., Juriasinghani, V., McLeod, D. S. & Lutty, G. A., Sep 2011, In : British Journal of Ophthalmology. 95, 9, p. 1323-1330 8 p.

Research output: Contribution to journalArticle

Developmental basis of nanophthalmos: MFRP is required for both prenatal ocular growth and postnatal emmetropization

Sundin, O. H., Dharmaraj, S., Bhutto, I. A., Hasegawa, T., McLeod, D. S., Merges, C. A., Silval, E. D., Maumenee, I. H. & Lutty, G. A., Mar 2008, In : Ophthalmic Genetics. 29, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Development of the human choriocapillaris

Lutty, G. A., Hasegawa, T., Baba, T., Grebe, R., Bhutto, I. & McLeod, D. S., Mar 2010, In : Eye (London, England). 24, 3, p. 408-415 8 p.

Research output: Contribution to journalArticle

Distribution and quantification of choroidal macrophages in human eyes with age-related macular degeneration

McLeod, D. S., Bhutto, I., Edwards, M., Silver, R. E., Seddon, J. M. & Lutty, G. A., Nov 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 14, p. 5843-5855 13 p.

Research output: Contribution to journalArticle

Effect of silicone oil tamponade on the rabbit optic nerve

Saitoh, A., Gong, H. Q., Mishima, K., Bhutto, I. A., Ohira, A. & Amemiya, T., 1997, In : Investigative Ophthalmology and Visual Science. 38, 4

Research output: Contribution to journalArticle

Effect of VEGF trap on normal retinal vascular development and oxygen-induced retinopathy in the dog

Lutty, G. A., McLeod, D. S., Bhutto, I. & Wiegand, S. J., Jun 2011, In : Investigative Ophthalmology and Visual Science. 52, 7, p. 4039-4047 9 p.

Research output: Contribution to journalArticle

Expression of pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in sickle cell retina and choroid

Kim, S. Y., Mocanu, C., Mcleod, D. S., Bhutto, I. A., Merges, C., Eid, M., Tong, P. & Lutty, G. A., Oct 1 2003, In : Experimental Eye Research. 77, 4, p. 433-445 13 p.

Research output: Contribution to journalArticle

Histologic study of living response to artificially synthesized hydroxyapatite implant: 1-Year follow-up

Saitoh, A., Tsuda, Y., Bhutto, I. A., Kitaoka, T. & Amemiya, T., Sep 1996, In : Plastic and Reconstructive Surgery. 98, 4, p. 706-710 5 p.

Research output: Contribution to journalArticle

Histopathological insights into choroidal vascular loss in clinically documented cases of age-related macular degeneration

Seddon, J. M., McLeod, D. S., Bhutto, I. A., Villalonga, M. B., Silver, R. E., Wenick, A., Edwards, M. & Lutty, G. A., Nov 1 2016, In : JAMA Ophthalmology. 134, 11, p. 1272-1280 9 p.

Research output: Contribution to journalArticle

Hypoxic retinal Müller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4

Xin, X., Rodrigues, M., Umapathi, M., Kashiwabuchi, F., Ma, T., Babapoor-Farrokhran, S., Wang, S., Hu, J., Bhutto, I., Welsbie, D. S., Duh, E. J., Handa, J., Eberhart, C. G., Lutty, G. A., Semenza, G. L., Montaner, S. & Sodhi, A., Sep 3 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 36

Research output: Contribution to journalArticle

Idiopathic preretinal glia in aging and age-related macular degeneration

Edwards, M., McLeod, D. S., Bhutto, I. A., Villalonga, M. B., Seddon, J. M. & Lutty, G. A., Mar 19 2015, (Accepted/In press) In : Experimental Eye Research.

Research output: Contribution to journalArticle

Immunohistochemical localization of low density lipoprotein receptor-related protein 1 and α2-Macroglobulin in retinal and choroidal tissue of proliferative retinopathies

Barcelona, P. F., Luna, J. D., Chiabrando, G. A., Juarez, C. P., Bhutto, I. A., Baba, T., McLeod, D. S., Sánchez, M. C. & Lutty, G. A., Aug 2010, In : Experimental Eye Research. 91, 2, p. 264-272 9 p.

Research output: Contribution to journalArticle

Impaired expression of thrombospondin-1 in eyes with age related macular degeneration

Uno, K., Bhutto, I. A., McLeod, D. S., Merges, C. & Lutty, G. A., Jan 2006, In : British Journal of Ophthalmology. 90, 1, p. 48-54 7 p.

Research output: Contribution to journalArticle

Increased choroidal mast cells and their degranulation in age-related macular degeneration

Bhutto, I. A., McLeod, D. S., Jing, T., Sunness, J. S., Seddon, J. M. & Lutty, G. A., Mar 1 2016, (Accepted/In press) In : British Journal of Ophthalmology.

Research output: Contribution to journalArticle

Increased Lipocalin-2 in the retinal pigment epithelium of Cryba1 cKO mice is associated with a chronic inflammatory response

Valapala, M., Edwards, M., Hose, S., Grebe, R., Bhutto, I. A., Cano, M., Berger, T., Mak, T. W., Wawrousek, E., Handa, J., Lutty, G. A., Samuel Zigler, J. & Sinha, D., Dec 1 2014, In : Aging Cell. 13, 6, p. 1091-1094 4 p.

Research output: Contribution to journalArticle

Localisation of SDF-1 and its receptor CXCR4 in retina and choroid of aged human eyes and in eyes with age related macular degeneration

Bhutto, I. A., McLeod, D. S., Merges, C., Hasegawa, T. & Lutty, G. A., Jul 2006, In : British Journal of Ophthalmology. 90, 7, p. 906-910 5 p.

Research output: Contribution to journalArticle

Localization of collagen XVIII and the endostatin portion of collagen XVIII in aged human control eyes and eyes with age-related macular degeneration

Bhutto, I. A., Kim, S. Y., McLeod, D. S., Merges, C., Fukai, N., Olsen, B. R. & Lutty, G. A., May 2004, In : Investigative Ophthalmology and Visual Science. 45, 5, p. 1544-1552 9 p.

Research output: Contribution to journalArticle

Low nitric oxide synthases (NOSs) in eyes with age-related macular degeneration (AMD)

Bhutto, I. A., Baba, T., Merges, C., McLeod, D. S. & Lutty, G. A., Jan 2010, In : Experimental Eye Research. 90, 1, p. 155-167 13 p.

Research output: Contribution to journalArticle

Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling

Valapala, M., Wilson, C., Hose, S., Bhutto, I. A., Grebe, R., Dong, A., Greenbaum, S., Gu, L., Sengupta, S., Cano, M., Hackett, S., Xu, G., Lutty, G. A., Dong, L., Sergeev, Y., Handa, J., Campochiaro, P. A., Wawrousek, E., Zigler, J. S. & Sinha, D., 2014, In : Autophagy. 10, 3, p. 480-496 17 p.

Research output: Contribution to journalArticle

Mast cell-derived tryptase in geographic atrophy

McLeod, D. S., Bhutto, I., Edwards, M., Gedam, M., Baldeosingh, R. & Lutty, G. A., Nov 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 13, p. 5887-5896 10 p.

Research output: Contribution to journalArticle

Maturation of the fetal human choriocapillaris

Baba, T., Grebe, R., Hasegawa, T., Bhutto, I., Merges, C., Scott McLeod, D. & Lutty, G. A., 2009, In : Investigative Ophthalmology and Visual Science. 50, 7, p. 3503-3511 9 p.

Research output: Contribution to journalArticle

Microvascular architecture of the rat choroid: Corrosion cast study

Bhutto, I. A. & Amemiya, T., Sep 1 2001, In : Anatomical Record. 264, 1, p. 63-71 9 p.

Research output: Contribution to journalArticle

Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease

Yazdankhah, M., Shang, P., Ghosh, S., Bhutto, I. A., Stepicheva, N., Grebe, R., Hose, S., Weiss, J., Luo, T., Mishra, S., Riazuddin, S. A., Ghosh, A., Handa, J. T., Lutty, G. A., Zigler, J. S. & Sinha, D., Jan 1 2019, (Accepted/In press) In : Autophagy.

Research output: Contribution to journalArticle

Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat

Samuel Zigler, J., Zhang, C., Grebe, R., Sehrawat, G., Hackler, L., Adhya, S., Hose, S., McLeod, D. S., Bhutto, I., Barbour, W., Parthasarathy, G., Zack, D. J., Sergeev, Y., Lutty, G. A., Handa, J. & Sinha, D., Feb 15 2011, In : Journal of Cell Science. 124, 4, p. 523-531 9 p.

Research output: Contribution to journalArticle

Nanoparticle-delivered biosensor for reactive oxygen species in diabetes

Prow, T. W., Bhutto, I., Grebe, R., Uno, K., Merges, C., Mcleod, D. S. & Lutty, G. A., Feb 2008, In : Vision Research. 48, 3, p. 478-485 8 p.

Research output: Contribution to journalArticle

Natural course of experimental choroidal neovascularization: Three-dimensional study with corrosion cast and scanning electron microscope

Kuroki, A. M., Bhutto, I. A., Kitaoka, T. & Amemiya, T., 2002, In : Ophthalmic Research. 34, 4, p. 200-205 6 p.

Research output: Contribution to journalArticle

Neutrophils homing into the retina trigger pathology in early age-related macular degeneration

Ghosh, S., Padmanabhan, A., Vaidya, T., Watson, A. M., Bhutto, I. A., Hose, S., Shang, P., Stepicheva, N., Yazdankhah, M., Weiss, J., Das, M., Gopikrishna, S., Aishwarya, Yadav, N., Berger, T., Mak, T. W., Xia, S., Qian, J., Lutty, G. A., Jayagopal, A. & 6 others, Zigler, J. S., Sethu, S., Handa, J. T., Watkins, S. C., Ghosh, A. & Sinha, D., Dec 1 2019, In : Communications Biology. 2, 1, 348.

Research output: Contribution to journalArticle

Open Access

Ocular Histopathology and Immunohistochemical Analysis in the Oldest Known Individual with Autosomal Dominant Vitreoretinochoroidopathy

Goldberg, M. F., McLeod, S., Tso, M., Packo, K., Edwards, M., Bhutto, I. A., Baldeosingh, R., Eberhart, C., Weber, B. H. F. & Lutty, G. A., Apr 1 2018, In : Ophthalmology Retina. 2, 4, p. 360-378 19 p.

Research output: Contribution to journalArticle

Ocular nanoparticle toxicity and transfection of the retina and retinal pigment epithelium

Prow, T. W., Bhutto, I., Kim, S. Y., Grebe, R., Merges, C., McLeod, D. S., Uno, K., Mennon, M., Rodriguez, L., Leong, K. & Lutty, G. A., Dec 2008, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 4, 4, p. 340-349 10 p.

Research output: Contribution to journalArticle

Paracrine modulation of CXCR4 by IGF-1 and VEGF: Implications for choroidal neovascularization

Sengupta, N., Afzal, A., Caballero, S., Chang, K. H., Shaw, L. C., Pang, J. J., Bond, V. C., Bhutto, I., Baba, T., Lutty, G. A. & Grant, M. B., May 2010, In : Investigative Ophthalmology and Visual Science. 51, 5, p. 2697-2704 8 p.

Research output: Contribution to journalArticle

Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration

Bhutto, I. A., McLeod, D. S., Hasegawa, T., Kim, S. Y., Merges, C., Tong, P. & Lutty, G. A., Jan 2006, In : Experimental Eye Research. 82, 1, p. 99-110 12 p.

Research output: Contribution to journalArticle

Poly(β-amino ester)-nanoparticle mediated transfection of retinal pigment epithelial cells in vitro and in vivo

Sunshine, J. C., Sunshine, S. B., Bhutto, I., Handa, J. & Green, J., May 21 2012, In : PLoS One. 7, 5, e37543.

Research output: Contribution to journalArticle

Reduction of endogenous angiogenesis inhibitors in bruch's membrane of the submacular region in eyes with age-related macular degeneration

Bhutto, I. A., Uno, K., Merges, C., Zhang, L., McLeod, D. S. & Lutty, G. A., May 2008, In : Archives of Ophthalmology. 126, 5, p. 670-678 9 p.

Research output: Contribution to journalArticle