Imran Bhutto

Research Associate

1993 …2019
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Research Output 1993 2019

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1993

Analytical and scanning electron microscopic study of intra-ocular foreign bodies

Bhutto, I. A., Imamura, N., Mishima, K. & Amemiya, T., Dec 1993, In : Medical Electron Microscopy. 26, 3-4, p. 231-235 5 p.

Research output: Contribution to journalArticle

Eye Foreign Bodies
Foreign Bodies
Iron
X-Rays
Electrons
1995

A case of orbital injury by bamboo chips

Jinbayashi, H., Bhutto, I. A. & Amemiya, T., 1995, In : Japanese Journal of Clinical Ophthalmology. 49, 4, p. 771-774 4 p.

Research output: Contribution to journalArticle

Foreign Bodies
Tomography
Wounds and Injuries
Magnetic Resonance Imaging
Orbit

A study of living response to artificially synthesized hydroxyapatite implant in the rabbit orbit

Saitoh, A., Tsuda, Y., Bhutto, I. A., Kitaoka, T. & Amemiya, T., 1995, In : Journal of Japanese Ophthalmological Society. 99, 4, p. 420-426 7 p.

Research output: Contribution to journalArticle

Orbit
Durapatite
Rabbits
Orbital Implants
Foreign-Body Reaction

Corrosion cast demonstration of retinal vasculature of normal wistar-kyoto rats

Bhutto, I. A. & Amemiya, T., 1995, In : Cells Tissues Organs. 153, 4, p. 290-300 11 p.

Research output: Contribution to journalArticle

Corrosion
Inbred WKY Rats
Veins
Arteries
Surgical Casts

Corrosion cast demonstration of retinal vasculature of normal Wistar-Kyoto rats

Bhutto, I. A. & Amemiya, T., 1995, In : Acta Anatomica. 153, 4, p. 290-300 11 p.

Research output: Contribution to journalArticle

Corrosion
Inbred WKY Rats
Veins
Arteries
Surgical Casts
Retinal Vessels
Corrosion
Inbred WKY Rats
Electron Scanning Microscopy
Retina
1996

Histologic study of living response to artificially synthesized hydroxyapatite implant: 1-Year follow-up

Saitoh, A., Tsuda, Y., Bhutto, I. A., Kitaoka, T. & Amemiya, T., Sep 1996, In : Plastic and Reconstructive Surgery. 98, 4, p. 706-710 5 p.

Research output: Contribution to journalArticle

Durapatite
Foreign-Body Reaction
Orbital Implants
Orbit
Electron Scanning Microscopy
Corrosion
Inbred SHR Rats
Blood Vessels
Retina
Blood Pressure
1997

Effect of silicone oil tamponade on the rabbit optic nerve

Saitoh, A., Gong, H. Q., Mishima, K., Bhutto, I. A., Ohira, A. & Amemiya, T., 1997, In : Investigative Ophthalmology and Visual Science. 38, 4

Research output: Contribution to journalArticle

Silicone Oils
Optic Nerve
Rabbits
Vacuoles
Electron Probe Microanalysis

Vascular changes in retinas of spontaneously hypertensive rats demonstrated by corrosion casts

Bhutto, I. A. & Amemiya, T., Jan 1997, In : Ophthalmic Research. 29, 1, p. 12-23 12 p.

Research output: Contribution to journalArticle

Corrosion
Inbred SHR Rats
Blood Vessels
Retina
Constriction
1998
Cilazapril
Retinal Vessels
Corrosion
Inbred SHR Rats
Rats
1999

Retinal capillary changes in Otsuka Long-Evans Tokushima fatty rats (spontaneously diabetic strain). Electron-microscopic study

Miyamura, N., Bhutto, I. A. & Amemiya, T., Sep 1999, In : Ophthalmic Research. 31, 5, p. 358-366 9 p.

Research output: Contribution to journalArticle

Inbred OLETF Rats
Electrons
Nerve Fibers
Pericytes
Corrosion

Vascular architecture of degenerated retina in WBN/Kob rats: Corrosion cast and electron microscopic study

Bhutto, I. A., Miyamura, N. & Amemiya, T., Sep 1999, In : Ophthalmic Research. 31, 5, p. 367-377 11 p.

Research output: Contribution to journalArticle

Corrosion
Blood Vessels
Retina
Electrons
Pericytes
2001
Corrosion
Choroid
Inbred WKY Rats
Ciliary Arteries
Blood Vessels

Corrosion casts and scanning electron microscopy of choroidal vasculature in rats with inherited hypercholesterolemia

Bhutto, I. A. & Amemiya, T., 2001, In : Current Eye Research. 23, 4, p. 240-247 8 p.

Research output: Contribution to journalArticle

Corrosion
Hypercholesterolemia
Electron Scanning Microscopy
Veins
Arteriovenous Anastomosis

Microvascular architecture of the rat choroid: Corrosion cast study

Bhutto, I. A. & Amemiya, T., Sep 1 2001, In : Anatomical Record. 264, 1, p. 63-71 9 p.

Research output: Contribution to journalArticle

Corrosion
Choroid
corrosion
Blood Vessels
blood vessels

Retinal vascular architecture is maintained in retinal degeneration: Corrosion cast and electron microscope study

Bhutto, I. A. & Amemiya, T., 2001, In : Eye (London, England). 15, 4, p. 531-538 8 p.

Research output: Contribution to journalArticle

Retinal Vessels
Retinal Degeneration
Corrosion
Electrons
Retina
Retinal Vessels
Corrosion
Inbred WKY Rats
Hypercholesterolemia
Diabetes Mellitus

Retinal vascular changes in rats with inherited hypercholesterolemia - Corrosion cast demonstration

Yamakawa, K., Bhutto, I. A., Lu, Z., Watanabe, Y. & Amemiya, T., 2001, In : Current Eye Research. 22, 4, p. 258-265 8 p.

Research output: Contribution to journalArticle

Retinal Vessels
Corrosion
Hypercholesterolemia
Inbred WKY Rats
Arterioles
2002
Inbred SHR Rats
Transmission Electron Microscopy
Electron Scanning Microscopy
Electrons
Corrosion

Natural course of experimental choroidal neovascularization: Three-dimensional study with corrosion cast and scanning electron microscope

Kuroki, A. M., Bhutto, I. A., Kitaoka, T. & Amemiya, T., 2002, In : Ophthalmic Research. 34, 4, p. 200-205 6 p.

Research output: Contribution to journalArticle

Choroidal Neovascularization
Corrosion
Light Coagulation
Electrons
Lasers
Cilazapril
Inbred OLETF Rats
Corrosion
Angiotensin-Converting Enzyme Inhibitors
Type 2 Diabetes Mellitus
2003

Expression of pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in sickle cell retina and choroid

Kim, S. Y., Mocanu, C., Mcleod, D. S., Bhutto, I. A., Merges, C., Eid, M., Tong, P. & Lutty, G. A., Oct 1 2003, In : Experimental Eye Research. 77, 4, p. 433-445 13 p.

Research output: Contribution to journalArticle

Choroid
Vascular Endothelial Growth Factor A
Retina
Oceans and Seas
pigment epithelium-derived factor
Inbred OLETF Rats
Diabetic Retinopathy
Theoretical Models
Retina
Electrons
2004

Localization of collagen XVIII and the endostatin portion of collagen XVIII in aged human control eyes and eyes with age-related macular degeneration

Bhutto, I. A., Kim, S. Y., McLeod, D. S., Merges, C., Fukai, N., Olsen, B. R. & Lutty, G. A., May 2004, In : Investigative Ophthalmology and Visual Science. 45, 5, p. 1544-1552 9 p.

Research output: Contribution to journalArticle

Collagen Type XVIII
Endostatins
Macular Degeneration
Choroid
Bruch Membrane
2006

Impaired expression of thrombospondin-1 in eyes with age related macular degeneration

Uno, K., Bhutto, I. A., McLeod, D. S., Merges, C. & Lutty, G. A., Jan 2006, In : British Journal of Ophthalmology. 90, 1, p. 48-54 7 p.

Research output: Contribution to journalArticle

Thrombospondin 1
Macular Degeneration
Retinal Pigment Epithelium
Basement Membrane
Blood Vessels

Localisation of SDF-1 and its receptor CXCR4 in retina and choroid of aged human eyes and in eyes with age related macular degeneration

Bhutto, I. A., McLeod, D. S., Merges, C., Hasegawa, T. & Lutty, G. A., Jul 2006, In : British Journal of Ophthalmology. 90, 7, p. 906-910 5 p.

Research output: Contribution to journalArticle

CXCR4 Receptors
Chemokine CXCL12
Choroid
Macular Degeneration
Retina

Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration

Bhutto, I. A., McLeod, D. S., Hasegawa, T., Kim, S. Y., Merges, C., Tong, P. & Lutty, G. A., Jan 2006, In : Experimental Eye Research. 82, 1, p. 99-110 12 p.

Research output: Contribution to journalArticle

Choroid
Macular Degeneration
Vascular Endothelial Growth Factor A
Bruch Membrane
Antibodies

The expression of advanced glycation endproduct receptors in rpe cells associated with basal deposits in human maculas

Yamada, Y., Ishibashi, K., Ishibashi, K., Bhutto, I. A., Tian, J., Lutty, G. A. & Handa, J., May 2006, In : Experimental Eye Research. 82, 5, p. 840-848 9 p.

Research output: Contribution to journalArticle

Bruch Membrane
Macular Degeneration
Staining and Labeling
Streptavidin
Advanced Glycosylation End Product-Specific Receptor
2007

The embryonic human choriocapillaris develops by hemo-vasculogenesis

Hasegawa, T., McLeod, D. S., Bhutto, I. A., Prow, T., Merges, C. A., Grebe, R. & Lutty, G. A., Aug 2007, In : Developmental Dynamics. 236, 8, p. 2089-2100 12 p.

Research output: Contribution to journalArticle

Erythroblasts
Endothelial Cells
Blood Vessels
Vascular Endothelial Growth Factor Receptor-2
Pregnancy
2008

Developmental basis of nanophthalmos: MFRP is required for both prenatal ocular growth and postnatal emmetropization

Sundin, O. H., Dharmaraj, S., Bhutto, I. A., Hasegawa, T., McLeod, D. S., Merges, C. A., Silval, E. D., Maumenee, I. H. & Lutty, G. A., Mar 2008, In : Ophthalmic Genetics. 29, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Growth
Refractive Errors
Pregnancy
Pigment Epithelium of Eye

Nanoparticle-delivered biosensor for reactive oxygen species in diabetes

Prow, T. W., Bhutto, I., Grebe, R., Uno, K., Merges, C., Mcleod, D. S. & Lutty, G. A., Feb 2008, In : Vision Research. 48, 3, p. 478-485 8 p.

Research output: Contribution to journalArticle

Antioxidant Response Elements
Biosensing Techniques
Nanoparticles
Reactive Oxygen Species
Oxidative Stress

Ocular nanoparticle toxicity and transfection of the retina and retinal pigment epithelium

Prow, T. W., Bhutto, I., Kim, S. Y., Grebe, R., Merges, C., McLeod, D. S., Uno, K., Mennon, M., Rodriguez, L., Leong, K. & Lutty, G. A., Dec 2008, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 4, 4, p. 340-349 10 p.

Research output: Contribution to journalArticle

Retinal Pigments
Retinal Pigment Epithelium
Pigments
Nanoparticles
Transfection

Reduction of endogenous angiogenesis inhibitors in bruch's membrane of the submacular region in eyes with age-related macular degeneration

Bhutto, I. A., Uno, K., Merges, C., Zhang, L., McLeod, D. S. & Lutty, G. A., May 2008, In : Archives of Ophthalmology. 126, 5, p. 670-678 9 p.

Research output: Contribution to journalArticle

Bruch Membrane
Angiogenesis Inhibitors
Macular Degeneration
Endostatins
Thrombospondin 1

βA3/A1-crystallin in astroglial cells regulates retinal vascular remodeling during development

Sinha, D., Klise, A., Sergeev, Y., Hose, S., Bhutto, I. A., Hackler, L., Malpic-llanos, T., Samtani, S., Grebe, R., Goldberg, M. F., Hejtmancik, J. F., Nath, A., Zack, D. J., Fariss, R. N., McLeod, D. S., Sundin, O., Broman, K. W., Lutty, G. A. & Zigler, J. S., Jan 2008, In : Molecular and Cellular Neuroscience. 37, 1, p. 85-95 11 p.

Research output: Contribution to journalArticle

Retinal Vessels
Crystallins
Astrocytes
Retina
Blood Vessels
2009

Maturation of the fetal human choriocapillaris

Baba, T., Grebe, R., Hasegawa, T., Bhutto, I., Merges, C., Scott McLeod, D. & Lutty, G. A., 2009, In : Investigative Ophthalmology and Visual Science. 50, 7, p. 3503-3511 9 p.

Research output: Contribution to journalArticle

Pericytes
Pregnancy
Endothelial Cells
Carbonic Anhydrase IV
Transmission Electron Microscopy

Relationship between RPE and choriocapillaris in age-related macular degeneration

Mcleod, D. S., Grebe, R., Bhutto, I., Merges, C., Baba, T. & Lutty, G. A., 2009, In : Investigative Ophthalmology and Visual Science. 50, 10, p. 4982-4991 10 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Macular Degeneration
Retinal Pigments
Geographic Atrophy
Atrophy
2010

A rat model for choroidal neovascularization using subretinal lipid hydroperoxide injection

Baba, T., Bhutto, I. A., Merges, C., Grebe, R., Emmert, D., McLeod, D. S., Armstrong, D. & Lutty, G. A., 2010, In : American Journal of Pathology. 176, 6, p. 3085-3097 13 p.

Research output: Contribution to journalArticle

Choroidal Neovascularization
Lipid Peroxides
Injections
Macular Degeneration
Bruch Membrane

Development of the human choriocapillaris

Lutty, G. A., Hasegawa, T., Baba, T., Grebe, R., Bhutto, I. & McLeod, D. S., Mar 2010, In : Eye (London, England). 24, 3, p. 408-415 8 p.

Research output: Contribution to journalArticle

Human Development
Pregnancy
Vascular Endothelial Growth Factor Receptor-2
Pericytes
Blood Vessels

Immunohistochemical localization of low density lipoprotein receptor-related protein 1 and α2-Macroglobulin in retinal and choroidal tissue of proliferative retinopathies

Barcelona, P. F., Luna, J. D., Chiabrando, G. A., Juarez, C. P., Bhutto, I. A., Baba, T., McLeod, D. S., Sánchez, M. C. & Lutty, G. A., Aug 2010, In : Experimental Eye Research. 91, 2, p. 264-272 9 p.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-2
Low Density Lipoprotein Receptor-Related Protein-1
Lipoprotein Receptors
Macroglobulins
Retina

Low nitric oxide synthases (NOSs) in eyes with age-related macular degeneration (AMD)

Bhutto, I. A., Baba, T., Merges, C., McLeod, D. S. & Lutty, G. A., Jan 2010, In : Experimental Eye Research. 90, 1, p. 155-167 13 p.

Research output: Contribution to journalArticle

Macular Degeneration
Nitric Oxide Synthase
Choroid
Nitric Oxide
Retina

Paracrine modulation of CXCR4 by IGF-1 and VEGF: Implications for choroidal neovascularization

Sengupta, N., Afzal, A., Caballero, S., Chang, K. H., Shaw, L. C., Pang, J. J., Bond, V. C., Bhutto, I., Baba, T., Lutty, G. A. & Grant, M. B., May 2010, In : Investigative Ophthalmology and Visual Science. 51, 5, p. 2697-2704 8 p.

Research output: Contribution to journalArticle

Choroidal Neovascularization
Vascular Endothelial Growth Factor A
Intercellular Signaling Peptides and Proteins
Lasers
Angiogenesis Modulating Agents

Role of Nrf2 in retinal vascular development and the vaso-obliterative phase of oxygen-induced retinopathy

Uno, K., Prow, T. W., Bhutto, I. A., Yerrapureddy, A., McLeod, D. S., Yamamoto, M., Reddy, S. P. & Lutty, G. A., Apr 2010, In : Experimental Eye Research. 90, 4, p. 493-500 8 p.

Research output: Contribution to journalArticle

NF-E2-Related Factor 2
Retinal Vessels
Oxygen
Hyperoxia
Retina
2011

C-reactive protein and complement factor H in aged human eyes and eyes with age-related macular degeneration

Bhutto, I. A., Baba, T., Merges, C., Juriasinghani, V., McLeod, D. S. & Lutty, G. A., Sep 2011, In : British Journal of Ophthalmology. 95, 9, p. 1323-1330 8 p.

Research output: Contribution to journalArticle

Complement Factor H
Macular Degeneration
C-Reactive Protein
Bruch Membrane
Inflammation

Effect of VEGF trap on normal retinal vascular development and oxygen-induced retinopathy in the dog

Lutty, G. A., McLeod, D. S., Bhutto, I. & Wiegand, S. J., Jun 2011, In : Investigative Ophthalmology and Visual Science. 52, 7, p. 4039-4047 9 p.

Research output: Contribution to journalArticle

Retinal Vessels
Vascular Endothelial Growth Factor A
Dogs
Oxygen
Retinopathy of Prematurity

Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat

Samuel Zigler, J., Zhang, C., Grebe, R., Sehrawat, G., Hackler, L., Adhya, S., Hose, S., McLeod, D. S., Bhutto, I., Barbour, W., Parthasarathy, G., Zack, D. J., Sergeev, Y., Lutty, G. A., Handa, J. & Sinha, D., Feb 15 2011, In : Journal of Cell Science. 124, 4, p. 523-531 9 p.

Research output: Contribution to journalArticle

Phagosomes
Crystallins
Epithelium
Mutation
Genes
2012
Nitric Oxide Synthase Type I
Nitric Oxide Synthase Type III
Pericytes
Nitric Oxide
Endothelial Cells

Poly(β-amino ester)-nanoparticle mediated transfection of retinal pigment epithelial cells in vitro and in vivo

Sunshine, J. C., Sunshine, S. B., Bhutto, I., Handa, J. & Green, J., May 21 2012, In : PLoS One. 7, 5, e37543.

Research output: Contribution to journalArticle

Retinal Pigments
nanoparticles
transfection
Nanoparticles
Transfection

Systematic assessment of microneedle injection into the mouse cornea.

Matthaei, M., Meng, H., Bhutto, I., Xu, Q., Boelke, E., Hanes, J. S. & Jun, A., 2012, In : European Journal of Medical Research. 17, p. 19 1 p.

Research output: Contribution to journalArticle

Cornea
Needles
Injections
Glass
Corneal Perforation

The deletion of Math5 disrupts retinal blood vessel and glial development in mice

Edwards, M., McLeod, D. S., Li, R., Grebe, R., Bhutto, I., Mu, X. & Lutty, G. A., Mar 2012, In : Experimental Eye Research. 96, 1, p. 147-156 10 p.

Research output: Contribution to journalArticle

Retinal Vessels
Neuroglia
Retina
Ganglia
Blood Vessels