Imran Bhutto

Research Associate

1993 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2019

Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease

Yazdankhah, M., Shang, P., Ghosh, S., Bhutto, I. A., Stepicheva, N., Grebe, R., Hose, S., Weiss, J., Luo, T., Mishra, S., Riazuddin, S. A., Ghosh, A., Handa, J. T., Lutty, G. A., Zigler, J. S. & Sinha, D., Jan 1 2019, (Accepted/In press) In : Autophagy.

Research output: Contribution to journalArticle

Neutrophils homing into the retina trigger pathology in early age-related macular degeneration

Ghosh, S., Padmanabhan, A., Vaidya, T., Watson, A. M., Bhutto, I. A., Hose, S., Shang, P., Stepicheva, N., Yazdankhah, M., Weiss, J., Das, M., Gopikrishna, S., Aishwarya, Yadav, N., Berger, T., Mak, T. W., Xia, S., Qian, J., Lutty, G. A., Jayagopal, A. & 6 others, Zigler, J. S., Sethu, S., Handa, J. T., Watkins, S. C., Ghosh, A. & Sinha, D., Dec 1 2019, In : Communications Biology. 2, 1, 348.

Research output: Contribution to journalArticle

Open Access
2018

An Acute Injury Model for the Phenotypic Characteristics of Geographic Atrophy

Bhutto, I. A., Ogura, S., Baldeosingh, R., McLeod, D. S., Lutty, G. A. & Edwards, M. M., Mar 20 2018, In : Investigative ophthalmology & visual science. 59, 4, p. AMD143-AMD151

Research output: Contribution to journalArticle

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration

Ghosh, S., Shang, P., Terasaki, H., Stepicheva, N., Hose, S., Yazdankhah, M., Weiss, J., Sakamoto, T., Bhutto, I. A., Xia, S., Zigler, J. S., Kannan, R., Qian, J., Handa, J. T. & Sinha, D., Mar 20 2018, In : Investigative ophthalmology & visual science. 59, 4, p. AMD104-AMD113

Research output: Contribution to journalArticle

Ocular Histopathology and Immunohistochemical Analysis in the Oldest Known Individual with Autosomal Dominant Vitreoretinochoroidopathy

Goldberg, M. F., McLeod, S., Tso, M., Packo, K., Edwards, M., Bhutto, I. A., Baldeosingh, R., Eberhart, C., Weber, B. H. F. & Lutty, G. A., Apr 1 2018, In : Ophthalmology Retina. 2, 4, p. 360-378 19 p.

Research output: Contribution to journalArticle

2017

Activating the AKT2-nuclear factor-κB-lipocalin-2 axis elicits an inflammatory response in age-related macular degeneration

Ghosh, S., Shang, P., Yazdankhah, M., Bhutto, I., Hose, S., Montezuma, S. R., Luo, T., Chattopadhyay, S., Qian, J., Lutty, G. A., Ferrington, D. A., Zigler, J. S. & Sinha, D., 2017, (Accepted/In press) In : Journal of Pathology.

Research output: Contribution to journalArticle

Mast cell-derived tryptase in geographic atrophy

McLeod, D. S., Bhutto, I., Edwards, M., Gedam, M., Baldeosingh, R. & Lutty, G. A., Nov 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 13, p. 5887-5896 10 p.

Research output: Contribution to journalArticle

Subretinal glial membranes in eyes with geographic atrophy

Edwards, M., McLeod, D. S., Bhutto, I. A., Grebe, R., Duffy, M. & Lutty, G. A., Mar 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 3, p. 1352-1367 16 p.

Research output: Contribution to journalArticle

The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling

Shang, P., Valapala, M., Grebe, R., Hose, S., Ghosh, S., Bhutto, I. A., Handa, J., Lutty, G. A., Lu, L., Wan, J., Qian, J., Sergeev, Y., Puertollano, R., Zigler, J. S., Xu, G. T. & Sinha, D., 2017, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle

2016

Albumen transport to bruch’s membrane and RPE by choriocapillaris caveolae

Nakanishi, M., Grebe, R., Bhutto, I. A., Edwards, M., Scott Mcleod, D. & Lutty, G. A., Apr 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 4, p. 2213-2224 12 p.

Research output: Contribution to journalArticle

Distribution and quantification of choroidal macrophages in human eyes with age-related macular degeneration

McLeod, D. S., Bhutto, I., Edwards, M., Silver, R. E., Seddon, J. M. & Lutty, G. A., Nov 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 14, p. 5843-5855 13 p.

Research output: Contribution to journalArticle

Histopathological insights into choroidal vascular loss in clinically documented cases of age-related macular degeneration

Seddon, J. M., McLeod, D. S., Bhutto, I. A., Villalonga, M. B., Silver, R. E., Wenick, A., Edwards, M. & Lutty, G. A., Nov 1 2016, In : JAMA Ophthalmology. 134, 11, p. 1272-1280 9 p.

Research output: Contribution to journalArticle

Increased choroidal mast cells and their degranulation in age-related macular degeneration

Bhutto, I. A., McLeod, D. S., Jing, T., Sunness, J. S., Seddon, J. M. & Lutty, G. A., Mar 1 2016, (Accepted/In press) In : British Journal of Ophthalmology.

Research output: Contribution to journalArticle

2015

Idiopathic preretinal glia in aging and age-related macular degeneration

Edwards, M., McLeod, D. S., Bhutto, I. A., Villalonga, M. B., Seddon, J. M. & Lutty, G. A., Mar 19 2015, (Accepted/In press) In : Experimental Eye Research.

Research output: Contribution to journalArticle

Small-molecule-directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells

Maruotti, J., Sripathi, S. R., Bharti, K., Fuller, J., Wahlin, K. J., Ranganathan, V., Sluch, V. M., Berlinicke, C. A., Davis, J., Kim, C., Zhao, L., Wan, J., Qian, J., Corneo, B., Temple, S., Dubey, R., Olenyuk, B. Z., Bhutto, I., Lutty, G. A. & Zack, D. J., Sep 1 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 35, p. 10950-10955 6 p.

Research output: Contribution to journalArticle

Systemic and intravitreal delivery of dendrimers to activated microglia/macrophage in ischemia/reperfusion mouse retina

Kambhampati, S. P., Clunies-Ross, A. J. M., Bhutto, I., Mishra, M. K., Edwards, M., McLeod, D. S., Kannan, R. M. & Lutty, G., Jan 1 2015, In : Investigative Ophthalmology and Visual Science. 56, 8, p. 4413-4424 12 p.

Research output: Contribution to journalArticle

2014

Increased Lipocalin-2 in the retinal pigment epithelium of Cryba1 cKO mice is associated with a chronic inflammatory response

Valapala, M., Edwards, M., Hose, S., Grebe, R., Bhutto, I. A., Cano, M., Berger, T., Mak, T. W., Wawrousek, E., Handa, J. T., Lutty, G. A., Samuel Zigler, J. & Sinha, D., Dec 1 2014, In : Aging Cell. 13, 6, p. 1091-1094 4 p.

Research output: Contribution to journalArticle

Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling

Valapala, M., Wilson, C., Hose, S., Bhutto, I. A., Grebe, R., Dong, A., Greenbaum, S., Gu, L., Sengupta, S., Cano, M., Hackett, S., Xu, G., Lutty, G. A., Dong, L., Sergeev, Y., Handa, J. T., Campochiaro, P., Wawrousek, E., Zigler, J. S. & Sinha, D., Mar 2014, In : Autophagy. 10, 3, p. 480-496 17 p.

Research output: Contribution to journalArticle

Response to the letter by Huisingh and McGewin: Cluster of Urrets-Zavalia syndrome: A sequel of toxic anterior segment syndrome

Nizamani, N. B., Bhutto, I. A. & Talpur, K. I., Mar 2014, In : British Journal of Ophthalmology. 98, 3, p. 414 1 p.

Research output: Contribution to journalArticle

Vascular progenitors from cord blood-derived induced pluripotent stem cells possess augmented capacity for regenerating ischemic retinal vasculature

Park, T. S., Bhutto, I., Zimmerlin, L., Huo, J. S., Nagaria, P., Miller, D., Rufaihah, A. J., Talbot, C., Aguilar, J., Grebe, R., Merges, C., Reijo-Pera, R., Feldman, R. A., Rassool, F., Cooke, J., Lutty, G. & Zambidis, E. T., Jan 21 2014, In : Circulation. 129, 3, p. 359-372 14 p.

Research output: Contribution to journalArticle

2013

A simple and scalable process for the differentiation of retinal pigment epithelium from human pluripotent stem cells

Maruotti, J., Wahlin, K., Gorrell, D., Bhutto, I., Lutty, G. & Zack, D. J., 2013, In : Stem Cells Translational Medicine. 2, 5, p. 341-354 14 p.

Research output: Contribution to journalArticle

Cluster of Urrets-Zavalia syndrome: A sequel of toxic anterior segment syndrome

Nizamani, N. B., Bhutto, I. A. & Talpur, K. I., Aug 1 2013, In : British Journal of Ophthalmology. 97, 8, p. 976-979 4 p.

Research output: Contribution to journalArticle

Hypoxic retinal Müller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4

Xin, X., Rodrigues, M., Umapathi, M., Kashiwabuchi, F., Ma, T., Babapoor-Farrokhran, S., Wang, S., Hu, J., Bhutto, I., Welsbie, D. S., Duh, E. J., Handa, J. T., Eberhart, C. G., Lutty, G., Semenza, G. L., Montaner, S. & Sodhi, A., Sep 3 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 36, p. E3425-E3434

Research output: Contribution to journalArticle

VEGF secreted by hypoxic Müller cells induces MMP-2 expression and activity in endothelial cells to promote retinal neovascularization in proliferative diabetic retinopathy

Rodrigues, M., Xin, X., Jee, K., Babapoor-Farrokhran, S., Kashiwabuchi, F., Ma, T., Bhutto, I., Hassan, S. J., Daoud, Y., Baranano, D., Solomon, S., Lutty, G. A., Semenza, G. L., Montaner, S. & Sodhi, A., Nov 2013, In : Diabetes. 62, 11, p. 3863-3873 11 p.

Research output: Contribution to journalArticle

2012

Anatomy: Anatomy of the Ocular Vasculatures

Lutty, G. A., Bhutto, I. & McLeod, D. S., Jan 1 2012, Ocular Blood Flow. Springer Berlin Heidelberg, p. 3-24 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Poly(β-amino ester)-nanoparticle mediated transfection of retinal pigment epithelial cells in vitro and in vivo

Sunshine, J. C., Sunshine, S. B., Bhutto, I., Handa, J. T. & Green, J. J., May 21 2012, In : PloS one. 7, 5, e37543.

Research output: Contribution to journalArticle

Systematic assessment of microneedle injection into the mouse cornea.

Matthaei, M., Meng, H., Bhutto, I., Xu, Q., Boelke, E., Hanes, J. & Jun, A. S., 2012, In : European journal of medical research. 17, 1 p.

Research output: Contribution to journalArticle

Open Access

The deletion of Math5 disrupts retinal blood vessel and glial development in mice

Edwards, M. M., McLeod, D. S., Li, R., Grebe, R., Bhutto, I., Mu, X. & Lutty, G. A., Mar 1 2012, In : Experimental eye research. 96, 1, p. 147-156 10 p.

Research output: Contribution to journalArticle

βA3/A1-crystallin is required for proper astrocyte template formation and vascular remodeling in the retina

Sinha, D., Valapala, M., Bhutto, I., Patek, B., Zhang, C., Hose, S., Yang, F., Cano, M., Stark, W. J., Lutty, G. A., Zigler, J. S. & Wawrousek, E. F., Sep 1 2012, In : Transgenic Research. 21, 5, p. 1033-1042 10 p.

Research output: Contribution to journalArticle

2011

C-reactive protein and complement factor H in aged human eyes and eyes with age-related macular degeneration

Bhutto, I. A., Baba, T., Merges, C., Juriasinghani, V., McLeod, D. S. & Lutty, G. A., Sep 1 2011, In : British Journal of Ophthalmology. 95, 9, p. 1323-1330 8 p.

Research output: Contribution to journalArticle

Effect of VEGF trap on normal retinal vascular development and oxygen-induced retinopathy in the dog

Lutty, G. A., McLeod, D. S., Bhutto, I. & Wiegand, S. J., Jun 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 7, p. 4039-4047 9 p.

Research output: Contribution to journalArticle

Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat

Samuel Zigler, J., Zhang, C., Grebe, R., Sehrawat, G., Hackler, L., Adhya, S., Hose, S., McLeod, D. S., Bhutto, I., Barbour, W., Parthasarathy, G., Zack, D. J., Sergeev, Y., Lutty, G. A., Handa, J. & Sinha, D., Feb 15 2011, In : Journal of Cell Science. 124, 4, p. 523-531 9 p.

Research output: Contribution to journalArticle

2010

A rat model for choroidal neovascularization using subretinal lipid hydroperoxide injection

Baba, T., Bhutto, I. A., Merges, C., Grebe, R., Emmert, D., McLeod, D. S., Armstrong, D. & Lutty, G. A., Jun 2010, In : American Journal of Pathology. 176, 6, p. 3085-3097 13 p.

Research output: Contribution to journalArticle

Development of the human choriocapillaris

Lutty, G. A., Hasegawa, T., Baba, T., Grebe, R., Bhutto, I. & McLeod, D. S., Mar 2010, In : Eye. 24, 3, p. 408-415 8 p.

Research output: Contribution to journalArticle

Immunohistochemical localization of low density lipoprotein receptor-related protein 1 and α2-Macroglobulin in retinal and choroidal tissue of proliferative retinopathies

Barcelona, P. F., Luna, J. D., Chiabrando, G. A., Juarez, C. P., Bhutto, I. A., Baba, T., McLeod, D. S., Sánchez, M. C. & Lutty, G. A., Aug 1 2010, In : Experimental eye research. 91, 2, p. 264-272 9 p.

Research output: Contribution to journalArticle

Low nitric oxide synthases (NOSs) in eyes with age-related macular degeneration (AMD)

Bhutto, I. A., Baba, T., Merges, C., McLeod, D. S. & Lutty, G. A., Jan 1 2010, In : Experimental eye research. 90, 1, p. 155-167 13 p.

Research output: Contribution to journalArticle

Paracrine modulation of CXCR4 by IGF-1 and VEGF: Implications for choroidal neovascularization

Sengupta, N., Afzal, A., Caballero, S., Chang, K. H., Shaw, L. C., Pang, J. J., Bond, V. C., Bhutto, I., Baba, T., Lutty, G. A. & Grant, M. B., May 2010, In : Investigative Ophthalmology and Visual Science. 51, 5, p. 2697-2704 8 p.

Research output: Contribution to journalArticle

Role of Nrf2 in retinal vascular development and the vaso-obliterative phase of oxygen-induced retinopathy

Uno, K., Prow, T. W., Bhutto, I. A., Yerrapureddy, A., McLeod, D. S., Yamamoto, M., Reddy, S. P. & Lutty, G. A., Apr 1 2010, In : Experimental eye research. 90, 4, p. 493-500 8 p.

Research output: Contribution to journalArticle

2009

Maturation of the fetal human choriocapillaris

Baba, T., Grebe, R., Hasegawa, T., Bhutto, I., Merges, C., Scott McLeod, D. & Lutty, G. A., 2009, In : Investigative Ophthalmology and Visual Science. 50, 7, p. 3503-3511 9 p.

Research output: Contribution to journalArticle

Relationship between RPE and choriocapillaris in age-related macular degeneration

Mcleod, D. S., Grebe, R., Bhutto, I., Merges, C., Baba, T. & Lutty, G. A., Dec 1 2009, In : Investigative Ophthalmology and Visual Science. 50, 10, p. 4982-4991 10 p.

Research output: Contribution to journalArticle

2008

Developmental basis of nanophthalmos: MFRP is required for both prenatal ocular growth and postnatal emmetropization

Sundin, O. H., Dharmaraj, S., Bhutto, I. A., Hasegawa, T., McLeod, D. S., Merges, C. A., Silval, E. D., Maumenee, I. H. & Lutty, G. A., Mar 2008, In : Ophthalmic Genetics. 29, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Nanoparticle-delivered biosensor for reactive oxygen species in diabetes

Prow, T. W., Bhutto, I., Grebe, R., Uno, K., Merges, C., Mcleod, D. S. & Lutty, G. A., Feb 1 2008, In : Vision Research. 48, 3, p. 478-485 8 p.

Research output: Contribution to journalArticle

Ocular nanoparticle toxicity and transfection of the retina and retinal pigment epithelium

Prow, T. W., Bhutto, I., Kim, S. Y., Grebe, R., Merges, C., McLeod, D. S., Uno, K., Mennon, M., Rodriguez, L., Leong, K. & Lutty, G. A., Dec 1 2008, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 4, 4, p. 340-349 10 p.

Research output: Contribution to journalArticle

Reduction of endogenous angiogenesis inhibitors in bruch's membrane of the submacular region in eyes with age-related macular degeneration

Bhutto, I. A., Uno, K., Merges, C., Zhang, L., McLeod, D. S. & Lutty, G. A., May 1 2008, In : Archives of ophthalmology. 126, 5, p. 670-678 9 p.

Research output: Contribution to journalArticle

βA3/A1-crystallin in astroglial cells regulates retinal vascular remodeling during development

Sinha, D., Klise, A., Sergeev, Y., Hose, S., Bhutto, I. A., Hackler, L., Malpic-llanos, T., Samtani, S., Grebe, R., Goldberg, M. F., Hejtmancik, J. F., Nath, A., Zack, D. J., Fariss, R. N., McLeod, D. S., Sundin, O., Broman, K. W., Lutty, G. A. & Zigler, J. S., Jan 1 2008, In : Molecular and Cellular Neuroscience. 37, 1, p. 85-95 11 p.

Research output: Contribution to journalArticle

2007

The embryonic human choriocapillaris develops by hemo-vasculogenesis

Hasegawa, T., McLeod, D. S., Bhutto, I. A., Prow, T., Merges, C. A., Grebe, R. & Lutty, G. A., Aug 1 2007, In : Developmental Dynamics. 236, 8, p. 2089-2100 12 p.

Research output: Contribution to journalArticle

2006

Impaired expression of thrombospondin-1 in eyes with age related macular degeneration

Uno, K., Bhutto, I. A., McLeod, D. S., Merges, C. & Lutty, G. A., Jan 1 2006, In : British Journal of Ophthalmology. 90, 1, p. 48-54 7 p.

Research output: Contribution to journalArticle

Localisation of SDF-1 and its receptor CXCR4 in retina and choroid of aged human eyes and in eyes with age related macular degeneration

Bhutto, I. A., McLeod, D. S., Merges, C., Hasegawa, T. & Lutty, G. A., Jul 1 2006, In : British Journal of Ophthalmology. 90, 7, p. 906-910 5 p.

Research output: Contribution to journalArticle