Ie Ming Shih

Professor

1990 …2020

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2020

Assessing aneuploidy with repetitive element sequencing

Douville, C., Cohen, J. D., Ptak, J., Popoli, M., Schaefer, J., Silliman, N., Dobbyn, L., Schoen, R. E., Tie, J., Gibbs, P., Goggins, M., Wolfgang, C. L., Wang, T. L., Shih, I. M., Karchin, R., Lennon, A. M., Hruban, R. H., Tomasetti, C., Bettegowda, C., Kinzler, K. W. & 2 others, Papadopoulos, N. & Vogelstein, B., Mar 3 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 9, p. 4858-4863 6 p.

Research output: Contribution to journalArticle

Epithelial Cells in Endometriosis and Adenomyosis Upregulate STING Expression

Qu, H., Li, L., Wang, T. L., Seckin, T., Segars, J. & Shih, I. M., Jun 1 2020, In : Reproductive Sciences. 27, 6, p. 1276-1284 9 p.

Research output: Contribution to journalArticle

Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming

Suryo Rahmanto, Y., Shen, W., Shi, X., Chen, X., Yu, Y., Yu, Z. C., Miyamoto, T., Lee, M. H., Singh, V., Asaka, R., Shimberg, G., Vitolo, M. I., Martin, S. S., Wirtz, D., Drapkin, R., Xuan, J., Wang, T. L. & Shih, I. M., Dec 1 2020, In : Nature communications. 11, 1, 2717.

Research output: Contribution to journalArticle

Open Access

NAC1 attenuates BCL6 negative autoregulation and functions as a BCL6 coactivator of FOXQ1 transcription in cancer cells

Gao, M., Herlinger, A. L., Wu, R., Wang, T. L., Shih, I. M., Kong, B., Rangel, L. B. A. & Yang, J. M., May 31 2020, In : Aging. 12, 10, p. 9275-9291 17 p.

Research output: Contribution to journalArticle

2019

BRAFV600E-mutated ovarian serous borderline tumors are at relatively low risk for progression to serous carcinoma

Herman Chui, M., Kjaer, S. K., Frederiksen, K., Hannibal, C. G., Wang, T. L., Vang, R. & Shih, I. M., Jan 1 2019, In : Oncotarget. 10, 64, p. 6870-6878 9 p.

Research output: Contribution to journalArticle

Clinicopathologic and Molecular Features of Paired Cases of Metachronous Ovarian Serous Borderline Tumor and Subsequent Serous Carcinoma

Chui, M. H., Xing, D., Zeppernick, F., Wang, Z. Q., Hannibal, C. G., Frederiksen, K., Kjaer, S. K., Cope, L., Kurman, R. J., Shih, I. M., Wang, T. L. & Vang, R., Nov 1 2019, In : American Journal of Surgical Pathology. 43, 11, p. 1462-1472 11 p.

Research output: Contribution to journalArticle

Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment

Hu, Z., Zhou, J., Jiang, J., Yuan, J., Zhang, Y., Wei, X., Loo, N., Wang, Y., Pan, Y., Zhang, T., Zhong, X., Long, M., Montone, K. T., Tanyi, J. L., Fan, Y., Wang, T. L., Shih, I. M., Hu, X. & Zhang, L., Dec 1 2019, In : Nature communications. 10, 1, 733.

Research output: Contribution to journalArticle

Open Access

Genomic landscape and evolutionary trajectories of ovarian cancer precursor lesions

Wu, R. C., Wang, P., Lin, S. F., Zhang, M., Song, Q., Chu, T., Wang, B. G., Kurman, R. J., Vang, R., Kinzler, K., Tomasetti, C., Jiao, Y., Shih, I. M. & Wang, T. L., May 2019, In : Journal of Pathology. 248, 1, p. 41-50 10 p.

Research output: Contribution to journalArticle

International Society of Gynecological Pathologists (ISGyP) Endometrial Cancer Project: Guidelines from the Special Techniques and Ancillary Studies Group

Cho, K. R., Cooper, K., Croce, S., Djordevic, B., Herrington, S., Howitt, B., Hui, P., Ip, P., Koebel, M., Lax, S., Quade, B. J., Shaw, P., Vidal, A., Yemelyanova, A., Clarke, B., Hedrick Ellenson, L., Longacre, T. A., Shih, I. M., Glenn McCluggage, W., Malpica, A. & 3 others, Oliva, E., Parkash, V. & Matias-Guiu, X., Jan 1 2019, In : International Journal of Gynecological Pathology. 38, 1, p. S114-S122

Research output: Contribution to journalArticle

Long Interspersed Nuclear Element 1 Retrotransposons Become Deregulated during the Development of Ovarian Cancer Precursor Lesions

Pisanic, T. R., Asaka, S., Lin, S. F., Yen, T. T., Sun, H., Bahadirli-Talbott, A., Wang, T. H., Burns, K. H., Wang, T. L. & Shih, I. M., Mar 2019, In : American Journal of Pathology. 189, 3, p. 513-520 8 p.

Research output: Contribution to journalArticle

Loss of ARID1A in tumor cells renders selective vulnerability to combined ionizing radiation and PARP inhibitor therapy

Park, Y., Chui, M. H., Rahmanto, Y. S., Yu, Z. C., Shamanna, R. A., Bellani, M. A., Gaillard, S., Ayhan, A., Viswanathan, A., Seidman, M. M., Franco, S., Leung, A. K. L., Bohr, V. A., Shih, I. M. & Wang, T. L., Sep 15 2019, In : Clinical Cancer Research. 25, 18, p. 5584-5593 10 p.

Research output: Contribution to journalArticle

Oncogenic BRAF and KRAS mutations in endosalpingiosis

Chui, M. H. & Shih, I. M., Jan 1 2019, (Accepted/In press) In : Journal of Pathology.

Research output: Contribution to journalArticle

Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities

Clinical Proteomic Tumor Analysis Consortium, May 2 2019, In : Cell. 177, 4, p. 1035-1049.e19

Research output: Contribution to journalArticle

Open Access

Proteome-wide tyrosine phosphorylation analysis reveals dysregulated signaling pathways in ovarian tumors

Song, G., Chen, L., Zhang, B., Song, Q., Yu, Y., Moore, C., Wang, T. L., Shih, I. M., Zhang, H., Chan, D. W., Zhang, Z. & Zhu, H., Mar 2019, In : Molecular and Cellular Proteomics. 18, 3, p. 448-460 13 p.

Research output: Contribution to journalArticle

PVRIG and PVRL2 are induced in cancer and inhibit CD8 + T-cell function

Whelan, S., Ophir, E., Kotturi, M. F., Levy, O., Ganguly, S., Leung, L., Vaknin, I., Kumar, S., Dassa, L., Hansen, K., Bernados, D., Murter, B., Soni, A., Taube, J. M., Fader, A. N., Wang, T. L., Shih, I. M., White, M., Pardoll, D. M. & Liang, S. C., Feb 2019, In : Cancer Immunology Research. 7, 2, p. 257-268 12 p.

Research output: Contribution to journalArticle

Spleen tyrosine kinase activity regulates epidermal growth factor receptor signaling pathway in ovarian cancer

Yu, Y., Suryo Rahmanto, Y., Shen, Y. A., Ardighieri, L., Davidson, B., Gaillard, S., Ayhan, A., Shi, X., Xuan, J., Wang, T. L. & Shih, I. M., Sep 2019, In : EBioMedicine. 47, p. 184-194 11 p.

Research output: Contribution to journalArticle

Open Access

TET1 reprograms the epithelial ovarian cancer epigenome and reveals casein kinase 2α as a therapeutic target

Chen, L. Y., Huang, R. L., Chan, M. W. Y., Yan, P. S., Huang, T. S., Wu, R. C., Suryo Rahmanto, Y., Su, P. H., Weng, Y. C., Chou, J. L., Chao, T. K., Wang, Y. C., Shih, I. M. & Lai, H. C., Jul 2019, In : Journal of Pathology. 248, 3, p. 363-376 14 p.

Research output: Contribution to journalArticle

2018

Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers

Wang, Y., Li, L., Douville, C., Cohen, J. D., Yen, T. T., Kinde, I., Sundfelt, K., Kjær, S. K., Hruban, R. H., Shih, I. M., Wang, T. L., Kurman, R. J., Springer, S., Ptak, J., Popoli, M., Schaefer, J., Silliman, N., Dobbyn, L., Tanner, E. J., Angarita, A. & 17 others, Lycke, M., Jochumsen, K., Afsari, B., Danilova, L., Levine, D. A., Jardon, K., Zeng, X., Arseneau, J., Fu, L., Diaz, L. A., Karchin, R., Tomasetti, C., Kinzler, K. W., Vogelstein, B., Fader, A. N., Gilbert, L. & Papadopoulos, N., Mar 21 2018, In : Science translational medicine. 10, 433, 8793.

Research output: Contribution to journalArticle

Fallopian tube lesions in women at high risk for ovarian cancer: A multicenter study

Visvanathan, K., Shaw, P., May, B. J., Bahadirli-Talbott, A., Kaushiva, A., Risch, H., Narod, S., Wang, T. L., Parkash, V., Vang, R., Levine, D. A., Soslow, R., Kurman, R. & Shih, I. M., Nov 2018, In : Cancer Prevention Research. 11, 11, p. 697-705 9 p.

Research output: Contribution to journalArticle

Independent development of endometrial epithelium and stroma within the same endometriosis

Noë, M., Ayhan, A., Wang, T. L. & Shih, I. M., Jul 2018, In : Journal of Pathology. 245, 3, p. 265-269 5 p.

Research output: Contribution to journalArticle

Inhibition of ovarian tumor cell invasiveness by targeting SYK in the tyrosine kinase signaling pathway

Yu, Y., Suryo Rahmanto, Y., Lee, M. H., Wu, P. H., Phillip, J. M., Huang, C. H., Vitolo, M. I., Gaillard, S., Martin, S. S., Wirtz, D., Shih, I. M. & Wang, T-L., Apr 11 2018, (Accepted/In press) In : Oncogene. p. 1-12 12 p.

Research output: Contribution to journalArticle

Loss of ARID1A expression in endometrial samplings is associated with the risk of endometrial carcinoma

Yen, T. T., Miyamoto, T., Asaka, S., Chui, M. H., Wang, Y., Lin, S. F., Stone, R. L., Fader, A. N., Asaka, R., Kashima, H., Shiozawa, T., Wang, T. L., Shih, I. M. & Tanner, E. J., Sep 2018, In : Gynecologic oncology. 150, 3, p. 426-431 6 p.

Research output: Contribution to journalArticle

Methylomic analysis of ovarian cancers identifies tumor-specific alterations readily detectable in early precursor lesions

Pisanic, T. R., Cope, L. M., Lin, S. F., Yen, T. T., Athamanolap, P., Asaka, R., Nakayama, K., Fader, A. N., Wang, T. H., Shih, I. M. & Wang, T. L., Dec 15 2018, In : Clinical Cancer Research. 24, 24, p. 6536-6547 12 p.

Research output: Contribution to journalArticle

Repurposing Pan-HDAC Inhibitors for ARID1A-Mutated Ovarian Cancer

Fukumoto, T., Park, P. H., Wu, S., Fatkhutdinov, N., Karakashev, S., Nacarelli, T., Kossenkov, A. V., Speicher, D. W., Jean, S., Zhang, L., Wang, T. L., Shih, I. M., Conejo-Garcia, J. R., Bitler, B. G. & Zhang, R., Mar 27 2018, In : Cell Reports. 22, 13, p. 3393-3400 8 p.

Research output: Contribution to journalArticle

2017

Cancer-associated mutations in endometriosis without cancer

Anglesio, M. S., Papadopoulos, N., Ayhan, A., Nazeran, T. M., Noë, M., Horlings, H. M., Lum, A., Jones, S., Senz, J., Seckin, T., Ho, J., Wu, R. C., Lac, V., Ogawa, H., Tessier-Cloutier, B., Alhassan, R., Wang, A., Wang, Y., Cohen, J. D., Wong, F. & 20 others, Hasanovic, A., Orr, N., Zhang, M., Popoli, M., McMahon, W., Wood, L. D., Mattox, A., Allaire, C., Segars, J., Williams, C., Tomasetti, C., Boyd, N., Kinzler, K. W., Gilks, C. B., Diaz, L., Wang, T. L., Vogelstein, B., Yong, P. J., Huntsman, D. G. & Shih, I. M., May 11 2017, In : New England Journal of Medicine. 376, 19, p. 1835-1848 14 p.

Research output: Contribution to journalArticle

Cancer Implications for Patients with Endometriosis

Wilbur, M. A., Shih, I. M., Segars, J. & Nickles Fader, A. N., Jan 1 2017, In : Seminars in Reproductive Medicine. 35, 1, p. 110-116 7 p.

Research output: Contribution to journalArticle

CCNE1 copy-number gain and overexpression identify ovarian clear cell carcinoma with a poor prognosis

Ayhan, A., Kuhn, E., Wu, R. C., Ogawa, H., Bahadirli-Talbott, A., Mao, T. L., Sugimura, H., Shih, I. M. & Wang, T. L., Feb 1 2017, In : Modern Pathology. 30, 2, p. 297-303 7 p.

Research output: Contribution to journalArticle

CINdex: A Bioconductor Package for Analysis of Chromosome Instability in DNA Copy Number Data

Song, L., Bhuvaneshwar, K., Wang, Y., Feng, Y., Shih, I. M., Madhavan, S. & Gusev, Y., Dec 13 2017, In : Cancer Informatics. 16

Research output: Contribution to journalArticle

Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden

Stone, M. L., Chiappinelli, K. B., Li, H., Murphy, L. M., Travers, M. E., Topper, M. J., Mathios, D., Lim, M., Shih, I. M., Wang, T. L., Hung, C. F., Bhargava, V., Wiehagen, K. R., Cowley, G. S., Bachman, K. E., Strick, R., Strissel, P. L., Baylin, S. B. & Zahnow, C. A., Dec 19 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 51, p. E10981-E10990

Research output: Contribution to journalArticle

High grade serous ovarian carcinomas originate in the fallopian tube

Labidi-Galy, S. I., Papp, E., Hallberg, D., Niknafs, N., Adleff, V., Noe, M., Bhattacharya, R., Novak, M., Jones, S., Phallen, J., Hruban, C. A., Hirsch, M. S., Lin, D. I., Schwartz, L., Maire, C. L., Tille, J. C., Bowden, M., Ayhan, A., Wood, L. D., Scharpf, R. B. & 6 others, Kurman, R., Wang, T. L., Shih, I. M., Karchin, R., Drapkin, R. & Velculescu, V. E., Dec 1 2017, In : Nature communications. 8, 1, 1093.

Research output: Contribution to journalArticle

Human transposon insertion profiling: Analysis, visualization and identification of somatic LINE-1 insertions in ovarian cancer

Tang, Z., Steranka, J. P., Ma, S., Grivainis, M., Rodić, N., Huang, C. R. L., Shih, I. M., Wang, T. L., Boeke, J. D., Fenyö, D. & Burns, K. H., Jan 31 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 5, p. E733-E740

Research output: Contribution to journalArticle

Molecular analysis of high-grade serous ovarian carcinoma with and without associated serous tubal intra-epithelial carcinoma

Ducie, J., Dao, F., Considine, M., Olvera, N., Shaw, P. A., Kurman, R. J., Shih, I. M., Soslow, R. A., Cope, L. & Levine, D. A., Dec 1 2017, In : Nature communications. 8, 1, 990.

Research output: Contribution to journalArticle

Mutation of NRAS is a rare genetic event in ovarian low-grade serous carcinoma

Xing, D., Suryo Rahmanto, Y., Zeppernick, F., Hannibal, C. G., Kjaer, S. K., Vang, R. S., Shih, I. M. & Wang, T-L., Oct 1 2017, In : Human Pathology. 68, p. 87-91 5 p.

Research output: Contribution to journalArticle

Primary cytoreductive surgery and adjuvant hormonal monotherapy in women with advanced low-grade serous ovarian carcinoma: Reducing overtreatment without compromising survival?

Nickles Fader, A. N., Bergstrom, J., Jernigan, A., Tanner, E. J., Roche, K. L., Stone, R., Levinson, K., Ricci, S., Wethingon, S., Wang, T-L., Shih, I. M., Yang, B., Zhang, G., Armstrong, D. K., Gaillard, S., Michener, C., DeBernardo, R. & Rose, P. G., 2017, (Accepted/In press) In : Gynecologic Oncology.

Research output: Contribution to journalArticle

The novel ZIP4 regulation and its role in ovarian cancer

Fan, Q., Cai, Q., Li, P., Wang, W., Wang, J., Gerry, E., Wang, T. L., Shih, I. M., Nephew, K. P. & Xu, Y., 2017, In : Oncotarget. 8, 52, p. 90090-90107 18 p.

Research output: Contribution to journalArticle

2016

Biologically inspired survival analysis based on integrating gene expression as mediator with genomic variants

Youssef, I., Clarke, R., Shih, I. M., Wang, Y. & Yu, G., Oct 1 2016, In : Computers in Biology and Medicine. 77, p. 231-239 9 p.

Research output: Contribution to journalArticle

CCNE1 amplification and centrosome number abnormality in serous tubal intraepithelial carcinoma: Further evidence supporting its role as a precursor of ovarian high-grade serous carcinoma

Kuhn, E., Wang, T. L., Doberstein, K., Bahadirli-Talbott, A., Ayhan, A., Sehdev, A. S., Drapkin, R., Kurman, R. J. & Shih, I. M., Oct 1 2016, In : Modern Pathology. 29, 10, p. 1254-1261 8 p.

Research output: Contribution to journalArticle

Diagnostic potential of tumor DNA from ovarian cyst fluid

Wang, Y., Sundfeldt, K., Mateoiu, C., Shih, I. M., Kurman, R. J., Schaefer, J., Silliman, N., Kinde, I., Springer, S., Foote, M., Kristjansdottir, B., James, N., Kinzler, K. W., Papadopoulos, N., Diaz, L. A. & Vogelstein, B., Jul 15 2016, In : eLife. 5, 2016JULY, e15175.

Research output: Contribution to journalArticle

Expression of cell competition markers at the interface between p53 signature and normal epithelium in the human fallopian tube

Kito, M., Maeda, D., Kudo-Asabe, Y., Sato, N., Shih, I. M., Wang, T. L., Tanaka, M., Terada, Y. & Goto, A., Jun 1 2016, In : PloS one. 11, 6, e0156069.

Research output: Contribution to journalArticle

Inactivating ARID1A tumor suppressor enhances TERT transcription and maintains telomere length in cancer cells

Rahmanto, Y. S., Jung, J. G., Wu, R. C., Kobayashi, Y., Heaphy, C. M., Meeker, A. K., Wang, T. L. & Shih, I. M., Jan 1 2016, In : Journal of Biological Chemistry. 291, 18, p. 9690-9699 10 p.

Research output: Contribution to journalArticle

Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer

the CPTAC Investigators, Jul 28 2016, In : Cell. 166, 3, p. 755-765 11 p.

Research output: Contribution to journalArticle

Ovarian cancer chemoresistance relies on the stem cell reprogramming factor PBX1

Jung, J. G., Shih, I. M., Park, J. T., Gerry, E., Kim, T. H., Ayhan, A., Handschuh, K., Davidson, B., Fader, A. N., Selleri, L. & Wang, T. L., Nov 1 2016, In : Cancer Research. 76, 21, p. 6351-6361 11 p.

Research output: Contribution to journalArticle

2015

ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors

Shen, J., Peng, Y., Wei, L., Zhang, W., Yang, L., Lan, L., Kapoor, P., Ju, Z., Mo, Q., Shih, I. M., Uray, I. P., Wu, X., Brown, P. H., Shen, X., Mills, G. B. & Peng, G., Jul 1 2015, In : Cancer discovery. 5, 7, p. 752-767 16 p.

Research output: Contribution to journalArticle