Huijun Wei

Assistant Professor

20012019
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Research Output 2001 2019

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Article
2019

Development of a PC12 Cell Based Assay for Screening Catechol- O-methyltransferase Inhibitors

Zhang, G., Buchler, I. P., Depasquale, M., Wormald, M., Liao, G., Wei, H., Barrow, J. & Carr, G., Oct 16 2019, In : ACS Chemical Neuroscience. 10, 10, p. 4221-4226 6 p.

Research output: Contribution to journalArticle

PC12 Cells
Catechol O-Methyltransferase
Assays
Screening
Metabolites

Synthesis and characterization of novel isoform-selective IP6K1 inhibitors

Wormald, M. M., Ernst, G., Wei, H. & Barrow, J., Oct 1 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 19, 126628.

Research output: Contribution to journalArticle

Protein Isoforms
Solubility
Lead compounds
Phenotype
Physiology

Synthesis and Evaluation of Bicyclic Hydroxypyridones as Inhibitors of Catechol O-Methyltransferase

Ernst, G., Akuma, D., Au, V., Buchler, I. P., Byers, S., Carr, G. V., Defays, S., De León, P., Demaude, T., Depasquale, M., Durieu, V., Huang, Y., Jigorel, E., Kimos, M., Kolobova, A., Montel, F., Moureau, F., Poslusney, M., Swinnen, D., Vandergeten, M. C. & 5 others, Van Houtvin, N., Wei, H., White, N., Wood, M. & Barrow, J. C., Jan 1 2019, (Accepted/In press) In : ACS Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

Rats
Pyridones
Catechol O-Methyltransferase
Pharmacokinetics
Biomarkers
2018

Novel inhibitors of As(III) S-adenosylmethionine methyltransferase (AS3MT) identified by virtual screening

Bürli, R. W., Wei, H., Ernst, G., Mariga, A., Hardern, I. M., Herlihy, K., Cross, A. J., Wesolowski, S. S., Chen, H., McKay, R. D. G., Weinberger, D., Brandon, N. J. & Barrow, J., Oct 15 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 19, p. 3231-3235 5 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Methyltransferases
Screening
Enzyme Assays
Scaffolds

Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase

Buchler, I., Akuma, D., Au, V., Carr, G., De León, P., Depasquale, M., Ernst, G., Huang, Y., Kimos, M., Kolobova, A., Poslusney, M., Wei, H., Swinnen, D., Montel, F., Moureau, F., Jigorel, E., Schulze, M. S. E. D., Wood, M. & Barrow, J., Nov 8 2018, In : Journal of Medicinal Chemistry. 61, 21, p. 9647-9665 19 p.

Research output: Contribution to journalArticle

Oxyquinoline
Dopamine
Catalytic Domain
Quinolines
Catechol O-Methyltransferase
2017

Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity

Wormald, M., Liao, G., Kimos, M., Barrow, J. & Wei, H., Nov 1 2017, In : PLoS One. 12, 11, e0188852.

Research output: Contribution to journalArticle

Assays
phosphotransferases (kinases)
Throughput
Inositol
assays
2016

A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus

Li, M., Jaffe, A., Straub, R. E., Tao, R., Shin, J. H., Wang, Y., Chen, Q., Li, C., Jia, Y., Ohi, K., Maher, B., Brandon, N. J., Cross, A., Chenoweth, J. G., Hoeppner, D. J., Wei, H., Hyde, T., McKay, R., Kleinman, J. & Weinberger, D., Jun 1 2016, In : Nature Medicine. 22, 6, p. 649-656 8 p.

Research output: Contribution to journalArticle

Schizophrenia
Protein Isoforms
Genes
Polymorphism
Minisatellite Repeats
Ants
Proteasome Endopeptidase Complex
Drug Discovery
Schizophrenia
Electrophysiological Phenomena
2015

In vitro pharmacological characterization of vorapaxar, a novel platelet thrombin receptor antagonist

Hawes, B. E., Zhai, Y., Hesk, D., Wirth, M., Wei, H., Chintala, M. & Seiffert, D., Jan 1 2015, In : European Journal of Pharmacology. 762, 1, p. 221-228 8 p., 70010.

Research output: Contribution to journalArticle

PAR-1 Receptor
Thrombin Receptors
Blood Platelets
Pharmacology
Thrombin
2014

A novel approach to assess the spontaneous gastrointestinal bleeding risk of antithrombotic agents using Apcmin/+ mice

Wei, H., Shang, J., Keohane, C. A., Wang, M., Li, Q., Ni, W., O'Neill, K. & Chintala, M., Jan 16 2014, In : Thrombosis and Haemostasis. 111, 6, p. 1121-1132 12 p.

Research output: Contribution to journalArticle

Fibrinolytic Agents
Hemorrhage
clopidogrel
Intracranial Hemorrhages
Vascular System Injuries
2008

Cdc55p-mediated E4orf4 growth inhibition in Saccharomyces cerevisiae is mediated only in part via the catalytic subunit of protein phosphatase 2A

Li, Y., Wei, H., Hsieh, T. C. & Pallas, D. C., Apr 1 2008, In : Journal of Virology. 82, 7, p. 3612-3623 12 p.

Research output: Contribution to journalArticle

Protein Phosphatase 2
phosphoprotein phosphatase
protein subunits
growth retardation
Open Reading Frames
2007

β-Arrestin-mediated β1-adrenergic receptor transactivation of the EGFR confers cardioprotection

Noma, T., Lemaire, A., Naga Prasad, S. V., Barki-Harrington, L., Tilley, D. G., Chen, J., Le Corvoisier, P., Violin, J. D., Wei, H., Lefkowitz, R. J. & Rockman, H. A., Sep 4 2007, In : Journal of Clinical Investigation. 117, 9, p. 2445-2448 4 p.

Research output: Contribution to journalArticle

Arrestin
GTP-Binding Proteins
Adrenergic Receptors
Transcriptional Activation
G-Protein-Coupled Receptor Kinase 5
2005

A novel assay for protein phosphatase 2A (PP2A) complexes in vivo reveals differential effects of covalent modifications on different Saccharomyces cerevisiae PP2A heterotrimers

Gentry, M. S., Li, Y., Wei, H., Syed, F. F., Patel, S. H., Hallberg, R. L. & Pallas, D. C., Jun 1 2005, In : Eukaryotic Cell. 4, 6, p. 1029-1040 12 p.

Research output: Contribution to journalArticle

Saccharomyces cerevisiae Proteins
Protein Phosphatase 2
phosphoprotein phosphatase
Saccharomyces cerevisiae
assays

Functional antagonism of different G protein-coupled receptor kinases for β-arrestin-mediated angiotensin II receptor signaling

Kim, J., Ahn, S., Ren, X. R., Whalen, E. J., Reiter, E., Wei, H. & Lefkowitz, R. J., Feb 1 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 5, p. 1442-1447 6 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptor Kinases
Arrestin
Angiotensin Receptors
Arrestins
Extracellular Signal-Regulated MAP Kinases
2004

Differential kinetic and spatial patterns of β-arrestin and G protein-mediated ERK activation by the angiotensin II receptor

Ahn, S., Shenoy, S. K., Wei, H. & Lefkowitz, R. J., Aug 20 2004, In : Journal of Biological Chemistry. 279, 34, p. 35518-35525 8 p.

Research output: Contribution to journalArticle

Arrestin
Angiotensin Receptors
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
GTP-Binding Proteins

Reciprocal Regulation of Angiotensin Receptor-activated Extracellular Signal-regulated Kinases by β-Arrestins 1 and 2

Ahn, S., Wei, H., Garrison, T. R. & Lefkowitz, R. J., Feb 27 2004, In : Journal of Biological Chemistry. 279, 9, p. 7807-7811 5 p.

Research output: Contribution to journalArticle

Arrestins
Arrestin
Angiotensin Type 1 Receptor
Angiotensin Receptors
Mitogen-Activated Protein Kinase 3

Stable interaction between β-arrestin 2 and angiotensin type 1A receptor is required for β-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2

Wei, H., Ahn, S., Barnes, W. G. & Lefkowitz, R. J., Nov 12 2004, In : Journal of Biological Chemistry. 279, 46, p. 48255-48261 7 p.

Research output: Contribution to journalArticle

Arrestin
Angiotensin Type 1 Receptor
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
Chemical activation
2003

Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2

Wei, H., Ahn, S., Shenoy, S. K., Karnik, S. S., Hunyady, L., Luttrell, L. M. & Lefkowitz, R. J., Sep 16 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 19, p. 10782-10787 6 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
GTP-Binding Proteins
Angiotensin II
Angiotensin Type 1 Receptor
2001

Carboxymethylation of the PP2A catalytic subunit in Saccharomyces cerevisiae is required for efficient interaction with the B-type subunits Cdc55p and Rts1p

Wei, H., Ashby, D. G., Moreno, C. S., Ogris, E., Yeong, F. M., Corbett, A. H. & Pallas, D. C., Jan 12 2001, In : Journal of Biological Chemistry. 276, 2, p. 1570-1577 8 p.

Research output: Contribution to journalArticle

Protein Phosphatase 2
Yeast
Saccharomyces cerevisiae
Catalytic Domain
Methylation