Howard M Lederman

Professor

1972 …2018
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Research Output 1972 2018

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2018

Health supervision for people with Bloom syndrome

Cunniff, C., Djavid, A. R., Carrubba, S., Cohen, B. A., Ellis, N. A., Levy, C. F., Jeong, S., Lederman, H. M., Vogiatzi, M., Walsh, M. F. & Zauber, A. G., Jan 1 2018, (Accepted/In press) In : American Journal of Medical Genetics, Part A.

Research output: Contribution to journalArticle

Bloom Syndrome
Health
Growth Disorders
Exanthema
Registries

Inflammation and transcriptional responses of peripheral blood mononuclear cells in classic ataxia telangiectasia

McGrath-Morrow, S. A., Ndeh, R., Collaco, M., Rothblum-Oviatt, C., Wright, J., O’Reilly, M. A., Singer, B. D. & Lederman, H. M., Dec 1 2018, In : PLoS One. 13, 12, e0209496.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
mononuclear leukocytes
Blood Cells
Blood
Genes
2016
Ataxia Telangiectasia
Deglutition
Young Adult
Respiration
Swallows

Ataxia-telangiectasia (A-T): An emerging dimension of premature ageing

Shiloh, Y. & Lederman, H. M., Apr 1 2016, (Accepted/In press) In : Ageing Research Reviews.

Research output: Contribution to journalArticle

Premature Aging
Ataxia Telangiectasia
Automatic teller machines
Endocrine Gland Neoplasms
Aging of materials

Overview of infections in the immunocompromised host

Dropulic, L. K. & Lederman, H. M., 2016, In : Microbiology spectrum. 4, 4, DMIH2-0026-2016.

Research output: Contribution to journalArticle

Immunocompromised Host
Infection
defect
Architectural Accessibility
Adaptive Immunity

Patterns of immune development in urban preschoolers with recurrent wheeze and/or atopy

Gern, J. E., Calatroni, A., Jaffee, K. F., Lynn, H., Dresen, A., Cruikshank, W. W., Lederman, H. M., Sampson, H. A., Shreffler, W., Bacharier, L. B., Gergen, P. J., Gold, D. R., Kattan, M., O'Connor, G. T., Sandel, M. T., Wood, R. A. & Bloomberg, G. R., Jan 11 2016, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Urban Renewal
Cytokines
Allergens
Parturition
Respiratory Sounds
2015
Ataxia Telangiectasia
Interleukin-6
Lung
Serum
Interleukin-8

Spontaneous ATM Gene Reversion in A-T iPSC to Produce an Isogenic Cell Line

Lin, L., Swerdel, M. R., Lazaropoulos, M. P., Hoffman, G. S., Toro-Ramos, A. J., Wright, J., Lederman, H. M., Chen, J., Moore, J. C. & Hart, R. P., Dec 8 2015, In : Stem Cell Reports. 5, 6, p. 1097-1108 12 p.

Research output: Contribution to journalArticle

Automatic teller machines
Genes
Ataxia Telangiectasia Mutated Proteins
Cells
Cell Line
2014

Cerebral abnormalities in adults with ataxia-telangiectasia

Lin, D., Barker, P. B., Lederman, H. M. & Crawford, T. O., Jan 2014, In : American Journal of Neuroradiology. 35, 1, p. 119-123 5 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Telangiectasis
Nervous System
Hemosiderin
Vascular Malformations

Immunologic effects of hydroxyurea in sickle cell anemia

BABY HUG Investigators, Oct 1 2014, In : Pediatrics. 134, 4, p. 686-695 10 p.

Research output: Contribution to journalArticle

Hydroxyurea
Sickle Cell Anemia
Measles-Mumps-Rubella Vaccine
Immunization Schedule
Measles

Pulmonary function in children and young adults with ataxia telangiectasia

McGrath-Morrow, S. A., Lederman, H. M., Aherrera, A. D., Lefton-Greif, M., Crawford, T. O., Ryan, T., Wright, J. & Collaco, M., Jan 2014, In : Pediatric Pulmonology. 49, 1, p. 84-90 7 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Young Adult
Vital Capacity
Lung
gamma-Globulins

Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contacts

Shearer, W. T., Fleisher, T. A., Buckley, R. H., Ballas, Z., Ballow, M., Blaese, R. M., Bonilla, F. A., Conley, M. E., Cunningham-Rundles, C., Filipovich, A. H., Fuleihan, R., Gelfand, E. W., Hernandez-Trujillo, V., Holland, S. M., Hong, R., Lederman, H. M., Malech, H. L., Miles, S., Notarangelo, L. D., Ochs, H. D. & 7 others, Orange, J. S., Puck, J. M., Routes, J. M., Stiehm, E. R., Sullivan, K., Torgerson, T. & Winkelstein, J., 2014, In : The Journal of Allergy and Clinical Immunology. 133, 4, p. 961-966 6 p.

Research output: Contribution to journalArticle

Viral Vaccines
Bacterial Vaccines
Vaccines
Communicable Diseases
Infection
2013

A child with chronic granulomatous disease

Boyd, M. A., Lederman, H. M. & Travassos, M. A., 2013, In : Journal of Pediatric Infectious Diseases. 8, 2, p. 107-109 3 p.

Research output: Contribution to journalArticle

Chronic Granulomatous Disease
Burkholderia cepacia
Lung
Staphylococcus aureus
Infection

Disorders of Upper Limb Movements in Ataxia-Telangiectasia

Shaikh, A. G., Zee, D. S., Mandir, A. S., Lederman, H. M. & Crawford, T. O., Jun 27 2013, In : PLoS One. 8, 6, e67042.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Tremor
limbs (animal)
Upper Extremity
Dyskinesias
2012

Anesthetic and perioperative risk in the patient with Ataxia-Telangiectasia

Lockman, J. L., Iskander, A. J., Bembea, M., Crawford, T. O., Lederman, H. M., McGrath-Morrow, S. A. & Easley, R. B., Mar 2012, In : Paediatric Anaesthesia. 22, 3, p. 256-262 7 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Anesthetics
Perioperative Care
Inborn Genetic Diseases
Patient Discharge

Evaluation of a patient with hyper-IgM syndrome

Uygungil, B., Bonilla, F. & Lederman, H. M., Jun 2012, In : The Journal of Allergy and Clinical Immunology. 129, 6, p. 1692-1693 2 p.

Research output: Contribution to journalArticle

Hyper-IgM Immunodeficiency Syndrome
DNA Repair-Deficiency Disorders
Ectodermal Dysplasia
Ataxia Telangiectasia
Opportunistic Infections

Longitudinal relationship of early life immunomodulatory T cell phenotype and function to development of allergic sensitization in an urban cohort

McLoughlin, R. M., Calatroni, A., Visness, C. M., Wallace, P. K., Cruikshank, W. W., Tuzova, M., Ly, N. P., Ruiz-Perez, B., Kattan, M., Bloomberg, G. R., Lederman, H. M., Gern, J. E. & Gold, D. R., Mar 2012, In : Clinical and Experimental Allergy. 42, 3, p. 392-404 13 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Phenotype
Eczema
Parturition
Interleukin-10

Ochroconis gallopava infection in a patient with chronic granulomatous disease: Case report and review of the literature

Meriden, Z., Marr, K., Lederman, H. M., Illei, P. B., Villa, K., Riedel, S., Carroll, K. C. & Zhang, S. X., Nov 2012, In : Medical Mycology. 87, 8, p. 883-889 7 p.

Research output: Contribution to journalArticle

Ochroconis
Chronic Granulomatous Disease
chronic diseases
case studies
Infection

The critically ill patient with ataxia-telangiectasia: A case series

Lockman, J. L., Iskander, A. J., Bembea, M., Crawford, T. O., Lederman, H. M., McGrath-Morrow, S. A. & Easley, R. B., Mar 2012, In : Pediatric Critical Care Medicine. 13, 2

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Critical Illness
Intensive Care Units
Critical Care
Pediatric Intensive Care Units
2011
Ataxia Telangiectasia
Gastrostomy
Caregivers
Safety
Enteral Nutrition
2010
Ataxia Telangiectasia
Interleukin-8
Serum
Cross-Sectional Studies

Evaluation and management of pulmonary disease in ataxia-telangiectasia

McGrath-Morrow, S. A., Gower, W. A., Rothblum-Oviatt, C., Brody, A. S., Langston, C., Fan, L. L., Lefton-Greif, M., Crawford, T. O., Troche, M., Sandlund, J. T., Auwaerter, P. G., Easley, B., Loughlin, G. M., Carroll, J. L. & Lederman, H. M., Sep 2010, In : Pediatric Pulmonology. 45, 9, p. 847-859 13 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Lung Diseases
Skin Abnormalities
Population
Nervous System Malformations
Gastrointestinal Tract
Liver
Hepatomegaly
Immune System Diseases
Antigen-Antibody Complex
2008

Polysomnographic values in adolescents with ataxia telangiectasia

McGrath-Morrow, S. A., Sterni, L. M., McGinley, B., Lefton-Greif, M., Rosquist, K. & Lederman, H. M., Jul 2008, In : Pediatric Pulmonology. 43, 7, p. 674-679 6 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Sleep
Polysomnography
Respiration
Apnea

Pulmonary function in adolescents with ataxia telangiectasia

McGrath-Morrow, S. A., Lefton-Greif, M., Rosquist, K., Crawford, T. O., Kelly, A., Zeitlin, P., Carson, K. A. & Lederman, H. M., Jan 2008, In : Pediatric Pulmonology. 43, 1, p. 59-66 8 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Spirometry
Vital Capacity
Lung
Total Lung Capacity
2007

Ataxia-telangiectasia: Mild neurological presentation despite null ATM mutation and severe cellular phenotype

Alterman, N., Fattal-Valevski, A., Moyal, L., Crawford, T. O., Lederman, H. M., Ziv, Y. & Shiloh, Y., Aug 15 2007, In : American Journal of Medical Genetics, Part A. 143, 16, p. 1827-1834 8 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Phenotype
Mutation
Double-Stranded DNA Breaks
Genomic Instability
Common Variable Immunodeficiency
Gastrointestinal Tract
Pathology
Plasma Cells
Biopsy
2006

Proton MR spectroscopic imaging in ataxia-telangiectasia

Lin, D., Crawford, T. O., Lederman, H. M. & Barker, P. B., Aug 2006, In : Neuropediatrics. 37, 4, p. 241-246 6 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Basal Ganglia
Protons
Creatine
Choline

Standardization and performance evaluation of mononuclear cell cytokine secretion assays in a multicenter study

Shreffler, W. G., Visness, C. M., Burger, M., Cruikshank, W. W., Lederman, H. M., de la Morena, M., Grindle, K., Calatroni, A., Sampson, H. A. & Gern, J. E., 2006, In : BMC Immunology. 7, 29.

Research output: Contribution to journalArticle

Cryopreservation
Multicenter Studies
Cytokines
Fetal Blood
Interleukin-10

Survival probability in ataxia telangiectasia

Crawford, T. O., Skolasky, R., Fernandez, R., Rosquist, K. J. & Lederman, H. M., Jul 2006, In : Archives of Disease in Childhood. 91, 7, p. 610-611 2 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Life Expectancy
Neurodegenerative Diseases
Survival
Infection

X-linked agammaglobulinemia: Report on a United States registry of 201 patients

Winkelstein, J. A., Marino, M. C., Lederman, H. M., Jones, S. M., Sullivan, K., Burks, A. W., Conley, M. E., Cunningham-Rundles, C. & Ochs, H. D., Jul 2006, In : Medicine. 85, 4, p. 193-202 10 p.

Research output: Contribution to journalArticle

Registries
Hepatitis
Sepsis
Bruton type agammaglobulinemia
Enterovirus Infections
2005

How infrequent are opportunistic diseases and immune reconstitution syndromes among HIV-infected individuals who have favorable CD4+ cell count responses to antiretroviral therapy? [4] (multiple letters)

Phillips, P., Koletar, S. L., Williams, P. L., Wu, J., McCutchan, J. A., Cohn, S. E., Murphy, R. L., Lederman, H. M. & Currier, J. S., May 1 2005, In : Clinical Infectious Diseases. 40, 9, p. 1379-1381 3 p.

Research output: Contribution to journalArticle

AIDS-Related Opportunistic Infections
Immune Reconstitution Inflammatory Syndrome
Anti-HIV Agents
Immune System Diseases
Highly Active Antiretroviral Therapy
2004

Helicobacter cinaedi bacteremia presenting as macules in an afebrile patient with X-linked agammaglobulinemia

Simons, E., Spacek, L. A., Lederman, H. M. & Winkelstein, J. A., Dec 2004, In : Infection. 32, 6, p. 367-368 2 p.

Research output: Contribution to journalArticle

Helicobacter
Bacteremia
Immunocompromised Host
Skin
Fever

Immunodeficiency and infections in ataxia-telangiectasia

Nowak-Wegrzyn, A., Crawford, T. O., Winkelstein, J. A., Carson, K. A. & Lederman, H. M., Apr 2004, In : Journal of Pediatrics. 144, 4, p. 505-511 7 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Infection
Immunoglobulin G
Molluscum Contagiosum
Viral Vaccines

Long-term follow-up of HIV-infected individuals who have significant increases in CD4+ cell counts during antiretroviral therapy

Koletar, S. L., Williams, P. L., Wu, J., McCutchan, J. A., Cohro, S. E., Murphy, R. L., Lederman, H. M. & Currier, J. S., Nov 15 2004, In : Clinical Infectious Diseases. 39, 10, p. 1500-1506 7 p.

Research output: Contribution to journalArticle

CD4 Lymphocyte Count
HIV
Highly Active Antiretroviral Therapy
Therapeutics
RNA

Stamping out Staphylococcus

Lederman, H. M., Uzel, G., Blackwood, R. A. & Sullivan, K. E., Oct 2004, In : Clinical Immunology. 113, 1, p. 19-21 3 p.

Research output: Contribution to journalArticle

Staphylococcal Skin Infections
Mupirocin
Intranasal Administration
Methicillin Resistance
Down Syndrome
2003

A study of discontinuing maintenance therapy in human immunodeficiency virus-infected subjects with disseminated Mycobacterium avium complex: AIDS clinical trial group 393 study team

Aberg, J. A., Williams, P. L., Liu, T., Lederman, H. M., Hafner, R., Torriani, F. J., Lennox, J. L., Dube, M. P., MacGregor, R. R., Currier, J. S., Nevin, T., Zhou, Y., Owens, S., Hojczyk, P., Conklin, M., Wallis, R. S., Inderlied, C., Purdue, L., McFeely, J., Laverty, M. & 19 others, Ortiz, O., Thompson, J. B., Wiggins, I., Craft, J., Goldman, M., Colletti, M. A., Sha, B., Arri, C., Slamowit, D., Lee, S., Santangelo, J., Canmann, S., Johnson, S., Ogata-Arakaki, D., Shiramizu, B., Frarey, L., Van Der Horst, C., Shank, D. & Canchola, F., Apr 1 2003, In : Journal of Infectious Diseases. 187, 7, p. 1046-1052 7 p.

Research output: Contribution to journalArticle

Mycobacterium avium Complex
Acquired Immunodeficiency Syndrome
Clinical Trials
HIV
Highly Active Antiretroviral Therapy

Incomplete Immune Reconstitution after Initiation of Highly Active Antiretroviral Therapy in Human Immunodeficiency Virus-Infected Patients with Severe CD4+ Cell Depletion

Lederman, H. M., Williams, P. L., Wu, J. W., Evans, T. G., Cohn, S. E., McCutchan, J. A., Koletar, S. L., Hafner, R., Connick, E., Valentine, F. T., McElrath, M. J., Roberts, N. J. & Currier, J. S., Dec 15 2003, In : Journal of Infectious Diseases. 188, 12, p. 1794-1803 10 p.

Research output: Contribution to journalArticle

Azithromycin
Highly Active Antiretroviral Therapy
CD4 Lymphocyte Count
HIV
Mycobacterium avium Complex

Remission of severe autoimmune enteropathy after treatment with high-dose cyclophosphamide

Oliva-Hemker, M., Loeb, D. M., Abraham, S. C. & Lederman, H. M., May 2003, In : Journal of Pediatric Gastroenterology and Nutrition. 36, 5, p. 639-643 5 p.

Research output: Contribution to journalArticle

Remission Induction
immunosuppressive agents
Intestinal Diseases
autoantibodies
cyclophosphamide
2002

Cryptosporidiosis stimulates an inflammatory intestinal response in malnourished Haitian children

Kirkpatrick, B. D., Daniels, M. M., Jean, S. S., Pape, J. W., Karp, C., Littenberg, B., Fitzgerald, D. W., Lederman, H. M., Nataro, J. P. & Sears, C. L., Jul 1 2002, In : Journal of Infectious Diseases. 186, 1, p. 94-101 8 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Cryptosporidiosis
Diarrhea
Morbidity
Mortality

Ocular manifestations of ataxia-telangiectasia

Farr, A. K., Shalev, B., Crawford, T. O., Lederman, H. M., Winkelstein, J. A. & Repka, M. X., Dec 1 2002, In : American Journal of Ophthalmology. 134, 6, p. 891-896 6 p.

Research output: Contribution to journalArticle

Eye Manifestations
Ataxia Telangiectasia
Visual Acuity
Conjunctiva
Strabismus

Signal transduction through the B cell antigen receptor is normal in ataxia-telangiectasia B lymphocytes

Speck, P., Ikeda, M., Ikeda, A., Lederman, H. M. & Longnecker, R., Feb 8 2002, In : Journal of Biological Chemistry. 277, 6, p. 4123-4127 5 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Signal transduction
B-Cell Antigen Receptors
Lymphocytes
Human Herpesvirus 4
2001
Immunology
Binary Outcomes
Lymphocytes
Experiment
Clustered Data

Fatal warm autoimmune hemolytic anemia resulting from IgM autoagglutinins in an infant with severe combined immunodeficiency

Nowak-Wegrzyn, A., King, K. E., Shirey, R. S., Chen, A. R., McDonough, C. & Lederman, H. M., 2001, In : Journal of Pediatric Hematology/Oncology. 23, 4, p. 250-252 3 p.

Research output: Contribution to journalArticle

Autoimmune Hemolytic Anemia
Severe Combined Immunodeficiency
Immunoglobulin M
Autoimmune Diseases
Agglutination

Skin test reactivity and cellular immune responses to Mycobacterium avium sensitin in AIDS patients at risk for disseminated M. avium infection

Von Reyn, C. F., Williams, P. L., Lederman, H. M., McCutchan, J. A., Koletar, S. L., Murphy, R. L., Cohn, S. E., Evans, T., Heald, A. E., Colquhoun, D., Bassily, E. L. & Currier, J. S., 2001, In : Clinical and Diagnostic Laboratory Immunology. 8, 6, p. 1277-1278 2 p.

Research output: Contribution to journalArticle

Mycobacterium avium
Mycobacterium Infections
Lymphocytes
Skin Tests
Cellular Immunity

Successful treatment of enterovirus infection with the use of pleconaril in 2 infants with severe combined immunodeficiency.

Nowak-Wegrzyn, A., Phipatanakul, W., Winkelstein, J. A., Forman, M. S. & Lederman, H. M., Jan 2001, In : Clinical Infectious Diseases. 32, 1

Research output: Contribution to journalArticle

Enterovirus Infections
Severe Combined Immunodeficiency
Therapeutics
pleconaril
2000

Discontinuation of Mycobacterium avium complex prophylaxis in patients with antiretroviral therapy - Induced increases in CD4+ cell count: A randomized, double-blind, placebo-controlled trial

Currier, J. S., Williams, P. L., Koletar, S. L., Cohn, S. E., Murphy, R. L., Heald, A. E., Hafner, R., Bassily, E. L., Lederman, H. M., Knirsch, C., Benson, C. A., Valdez, H., Aberg, J. A. & McCutchan, J. A., Oct 3 2000, In : Annals of Internal Medicine. 133, 7, p. 493-503 11 p.

Research output: Contribution to journalArticle

Mycobacterium avium Complex
CD4 Lymphocyte Count
Azithromycin
Placebos
HIV-1

JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome

Chatila, T. A., Blaeser, F., Ho, N., Lederman, H. M., Voulgaropoulos, C., Helms, C. & Bowcock, A. M., 2000, In : Journal of Clinical Investigation. 106, 12

Research output: Contribution to journalArticle

Autoimmunity
Head
Phenotype
Self Tolerance
Leucine Zippers

Judgment of duration in individuals with ataxia-telangiectasia

Mostofsky, S. H., Kunze, J. C., Cutting, L. E., Lederman, H. M. & Denckla, M. B., 2000, In : Developmental Neuropsychology. 17, 1, p. 63-74 12 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Cerebellum
Cerebellar Cortex
Intelligence
Population

Lymphoid malignancy as a presenting sign of ataxia-telangiectasia

Loeb, D. M., Lederman, H. M. & Winkelstein, J. A., Sep 2000, In : Journal of Pediatric Hematology/Oncology. 22, 5, p. 464-467 4 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Neoplasms
Ataxia
Genetic Counseling
Drug Therapy