Herschel Wade

Associate Professor

19962018
If you made any changes in Pure these will be visible here soon.

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Catalytic Antibodies Medicine & Life Sciences
MDR Genes Medicine & Life Sciences
Binding energy Chemical Compounds
Catalysis Medicine & Life Sciences
Antibodies Engineering & Materials Science
Genes Chemical Compounds
Ligands Medicine & Life Sciences
Proteins Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1996 2018

Probing Ligand Structure-Activity Relationships in PregnaneX Receptor (PXR): Efavirenz and 8-Hydroxyefavirenz Exhibit Divergence in Activation

Narayanan, B., Lade, J. M., Heck, C. J. S., Dietz, K. D., Wade, H. & Bumpus, N. N. Jan 1 2018 (Accepted/In press) In : ChemMedChem.

Research output: Contribution to journalArticle

efavirenz
Structure-Activity Relationship
Chemical activation
Ligands
Assays

Unconventional Coupling between Ligand Recognition and Allosteric Control in the Multidrug Resistance Gene Regulator, BmrR

Bachas, S., Kohrs, B. & Wade, H. 2017 (Accepted/In press) In : ChemMedChem.

Research output: Contribution to journalArticle

MDR Genes
Genes
Ligands
Chemical activation
Switches

Charge is Major Determinant of Activation of the Ligand-Responsive Multidrug Resistance Gene Regulator, BmrR

Bachas, S., Kohr, B. & Wade, H. 2016 (Accepted/In press) In : ChemMedChem.

Research output: Contribution to journalArticle

MDR Genes
Genes
Chemical activation
Ligands
Eukaryotic Cells

Solution-Binding and Molecular Docking Approaches Combine to Provide an Expanded View of Multidrug Recognition in the MDR Gene Regulator BmrR

Gunio, D., Froehlig, J., Pappas, K., Ferguson, U. & Wade, H. Feb 22 2016 In : Journal of Chemical Information and Modeling. 56, 2, p. 377-389 13 p.

Research output: Contribution to journalArticle

Mitteldeutscher Rundfunk
Genes
Ligands
simulation
Proteins

Solution Binding and Structural Analyses Reveal Potential Multidrug Resistance Functions for SAV2435 and CTR107 and Other GyrI-like Proteins

Moreno, A., Froehlig, J. R., Bachas, S., Gunio, D., Alexander, T., Vanya, A. & Wade, H. Aug 30 2016 In : Biochemistry. 55, 34, p. 4850-4863 14 p.

Research output: Contribution to journalArticle

Multiple Drug Resistance
Crystal structure
Pumps
P-Glycoproteins
Poisons