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Proteins Chemical Compounds
Catalytic Antibodies Medicine & Life Sciences
Substrates Chemical Compounds
Antibodies Medicine & Life Sciences
Genes Chemical Compounds
Catalysis Chemical Compounds
Ligands Medicine & Life Sciences
Binding energy Chemical Compounds

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Research Output 1996 2017

Unconventional Coupling between Ligand Recognition and Allosteric Control in the Multidrug Resistance Gene Regulator, BmrR

Bachas, S., Kohrs, B. & Wade, H. 2017 (Accepted/In press) In : ChemMedChem.

Research output: Research - peer-reviewArticle

Genes
Ligands
MDR Genes
Chemical activation
Switches

Charge is Major Determinant of Activation of the Ligand-Responsive Multidrug Resistance Gene Regulator, BmrR

Bachas, S., Kohr, B. & Wade, H. 2016 (Accepted/In press) In : ChemMedChem.

Research output: Research - peer-reviewArticle

Genes
Chemical activation
Ligands
MDR Genes
Xenobiotics

Solution-Binding and Molecular Docking Approaches Combine to Provide an Expanded View of Multidrug Recognition in the MDR Gene Regulator BmrR

Gunio, D., Froehlig, J., Pappas, K., Ferguson, U. & Wade, H. Feb 22 2016 In : Journal of Chemical Information and Modeling. 56, 2, p. 377-389 13 p.

Research output: Research - peer-reviewArticle

Genes
Ligands
Mitteldeutscher Rundfunk
simulation
Proteins

Solution Binding and Structural Analyses Reveal Potential Multidrug Resistance Functions for SAV2435 and CTR107 and Other GyrI-like Proteins

Moreno, A., Froehlig, J. R., Bachas, S., Gunio, D., Alexander, T., Vanya, A. & Wade, H. Aug 30 2016 In : Biochemistry. 55, 34, p. 4850-4863 14 p.

Research output: Research - peer-reviewArticle

Crystal structure
Pumps
Proteins
Multiple Drug Resistance
P-Glycoproteins

Allosteric coupling via distant disorder-to-order transitions

Eginton, C., Cressman, W. J., Bachas, S., Wade, H. & Beckett, D. 2014 In : Journal of Molecular Biology. 427, 8, p. 1695-1704 10 p.

Research output: Research - peer-reviewArticle

Dimerization
Proteins
Co-Repressor Proteins
Alanine
Escherichia coli