Hernando Lopez-Bertoni

Assistant Professor

20102019
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Research Output 2010 2019

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Article
2019

Extracellular matrix protein tenascin C increases phagocytosis mediated by CD47 Loss of function in glioblastoma

Ma, D., Liu, S., Lal, B., Wei, S., Wang, S., Zhan, D., Zhang, H., Lee, R., Gao, P., Lopez-Bertoni, H., Ying, M., Li, J. J., Laterra, J. J., Wilson, M. A. & Xia, S., Jan 1 2019, In : Cancer Research. 79, 10, p. 2697-2708 12 p.

Research output: Contribution to journalArticle

Tenascin
Extracellular Matrix Proteins
Glioblastoma
Protein C
Phagocytosis

TET1 regulates DNA repair in human glial cells

Kuhns, K. J., Lopez-Bertoni, H., Coulter, J. B. & Bressler, J., Oct 1 2019, In : Toxicology and Applied Pharmacology. 380, 114646.

Research output: Contribution to journalArticle

Neuroglia
DNA Repair
Repair
DNA
Ionizing radiation
2018

Bioreducible Polymeric Nanoparticles Containing Multiplexed Cancer Stem Cell Regulating miRNAs Inhibit Glioblastoma Growth and Prolong Survival

Lopez-Bertoni, H., Kozielski, K. L., Rui, Y., Lal, B., Vaughan, H., Wilson, D. R., Mihelson, N., Eberhart, C. G., Laterra, J. J. & Green, J., Jul 11 2018, In : Nano Letters. 18, 7, p. 4086-4094 9 p.

Research output: Contribution to journalArticle

stem cells
Stem cells
MicroRNAs
Tumors
delivery

Crizotinib and erlotinib inhibits growth of c-Met+/EGFRvIII+ primary human glioblastoma xenografts

Goodwin, C. R., Rath, P., Oyinlade, O., Lopez-Bertoni, H., Mughal, S., Xia, S., Li, Y., Kaur, H., Zhou, X., Ahmed, A. K., Ho, S., Olivi, A. & Lal, B., Aug 1 2018, In : Clinical Neurology and Neurosurgery. 171, p. 26-33 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Heterografts
Growth
Epidermal Growth Factor Receptor
Neoplasms
2017

TET1 deficiency attenuates the DNA damage response and promotes resistance to DNA damaging agents

Coulter, J. B., Lopez-Bertoni, H., Kuhns, K. J., Lee, R., Laterra, J. J. & Bressler, J., Nov 1 2017, (Accepted/In press) In : Epigenetics. p. 1-11 11 p.

Research output: Contribution to journalArticle

DNA Damage
Cyclin B1
Genomic Instability
DNA
Ionizing Radiation
2016

Analysis of SOX2-regulated transcriptome in glioma stem cells

Acanda De La Rocha, A. M., Lopez-Bertoni, H., Guruceaga, E., González-Huarriz, M., Martínez-Vélez, N., Xipell, E., Fueyo, J., Gomez-Manzano, C. & Alonso, M. M., Sep 1 2016, In : PLoS One. 11, 9

Research output: Contribution to journalArticle

Stem cells
Transcriptome
transcriptome
Glioma
stem cells

Epigenetic modulation of a miR-296-5p: HMGA1 axis regulates Sox2 expression and glioblastoma stem cells

Lopez-Bertoni, H., Lal, B., Michelson, N., Guerrero-Cázares, H., Quiñones-Hinojosa, A., Li, Y. & Laterra, J. J., Feb 22 2016, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Glioblastoma
Epigenomics
Stem Cells
Neoplastic Stem Cells
Neoplasms
2015

DNMT-dependent suppression of microRNA regulates the induction of GBM tumor-propagating phenotype by Oct4 and Sox2

Lopez-Bertoni, H., Lal, B., Li, A., Caplan, M., Guerrero-Cázares, H., Eberhart, C. G., Quiñones-Hinojosa, A., Glas, M., Scheffler, B., Laterra, J. J. & Li, Y., Jul 23 2015, In : Oncogene. 34, 30, p. 3994-4004 11 p.

Research output: Contribution to journalArticle

Transferases
MicroRNAs
Phenotype
DNA
Neoplasms
Neoplastic Stem Cells
DNA Methylation
Glioblastoma
MicroRNAs
Transcription Factors
2014

The carboxyl-terminal tail of Noxa protein regulates the stability of Noxa and Mcl-1

Pang, X., Zhang, J., Lopez-Bertoni, H., Wang, Y., Li, W., O'Neill, K. L., Evans, J. J. D., George, N. M., Long, J., Chen, Y. & Luo, X., Jun 20 2014, In : Journal of Biological Chemistry. 289, 25, p. 17802-17811 10 p.

Research output: Contribution to journalArticle

Noxae
Protein Stability
Proteins
Degradation
Ubiquitination
2012

Perturbing pro-survival proteins using quinoxaline derivatives: A structure-activity relationship study

Rajule, R., Bryant, V. C., Lopez-Bertoni, H., Luo, X. & Natarajan, A., Apr 1 2012, In : Bioorganic and Medicinal Chemistry. 20, 7, p. 2227-2234 8 p.

Research output: Contribution to journalArticle

Quinoxalines
Structure-Activity Relationship
Apoptosis
Derivatives
Proteins

Pivotal role of inosine triphosphate pyrophosphatase in maintaining genome stability and the prevention of apoptosis in human cells

Menezes, M. R., Waisertreiger, I. S. R., Lopez-Bertoni, H., Luo, X. & Pavlov, Y. I., Feb 27 2012, In : PLoS One. 7, 2, e32313.

Research output: Contribution to journalArticle

Pyrophosphatases
Inosine Triphosphate
pyrophosphatases
Genomic Instability
apoptosis
2011

2,3-Substituted quinoxalin-6-amine analogs as antiproliferatives: A structure-activity relationship study

Chen, Q., Bryant, V. C., Lopez-Bertoni, H., Kelly, D. L., Luo, X. & Natarajan, A., Apr 1 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 7, p. 1929-1932 4 p.

Research output: Contribution to journalArticle

Quinoxalines
Structure-Activity Relationship
Amines
Cells
Caspase 7

Active Bax and Bak are functional holins

Pang, X., Moussa, S. H., Targy, N. M., Bose, J. L., George, N. M., Gries, C., Lopez-Bertoni, H., Zhang, L., Bayles, K. W., Young, R. & Luo, X., Nov 1 2011, In : Genes and Development. 25, 21, p. 2278-2290 13 p.

Research output: Contribution to journalArticle

Mitochondrial Membranes
Bacteriophages
Proteins
Membranes
Cell Wall

Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways

Zhang, L., Lopez-Bertoni, H., George, N. M., Liu, X., Pang, X. & Luo, X., May 1 2011, In : Cell Death and Differentiation. 18, 5, p. 864-873 10 p.

Research output: Contribution to journalArticle

Noxae
TNF-Related Apoptosis-Inducing Ligand
Apoptosis
Endoplasmic Reticulum Stress
Proteasome Endopeptidase Complex
2010

Perturbation of the Bcl-2 network and an induced Noxa/Bcl-xL interaction trigger mitochondrial dysfunction after DNA damage

Lopez-Bertoni, H., Zhang, L., George, N. M., Liu, X., Pang, X., Evans, J. J. D., Targy, N. M. & Luo, X., May 14 2010, In : Journal of Biological Chemistry. 285, 20, p. 15016-15026 11 p.

Research output: Contribution to journalArticle

Noxae
DNA Damage
Apoptosis
DNA
Camptothecin