Harry C Dietz

Professor

1991 …2019
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Fingerprint Dive into the research topics where Harry C Dietz is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Marfan Syndrome Medicine & Life Sciences
Loeys-Dietz Syndrome Medicine & Life Sciences
Mutation Medicine & Life Sciences
Aortic Aneurysm Medicine & Life Sciences
Thoracic Aortic Aneurysm Medicine & Life Sciences
Transforming Growth Factors Medicine & Life Sciences
Dissection Medicine & Life Sciences
Aneurysm Medicine & Life Sciences

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Research Output 1991 2019

Calpain 9 as a therapeutic target in TGFβ-induced mesenchymal transition and fibrosis

Kim, D. H., Beckett, J. D., Nagpal, V., Seman-Senderos, M. A., Gould, R. A., Creamer, T. J., MacFarlane, E., Chen, Y., Bedja, D., Butcher, J. T., Mitzner, W. A., Rouf, R., Hata, S., Warren, D. & Dietz, H. C., Jul 17 2019, In : Science translational medicine. 11, 501, eaau2814.

Research output: Contribution to journalArticle

Calpain
Transforming Growth Factors
Fibrosis
Myofibroblasts
Therapeutics

Confirmation of the role of pathogenic SMAD6 variants in bicuspid aortic valve-related aortopathy

Luyckx, I., MacCarrick, G., Kempers, M., Meester, J., Geryl, C., Rombouts, O., Peeters, N., Claes, C., Boeckx, N., Sakalihasan, N., Jacquinet, A., Hoischen, A., Vandeweyer, G., Van Lent, S., Saenen, J., Van Craenenbroeck, E., Timmermans, J., Duijnhouwer, A., Dietz, H. C., Van Laer, L. & 2 others, Loeys, B. & Verstraeten, A., Jan 1 2019, In : European Journal of Human Genetics.

Research output: Contribution to journalArticle

Thoracic Aortic Aneurysm
Craniosynostoses
Penetrance
Alleles
Bicuspid Aortic Valve

Copy number variation analysis in bicuspid aortic valve-related aortopathy identifies TBX20 as a contributing gene

MIBAVA Leducq consortium, Jul 1 2019, In : European Journal of Human Genetics. 27, 7, p. 1033-1043 11 p.

Research output: Contribution to journalArticle

Thoracic Aortic Aneurysm
Genes
Congenital Heart Defects
Bicuspid Aortic Valve
Exome

Epigenetic activation and memory at a TGFB2 enhancer in systemic sclerosis

Shin, J. Y., Beckett, J. D., Bagirzadeh, R., Creamer, T. J., Shah, A., McMahan, Z., Paik, J., Sampedro, M. M., MacFarlane, E., Beer, M. A., Warren, D., Wigley, F. & Dietz, H. C., Jan 1 2019, In : Science translational medicine. 11, 497, eaaw0790.

Research output: Contribution to journalArticle

Systemic Scleroderma
Epigenomics
Fibrosis
Skin
Autocrine Communication

Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome

MacFarlane, E., Parker, S. J., Shin, J. Y., Ziegler, S. G., Creamer, T. J., Bagirzadeh, R., Bedja, D., Chen, Y., Calderon, J. F., Weissler, K., Frischmeyer-Guerrerio, P. A., Lindsay, M. E., Habashi, J. & Dietz, H. C., Feb 1 2019, In : Journal of Clinical Investigation. 129, 2, p. 659-675 17 p.

Research output: Contribution to journalArticle

Loeys-Dietz Syndrome
Aortic Aneurysm
Transforming Growth Factors
Vascular Smooth Muscle
Smooth Muscle Myocytes