1994 …2021

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2021

Phthalate inhibits Leydig cell differentiation and promotes adipocyte differentiation

Hao, X., Guan, X., Zhao, X., Ji, M., Wen, X., Chen, P., Chen, F., Yang, J., Lian, Q., Ye, L. & Chen, H., Jan 2021, In : Chemosphere. 262, 127855.

Research output: Contribution to journalArticle

2020

Cholesterol accumulation, lipid droplet formation, and steroid production in Leydig cells: Role of translocator protein (18-kDa)

Chung, J. Y., Chen, H., Papadopoulos, V. & Zirkin, B., May 1 2020, In : Andrology. 8, 3, p. 719-730 12 p.

Research output: Contribution to journalArticle

Effects of pharmacologically induced Leydig cell testosterone production on intratesticular testosterone and spermatogenesis

Chung, J. Y., Brown, S., Chen, H., Liu, J., Papadopoulos, V. & Zirkin, B., Feb 14 2020, In : Biology of reproduction. 102, 2, p. 489-498 10 p.

Research output: Contribution to journalArticle

2019

Acute effects of the translocator protein drug ligand FGIN-1-27 on serum testosterone and luteinizing hormone levels in male Sprague-Dawley rats

Chen, F., Lu, H., Chen, P., Zhao, X., Guan, X., Liang, Q., Zirkin, B. R., Ye, L. & Chen, H., Jan 1 2019, In : Biology of reproduction. 100, 3, p. 824-832 9 p.

Research output: Contribution to journalArticle

Open Access

Characterization and differentiation of CD51+ Stem Leydig cells in adult mouse testes

Chen, P., Guan, X., Zhao, X., Chen, F., Yang, J., Wang, Y., Hu, Y., Lian, Q. & Chen, H., Aug 1 2019, In : Molecular and Cellular Endocrinology. 493, 110449.

Research output: Contribution to journalArticle

Characterization of stem cells associated with seminiferous tubule of adult rat testis for their potential to form Leydig cells

Guan, X., Chen, P., Zhao, X., Hao, X., Chen, F., Ji, M., Wen, X., Lin, H., Ye, L. & Chen, H., Dec 2019, In : Stem Cell Research. 41, 101593.

Research output: Contribution to journalArticle

Open Access

Effects of spermatogenic cycle on Stem Leydig cell proliferation and differentiation

Guan, X., Chen, F., Chen, P., Zhao, X., Mei, H., Liu, J., Lian, Q., Zirkin, B. R. & Chen, H., Feb 5 2019, In : Molecular and Cellular Endocrinology. 481, p. 35-43 9 p.

Research output: Contribution to journalArticle

2018

Long -term maintenance of luteinizing Hormone–Responsive testosterone formation by primary rat Leydig cells in vitro

Wang, Y., Huang, S., Wang, Z., Chen, F., Chen, P., Zhao, X., Lin, H., Ge, R., Zirkin, B. R. & Chen, H., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Endocrinology.

Research output: Contribution to journalArticle

Nasal delivery of nerve growth factor rescue hypogonadism by up-regulating GnRH and testosterone in aging male mice

Luo, J., Yang, Y., Zhang, T., Su, Z., Yu, D., Lin, Q., Chen, H., Zhang, Q., Xiang, Q., Xue, W., Ge, R. & Huang, Y., Jan 1 2018, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Testosterone replacement in transgenic sickle cell mice controls priapic activity and upregulates PDE5 expression and eNOS activity in the penis

Musicki, B., Karakus, S., Akakpo, W., Silva, F. H., Liu, J., Chen, H., Zirkin, B. R. & Burnett, A. L., Jan 2018, In : Andrology. 6, 1, p. 184-191 8 p.

Research output: Contribution to journalArticle

2017

A role of KIT receptor signaling for proliferation and differentiation of rat stem Leydig cells in vitro

Liu, S., Chen, X., Wang, Y., Li, L., Wang, G., Li, X., Chen, H., Guo, J., Lin, H., Lian, Q. Q. & Ge, R. S., Mar 15 2017, In : Molecular and Cellular Endocrinology. 444, p. 1-8 8 p.

Research output: Contribution to journalArticle

Direct Reprogramming of Mouse Fibroblasts toward Leydig-like Cells by Defined Factors

Yang, Y., Li, Z., Wu, X., Chen, H., Xu, W., Xiang, Q., Zhang, Q., Chen, J., Ge, R. S., Su, Z. & Huang, Y., Jan 10 2017, In : Stem Cell Reports. 8, 1, p. 39-53 15 p.

Research output: Contribution to journalArticle

Leydig cell stem cells: Identification, proliferation and differentiation

Chen, H., Wang, Y., Ge, R. & Zirkin, B. R., Apr 15 2017, In : Molecular and Cellular Endocrinology. 445, p. 65-73 9 p.

Research output: Contribution to journalArticle

Transdifferentiation of adult rat stem Leydig cells into prostatic and uterine epithelium, but not epidermis

Nanjappa, M. K., Medrano, T. I., Prins, G. S., Chen, H., Zirkin, B. R. & Cooke, P. S., Nov 2017, In : Andrology. 5, 6, p. 1165-1173 9 p.

Research output: Contribution to journalArticle

2016

Age and testosterone mediate influenza pathogenesis in male mice

Vom Steeg, L. G., Vermillion, M. S., Hall, O. J., Alam, O., McFarland, R., Chen, H., Zirkin, B. & Klein, S. L., 2016, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 311, 6, p. L1234-L1244

Research output: Contribution to journalArticle

Regulation of seminiferous tubule-associated stem Leydig cells in adult rat testes

Li, X., Wang, Z., Jiang, Z., Guo, J., Zhang, Y., Li, C., Chung, J., Folmer, J., Liu, J., Lian, Q., Ge, R., Zirkin, B. R. & Chen, H., Mar 8 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 10, p. 2666-2671 6 p.

Research output: Contribution to journalArticle

Transplantation of alginate-encapsulated seminiferous tubules and interstitial tissue into adult rats: Leydig stem cell differentiation in vivo?

Chen, H., Jin, S., Huang, S., Folmer, J., Liu, J., Ge, R. & Zirkin, B. R., Nov 15 2016, In : Molecular and Cellular Endocrinology. 436, p. 250-258 9 p.

Research output: Contribution to journalArticle

2015

Developmental and endocrine regulation of kisspeptin expression in mouse leydig cells

Salehi, S., Adeshina, I., Chen, H., Zirkin, B. R., Hussain, M. A., Wondisford, F., Wolfe, A. & Radovick, S., Apr 1 2015, In : Endocrinology. 156, 4, p. 1514-1522 9 p.

Research output: Contribution to journalArticle

Knockout of the transcription factor Nrf2: Effects on testosterone production by aging mouse Leydig cells

Chen, H., Jin, S., Guo, J., Kombairaju, P., Biswal, S. & Zirkin, B. R., Jul 5 2015, In : Molecular and Cellular Endocrinology. 409, p. 113-120 8 p.

Research output: Contribution to journalArticle

Mechanism of testosterone deficiency in the transgenic sickle cell mouse

Musicki, B., Zhang, Y., Chen, H., Brown, T. R., Zirkin, B. R. & Burnett, A. L., May 29 2015, In : PloS one. 10, 5, e0128694.

Research output: Contribution to journalArticle

Steroidogenic fate of the Leydig cells that repopulate the testes of young and aged Brown Norway rats after elimination of the preexisting Leydig cells

Chen, H., Guo, J., Ge, R., Lian, Q., Papadopoulos, V. & Zirkin, B. R., Dec 1 2015, In : Experimental Gerontology. 72, p. 8-15 8 p.

Research output: Contribution to journalArticle

2014

Microsurgical rat varicocele model

Najari, B. B., Li, P. S., Ramasamy, R., Katz, M., Sheth, S., Robinson, B., Chen, H., Zirkin, B., Schlegel, P. N. & Goldstein, M., Feb 1 2014, In : Journal of Urology. 191, 2, p. 548-553 6 p.

Research output: Contribution to journalArticle

Regulation of the proliferation and differentiation of leydig stem cells in the adult testis

Odeh, H. M., Kleinguetl, C., Ge, R., Zirkin, B. R. & Chen, H., 2014, In : Biology of reproduction. 90, 6, 123.

Research output: Contribution to journalArticle

2013

Aging and luteinizing hormone effects on reactive oxygen species production and DNA damage in rat leydig cells

Beattie, M. C., Chen, H., Fan, J., Papadopoulos, V., Miller, P. & Zirkin, B. R., Apr 2013, In : Biology of reproduction. 88, 4, 100.

Research output: Contribution to journalArticle

Drug ligand-induced activation of translocator protein (TSPO) stimulates steroid production by aged Brown Norway rat leydig cells

Chung, J. Y., Chen, H., Midzak, A., Burnett, A. L., Papadopoulos, V. & Zirkin, B. R., Jun 1 2013, In : Endocrinology. 154, 6, p. 2156-2165 10 p.

Research output: Contribution to journalArticle

Oxidative stress and phthalate-induced down-regulation of steroidogenesis in MA-10 Leydig cells

Zhou, L., Beattie, M. C., Lin, C. Y., Liu, J., Traore, K., Papadopoulos, V., Zirkin, B. R. & Chen, H., Dec 1 2013, In : Reproductive Toxicology. 42, p. 95-101 7 p.

Research output: Contribution to journalArticle

2012

Identification, proliferation, and differentiation of adult leydig stem cells

Stanley, E., Lin, C. Y., Jin, S., Liu, J., Sottas, C. M., Ge, R., Zirkin, B. R. & Chen, H., Oct 1 2012, In : Endocrinology. 153, 10, p. 5002-5010 9 p.

Research output: Contribution to journalArticle

Simultaneous quantification of steroids in rat intratesticular fluid by HPLC-isotope dilution tandem mass spectrometry

Renne, A., Luo, L., Jarow, J., Wright, W. W., Brown, T. R., Chen, H., Zirkin, B. R. & Friesen, M. D., Jul 2012, In : Journal of andrology. 33, 4, p. 691-698 8 p.

Research output: Contribution to journalArticle

2011

ATP synthesis, mitochondrial function, and steroid biosynthesis in rodent primary and tumor leydig cells

Midzak, A. S., Chen, H., Aon, M. A., Papadopoulos, V. & Zirkin, B. R., May 2011, In : Biology of reproduction. 84, 5, p. 976-985 10 p.

Research output: Contribution to journalArticle

Stem Leydig cell differentiation: Gene expression during development of the adult rat population of Leydig cells

Stanley, E. L., Johnston, D. S., Fan, J., Papadopoulos, V., Chen, H., Ge, R. S., Zirkin, B. R. & Jelinsky, S. A., Dec 1 2011, In : Biology of reproduction. 85, 6, p. 1161-1166 6 p.

Research output: Contribution to journalArticle

2010

Effect of glutathione redox state on Leydig cell susceptibility to acute oxidative stress

Chen, H., Zhou, L., Lin, C. Y., Beattie, M. C., Liu, J. & Zirkin, B. R., Jul 2010, In : Molecular and Cellular Endocrinology. 323, 2, p. 147-154 8 p.

Research output: Contribution to journalArticle

Molecular mechanisms mediating the effect of mono-(2-ethylhexyl) phthalate on hormone-stimulated steroidogenesis in MA-10 mouse tumor leydig cells

Fan, J., Traore, K., Li, W., Amri, H., Huang, H., Wu, C., Chen, H., Zirkin, B. & Papadopoulos, V., Jul 2010, In : Endocrinology. 151, 7, p. 3348-3362 15 p.

Research output: Contribution to journalArticle

2008

Effect of glutathione depletion on Leydig cell steroidogenesis in young and old Brown Norway rats

Chen, H., Pechenino, A. S., Liu, J., Beattie, M. C., Brown, T. R. & Zirkin, B. R., May 2008, In : Endocrinology. 149, 5, p. 2612-2619 8 p.

Research output: Contribution to journalArticle

Gestational exposure to atrazine: Effects on the postnatal development of male offspring

Rosenberg, B. G., Chen, H., Folmer, J., Liu, J., Papadopoulos, V. & Zirkin, B. R., May 2008, In : Journal of andrology. 29, 3, p. 304-311 8 p.

Research output: Contribution to journalArticle

2007

Cyclooxygenases in rat Leydig cells: Effects of luteinizing hormone and aging

Chen, H., Luo, L., Liu, J. & Zirkin, B. R., Feb 1 2007, In : Endocrinology. 148, 2, p. 735-742 8 p.

Research output: Contribution to journalArticle

2006

Aging and the brown norway rat leydig cell antioxidant defense system

Luo, L., Chen, H., Trush, M. A., Show, M. D., Anway, M. D. & Zirkin, B. R., Mar 2006, In : Journal of andrology. 27, 2, p. 240-247 8 p.

Research output: Contribution to journalArticle

2005

Aging and caloric restriction: Effects on Leydig cell steroidogenesis

Chen, H., Luo, L., Liu, J., Brown, T. & Zirkin, B. R., Jun 1 2005, In : Experimental Gerontology. 40, 6, p. 498-505 8 p.

Research output: Contribution to journalArticle

Gene expression in rat leydig cells during development from the progenitor to adult stage: A cluster analysis

Ge, R. S., Dong, Q., Sottas, C. M., Chen, H., Zirkin, B. R. & Hardy, M. P., Jun 2005, In : Biology of reproduction. 72, 6, p. 1405-1415 11 p.

Research output: Contribution to journalArticle

Vitamin E, aging and Leydig cell steroidogenesis

Chen, H., Liu, J., Luo, L., Baig, M. U., Kim, J. M. & Zirkin, B. R., Aug 1 2005, In : Experimental Gerontology. 40, 8-9, p. 728-736 9 p.

Research output: Contribution to journalArticle

2004

Gene expression by the anterior pituitary gland: Effects of age and caloric restriction

Chen, H., Jul 30 2004, In : Molecular and Cellular Endocrinology. 222, 1-2, p. 21-31 11 p.

Research output: Contribution to journalArticle

Leydig cell gene expression: Effects of age and caloric restriction

Chen, H., Irizarry, R. A., Luo, L. & Zirkin, B. R., Jan 2004, In : Experimental Gerontology. 39, 1, p. 31-43 13 p.

Research output: Contribution to journalArticle

2002

Age-related decreases in Leydig cell testosterone production are not restored by exposure to LH in vitro

Chen, H., Hardy, M. P. & Zirkin, B. R., Jan 1 2002, In : Endocrinology. 143, 5, p. 1637-1642 6 p.

Research output: Contribution to journalArticle

Open Access

Cholesterol transport, peripheral benzodiazepine receptor, and steroidogenesis in aging Leydig cells

Culty, M., Luo, L., Yao, Z. X., Chen, H., Papadopoulos, V. & Zirkin, B. R., Jan 1 2002, In : Journal of andrology. 23, 3, p. 439-447 9 p.

Research output: Contribution to journalArticle

Perspectives and editorials: Editorial commentary

Culty, M., Luo, L., Yao, Z., Chen, H., Papadopoulos, V., Zirkin, B. & Weissman, B. A., Jan 1 2002, In : Journal of andrology. 23, 3, p. 326-327 2 p.

Research output: Contribution to journalArticle

2001

Age-related increase in mitochondrial superoxide generation in the testosterone-producing cells of Brown Norway rat testes: Relationship to reduced steroidogenic function?

Chen, H., Cangello, D., Benson, S., Folmer, J., Zhu, H., Trush, M. A. & Zirkin, B. R., Aug 15 2001, In : Experimental Gerontology. 36, 8, p. 1361-1373 13 p.

Research output: Contribution to journalArticle

Assessment of the androgen environment within the human testis: Minimally invasive method to obtain intratesticular fluid

Jarow, J. P., Chen, H., Rosner, W., Trentacoste, S. & Zirkin, B. R., Jan 1 2001, In : Journal of andrology. 22, 4, p. 640-645 6 p.

Research output: Contribution to journalArticle