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Research Output 1994 2019

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2019

Acute effects of the translocator protein drug ligand FGIN-1-27 on serum testosterone and luteinizing hormone levels in male Sprague-Dawley rats

Chen, F., Lu, H., Chen, P., Zhao, X., Guan, X., Liang, Q., Zirkin, B. R., Ye, L. & Chen, H., Jan 1 2019, In : Biology of Reproduction. 100, 3, p. 824-832 9 p.

Research output: Contribution to journalArticle

Open Access
Luteinizing Hormone
Sprague Dawley Rats
Testosterone
Ligands
Serum

Characterization and differentiation of CD51+ Stem Leydig cells in adult mouse testes

Chen, P., Guan, X., Zhao, X., Chen, F., Yang, J., Wang, Y., Hu, Y., Lian, Q. & Chen, H., Aug 1 2019, In : Molecular and Cellular Endocrinology. 493, 110449.

Research output: Contribution to journalArticle

Leydig Cells
Stem cells
Testis
Stem Cells
Macrophages

Characterization of stem cells associated with seminiferous tubule of adult rat testis for their potential to form Leydig cells

Guan, X., Chen, P., Zhao, X., Hao, X., Chen, F., Ji, M., Wen, X., Lin, H., Ye, L. & Chen, H., Dec 2019, In : Stem Cell Research. 41, 101593.

Research output: Contribution to journalArticle

Open Access
Seminiferous Tubules
Leydig Cells
Testis
Stem Cells
Nestin
2018

Effects of spermatogenic cycle on Stem Leydig cell proliferation and differentiation

Guan, X., Chen, F., Chen, P., Zhao, X., Mei, H., Liu, J., Lian, Q., Zirkin, B. R. & Chen, H., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Endocrinology.

Research output: Contribution to journalArticle

Leydig Cells
Cell proliferation
Stem cells
Cell Differentiation
Stem Cells

Long -term maintenance of luteinizing Hormone–Responsive testosterone formation by primary rat Leydig cells in vitro

Wang, Y., Huang, S., Wang, Z., Chen, F., Chen, P., Zhao, X., Lin, H., Ge, R., Zirkin, B. R. & Chen, H., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Endocrinology.

Research output: Contribution to journalArticle

Leydig Cells
Testosterone
Rats
Luteinizing Hormone
Diethylhexyl Phthalate

Nasal delivery of nerve growth factor rescue hypogonadism by up-regulating GnRH and testosterone in aging male mice

Luo, J., Yang, Y., Zhang, T., Su, Z., Yu, D., Lin, Q., Chen, H., Zhang, Q., Xiang, Q., Xue, W., Ge, R. & Huang, Y., Jan 1 2018, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Hypogonadism
Nerve Growth Factor
Nose
Gonadotropin-Releasing Hormone
Testosterone
2017

A role of KIT receptor signaling for proliferation and differentiation of rat stem Leydig cells in vitro

Liu, S., Chen, X., Wang, Y., Li, L., Wang, G., Li, X., Chen, H., Guo, J., Lin, H., Lian, Q. Q. & Ge, R. S., Mar 15 2017, In : Molecular and Cellular Endocrinology. 444, p. 1-8 8 p.

Research output: Contribution to journalArticle

Leydig Cells
Stem cells
Rats
Stem Cells
Proto-Oncogene Proteins c-kit

Direct Reprogramming of Mouse Fibroblasts toward Leydig-like Cells by Defined Factors

Yang, Y., Li, Z., Wu, X., Chen, H., Xu, W., Xiang, Q., Zhang, Q., Chen, J., Ge, R. S., Su, Z. & Huang, Y., Jan 10 2017, In : Stem Cell Reports. 8, 1, p. 39-53 15 p.

Research output: Contribution to journalArticle

Leydig Cells
Fibroblasts
Testosterone
Gene expression
Androgens

Testosterone replacement in transgenic sickle cell mice controls priapic activity and upregulates PDE5 expression and eNOS activity in the penis

Musicki, B., Karakus, S., Akakpo, W., Silva, F. H., Liu, J., Chen, H., Zirkin, B. R. & Burnett, A., Jan 1 2017, (Accepted/In press) In : Andrology.

Research output: Contribution to journalArticle

Penis
Testosterone
Up-Regulation
Priapism
Sickle Cell Anemia

Transdifferentiation of adult rat stem Leydig cells into prostatic and uterine epithelium, but not epidermis

Nanjappa, M. K., Medrano, T. I., Prins, G. S., Chen, H., Zirkin, B. R. & Cooke, P. S., Nov 1 2017, In : Andrology. 5, 6, p. 1165-1173 9 p.

Research output: Contribution to journalArticle

Leydig Cells
Epidermis
Stem Cells
Epithelium
Mesoderm
2016

Age and testosterone mediate influenza pathogenesis in male mice

Vom Steeg, L. G., Vermillion, M. S., Hall, O. J., Alam, O., McFarland, R., Chen, H., Zirkin, B. R. & Klein, S. L., 2016, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 311, 6, p. L1234-L1244

Research output: Contribution to journalArticle

Human Influenza
Testosterone
Lung
Pathology
Influenza A virus

Leydig cell stem cells: Identification, proliferation and differentiation

Chen, H., Wang, Y., Ge, R. & Zirkin, B. R., Jul 16 2016, (Accepted/In press) In : Molecular and Cellular Endocrinology.

Research output: Contribution to journalArticle

Leydig Cells
Stem cells
Cell Differentiation
Stem Cells
Cell Proliferation

Regulation of seminiferous tubule-associated stem Leydig cells in adult rat testes

Li, X., Wang, Z., Jiang, Z., Guo, J., Zhang, Y., Li, C., Chung, J. Y., Folmer, J., Liu, J., Lian, Q., Ge, R., Zirkin, B. R. & Chen, H., Mar 8 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 10, p. 2666-2671 6 p.

Research output: Contribution to journalArticle

Seminiferous Tubules
Leydig Cells
Testis
Stem Cells
Hedgehogs
Sprague Dawley Rats
Rats
Histology
Weights and Measures
Testis

Transplantation of alginate-encapsulated seminiferous tubules and interstitial tissue into adult rats: Leydig stem cell differentiation in vivo?

Chen, H., Jin, S., Huang, S., Folmer, J., Liu, J., Ge, R. & Zirkin, B. R., Nov 15 2016, In : Molecular and Cellular Endocrinology. 436, p. 250-258 9 p.

Research output: Contribution to journalArticle

Seminiferous Tubules
Leydig Cells
Stem cells
Testosterone
Rats
2015

Developmental and endocrine regulation of kisspeptin expression in mouse leydig cells

Salehi, S., Adeshina, I., Chen, H., Zirkin, B. R., Hussain, M., Wondisford, F., Wolfe, A. & Radovick, S., Apr 1 2015, In : Endocrinology. 156, 4, p. 1514-1522 9 p.

Research output: Contribution to journalArticle

Kisspeptins
Leydig Cells
Testis
Sexual Maturation
Seminiferous Tubules

Knockout of the transcription factor Nrf2: Effects on testosterone production by aging mouse Leydig cells

Chen, H., Jin, S., Guo, J., Kombairaju, P., Biswal, S. & Zirkin, B. R., Jul 5 2015, In : Molecular and Cellular Endocrinology. 409, p. 113-120 8 p.

Research output: Contribution to journalArticle

Leydig Cells
Testosterone
Transcription Factors
Aging of materials
Antioxidants

Leydig cell aging and hypogonadism

Beattie, M. C., Adekola, L., Papadopoulos, V., Chen, H. & Zirkin, B. R., Aug 1 2015, In : Experimental Gerontology. 68, p. 87-91 5 p.

Research output: Contribution to journalArticle

Hypogonadism
Leydig Cells
Cell Aging
Aging of materials
Luteinizing Hormone

Mechanism of testosterone deficiency in the transgenic sickle cell mouse

Musicki, B., Zhang, Y., Chen, H., Brown, T. R., Zirkin, B. R. & Burnett, A., May 29 2015, In : PLoS One. 10, 5, e0128694.

Research output: Contribution to journalArticle

testosterone
Testosterone
genetically modified organisms
mice
Oxidative stress

Steroidogenic fate of the Leydig cells that repopulate the testes of young and aged Brown Norway rats after elimination of the preexisting Leydig cells

Chen, H., Guo, J., Ge, R., Lian, Q., Papadopoulos, V. & Zirkin, B. R., Dec 1 2015, In : Experimental Gerontology. 72, p. 8-15 8 p.

Research output: Contribution to journalArticle

Leydig Cells
Testis
Rats
ethylene dimethanesulfonate
Testosterone
2014

Microsurgical rat varicocele model

Najari, B. B., Li, P. S., Ramasamy, R., Katz, M., Sheth, S., Robinson, B., Chen, H., Zirkin, B. R., Schlegel, P. N. & Goldstein, M., Feb 2014, In : Journal of Urology. 191, 2, p. 548-553 6 p.

Research output: Contribution to journalArticle

Varicocele
Renal Veins
Ligation
Spermatic Cord
Sperm Motility
Testosterone
Leydig Cells
Hypogonadism
Literature
Cell Physiological Phenomena

Regulation of the proliferation and differentiation of leydig stem cells in the adult testis

Odeh, H. M., Kleinguetl, C., Ge, R., Zirkin, B. R. & Chen, H., 2014, In : Biology of Reproduction. 90, 6, 123.

Research output: Contribution to journalArticle

Leydig Cells
Testis
Stem Cells
Seminiferous Tubules
Cell Proliferation
2013

Aging and luteinizing hormone effects on reactive oxygen species production and DNA damage in rat leydig cells

Beattie, M. C., Chen, H., Fan, J., Papadopoulos, V., Miller, P. & Zirkin, B. R., Apr 2013, In : Biology of Reproduction. 88, 4, 100.

Research output: Contribution to journalArticle

Leydig Cells
Luteinizing Hormone
DNA Damage
Reactive Oxygen Species
Microarray Analysis

Drug ligand-induced activation of translocator protein (TSPO) stimulates steroid production by aged Brown Norway rat leydig cells

Chung, J. Y., Chen, H., Midzak, A., Burnett, A., Papadopoulos, V. & Zirkin, B. R., Jun 1 2013, In : Endocrinology. 154, 6, p. 2156-2165 10 p.

Research output: Contribution to journalArticle

Leydig Cells
Steroids
Ligands
Pharmaceutical Preparations
Proteins

Oxidative stress and phthalate-induced down-regulation of steroidogenesis in MA-10 Leydig cells

Zhou, L., Beattie, M. C., Lin, C. Y., Liu, J., Traore, K., Papadopoulos, V., Zirkin, B. R. & Chen, H., Dec 2013, In : Reproductive Toxicology. 42, p. 95-101 7 p.

Research output: Contribution to journalArticle

Oxidative stress
Leydig Cells
Oxidative Stress
Down-Regulation
Progesterone
2012

Identification, proliferation, and differentiation of adult leydig stem cells

Stanley, E., Lin, C. Y., Jin, S., Liu, J., Sottas, C. M., Ge, R., Zirkin, B. R. & Chen, H., Oct 1 2012, In : Endocrinology. 153, 10, p. 5002-5010 9 p.

Research output: Contribution to journalArticle

Adult Stem Cells
Leydig Cells
Testosterone
Seminiferous Tubules
Testis

Simultaneous quantification of steroids in rat intratesticular fluid by HPLC-isotope dilution tandem mass spectrometry

Renne, A., Luo, L., Jarow, J., Wright, W. W., Brown, T. R., Chen, H., Zirkin, B. R. & Friesen, M. D., Jul 2012, In : Journal of Andrology. 33, 4, p. 691-698 8 p.

Research output: Contribution to journalArticle

Tandem Mass Spectrometry
Isotopes
Steroids
High Pressure Liquid Chromatography
Dihydrotestosterone
2011

ATP synthesis, mitochondrial function, and steroid biosynthesis in rodent primary and tumor leydig cells

Midzak, A. S., Chen, H., Aon, M. A., Papadopoulos, V. & Zirkin, B. R., May 2011, In : Biology of Reproduction. 84, 5, p. 976-985 10 p.

Research output: Contribution to journalArticle

Leydig Cell Tumor
Rodentia
Adenosine Triphosphate
Steroids
Leydig Cells

Stem Leydig cell differentiation: Gene expression during development of the adult rat population of Leydig cells

Stanley, E. L., Johnston, D. S., Fan, J., Papadopoulos, V., Chen, H., Ge, R. S., Zirkin, B. R. & Jelinsky, S. A., Dec 1 2011, In : Biology of Reproduction. 85, 6, p. 1161-1166 6 p.

Research output: Contribution to journalArticle

Leydig Cells
Cell Differentiation
Stem Cells
Gene Expression
Population
2010

Effect of glutathione redox state on Leydig cell susceptibility to acute oxidative stress

Chen, H., Zhou, L., Lin, C. Y., Beattie, M. C., Liu, J. & Zirkin, B. R., Jul 2010, In : Molecular and Cellular Endocrinology. 323, 2, p. 147-154 8 p.

Research output: Contribution to journalArticle

diethyl maleate
Oxidative stress
Leydig Cells
Oxidation-Reduction
Progesterone

Molecular mechanisms mediating the effect of mono-(2-ethylhexyl) phthalate on hormone-stimulated steroidogenesis in MA-10 mouse tumor leydig cells

Fan, J., Traore, K., Li, W., Amri, H., Huang, H., Wu, C., Chen, H., Zirkin, B. R. & Papadopoulos, V., Jul 2010, In : Endocrinology. 151, 7, p. 3348-3362 15 p.

Research output: Contribution to journalArticle

Leydig Cell Tumor
Chorionic Gonadotropin
Hormones
Leydig Cells
Steroids

Stem Leydig cells: From fetal to aged animals

Chen, H., Stanley, E., Jin, S. & Zirkin, B. R., Dec 2010, In : Birth Defects Research Part C - Embryo Today: Reviews. 90, 4, p. 272-283 12 p.

Research output: Contribution to journalArticle

Leydig Cells
Stem Cells
Testis
Mesenchymal Stromal Cells
Testosterone
2009

Leydig cell aging and the mechanisms of reduced testosterone synthesis

Midzak, A. S., Chen, H., Papadopoulos, V. & Zirkin, B. R., Feb 5 2009, In : Molecular and Cellular Endocrinology. 299, 1, p. 23-31 9 p.

Research output: Contribution to journalArticle

Leydig Cells
Cell Aging
Testosterone
Aging of materials
Cytology

Leydig cells: From stem cells to aging

Chen, H., Ge, R. S. & Zirkin, B. R., Jul 10 2009, In : Molecular and Cellular Endocrinology. 306, 1-2, p. 9-16 8 p.

Research output: Contribution to journalArticle

Leydig Cells
Cell Aging
Stem cells
Testosterone
Stem Cells
2008

Effect of glutathione depletion on Leydig cell steroidogenesis in young and old Brown Norway rats

Chen, H., Pechenino, A. S., Liu, J., Beattie, M. C., Brown, T. R. & Zirkin, B. R., May 2008, In : Endocrinology. 149, 5, p. 2612-2619 8 p.

Research output: Contribution to journalArticle

Leydig Cells
Glutathione
Testosterone
Buthionine Sulfoximine
Antioxidants

Gestational exposure to atrazine: Effects on the postnatal development of male offspring

Rosenberg, B. G., Chen, H., Folmer, J., Liu, J., Papadopoulos, V. & Zirkin, B. R., May 2008, In : Journal of Andrology. 29, 3, p. 304-311 8 p.

Research output: Contribution to journalArticle

Atrazine
Androgens
Testosterone
Seminal Vesicles
Live Birth
2007

Cyclooxygenases in rat Leydig cells: Effects of luteinizing hormone and aging

Chen, H., Luo, L., Liu, J. & Zirkin, B. R., Feb 2007, In : Endocrinology. 148, 2, p. 735-742 8 p.

Research output: Contribution to journalArticle

Leydig Cells
Prostaglandin-Endoperoxide Synthases
Luteinizing Hormone
Testosterone
Gonadotrophs
Leydig Cells
Luteinizing Hormone
Testosterone
Electron Transport
Mitochondria
2006

Aging and the brown norway rat leydig cell antioxidant defense system

Luo, L., Chen, H., Trush, M. A., Show, M. D., Anway, M. D. & Zirkin, B. R., Mar 2006, In : Journal of Andrology. 27, 2, p. 240-247 8 p.

Research output: Contribution to journalArticle

Leydig Cells
Antioxidants
Testis
Glutathione Peroxidase
Glutathione
2005

Aging and caloric restriction: Effects on Leydig cell steroidogenesis

Chen, H., Luo, L., Liu, J., Brown, T. & Zirkin, B. R., Jun 2005, In : Experimental Gerontology. 40, 6, p. 498-505 8 p.

Research output: Contribution to journalArticle

Caloric Restriction
Leydig Cells
Testosterone
Aging of materials
Rats

Gene expression in rat leydig cells during development from the progenitor to adult stage: A cluster analysis

Ge, R. S., Dong, Q., Sottas, C. M., Chen, H., Zirkin, B. R. & Hardy, M. P., Jun 2005, In : Biology of Reproduction. 72, 6, p. 1405-1415 11 p.

Research output: Contribution to journalArticle

Leydig Cells
Cluster Analysis
Gene Expression
Stem Cells
Enzymes
Leydig Cells
Cell Aging
Testosterone
Enzymes
Cyclic AMP

Vitamin E, aging and Leydig cell steroidogenesis

Chen, H., Liu, J., Luo, L., Baig, M. U., Kim, J. M. & Zirkin, B. R., Aug 2005, In : Experimental Gerontology. 40, 8-9, p. 728-736 9 p.

Research output: Contribution to journalArticle

Leydig Cells
Vitamin E
Aging of materials
Rats
Nutrition
2004
Leydig Cells
Cyclic AMP
Testosterone
Signal Transduction
LH Receptors

Gene expression by the anterior pituitary gland: Effects of age and caloric restriction

Chen, H., Jul 30 2004, In : Molecular and Cellular Endocrinology. 222, 1-2, p. 21-31 11 p.

Research output: Contribution to journalArticle

Caloric Restriction
Anterior Pituitary Gland
Gene expression
Genes
Gene Expression

Leydig cell gene expression: Effects of age and caloric restriction

Chen, H., Irizarry, R. A., Luo, L. & Zirkin, B. R., Jan 2004, In : Experimental Gerontology. 39, 1, p. 31-43 13 p.

Research output: Contribution to journalArticle

Caloric Restriction
Leydig Cells
Gene expression
Genes
Gene Expression
2002

Age-related decreases in Leydig cell testosterone production are not restored by exposure to LH in vitro

Chen, H., Hardy, M. P. & Zirkin, B. R., 2002, In : Endocrinology. 143, 5, p. 1637-1642 6 p.

Research output: Contribution to journalArticle

Leydig Cells
Testosterone
Gonadotrophs
In Vitro Techniques
Colforsin

Another piece in the maddening puzzle of declining steroidogenesis in aging Leydig cells

Culty, M., Luo, L., Yao, Z., Chen, H., Papadopoulos, V., Zirkin, B. R. & Hales, D. B., 2002, In : Journal of Andrology. 23, 3, p. 327-329 3 p.

Research output: Contribution to journalArticle

Cholesterol transport, peripheral benzodiazepine receptor, and steroidogenesis in aging Leydig cells

Culty, M., Luo, L., Yao, Z. X., Chen, H., Papadopoulos, V. & Zirkin, B. R., 2002, In : Journal of Andrology. 23, 3, p. 439-447 9 p.

Research output: Contribution to journalArticle

Leydig Cells
GABA-A Receptors
Aminoglutethimide
Cholesterol
Testosterone