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Research Output 2001 2019

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Article
2019

A Public BCR Present in a Unique Dual-Receptor-Expressing Lymphocyte from Type 1 Diabetes Patients Encodes a Potent T Cell Autoantigen

Ahmed, R., Omidian, Z., Giwa, A., Cornwell, B., Majety, N., Bell, D. R., Lee, S., Zhang, H., Michels, A., Desiderio, S., Sadegh-Nasseri, S., Rabb, H., Gritsch, S., Suva, M. L., Cahan, P., Zhou, R., Jie, C., Donner, T. & Hamad, A. R. A., May 30 2019, In : Cell. 177, 6, p. 1583-1599.e16

Research output: Contribution to journalArticle

T-cells
Lymphocytes
Autoantigens
Medical problems
Type 1 Diabetes Mellitus

Extracellular matrix protein tenascin C increases phagocytosis mediated by CD47 Loss of function in glioblastoma

Ma, D., Liu, S., Lal, B., Wei, S., Wang, S., Zhan, D., Zhang, H., Lee, R. S., Gao, P., Lopez-Bertoni, H., Ying, M., Li, J. J., Laterra, J., Wilson, M. A. & Xia, S., Jan 1 2019, In : Cancer Research. 79, 10, p. 2697-2708 12 p.

Research output: Contribution to journalArticle

Tenascin
Extracellular Matrix Proteins
Glioblastoma
Protein C
Phagocytosis

Single-cell sequencing defines genetic heterogeneity in pancreatic cancer precursor lesions

Kuboki, Y., Fischer, C. G., Beleva Guthrie, V., Huang, W., Yu, J., Chianchiano, P., Hosoda, W., Zhang, H., Zheng, L., Shao, X., Thompson, E. D., Waters, K., Poling, J., He, J., Weiss, M. J., Wolfgang, C. L., Goggins, M. G., Hruban, R. H., Roberts, N. J., Karchin, R. & 1 others, Wood, L. D., Jan 1 2019, (Accepted/In press) In : Journal of Pathology.

Research output: Contribution to journalArticle

Genetic Heterogeneity
Pancreatic Neoplasms
Neoplasms
Mutation
Genes

The Latent Human Immunodeficiency Virus (HIV) Reservoir Resides Primarily in CD32-CD4+ T Cells in Perinatally HIV-Infected Adolescents With Long-Term Virologic Suppression

Dhummakupt, A., Siems, L. V., Singh, D., Chen, Y. H., Anderson, T., Collinson-Streng, A., Zhang, H., Patel, P., Agwu, A. & Persaud, D., Jan 1 2019, In : The Journal of infectious diseases. 219, 1, p. 80-88 9 p.

Research output: Contribution to journalArticle

HIV
T-Lymphocytes
Pyridinolcarbamate
Proviruses
Fc Receptors
2018

Heterozygous IDH1R132H/WT created by “single base editing” inhibits human astroglial cell growth by downregulating YAP

Wei, S., Wang, J., Oyinlade, O., Ma, D., Wang, S., Kratz, L., Lal, B., Xu, Q., Liu, S., Shah, S. R., Zhang, H., Li, Y., Quiñones-Hinojosa, A., Zhu, H., Huang, Z. Y., Cheng, L., Qian, J. & Xia, S., May 30 2018, (Accepted/In press) In : Oncogene. p. 1-15 15 p.

Research output: Contribution to journalArticle

Isocitrate Dehydrogenase
Down-Regulation
Growth
Proteins
Mutation

The role of CD32 during HIV-1 infection

Bertagnolli, L. N., White, J. A., Simonetti, F. R., Beg, S. A., Lai, J., Tomescu, C., Murray, A. J., Antar, A., Zhang, H., Margolick, J. B., Hoh, R., Deeks, S. G., Tebas, P., Montaner, L. J., Siliciano, R. F., Laird, G. & Siliciano, J. M., Sep 20 2018, In : Nature. 561, 7723, p. E17-E19

Research output: Contribution to journalArticle

human immunodeficiency virus
infection
2017
Insulin-Secreting Cells
Display devices
Insulin
Glucose
Autoantigens

Transcriptional Reprogramming during Effector-to-Memory Transition Renders CD4+ T Cells Permissive for Latent HIV-1 Infection

Shan, L., Deng, K., Gao, H., Xing, S., Capoferri, A. A., Durand, C., Rabi, S. A., Laird, G., Kim, M., Hosmane, N. N., Yang, H. C., Zhang, H., Margolick, J. B., Li, L., Cai, W., Ke, R., Flavell, R. A., Siliciano, J. M. & Siliciano, R. F., Oct 17 2017, In : Immunity. 47, 4, p. 766-775.e3

Research output: Contribution to journalArticle

HIV Infections
HIV-1
T-Lymphocytes
Infection
Viral Gene Expression Regulation
2016

Association of acute myeloid leukemia’s most immature phenotype with risk groups and outcomes

Gerber, J. M., Zeidner, J. F., Morse, S., Blackford, A. L., Perkins, B., Yanagisawa, B., Zhang, H., Morsberger, L., Karp, J., Ning, Y., Gocke, C., Rosner, G., Smith, B. D. & Jones, R. J., Apr 30 2016, In : Haematologica. 101, 5, p. 607-616 10 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Leukemia
Phenotype
Aldehyde Dehydrogenase
Stem Cells

Disruption of membrane by colistin kills uropathogenic Escherichia coli persisters and enhances killing of other antibiotics

Cui, P., Niu, H., Shi, W., Zhang, S., Zhang, H., Margolick, J. B., Zhang, W. & Zhang, Y., Nov 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 11, p. 6867-6871 5 p.

Research output: Contribution to journalArticle

Uropathogenic Escherichia coli
Colistin
Anti-Bacterial Agents
Gentamicins
Membranes

Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells

Hansen, E. C., Ransom, M., Hesselberth, J. R., Hosmane, N. N., Capoferri, A. A., Bruner, K. M., Pollack, R. A., Zhang, H., Drummond, M. B., Siliciano, J. M., Siliciano, R. F. & Stivers, J., Sep 20 2016, In : eLife. 5, September, e18447.

Research output: Contribution to journalArticle

Uracil
Myeloid Cells
HIV-1
DNA
Viral DNA

p120 catenin suppresses basal epithelial cell extrusion in invasive pancreatic neoplasia

Hendley, A. M., Wang, Y. J., Polireddy, K., Alsina, J., Ahmed, I., Lafaro, K. J., Zhang, H., Roy, N., Savidge, S. G., Cao, Y., Hebrok, M., Maitra, A., Reynolds, A. B., Goggins, M., Younes, M., Iacobuzio-Donahue, C. A., Leach, S. D. & Bailey, J. M., Jun 1 2016, In : Cancer Research. 76, 11, p. 3351-3363 13 p.

Research output: Contribution to journalArticle

Epithelial Cells
Neoplasms
Pancreatic Neoplasms
delta catenin
Epithelium
2015

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

Deng, K., Pertea, M., Rongvaux, A., Wang, L., Durand, C., Ghiaur, G., Lai, J., McHugh, H. L., Hao, H., Zhang, H., Margolick, J. B., Gurer, C., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Deeks, S. G., Strowig, T., Kumar, P., Siliciano, J. M., Salzberg, S. L. & 3 others, Flavell, R. A., Shan, L. & Siliciano, R. F., Jan 15 2015, In : Nature. 517, 7534, p. 381-385 5 p.

Research output: Contribution to journalArticle

Cytotoxic T-Lymphocytes
Viruses
Mutation
Epitopes
Virus Diseases

Flow cytometry based detection and isolation of Plasmodium falciparum liver stages in vitro

Dumoulin, P. C., Trop, S. A., Ma, J., Zhang, H., Sherman, M. A. & Levitskaya, J., Jun 12 2015, In : PLoS One. 10, 6, e0129623.

Research output: Contribution to journalArticle

Flow cytometry
Plasmodium falciparum
Liver
flow cytometry
Flow Cytometry
2014

Cardiac fibroblasts mediate IL-17A-driven inflammatory dilated cardiomyopathy

Wu, L., Ong, S. F., Talor, M. V., Barin, J. G., Baldeviano, G. C., Kass, D. A., Bedja, D., Zhang, H., Sheikh, A., Margolick, J. B., Iwakura, Y., Rose, N. R. & Cihakova, D., 2014, In : Journal of Experimental Medicine. 211, 7, p. 1449-1464 16 p.

Research output: Contribution to journalArticle

Interleukin-17
Dilated Cardiomyopathy
Fibroblasts
Monocytes
Granulocyte-Macrophage Colony-Stimulating Factor

DCLK1 marks a morphologically distinct subpopulation of cells with stem cell properties in preinvasive pancreatic cancer

Bailey, J. M., Alsina, J., Rasheed, Z. A., McAllister, F. M., Fu, Y. Y., Plentz, R., Zhang, H., Pasricha, P. J., Bardeesy, N., Matsui, W., Maitra, A. & Leach, S. D., Jan 2014, In : Gastroenterology. 146, 1, p. 245-256 12 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Stem Cells
Neoplastic Stem Cells
Neoplasms
Adenocarcinoma

Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility, and tropism to brain cancer

Feng, Y., Zhu, M., Dangelmajer, S., Lee, Y. M., Wijesekera, O., Castellanos, C. X., Denduluri, A., Chaichana, K. L., Li, Q., Zhang, H., Levchenko, A., Guerrero-Cazares, H. & Quiñones-Hinojosa, A., Jan 1 2014, In : Cell Death and Disease. 5, 12, e1567.

Research output: Contribution to journalArticle

Tropism
Mesenchymal Stromal Cells
Brain Neoplasms
Glioblastoma
Hypoxia

Late-emerging strains of HIV induce T-cell homeostasis failure by promoting bystander cell death and immune exhaustion in naïve CD4 and all CD8 T-cells

Kibirige, C. N., Menendez, F. A., Zhang, H., Nilles, T. L., Langan, S. & Margolick, J. B., 2014, In : Medical Hypotheses. 83, 1, p. 69-73 5 p.

Research output: Contribution to journalArticle

Homeostasis
Cell Death
HIV
T-Lymphocytes
Virion

Mesenchymal stem cells from human fat engineered to secrete BMP4 are nononcogenic, suppress brain cancer, and prolong survival

Li, Q., Wijesekera, O., Salas, S. J., Wang, J. Y., Zhu, M., Aprhys, C., Chaichana, K. L., Chesler, D. A., Zhang, H., Smith, C. L., Guerrero-Cazares, H., Levchenko, A. & Quinones-Hinojosa, A., May 1 2014, In : Clinical Cancer Research. 20, 9, p. 2375-2387 13 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 4
Glioblastoma
Mesenchymal Stromal Cells
Brain Neoplasms
Fats

NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation

Kim, J. H., Thimmulappa, R. K., Kumar, V., Cui, W., Kumar, S., Kombairaju, P., Zhang, H., Margolick, J., Matsui, W., Macvittie, T., Malhotra, S. V. & Biswal, S., Feb 3 2014, In : Journal of Clinical Investigation. 124, 2, p. 730-741 12 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Ionizing Radiation
Radiation
Mortality
Acute Radiation Syndrome

Oncogenic kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia

McAllister, F., Bailey, J. M., Alsina, J., Nirschl, C. J., Sharma, R., Fan, H., Rattigan, Y., Roeser, J. C., Lankapalli, R. H., Zhang, H., Jaffee, E., Drake, C. G., Housseau, F., Maitra, A., Kolls, J. K., Sears, C. L., Pardoll, A. M. & Leach, S. D., May 12 2014, In : Cancer Cell. 25, 5, p. 621-637 17 p.

Research output: Contribution to journalArticle

Interleukin-17
Neoplasms
Interleukin-17 Receptors
Chronic Pancreatitis
Epithelial Cells

Sprouty-2 regulates HIV-specific T cell polyfunctionality

Chiu, Y. L., Shan, L., Huang, H., Haupt, C., Bessell, C., Canaday, D. H., Zhang, H., Ho, Y. C., Powell, J., Oelke, M., Margolick, J. B., Blankson, J. N., Griffin, D. & Schneck, J. P., Jan 2 2014, In : Journal of Clinical Investigation. 124, 1, p. 198-208 11 p.

Research output: Contribution to journalArticle

HIV-2
T-Lymphocytes
MAP Kinase Signaling System
HIV
Antigens
Histone Deacetylase Inhibitors
HIV-1
T-Lymphocytes
Infection
Transformed Cell Line

Vinculin regulates assembly of talin: β3 integrin complexes

Nanda, S. Y., Hoang, T., Patel, P. & Zhang, H., 2014, In : Journal of Cellular Biochemistry. 115, 6, p. 1206-1216 11 p.

Research output: Contribution to journalArticle

Talin
Vinculin
Integrins
Chemical activation
Binding Sites
2013

A novel PCR assay for quantification of HIV-1 RNA

Shan, L., Rabi, S. A., Laird, G., Eisele, E. E., Zhang, H., Margolick, J. B. & Siliciano, R. F., Jun 2013, In : Journal of Virology. 87, 11, p. 6521-6525 5 p.

Research output: Contribution to journalArticle

Human immunodeficiency virus 1
HIV-1
RNA
Polymerase Chain Reaction
assays

Blockade of Kv1.3 Potassium Channels Inhibits Differentiation and Granzyme B Secretion of Human CD8+ T Effector Memory Lymphocytes

Hu, L., Wang, T., Gocke, A. R., Nath, A., Zhang, H., Margolick, J. B., Whartenby, K. & Calabresi, P., Jan 30 2013, In : PLoS One. 8, 1, e54267.

Research output: Contribution to journalArticle

Kv1.3 Potassium Channel
Granzymes
Lymphocytes
potassium channels
T-cells

Dynamics of the Major Histocompatibility Complex Class I Processing and Presentation Pathway in the Course of Malaria Parasite Development in Human Hepatocytes: Implications for Vaccine Development

Ma, J., Trop, S., Baer, S., Rakhmanaliev, E., Arany, Z., Dumoulin, P., Zhang, H., Romano, J. D., Coppens, I., Levitsky, V. & Levitskaya, J., Sep 25 2013, In : PLoS One. 8, 9, e75321.

Research output: Contribution to journalArticle

human development
vaccine development
major histocompatibility complex
Human Development
Major Histocompatibility Complex

Keratin intracellular concentration revisited: Implications for keratin function in surface epithelia

Feng, X., Zhang, H., Margolick, J. B. & Coulombe, P. A., Mar 2013, In : Journal of Investigative Dermatology. 133, 3, p. 850-853 4 p.

Research output: Contribution to journalArticle

Keratins

Podocalyxin-Like Protein Is Expressed in Glioblastoma Multiforme Stem-Like Cells and Is Associated with Poor Outcome

Binder, Z. A., SiuI-Mei, I. M., Eberhart, C. G., ap Rhys, C., Bai, R., Staedtke, V., Zhang, H., Smoll, N. R., Piantadosi, S., Piccirillo, S. G., DiMeco, F., Weingart, J. D., Vescovi, A., Olivi, A., Riggins, G. J. & Gallia, G. L., Oct 16 2013, In : PLoS One. 8, 10, e75945.

Research output: Contribution to journalArticle

Glioblastoma
oncospheres
Stem Cells
stems
protein synthesis

STAT3 regulates arginase-i in myeloid-derived suppressor cells from cancer patients

Vasquez-Dunddel, D., Pan, F., Zeng, Q., Gorbounov, M., Albesiano, E., Fu, J., Blosser, R. L., Tam, A. J., Bruno, T., Zhang, H., Pardoll, A. M. & Kim, Y., Apr 1 2013, In : Journal of Clinical Investigation. 123, 4, p. 1580-1589 10 p.

Research output: Contribution to journalArticle

Arginase
Neoplasms
Autoantigens
HLA-DR Antigens
Immunosuppressive Agents

Unique transcriptional profile of liver-resident memory CD8+ T cells induced by immunization with malaria sporozoites

Tse, S. W., Cockburn, I. A., Zhang, H., Scott, A. L. & Zavala, F. P., Jul 2013, In : Genes and Immunity. 14, 5, p. 302-309 8 p.

Research output: Contribution to journalArticle

Sporozoites
Malaria
Immunization
T-Lymphocytes
Liver
2012

A clinically relevant population of leukemic CD34 -CD38 - cells in acute myeloid leukemia

Gerber, J. M., Smith, B. D., Ngwang, B., Zhang, H., Vala, M. S., Morsberger, L., Galkin, S., Collector, M. I., Perkins, B., Levis, M. J., Griffin, C. A., Sharkis, S. J., Borowitz, M. J., Karp, J. & Jones, R. J., Apr 12 2012, In : Blood. 119, 15, p. 3571-3577 7 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Stem cells
Acute Myeloid Leukemia
Leukemia
Population

A protective role for human IL-10-expressing CD4 + T cells in colitis

Ranatunga, D. C., Ramakrishnan, A., Uprety, P., Wang, F., Zhang, H., Margolick, J. B., Brayton, C. & Bream, J., Aug 1 2012, In : Journal of Immunology. 189, 3, p. 1243-1252 10 p.

Research output: Contribution to journalArticle

Colitis
Interleukin-10
T-Lymphocytes
Histone Code
Mucous Membrane
Genomic Instability
DNA Damage
Phosphorylation
Chromosome Breakage
S Phase

Functional blockade of the voltage-gated potassium channel Kv1.3 mediates reversion of T effector to central memory lymphocytes through SMAD3/p21 cip1 signaling

Hu, L., Gocke, A. R., Knapp, E., Rosenzweig, J. M., Grishkan, I. V., Baxi, E. G., Zhang, H., Margolick, J. B., Whartenby, K. & Calabresi, P., Jan 6 2012, In : Journal of Biological Chemistry. 287, 2, p. 1261-1268 8 p.

Research output: Contribution to journalArticle

Voltage-Gated Potassium Channels
Lymphocytes
Autoimmune Diseases
T-cells
T-Lymphocytes
Hematopoietic Stem Cells
HIV-1
Bone Marrow
T-Lymphocytes
DNA
HIV-1
T-Lymphocytes
Quinolines
Cytokines
Carbamates

Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation

Shan, L., Deng, K., Shroff, N. S., Durand, C., Rabi, S. A., Yang, H. C., Zhang, H., Margolick, J. B., Blankson, J. N. & Siliciano, R. F., Mar 23 2012, In : Immunity. 36, 3, p. 491-501 11 p.

Research output: Contribution to journalArticle

HIV-1
Viruses
T-Lymphocytes
Highly Active Antiretroviral Therapy
Viral Cytopathogenic Effect
2011

Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation

Xing, S., Bullen, C. K., Shroff, N. S., Shan, L., Yang, H. C., Manucci, J. L., Bhat, S., Zhang, H., Margolick, J. B., Quinn, T. C., Margolis, D. M., Siliciano, J. M. & Siliciano, R. F., Jun 2011, In : Journal of Virology. 85, 12, p. 6060-6064 5 p.

Research output: Contribution to journalArticle

disulfiram
Disulfiram
Human immunodeficiency virus 1
HIV-1
T-lymphocytes

Influence of host gene transcription level and orientation on HIV-1 latency in a primary-cell model

Shan, L., Yang, H. C., Rabi, S. A., Bravo, H. C., Shroff, N. S., Irizarry, R. A., Zhang, H., Margolick, J. B., Siliciano, J. M. & Siliciano, R. F., Jun 2011, In : Journal of Virology. 85, 11, p. 5384-5393 10 p.

Research output: Contribution to journalArticle

Virus Latency
Human immunodeficiency virus 1
HIV-1
transcription (genetics)
Genes
2009
Oxyquinoline
Neoplastic Stem Cells
Paclitaxel
Stem Cells
Breast Neoplasms

Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation

Yang, H. C., Xing, S., Shan, L., O'Connell, K., Dinoso, J., Shen, A., Zhou, Y., Shrum, C. K., Han, Y., Liu, J., Zhang, H., Margolick, J. B. & Siliciano, R. F., Nov 2 2009, In : Journal of Clinical Investigation. 119, 11, p. 3473-3486 14 p.

Research output: Contribution to journalArticle

HIV-1
HIV
T-Lymphocytes
Highly Active Antiretroviral Therapy
Viruses
2008

NF-κB pathway inhibitors preferentially inhibit breast cancer stem-like cells

Zhou, J., Zhang, H., Gu, P., Bai, J., Margolick, J. B. & Zhang, Y., Oct 2008, In : Breast Cancer Research and Treatment. 111, 3, p. 419-427 9 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
MCF-7 Cells
Breast Neoplasms
Paclitaxel
Leukemia
Regulatory T-Lymphocytes
Human immunodeficiency virus 1
HIV-1
T-lymphocytes
T-Lymphocytes
2007

Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance

Zhou, J., Wulfkuhle, J., Zhang, H., Gu, P., Yang, Y., Deng, J., Margolick, J. B., Liotta, L. A., Petricoin, E. & Zhang, Y., Oct 9 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 41, p. 16158-16163 6 p.

Research output: Contribution to journalArticle

Side-Population Cells
Neoplastic Stem Cells
Sirolimus
Phosphoric Monoester Hydrolases
Maintenance
Virus Latency
Simian immunodeficiency virus
Virus Activation
Simian Immunodeficiency Virus
Macaca

Stability of the latent reservoir for HIV-1 in patients receiving valproic acid

Siliciano, J. M., Lai, J., Callender, M., Pitt, E., Zhang, H., Margolick, J. B., Gallant, J. E., Cofrancesco, J., Moore, R. D., Gange, S. J. & Siliciano, R. F., Mar 15 2007, In : Journal of Infectious Diseases. 195, 6, p. 833-836 4 p.

Research output: Contribution to journalArticle

Valproic Acid
HIV-1
Therapeutics
Viremia
Psychiatry
2006

In vitro modeling of the HIV-macrophage reservoir

Brown, A., Zhang, H., Lopez, P., Pardo-Villamizar, C. A. & Gartner, S., Nov 2006, In : Journal of Leukocyte Biology. 80, 5, p. 1127-1135 9 p.

Research output: Contribution to journalArticle

Macrophages
HIV
Population
nef Gene Products
Infection
2005

A novel assay allows genotyping of the latent reservoir for human immunodeficiency virus type 1 in the resting CD4+ T cells of viremic patients

Monie, D., Simmons, R. P., Nettles, R. E., Kieffer, T. L., Zhou, Y., Zhang, H., Karmon, S., Ingersoll, R., Chadwick, K., Zhang, H., Margolick, J. B., Quinn, T. C., Ray, S. C., Wind-Rotolo, M., Miller, M., Persaud, D. & Siliciano, R. F., Apr 2005, In : Journal of Virology. 79, 8, p. 5185-5202 18 p.

Research output: Contribution to journalArticle

Human immunodeficiency virus 1
genotyping
HIV-1
T-lymphocytes
T-Lymphocytes