Haig Kazazian

Professor

1965 …2020

Research output per year

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Research Output

1984

Concordance of a point mutation 5' to the (G)γ globin gene with (G)γβ+ hereditary persistence of fetal hemoglobin in the black population

Collins, F. S., Boehm, C. D., Waber, P. G., Stoeckert, C. J., Weissman, S. M., Forget, B. G. & Kazazian, H. H., 1984, In : Blood. 64, 6, p. 1292-1296 5 p.

Research output: Contribution to journalArticle

Open Access

Error in Prenatal Diagnosis by DNA Analysis

Boehm, C. D. & Kazazian, H. H., Jul 5 1984, In : New England Journal of Medicine. 311, 1, p. 58 1 p.

Research output: Contribution to journalLetter

Fetal hemoglobin synthesis in erythroid cultures in hereditary persistence of fetal hemoglobin and β(o)-thalassemia

Weinberg, R. S., Antonarakis, S. E., Kazazian, H. H., Dover, G. J., Orkin, S. H., Lenes, A. L., Schofield, J. M. & Alter, B. P., 1984, In : Blood. 63, 6, p. 1278-1284 7 p.

Research output: Contribution to journalArticle

Open Access

Hemoglobin E in Europeans: Further evidence for multiple origins of the β(E)-globin gene

Kazazian, H. H., Waber, P. G., Boehm, C. D., Lee, J. I., Antonarakis, S. E. & Fairbanks, V. F., Apr 13 1984, In : American journal of human genetics. 36, 1, p. 212-217 6 p.

Research output: Contribution to journalArticle

Molecular characterization of seven beta-thalassemia mutations in Asian Indians.

Kazazian, H. H., Orkin, S. H., Antonarakis, S. E., Sexton, J. P., Boehm, C. D., Goff, S. C. & Waber, P. G., Mar 1984, In : The EMBO journal. 3, 3, p. 593-596 4 p.

Research output: Contribution to journalArticle

Open Access

Nonuniform recombination within the human β-globin gene cluster

Chakravarti, A., Buetow, K. H., Antonarakis, S. E., Waber, P. G., Boehm, C. D. & Kazazian, H. H., Dec 1 1984, In : American journal of human genetics. 36, 6, p. 1239-1258 20 p.

Research output: Contribution to journalArticle

Origin of the β(S) globin gene in Blacks: The contribution of recurrent mutation or gene conversion or both

Antonarakis, S. E., Boehm, C. D., Serjeant, G. R., Theisen, C. E., Dover, G. J. & Kazazian, H. H., Jan 1 1984, In : Proceedings of the National Academy of Sciences of the United States of America. 81, 3 I, p. 853-856 4 p.

Research output: Contribution to journalArticle

Open Access

Quantification of the close association between DNA haplotypes and specific β-thalassaemia mutations in Mediterraneans

Kazazian, H. H., Orkin, S. H., Markham, A. F., Chapman, C. R., Youssoufian, H. & Waber, P. G., Dec 1 1984, In : Nature. 310, 5973, p. 152-154 3 p.

Research output: Contribution to journalArticle

Restriction site polymorphism in the phosphoglycerate kinase gene on the X chromosome

Hutz, M. H., Michelson, A. M., Antonarakis, S. E., Orkin, S. H. & Kazazian, H. H., Apr 1 1984, In : Human genetics. 66, 2-3, p. 217-219 3 p.

Research output: Contribution to journalArticle

The mutation and polymorphism of the human beta-globin gene and its surrounding DNA.

Orkin, S. H. & Kazazian, H. H., 1984, In : Annual review of genetics. 18, p. 131-171 41 p.

Research output: Contribution to journalReview article

β-Thalassemia in American Blacks: Novel mutations in the 'TATA' box and an acceptor splice site

Antonarakis, S. E., Irkin, S. H., Cheng, T. C., Scott, A. F., Sexton, J. P., Trusko, S. P., Charache, S. & Kazazian, H. H., 1984, In : Proceedings of the National Academy of Sciences of the United States of America. 81, 4 I, p. 1154-1158 5 p.

Research output: Contribution to journalArticle

β-Thalassemia in Chinese: Use of in vivo RNA analysis and oligonucleotide hybridization in systematic characterization of molecular defects

Cheng, T. C., Orkin, S. H., Antonarakis, S. E., Potter, M. J., Sexton, J. P., Markham, A. F., Giardina, P. J., Li, A. & Kazazian, H. H., 1984, In : Proceedings of the National Academy of Sciences of the United States of America. 81, 9 I, p. 2821-2825 5 p.

Research output: Contribution to journalArticle

Open Access
1983

ATA box transcription mutation in β-thalassemia

Orkin, S. H., Sexton, J. P., Cheng, T. C., Goff, S. C., Giardina, P. J. V., Joseph, I. L. & Hazazian, H. H., Jul 25 1983, In : Nucleic acids research. 11, 14, p. 4727-4734 8 p.

Research output: Contribution to journalArticle

Open Access

Gene structure and the nature of mutation.

Kazazian, H. H., Dec 1 1983, In : Mead Johnson Symposium on Perinatal and Developmental Medicine. 22, p. 3-11 9 p.

Research output: Contribution to journalReview article

Inactivation of an acceptor RNA splice site by a short deletion in β-thalassemia

Orkin, S. H., Sexton, J. P., Goff, S. C. & Kazazian, H. H., Dec 1 1983, In : Journal of Biological Chemistry. 258, 12, p. 7249-7251 3 p.

Research output: Contribution to journalArticle

Polymorphism and molecular pathology of the human beta-globin gene.

Orkin, S. H., Antonarakis, S. E. & Kazazian, H. H., Dec 1 1983, In : Progress in hematology. 13, p. 49-73 25 p.

Research output: Contribution to journalReview article

Prenatal diagnosis of hemoglobinopathies-1983

Boehm, C. D. & Kazazian, H. H., Jul 1983, In : Seminars in Perinatology. 7, 3, p. 175-183 9 p.

Research output: Contribution to journalArticle

Prenatal Diagnosis Using DNA Polymorphisms: Report on 95 Pregnancies at Risk for Sickle-Cell Disease or β-Thalassemia

Boehm, C. D., Antonarakis, S. E., Phillips, J. A., Stetten, G. & Kazazian, H. H., May 5 1983, In : New England Journal of Medicine. 308, 18, p. 1054-1058 5 p.

Research output: Contribution to journalArticle

The entire β-globin gene cluster is deleted in a form of γδβ thalassemia

Fearon, E. R., Kazazian, H. H., Waber, P. G., Lee, J. I., Antonarakis, S. E., Orkin, S. H., Vanin, E. F., Henthorn, P. S., Grosveld, F. G., Scott, A. F. & Buchanan, G. R., Jan 1 1983, In : Unknown Journal. 61, 6, p. 1269-1274 6 p.

Research output: Contribution to journalArticle

Open Access

Use of haplotype analysis in the beta-globin gene cluster to discover beta-thalassemia mutations.

Kazazian, H. H., Antonarakis, S. E., Cheng, T., Boehm, C. D. & Waber, P. G., Dec 1 1983, In : Progress in clinical and biological research. 134, p. 91-98 8 p.

Research output: Contribution to journalArticle

β-Globin locus is linked to the parathyroid hormone (PTH) locus and lies between the insulin and PTH loci in man

Antonarakis, S. E., Phillips, J. A., Mallonee, R. L., Kazazian, H. H., Fearon, E. R., Waber, P. G., Kronenberg, H. M., Ullrich, A. & Meyers, D. A., Jan 1 1983, In : Proceedings of the National Academy of Sciences of the United States of America. 80, 21 I, p. 6615-6619 5 p.

Research output: Contribution to journalArticle

Open Access

β-Thalassemia due to a deletion of the nucleotide which is substituted in the β(s)-globin gene

Kazazian, H. H., Orkin, S. H., Boehm, C. D., Sexton, J. P. & Antonarakis, S. E., Nov 26 1983, In : American journal of human genetics. 35, 5, p. 1028-1033 6 p.

Research output: Contribution to journalArticle

1982

Abnormal RNA processing due to the exon mutation of βE- globin gene

Orkin, S. H., Kazazian, H. H., Antonarakis, S. E., Ostrer, H., Goff, S. C. & Sexton, J. P., Dec 1 1982, In : Nature. 300, 5894, p. 768-769 2 p.

Research output: Contribution to journalArticle

Evidence for multiple origins of the β(E)-globin gene in Southeast Asia

Antonarakis, S. E., Orkin, S. H., Kazazian, H. H., Goff, S. C., Boehm, C. D., Waber, P. G., Sexton, J. P., Ostrer, H., Fairbanks, V. F. & Chakravarti, A., Dec 1 1982, In : Proceedings of the National Academy of Sciences of the United States of America. 79, 21 I, p. 6608-6611 4 p.

Research output: Contribution to journalArticle

Genetic diseases: Diagnosis by restriction endonuclease analysis

Antonarakis, S. E., Phillips, J. A. & Kazazian, H. H., Jun 1982, In : The Journal of pediatrics. 100, 6, p. 845-856 12 p.

Research output: Contribution to journalArticle

Hypoxanthine-Guanine Phosphoribosyltransferase in Human Erythroid Cells: Posttranslational Modification

Johnson, G. G., Ramage, A. L., Littlefield, J. W. & Kazazian, H. H., Mar 1 1982, In : Biochemistry. 21, 5, p. 960-966 7 p.

Research output: Contribution to journalArticle

Improved Detection of the Sickle Mutation by DNA Analysis: Application to Prenatal Diagnosis

Orkin, S. H., Little, P. F. R., Kazazian, H. H., Boehm, C. D., Orkin, S. H., Little, P. F. R., Kazazian, H. H., Boehm, C. D., Orkin, S. H., Little, P. F. R., Kazazian, H. H. & Boehm, C. D., Jul 1 1982, In : New England Journal of Medicine. 307, 1, p. 32-36 5 p.

Research output: Contribution to journalArticle

Linkage of β-thalassaemia mutations and β-globin gene polymorphisms with DNA polymorphisms in human β-globin gene cluster

Orkin, S. H., Kazazian, H. H., Antonarakis, S. E., Goff, S. C., Boehm, C. D., Sexton, J. P., Waber, P. G. & Giardina, P. J. V., Dec 1 1982, In : Nature. 296, 5858, p. 627-631 5 p.

Research output: Contribution to journalArticle

Nonrandom association of polymorphic restriction sites in the β-globin gene cluster

Antonarakis, S. E., Boehm, C. D., Giardina, P. J. V. & Kazazian, H. H., 1982, In : Proceedings of the National Academy of Sciences of the United States of America. 79, 1, p. 137-141 5 p.

Research output: Contribution to journalArticle

Open Access

Nonuniform deficiency of hexosaminidase a in tissues and fluids of two unrelated individuals

Thomas, G. H., Raghavan, S., Kolodny, E. H., Frisch, A., Neufeld, E. F., O’Brien, J. S., Reynolds, L. W., Miller, C. S., Shapiro, J., Kazazian, H. H. & Heller, R. H., Mar 1982, In : Pediatric research. 16, 3, p. 232-237 6 p.

Research output: Contribution to journalArticle

Open Access

Prenatal diagnosis by restriction analysis: methodology and experience.

Boehm, C. D., Phillips, J. A., Antonarakis, S. & Kazazian, H. H., Dec 1 1982, In : Progress in clinical and biological research. 98, p. 17-26 10 p.

Research output: Contribution to journalArticle

Workshop on DNA polymorphisms.

Cavalli-Sforza, L., Davies, K., Smith, K., Pearson, P., Gerald, P., Naylor, S., Kazazian, H., White, R., Elliot, R., Crippa, L., Young, B., Skolnick, M. & Nei, M., Dec 1 1982, In : Progress in clinical and biological research. 103 Pt A, p. 79-81 3 p.

Research output: Contribution to journalArticle

1981

Population heterogeneity of the Hpa I restriction site associated with the β globin gene: Implications for prenatal diagnosis

Panny, S. R., Scott, A. F., Smith, K. D., Phillips, J. A., Kazazian, H. H., Talbot, C. C. & Boehm, C. D., May 1 1981, In : American journal of human genetics. 33, 1, p. 25-35 11 p.

Research output: Contribution to journalArticle

The molecular basis of hemoglobin Grady

Scott, A. F., Phillips, J. A., Young, K. E., Kazazian, H. H., Smith, K. D., Charache, S. & Clegg, J. B., May 1 1981, In : American journal of human genetics. 33, 1, p. 129-133 5 p.

Research output: Contribution to journalArticle

1980

Prenatal diagnosis of β-thalassemias by amniocentesis: Linkage analysis using multiple polymorphic restriction endonuclease sites

Kazazian, H. H., Phillips, J. A., Boehm, C. D., Vik, T. A., Mahoney, M. J. & Ritchey, A. K., Dec 1 1980, In : Blood. 56, 5, p. 926-930 5 p.

Research output: Contribution to journalArticle

Unequal crossing-over: A common basis of single α-globin genes in Asians and American blacks with hemoglobin-H disease

Phillips, J. A., Vik, T. A., Scott, A. F., Young, K. E., Kazazian, H. H., Smith, K. D., Fairbanks, V. F. & Koenig, H. M., Aug 18 1980, In : Blood. 55, 6, p. 1066-1069 4 p.

Research output: Contribution to journalArticle

1979

A molecular basis for hemoglobin-H disease in American blacks

Phillips, J. A., Scott, A. F., Smith, K. D., Young, K. E., Lightbody, K. L., Jiji, R. M. & Kazazian, H. H., Dec 1 1979, In : Blood. 54, 6, p. 1439-1445 7 p.

Research output: Contribution to journalArticle

Oxygen transport in a woman with hemoglobin Hope/β+ thalassemia

Charache, S., Achuff, S., Winslow, R. & Kazazian, H., Jan 1 1979, In : Journal of Laboratory and Clinical Medicine. 93, 2, p. 316-320 5 p.

Research output: Contribution to journalArticle

Prenatal diagnosis of hemoglobinopathies by restriction endonuclease analysis: Pregnancies at risk for sickle cell anemia and S-O(Arab) disease

Phillips, J. A., Scott, A. F., Kazazian, H. H., Smith, K. D., Stetten, G. & Thomas, G. H., Dec 1 1979, In : Johns Hopkins Medical Journal. 145, 2, p. 57-60 4 p.

Research output: Contribution to journalArticle

Ratios of α- to β-globin RNA sequences in the erythropoietic mouse spleen

Phillips, J. A., Sedlak, D. M., Cheng, T. C. & Kazazian, H. H., Jan 15 1979, In : FEBS Letters. 97, 2, p. 327-329 3 p.

Research output: Contribution to journalArticle

The economic returns to community and hospital screening programs for a genetic disease

Swint, J. M., Shapiro, J. M., Corson, V. L., Reynolds, L. W., Thomas, G. H. & Kazazian, H. H., Jul 1979, In : Preventive Medicine. 8, 4, p. 463-470 8 p.

Research output: Contribution to journalArticle

1978

Characterization of 5'-terminal methylation of human α- and β-globin mRNAs

Cho, S., Cheng, T. & Kazazian, H. H., Dec 1 1978, In : Journal of Biological Chemistry. 253, 16, p. 5558-5561 4 p.

Research output: Contribution to journalArticle

Prenatal diagnosis in a fetus at risk for hemoglobin S-OArab disease

Kazazian, H. H., Dover, G. L., Lightbody, K. L. & Park, I. J., Jan 1 1978, In : Journal of Pediatrics. 93, 3, p. 502-504 3 p.

Research output: Contribution to journalArticle

Prenatal diagnosis of hemoglobinopathies.

Leonard, C. O. & Kazazian, H. H., Aug 1978, In : Pediatric clinics of North America. 25, 3, p. 631-642 12 p.

Research output: Contribution to journalArticle

Sequential methylation of globin mRNA in nucleated erythroid cells and reticulocytes of mice.

Cheng, T. & Kazazian, H. H., Jan 10 1978, In : Journal of Biological Chemistry. 253, 1, p. 246-251 6 p.

Research output: Contribution to journalArticle

Unadjusted carrier frequency for community screening programs.

Corson, V. L. & Kazazian, H. H., Mar 1 1978, In : American journal of human genetics. 30, 2, 1 p.

Research output: Contribution to journalEditorial

1977

Changing erythrocyte populations in juvenile chronic myelocytic leukemia: evidence for disordered regulation

Dover, G. J., Boyer, S. H., Zinkham, W. H., Kazazian, H. H., Pinney, D. J. & Sigler, A., Jan 1 1977, In : Unknown Journal. 49, 3, p. 355-365 11 p.

Research output: Contribution to journalArticle

Open Access

Commentary: Globin synthesis ratiosand α-thalassemia

Kazazian, H. H., Jul 1977, In : The Journal of pediatrics. 91, 1, p. 19-20 2 p.

Research output: Contribution to journalArticle