Haig Kazazian

Professor

1965 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

1991

Nonhomologous recombination in the human genome: Deletions in the human factor VIII gene

Woods-Samuels, P., Kazazian, H. H. & Antonarakis, S. E., May 1991, In : Genomics. 10, 1, p. 94-101 8 p.

Research output: Contribution to journalArticle

Phenylketonuria in U.S. blacks: Molecular analysis of the phenylalanine hydroxylase gene

Hofman, K. J., Steel, G., Kazazian, H. H. & Valle, D., Apr 23 1991, In : American journal of human genetics. 48, 4, p. 791-798 8 p.

Research output: Contribution to journalArticle

Prenatal diagnosis of β-thalassemia

Kazazian, H. H., Jun 1991, In : Seminars in Perinatology. 15, 3 SUPPL. 2, p. 15-24 10 p.

Research output: Contribution to journalArticle

Reverse transcriptase encoded by a human transposable element

Mathias, S. L., Scott, A. F., Kazazian, H. H., Boeke, J. D. & Gabriel, A., 1991, In : Science. 254, 5039, p. 1808-1810 3 p.

Research output: Contribution to journalArticle

Variation in hemoglobin F production among normal and sickle cell adults is not related to nucleotide substitutions in the gamma promoter regions

Economou, E. P., Antonarakis, S. E., Kazazian, H. H., Sergeant, G. R. & Dover, G. J., 1991, In : Blood. 77, 1, p. 174-177 4 p.

Research output: Contribution to journalArticle

Open Access
1990

A cluster of cystic fibrosis mutations in the first nucleotide-binding fold of the cystic fibrosis conductance regulator protein

Cutting, G. R., Kasch, L. M., Rosenstein, B. J., Zielenski, J., Tsui, L. C., Antonarakis, S. E. & Kazazian, H. H., Jan 1 1990, In : Nature. 346, 6282, p. 366-369 4 p.

Research output: Contribution to journalArticle

Characterization of a thrombin cleavage site mutation (Arg 1689 to Cys) in the factor VIII gene of two unrelated patients with cross-reacting material-positive hemophilia A

Arai, M., Higuchi, M., Antonarakis, S. E., Kazazian, H. H., Phillips, J. A., Janco, R. L. & Hoyer l., W., 1990, In : Blood. 75, 2, p. 384-389 6 p.

Research output: Contribution to journalArticle

Characterization of mutations in the factor VIII gene by direct sequencing of amplified genomic DNA

Higuchi, M., Wong, C., Kochhan, L., Olek, K., Aronis, S., Kasper, C. K., Kazazian, H. H. & Antonarakis, S. E., Jan 1990, In : Genomics. 6, 1, p. 65-71 7 p.

Research output: Contribution to journalArticle

Current status of prenatal diagnosis by DNA analysis

Kazazian, H. H., Dec 1 1990, In : Birth Defects: Original Article Series. 26, 3, p. 210-216 7 p.

Research output: Contribution to journalArticle

Ethnic distribution of β-thalassaemia in Indian subcontinent

Parikh, P., Cotton, M., Boehm, C. & Kazazian, H. H., Oct 20 1990, In : The Lancet. 336, 8721, 1 p.

Research output: Contribution to journalLetter

Evidence for involvement of a Robertsonian translocation 13 chromosome in formation of a ring chromosome 13

Stetten, G., Tuck-Muller, C. M., Blakemore, K. J., Wong, C., Kazazian, H. H. & Antonarakis, S. E., Dec 1 1990, In : Molecular Biology and Medicine. 7, 6, p. 479-484 6 p.

Research output: Contribution to journalArticle

Gene Defects in β‐Thalassemia and Their Prenatal Diagnosis

KAZAZIAN, HAIG. H., DOWLING, CAROL. E., BOEHM, CORINNE. D., WARREN, TINA. C., ECONOMOU, EFFROSINI. P., KATZ, JOEL. & ANTONARAKIS, STYLIANOS. E., Dec 1990, In : Annals of the New York Academy of Sciences. 612, 1, p. 1-14 14 p.

Research output: Contribution to journalArticle

Hemoglobin bart's disease in an italian boy: Interaction between α-thalassemia and hereditary persistence of fetal hemoglobin

Chui, D. H. K., Patterson, M., Dowling, C. E., Kazazian, H. H. & Kendall, A. G., Jul 19 1990, In : New England Journal of Medicine. 323, 3, p. 179-182 4 p.

Research output: Contribution to journalArticle

Intrinsic potential for high fetal hemoglobin production in a Druze family with β-thalassemia is due to an unlinked genetic determinant

Oppenheim, A., Yaari, A., Rund, D., Rachmilewitz, E. A., Nathan, D., Wong, C., Kazazian, H. H. & Miller, B., Dec 1990, In : Human genetics. 86, 2, p. 175-180 6 p.

Research output: Contribution to journalArticle

Isolation and characterization of the translation product of a β‐globin gene nonsense mutation (β121 GAA→TAA)

Adams, J. G., Steinberg, M. H. & Kazazian, H. H., Aug 1990, In : British journal of haematology. 75, 4, p. 561-567 7 p.

Research output: Contribution to journalArticle

Molecular Studies of β‐Thalassemia in Israel: Mutational Analysis and Expression Studies

RUND, D., FILON, D., DOWLING, C., KAZAZIAN, H. H., RACHMILEWITZ, E. A. & OPPENHEIM, A., Dec 1990, In : Annals of the New York Academy of Sciences. 612, 1, p. 98-105 8 p.

Research output: Contribution to journalArticle

MspI polymorphic site in intron 22 of the factor VIII gene in the Japanese population

Inaba, H., Fujimaki, M., Kazazian, H. H. & Antonarakis, S. E., Jan 1 1990, In : Human genetics. 84, 2, p. 214-215 2 p.

Research output: Contribution to journalArticle

Phylogeny of human β‐globin haplotypes and its implications for recent human evolution

Long, J. C., Chakravarti, A., Boehm, C. D., Antonarakis, S. & Kazazian, H. H., Jan 1990, In : American journal of physical anthropology. 81, 1, p. 113-130 18 p.

Research output: Contribution to journalArticle

Prenatal testing for Huntington disease

Corson, V., Quaid, K., Kasch, L. & Kazazian, H. H., Dec 1 1990, In : Birth Defects: Original Article Series. 26, 3, p. 226-230 5 p.

Research output: Contribution to journalArticle

The molecular basis of genetic disease

Boehm, C. D. & Kazazian, H. H., Dec 1990, In : Current Opinion in Biotechnology. 1, 2, p. 180-187 8 p.

Research output: Contribution to journalArticle

The thalassemia syndromes: Molecular basis and prenatal diagnosis in 1990

Kazazian, H. H., Jul 1990, In : Seminars in Hematology. 27, 3, p. 209-228 20 p.

Research output: Contribution to journalArticle

Two Patients with Cystic Fibrosis, Nonsense Mutations in Each Cystic Fibrosis Gene, and Mild Pulmonary Disease

Cutting, G. R., Kasch, L. M., Rosenstein, B. J., Tsui, L. C., Kazazian, H. H. & Antonarakis, S. E., Dec 13 1990, In : New England Journal of Medicine. 323, 24, p. 1685-1689 5 p.

Research output: Contribution to journalArticle

Use of denaturing gradient gel electrophoresis to detect point mutations in the factor VIII gene

Traytman, M. D., Higuchi, M., Kasper, C. K., Antonarakis, S. E. & Kazazian, H. H., Feb 1990, In : Genomics. 6, 2, p. 293-301 9 p.

Research output: Contribution to journalArticle

β‐Thalassemia Mutations in Sicily

MAGGIO, A., DI MARZO, R., GIAMBONA, A., RENDA, M., ACUTO, S., GIOCO, P. LO., D'ALCAMO, E., DI TRAPANI, F., MARINO, M., ABATE, I., SAMMARCO, P. & KAZAZIAN, H. H., Dec 1990, In : Annals of the New York Academy of Sciences. 612, 1, p. 67-73 7 p.

Research output: Contribution to journalArticle

1989

Characterization of a nondeleterious L1 insertion in an intron of the human factor VIII gene and further evidence of open reading frames in functional L1 elements

Woods-Samuels, P., Wong, C., Mathias, S. L., Scott, A. F., Kazazian, H. H. & Antonarakis, S. E., Apr 1989, In : Genomics. 4, 3, p. 290-296 7 p.

Research output: Contribution to journalArticle

Diagnosis by gene amplification

Kazazian, H. H., Aug 1989, In : The Journal of laboratory and clinical medicine. 114, 2, p. 95-96 2 p.

Research output: Contribution to journalEditorial

Direct characterization of factor VIII in plasma: Detection of a mutation altering a thrombin cleavage site (arginine-372 → histidine)

Arai, M., Inaba, H., Higuchi, M., Antonarakis, S. E., Kazazian, H. H., Fujimaki, M. & Hoyer, L. W., 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 11, p. 4277-4281 5 p.

Research output: Contribution to journalArticle

Open Access

Hinf I polymorphism 3′ to the human β-globin gene detected by the polymerase chain reaction (PCR)

Semenza, G. L., Dowling, C. E. & Kazazian, H. H., Mar 25 1989, In : Nucleic acids research. 17, 6, 1 p.

Research output: Contribution to journalComment/debate

Homozygous β-thalassemia without anemia

Safaya, S., Rieder, R. F., Dowling, C. E., Kazazian, H. H. & Adams, J. G., 1989, In : Blood. 73, 1, p. 324-328 5 p.

Research output: Contribution to journalArticle

Independent Origin of a βS‐Globin Gene in a Caucasian with Sickle Cell Anemia

GOOTENBERG, JOSEPH. E., BOEHM, CORINNE. D. & KAZAZIAN, HAIG. H., Jul 1989, In : Annals of the New York Academy of Sciences. 565, 1, p. 389-392 4 p.

Research output: Contribution to journalArticle

Linkage to the Huntington's disease locus in a family with unusual clinical and pathological features

Zweig, R. M., Koven, S. J., Hedreen, J. C., Maestri, N. E., Kazazian, H. H. & Folstein, S. E., Jul 1989, In : Annals of neurology. 26, 1, p. 78-84 7 p.

Research output: Contribution to journalArticle

Mild hemophilia A resulting from Arg-to-Leu substitution in exon 26 of the factor VIII gene

Inaba, H., Fujimaki, M., Kazazian, H. H. & Antonarakis, S. E., Mar 1 1989, In : Human genetics. 81, 4, p. 335-338 4 p.

Research output: Contribution to journalArticle

Molecular mechanism in the formation of a human ring chromosome 21

Wong, C., Kazazian, H. H., Stetten, G., Earnshaw, W. C., Van Keuren, M. L. & Antonarakis, S. E., Jan 1 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 6, p. 1914-1918 5 p.

Research output: Contribution to journalArticle

Open Access

Prenatal Diagnosis of Sickle Cell Anemia—1988

KAZAZIAN, HAIG. H., PHILLIPS, DEBORAH. G., DOWLING, CAROL. E. & BOEHM, CORINNE. D., Jul 1989, In : Annals of the New York Academy of Sciences. 565, 1, p. 44-47 4 p.

Research output: Contribution to journalArticle

Presymptomatic Diagnosis of Delayed-Onset Disease With Linked DNA Markers: The Experience in Huntington’s Disease

Brandt, J., Quaid, K. A., Folstein, S. E., Garber, P., Maestri, N. E., Abbott, M. H., Slavney, P. R., Franz, M. L., Kasch, L. & Kazazian, H. H., Jun 2 1989, In : JAMA: The Journal of the American Medical Association. 261, 21, p. 3108-3114 7 p.

Research output: Contribution to journalArticle

β-Thalassemia due to two novel nucleotide substitutions in consensus acceptor splice sequences of the β-globin gene

Wong, C., Antonarakis, S. E., Goff, S. C., Orkin, S. H., Forget, B. G., Nathan, D. G., Giardina, P. J. V. & Kazazian, H. H., Jan 1 1989, In : Blood. 73, 4, p. 914-918 5 p.

Research output: Contribution to journalArticle

1988

Accuracy and limitations of pulsed field gel electrophoresis in sizing partial deletions of the factor VIII gene

Cutting, G. R., Antonarakis, S. E., Youssoufian, H. & Kazazian, H. H., Dec 1 1988, In : Molecular Biology and Medicine. 5, 3, p. 173-184 12 p.

Research output: Contribution to journalArticle

A rapid DNA method for first-trimester prenatal diagnosis.

Di Marzo, R., Maggio, A., D'Agostino, S., Dowling, C. E., Wong, C. & Kazazian, H. H., Dec 1 1988, In : British journal of haematology. 70, 4, p. 504-505 2 p.

Research output: Contribution to journalLetter

Diagnosis of Sickle Cell Anemia and β-Thalassemia with Enzymatically Amplified DNA and Nonradioactive Allele-Specific Oligonucleotide Probes

Saiki, R. K., Chang, C. A., Levenson, C. H., Warren, T. C., Boehm, C. D., Kazazian, H. H. & Erlich, H. A., Sep 1 1988, In : New England Journal of Medicine. 319, 9, p. 537-541 5 p.

Research output: Contribution to journalArticle

Haemophilia A resulting from de novo insertion of L1 sequences represents a novel mechanism for mutation in man

Kazazian, H. H., Wong, C., Youssoufian, H., Scott, A. F., Phillips, D. G. & Antonarakis, S. E., Jan 1 1988, In : Nature. 332, 6160, p. 164-166 3 p.

Research output: Contribution to journalArticle

Macrorestriction mapping of COL4A1 and COL4A2 collagen genes on human chromosome 13q34

Cutting, G. R., Kazazian, H. H., Antonarakis, S. E., Killen, P. D., Yamada, Y. & Francomano, C. A., Oct 1988, In : Genomics. 3, 3, p. 256-263 8 p.

Research output: Contribution to journalArticle

Mild hemophilia A associated with a cryptic donor splice site mutation in intron 4 of the factor VIII gene

Youssoufian, H., Kazazian, H. H., Patel, A., Aronis, S., Tsiftis, G., Hoyer, L. W. & Antonarakis, S. E., Jan 1988, In : Genomics. 2, 1, p. 32-36 5 p.

Research output: Contribution to journalArticle

Moderately severe hemophilia A resulting from Glu→Gly substitution in exon 7 of the factor VIII gene

Youssoufian, H., Wong, C., Aronis, S., Platokoukis, H., Kazazian, H. H. & Antonarakis, S. E., Jan 1 1988, In : American journal of human genetics. 42, 6, p. 867-871 5 p.

Research output: Contribution to journalArticle

Molecular basis and prenatal diagnosis of β-thalassemia

Kazazian, H. H. & Boehm, C. D., Jan 1 1988, In : Blood. 72, 4, p. 1107-1116 10 p.

Research output: Contribution to journalReview article

Molecular characterization of a β0-thalassemia resulting from a 1.4 kilobase deletion

Anand, R., Boehm, C. D., Kazazian, H. H. & Vanin, E. F., Jan 1 1988, In : Blood. 72, 2, p. 636-641 6 p.

Research output: Contribution to journalArticle

Open Access

New amber mutation in a β-thalassemic gene with nonmeasurable levels of mutant messenger RNA in vivo

Atweh, G. F., Brickner, H. E., Zhu, X. X., Kazazian, H. H. & Forget, B. G., 1988, In : Journal of Clinical Investigation. 82, 2, p. 557-561 5 p.

Research output: Contribution to journalArticle

Open Access

Nonsense and missense mutations in hemophilia A: Estimate of the relative mutation rate at CG dinucleotides

Youssoufian, H., Antonarakis, S. E., Bell, W., Griffin, A. M. & Kazazian, H. H., Jan 1 1988, In : American journal of human genetics. 42, 5, p. 718-725 8 p.

Research output: Contribution to journalArticle