Haig Kazazian

Professor

1965 …2020

Research output per year

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Research Output

2000

Mobile elements and the human genome

Luning Prak, E. T. & Kazazian, H. H., Nov 2000, In : Nature Reviews Genetics. 1, 2, p. 134-144 11 p.

Research output: Contribution to journalReview article

Overview: Progress toward a new millennium of medical genetics

Kazazian, H. H., Jan 19 2000, In : Human mutation. 15, 1, p. 2-3 2 p.

Research output: Contribution to journalEditorial

Partial correction of murine hemophilia A with neo-antigenic murine factor VIII

Sarkar, R., Gao, G. P., Chirmule, N., Tazelaar, J. & Kazazian, H. H., Apr 10 2000, In : Human gene therapy. 11, 6, p. 881-894 14 p.

Research output: Contribution to journalArticle

Transduction of 3'-flanking sequences is common in L1 retrotransposition

Goodier, J. L., Ostertag, E. M. & Kazazian, H. H., Mar 1 2000, In : Human molecular genetics. 9, 4, p. 653-657 5 p.

Research output: Contribution to journalArticle

Open Access

VARIATION, DATABASES, and DISEASE: New directions for Human Mutation

Paalman, M. H., Cotton, R. G. H., Kazazian, J., Dadali, E. L., Fedotov, V. P., Nelis, E., Löfgren, A., Timmerman, V., Van Broeckhoven, C. & Evgrafov, O. V., Jan 1 2000, In : Human mutation. 16, 2, p. 97-98 2 p.

Research output: Contribution to journalEditorial

1999

Analysis of the promoter from an expanding mouse retrotransposon subfamily

Deberardinis, R. J. & Kazazian, H. H., Mar 15 1999, In : Genomics. 56, 3, p. 317-323 7 p.

Research output: Contribution to journalArticle

An estimated frequency of endogenous insertional mutations in humans [4]

Kazazian, J., 1999, In : Nature genetics. 22, 2, 1 p.

Research output: Contribution to journalLetter

Exon shuffling by L1 retrotransposition

Moran, J. V., DeBerardinis, R. J. & Kazazian, H. H., Mar 5 1999, In : Science. 283, 5407, p. 1530-1534 5 p.

Research output: Contribution to journalArticle

Full-length human L1 insertions retain the capacity for high frequency retrotransposition in cultured cells

Kimberland, M. L., Divoky, V., Prchal, J., Schwahn, U., Berger, W. & Kazazian, H. H., Jan 1 1999, In : Human molecular genetics. 8, 8, p. 1557-1560 4 p.

Research output: Contribution to journalArticle

Inhibitor antibody development and T cell response to human factor VIII in murine hemophilia A

Qian, J., Borovok, M., Bi, L., Kazazian, H. H. & Hoyer, L. W., 1999, In : Thrombosis and Haemostasis. 81, 2, p. 240-244 5 p.

Research output: Contribution to journalArticle

Lack of linkage or association between schizophrenia and the polymorphic trinucleotide repeat within the KCNN3 gene on chromosome 1q21

Antonarakis, S. E., Blouin, J. L., Lasseter, V. K., Gehrig, C., Radhakrishna, U., Nestadt, G., Housman, D. E., Kazazian, H. H., Kalman, K., Gutman, G., Fantino, E., Chandy, K. G., Gargus, J. J. & Pulver, A. E., Aug 20 1999, In : American Journal of Medical Genetics - Neuropsychiatric Genetics. 88, 4, p. 348-351 4 p.

Research output: Contribution to journalArticle

No evidence for linkage between schizophrenia and markers at chromosome 15q13-14

Curtis, L., Blouin, J. L., Radhakrishna, U., Gehrig, C., Lasseter, V. K., Wolyniec, P., Nestadt, G., Dombroski, B., Kazazian, H. H., Pulver, A. E., Housman, D., Bertrand, D. & Antonarakis, S. E., Apr 16 1999, In : American Journal of Medical Genetics - Neuropsychiatric Genetics. 88, 2, p. 109-112 4 p.

Research output: Contribution to journalArticle

Short-term correction of factor VIII deficiency in a murine model of hemophilia A after delivery of adenovirus murine factor VIII in utero

Lipshutz, G. S., Sarkar, R., Flebbe-Rehwaldt, L., Kazazian, H. & Gaensler, K. M. L., Nov 9 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 23, p. 13324-13329 6 p.

Research output: Contribution to journalArticle

1998

An actively retrotransposing, novel subfamily of mouse L1 elements

Naas, T. P., Deberardinis, R. J., Moran, J. V., Ostertag, E. M., Kingsmore, S. F., Seldin, M. F., Hayashizaki, Y., Martin, S. L. & Kazazian, H. H., Jan 15 1998, In : EMBO Journal. 17, 2, p. 590-597 8 p.

Research output: Contribution to journalArticle

A transmission disequilibrium and linkage analysis of D22S278 marker alleles in 574 families: Further support for a susceptibility locus for schizophrenia at 22q12

Schizophrenia Collaborative Linkage Group for Chromosome 22, Jul 27 1998, In : Schizophrenia Research. 32, 2, p. 115-121 7 p.

Research output: Contribution to journalArticle

Full-length L1 elements have arisen recently in the same 1-kb region of the gorilla and human genomes

DeBerardinis, R. J. & Kazazian, H. H., Oct 15 1998, In : Journal of Molecular Evolution. 47, 3, p. 292-301 10 p.

Research output: Contribution to journalArticle

Identification of sequence variants and analysis of the role of the catechol-O-methyl-transferase gene in schizophrenia susceptibility

Karayiorgou, M., Gogos, J. A., Galke, B. L., Wolyniec, P. S., Nestadt, G., Antonarakis, S. E., Kazazian, H. H., Housman, D. E. & Pulver, A. E., Mar 15 1998, In : Biological psychiatry. 43, 6, p. 425-431 7 p.

Research output: Contribution to journalArticle

Independent occurrence of the novel Arg2163 to His mutation in the factor VIII gene in three unrelated families with haemophila A with different phenotypes. Mutations in brief no. 126. Online.

Theophilus, B. D., Enayat, M. S., Higuchi, M., Kazazian, H. H., Antonarakis, S. E. & Hill, F. G., 1998, In : Human mutation. 11, 4, p. 334 1 p.

Research output: Contribution to journalArticle

Mobile elements and disease

Kazazian, H. H., Jun 1998, In : Current Opinion in Genetics and Development. 8, 3, p. 343-350 8 p.

Research output: Contribution to journalArticle

Rapid amplification of a retrotransposon subfamily is evolving the mouse genome

DeBerardinis, R. J., Goodier, J. L., Ostertag, E. M. & Kazazian, H. H., Nov 17 1998, In : Nature genetics. 20, 3, p. 288-290 3 p.

Research output: Contribution to journalArticle

Recommendations for a nomenclature system for human gene mutations

Antonarakis, S. E., Ashburner, M., Auerbach, A. D., Beaudet, A. L., Beckmann, J. S., Beutler, E., Cooper, D. N., Cotton, R. G. H., Den Dunnen, J. T., Desnick, R. J., Eng, C., Fasman, K. H., Goldman, D., Hayashi, K., Hutchinson, F., Kazazian, H. H., Keen, J., King, M. C., Lehvaslaiho, H., McAlpine, P. J. & 11 others, McKusick, V., Motulski, A. G., Povey, S., Schorderet, D. F., Scriver, C. R., Shows, T. B., Supertifurga, A., Tay, A. H. N., Tsui, L. C., Valle, D. & Vihinen, M., Jan 1 1998, In : Human mutation. 11, 1, p. 1-3 3 p.

Research output: Contribution to journalArticle

Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21

Blouin, J. L., Dombroski, B. A., Nath, S. K., Lasseter, V. K., Wolyniec, P. S., Nestadt, G., Thornquist, M., Ullrich, G., McGrath, J., Kasch, L., Lamacz, M., Thomas, M. G., Gehrig, C., Radhakrishna, U., Snyder, S. E., Balk, K. G., Neufeld, K., Swartz, K. L., DeMarchi, N., Papadimitriou, G. N. & 8 others, Dikeos, D. G., Stefanis, C. N., Chakravarti, A., Childs, B., Housman, D. E., Kazazian, H. H., Antonarakis, S. E. & Pulver, A. E., Sep 15 1998, In : Nature genetics. 20, 1, p. 70-73 4 p.

Research output: Contribution to journalArticle

The impact of L1 retrotransposons on the human genome

Kazazian, H. H. & Moran, J. V., Jun 8 1998, In : Nature genetics. 19, 1, p. 19-24 6 p.

Research output: Contribution to journalReview article

The molecular basis for cross-reacting material-positive hemophilia a due to missense mutations within the A2-domain of factor VIII

Amano, K., Sarkar, R., Pemberton, S., Kemball-Cook, G., Kazazian, H. H. & Kaufman, R. J., Jan 15 1998, In : Blood. 91, 2, p. 538-548 11 p.

Research output: Contribution to journalArticle

Open Access
1997

Many human L1 elements are capable of retrotransposition

Sassaman, D. M., Dombroski, B. A., Moran, J. V., Kimberland, M. L., Naas, T. P., DeBerardinis, R. J., Gabriel, A., Swergold, G. D. & Kazazian, H. H., May 1997, In : Nature genetics. 16, 1, p. 37-43 7 p.

Research output: Contribution to journalArticle

Partial correction of a severe molecular defect in hemophilia A, because of errors during expression of the factor VIII gene

Young, M., Inaba, H., Hoyer, L. W., Higuchi, M., Kazazian, H. H. & Antonarakis, S. E., Mar 1997, In : American journal of human genetics. 60, 3, p. 565-573 9 p.

Research output: Contribution to journalArticle

1996

A combined analysis of D22S278 marker alleles in affected sib-pairs: Support for a susceptibility locus for schizophrenia at chromosome 22q12

Gill, M., Vallada, H., Collier, D., Sham, P., Holmans, P., Murray, R., McGuffin, P., Nanko, S., Owen, M., Antonarakis, S., Housman, D., Kazazian, H., Nestadt, G., Pulver, A. E., Straub, R. E., MacLean, C. J., Walsh, D., Kendler, K. S. & DeLisi, L., 1996, In : American Journal of Medical Genetics - Neuropsychiatric Genetics. 67, 1, p. 40-45 6 p.

Research output: Contribution to journalArticle

Additional Support for Schizophrenia Linkage on Chromosomes 6 and 8: A Multicenter Study

Wildenauer, D. B., Schwab, S. G., Albus, M., Hallmayer, J., Lerer, B., Maier, W., Blackwood, D., Muir, W., St Clair, D., Morris, S., Moises, H. W., Yang, L., Kristbjarnarson, H., Helgason, T., Wiese, C., Collier, D. A., Holmans, P., Daniels, J., Rees, M., Asherson, P. & 107 others, Roberts, Q., Cardno, A., Arranz, M. J., Vallada, H., Ball, D., Kunugi, H., Murray, R. M., Powell, J. F., Nanko, S., Sham, P., Gill, M., McGuffin, P., Owen, M. J., Pulver, A. E., Antonarakis, S. E., Babb, R., Blouin, J. L., DeMarchi, N., Dombroski, B., Housman, D., Karayiorgou, M., Ott, J., Kasch, L., Kazazian, H., Lasseter, V. K., Loetscher, E., Luebbert, H., Nestadt, G., Ton, C., Wolyniec, P. S., Laurent, C., de Chaldee, M., Thibaut, F., Jay, M., Samolyk, D., Petit, M., Campion, D., Mallet, J., Straub, R. E., MacLean, C. J., Easter, S. M., O'Neill, F. A., Walsh, D., Kendler, K. S., Gejman, P. V., Cao, Q., Gershon, E., Badner, J., Beshah, E., Zhang, J., Riley, B. P., Rajagopalan, S., Mogudi-Carter, M., Jenkins, T., Williamson, R., DeLisi, L. E., Garner, C., Kelly, M., LeDuc, C., Cardon, L., Lichter, J., Harris, T., Loftus, J., Shields, G., Comasi, M., Vita, A., Smith, A., Dann, J., Joslyn, G., Gurling, H., Kalsi, G., Brynjolfsson, J., Curtis, D., Sigmundsson, T., Butler, R., Read, T., Murphy, P., Chen, A. C. H., Petursson, H., Byerley, B., Hoff, M., Holik, J., Coon, H., Levinson, D. F., Nancarrow, D. J., Crowe, R. R., Andreasen, N., Silverman, J. M., Mohs, R. C., Siever, L. J., Endicott, J., Sharpe, L., Walters, M. K., Lennon, D. P., Hayward, N. K., Sandkuijl, L. A., Mowry, B. J., Aschauer, H. N., Meszaros, K., Lenzinger, E., Fuchs, K., Yang, L., Heiden, A. M., Moises, H. W., Kruglyak, L., Daly, M. J. & Matise, T. C., 1996, In : American journal of medical genetics. 67, 6, p. 580-594 15 p.

Research output: Contribution to journalArticle

Analysis of factor VIII gene inversion mutations in 166 unrelated haemophilia A families: Frequency and utility in genetic counselling

Vnencak-Jones, C. L., Phillips, J. A., Janco, R. L., Cohen, M. P., Dupont, W. D., Kazazian, H. H. & Rossiter, J. P., Jan 1 1996, In : Haemophilia. 2, 1, p. 18-23 6 p.

Research output: Contribution to journalArticle

Corrigendum: The haemophilia A mutation search test and resource site, home page of the factor VIII mutation database: HAMSTeRS (Nucleic Acids Research (1996) 24 (100-102))

Wacey, A. I., Kemball-Cook, G., Kazazian, H. H., Antonarakis, S. E., Schwaab, R., Lindley, P. & Tuddenham, E. G. D., Jan 1 1996, In : Nucleic acids research. 24, 3, 1 p.

Research output: Contribution to journalComment/debate

Cystic fibrosis carrier population screening in the primary care setting

Loader, S., Caldwell, P., Kozyra, A., Levenkron, J. C., Boehm, C. D., Kazazian, H. H. & Rowley, P. T., 1996, In : American journal of human genetics. 59, 1, p. 234-247 14 p.

Research output: Contribution to journalArticle

Further characterization of factor VIII-deficient mice created by gene targeting: RNA and protein studies

Bi, L., Sarkar, R., Naas, T., Lawler, A. M., Pain, J., Shumaker, S. L., Bedian, V. & Kazazian, H. H., Nov 1 1996, In : Blood. 88, 9, p. 3446-3450 5 p.

Research output: Contribution to journalArticle

Open Access

Genotype and phenotype analysis at the 22q11 schizophrenia susceptibility locus

Karayiorgou, M., Gogos, J. A., Galke, B. L., Jeffery, J. A., Nestadt, G., Wolyniec, P. S., Antonarakis, S. E., Kazazian, H. H., Housman, D. E., Driscoll, D. A. & Pulver, A. E., Jan 1 1996, In : Cold Spring Harbor symposia on quantitative biology. 61, p. 835-843 9 p.

Research output: Contribution to journalArticle

High frequency retrotransposition in cultured mammalian cells

Moran, J. V., Holmes, S. E., Naas, T. P., DeBerardinis, R. J., Boeke, J. D. & Kazazian, H. H., Nov 29 1996, In : Cell. 87, 5, p. 917-927 11 p.

Research output: Contribution to journalArticle

Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition

Feng, Q., Moran, J. V., Kazazian, H. H. & Boeke, J. D., Nov 29 1996, In : Cell. 87, 5, p. 905-916 12 p.

Research output: Contribution to journalArticle

The changing profile of homozygous β-thalassemia: Demography, ethnicity, and age distribution of current North American patients and changes in two decades

Pearson, H. A., Cohen, A. R., Giardina, P. J. V. & Kazazian, H. H., Mar 18 1996, In : Pediatrics. 97, 3, p. 352-356 5 p.

Research output: Contribution to journalArticle

The haemophilia A mutation search test and resource site, home page of the factor VIII mutation database: HAMSTeRS

Wacey, A. I., Kemball-Cook, G., Kazazian, H. H., Antonarakis, S. E., Schwaab, R., Lindley, P. & Tuddenham, E. G. D., Dec 1 1996, In : Nucleic acids research. 24, 1, p. 98-99 2 p.

Research output: Contribution to journalArticle

The Johns Hopkins University Collaborative Schizophrenia Study: An epidemiologic-genetic approach to test the heterogeneity hypothesis and identify schizophrenia susceptibility genes

Pulver, A. E., Wolyniec, P. S., Housman, D., Kazazian, H. H., Antonarakis, S. E., Nestadt, G., Lasseter, V. K., Mcgrath, J. A., Dombroski, B., Karayiorgou, M., Ton, C., Blouin, J. L. & Kempf, L., 1996, In : Cold Spring Harbor symposia on quantitative biology. 61, p. 797-814 18 p.

Research output: Contribution to journalArticle

1995

Age at diagnosis as an indicator of eligibility for BRCA1 DNA testing in familial breast cancer

Giambona, A., Gioco, P. L., Marino, M., Abate, I., Di Marzo, R., Renda, M., Di Trapani, F., Messana, F., Siciliano, S., Rigano, P., Chehab, F. F., Kazazian, H. H. & Maggio, A., May 1 1995, In : Human genetics. 95, 5, p. 526-530 5 p.

Research output: Contribution to journalArticle

Anticipation and instability of IT-15 (CAG)(N) repeats in parent-offspring pairs with Huntington disease

Ranen, N. G., Stine, O. C., Abbott, M. H., Sherr, M., Codori, A. M., Franz, M. L., Chao, N. I., Chung, A. S., Pleasant, N., Callahan, C., Kasch, L. M., Ghaffari, M., Chase, G. A., Kazazian, H. H., Brandt, J., Folstein, S. E. & Ross, C. A., 1995, In : American journal of human genetics. 57, 3, p. 593-602 10 p.

Research output: Contribution to journalArticle

Factor VIII gene inversions in severe hemophilia A: Results of an international consortium study

Antonarakis, S. E., Rossiter, J. P., Young, M., Horst, J., De Moerloose, P., Sommer, S. S., Ketterling, R. P., Kazazian, H. H., Négrier, C., Vinciguerra, C., Gitschier, J., Goossens, M., Girodon, E., Ghanem, N., Plassa, F., Lavergne, J. M., Vidaud, M., Costa, J. M., Laurian, Y., Lin, S. W. & 46 others, Lin, S. R., Shen, M. C., Lillicrap, D., Taylor, S. A. M., Windsor, S., Valleix, S. V., Nafa, K., Sultan, Y., Delpech, M., Vnencak-Jones, C. L., Phillips, J. A., Ljung, R. C. R., Koumbarelis, E., Gialeraki, A., Mandalaki, T., Jenkins, P. V., Collins, P. W., Pasi, K. J., Goodeve, A., Peake, I., Preston, F. E., Schwartz, M., Scheibel, E., Ingerslev, J., Cooper, D. N., Millar, D. S., Kakkar, V. V., Giannelli, F., Naylor, J. A., Tizzano, E. F., Baiget, M., Domenech, M., Altisent, C., Tusell, J., Beneyto, M., Lorenzo, J. I., Gaucher, C., Mazurier, C., Peerlinck, K., Matthijs, G., Cassiman, J. J., Vermylen, J., Mori, P. G., Acquila, M., Caprino, D. & Inaba, H., Sep 15 1995, In : Blood. 86, 6, p. 2206-2212 7 p.

Research output: Contribution to journalArticle

Open Access

Follow-up report of potential linkage for schizophrenia on chromosome 22q: Part 3.

Lasseter, V. K., Pulver, A. E., Wolyniec, P. S., Nestadt, G., Meyers, D., Karayiorgou, M., Housman, D., Antonarakis, S., Kazazian, H. & Kasch, L., Apr 24 1995, In : American journal of medical genetics. 60, 2, p. 172-173 2 p.

Research output: Contribution to journalLetter

Molecular etiology of factor VIII deficiency in hemophilia A

Antonarakis, S. E., Kazazian, H. H. & Tuddenham, E. G. D., 1995, In : Human mutation. 5, 1, p. 1-22 22 p.

Research output: Contribution to journalArticle

Molecular etiology of factor VIII deficiency in hemophilia A

Antonarakis, S. E., Kazazian, H. H., Gitschier, J., Hutter, P., De Moerloose, P. & Morris, M. A., 1995, In : Advances in experimental medicine and biology. 386, p. 19-34 16 p.

Research output: Contribution to journalArticle

Schizophrenia: A genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes

Pulver, A. E., Lasseter, V. K., Kasch, L., Wolyniec, P., Nestadt, G., Blouin -, J. L., Kimberland, M., Babb, R., Vourlis, S., Chen, H., Lalioti, M., Morris, M. A., Karayiorgou, M., Ott, J., Meyers, D., Antonarakis, S. E., Housman, D. & Kazazian, H. H., 1995, In : American Journal of Medical Genetics - Neuropsychiatric Genetics. 60, 3, p. 252-260 9 p.

Research output: Contribution to journalArticle

Schizophrenia susceptibility and chromosome 6p24–22

Antonarakis, S. E., Blouin, J. L., Pulver, A. E., Wolyniec, P., Lasseter, V. K., Nestadt, G., Kasch, L., Babb, R., Kazazian, H. H., Dombroski, B., Kimberland, M., Ott, J., Housman, D., Karayiorgou, M. & MacLean, C. J., Nov 1995, In : Nature genetics. 11, 3, p. 235-236 2 p.

Research output: Contribution to journalArticle

Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A

Bi, L., Lawler, A. M., Antonarakis, S. E., High, K. A., Gearhart, J. D. & Kazazian, H. H., May 1995, In : Nature genetics. 10, 1, p. 119-121 3 p.

Research output: Contribution to journalArticle

The great heterogeneity of thalassemia molecular defects in Sicily

Giambona, A., Lo Gioco, P., Marino, M., Abate, I., Di Marzo, R., Renda, M., Di Trapani, F., Messana, F., Siciliano, S., Rigano, P., Chehab, F. F., Kazazian, H. H. & Maggio, A., Jan 1 1995, In : Human genetics. 95, 5, p. 526-530 5 p.

Research output: Contribution to journalArticle

Two novel β‐thalassemia alleles: Poly A signal (AATAAA→AAAA) and −92 C→T

Kimberland, M. L., Boehm, C. D. & Kazazian, H. H., 1995, In : Human mutation. 5, 3, p. 275-276 2 p.

Research output: Contribution to journalArticle

1994

A new retrotransposable human L1 element from the LRE2 locus on chromosome 1q produces a chimaeric insertion

Holmes, S. E., Dombroski, B. A., Krebs, C. M., Boehm, C. D. & Kazazian, H. H., Jun 1 1994, In : Nature genetics. 7, 2, p. 143-148 6 p.

Research output: Contribution to journalArticle