Haig Kazazian

Professor

1965 …2020

Research output per year

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Research Output

2007

L1 retrotransposition can occur early in human embryonic development

van den Hurk, J. A. J. M., Meij, I. C., del Carmen Seleme, M., Kano, H., Nikopoulos, K., Hoefsloot, L. H., Sistermans, E. A., de Wijs, I. J., Mukhopadhyay, A., Plomp, A. S., de Jong, P. T. V. M., Kazazian, H. H. & Cremers, F. P. M., Jul 1 2007, In : Human molecular genetics. 16, 13, p. 1587-1592 6 p.

Research output: Contribution to journalArticle

Metabolic phenotype of methylmalonic acidemia in mice and humans: The role of skeletal muscle

Chandler, R. J., Sloan, J., Fu, H., Tsai, M., Stabler, S., Allen, R., Kaestner, K. H., Kazazian, H. H. & Venditti, C. P., Oct 15 2007, In : BMC medical genetics. 8, 64.

Research output: Contribution to journalArticle

Progress in understanding the biology of the human mutagen LINE-1

Babushok, D. V. & Kazazian, H. H., Jun 1 2007, In : Human mutation. 28, 6, p. 527-539 13 p.

Research output: Contribution to journalReview article

2006

Extensive individual variation in L1 retrotransposition capability contributes to human genetic diversity

Del Carmen Seleme, M., Vetter, M. R., Cordaux, R., Bastone, L., Batzer, M. A. & Kazazian, H. H., Apr 25 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 17, p. 6611-6616 6 p.

Research output: Contribution to journalArticle

L1 integration in a transgenic mouse model

Babushok, D. V., Ostertag, E. M., Courtney, C. E., Choi, J. M. & Kazazian, H. H., Feb 2006, In : Genome research. 16, 2, p. 240-250 11 p.

Research output: Contribution to journalArticle

L1 retrotransposition in nondividing and primary human somatic cells

Kubo, S., Del Carmen Seleme, M., Soifer, H. S., Perez, J. L. G., Moran, J. V., Kazazian, H. H. & Kasahara, N., May 23 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 21, p. 8036-8041 6 p.

Research output: Contribution to journalArticle

Long-term efficacy of adeno-associated virus serotypes 8 and 9 in hemophilia a dogs and mice

Sarkar, R., Mucci, M., Addya, S., Tetreault, R., Bellinger, D. A., Nichols, T. C. & Kazazian, H. H., Apr 2006, In : Human gene therapy. 17, 4, p. 427-439 13 p.

Research output: Contribution to journalArticle

Propionyl-CoA and adenosylcobalamin metabolism in Caenorhabditis elegans: Evidence for a role of methylmalonyl-CoA epimerase in intermediary metabolism

Chandler, R. J., Aswani, V., Tsai, M. S., Falk, M., Wehrli, N., Stabler, S., Allen, R., Sedensky, M., Kazazian, H. H. & Venditti, C. P., Sep 1 2006, In : Molecular genetics and metabolism. 89, 1-2, p. 64-73 10 p.

Research output: Contribution to journalArticle

2005

Genetics: LINEs in mind

Ostertag, E. M. & Kazazian, H. H., Jun 16 2005, In : Nature. 435, 7044, p. 890-891 2 p.

Research output: Contribution to journalShort survey

L1 retrotransposon-mediated stable gene silencing

Yang, N., Zhang, L. & Kazazian, H. H., 2005, In : Nucleic acids research. 33, 6, p. 1-8 8 p.

Research output: Contribution to journalArticle

Lower inhibitor development in hemophilia A mice following administration of recombinant factor VIII-O-phospho-L-serine complex

Purohit, V. S., Ramani, K., Sarkar, R., Kazazian, H. H. & Balasubramanian, S. V., May 6 2005, In : Journal of Biological Chemistry. 280, 18, p. 17593-17600 8 p.

Research output: Contribution to journalArticle

Toward a human variome project

Cotton, R. G. H. & Kazazian, H. H., Dec 1 2005, In : Human mutation. 26, 6, 1 p.

Research output: Contribution to journalEditorial

Two independent retrotransposon insertions at the same site within the coding region of BTK.

Conley, M. E., Partain, J. D., Norland, S. M., Shurtleff, S. A. & Kazazian, H. H., Mar 2005, In : Human mutation. 25, 3, p. 324-325 2 p.

Research output: Contribution to journalArticle

2004

A potential role for the nucleous in L1 retrotransposition

Goodier, J. L., Ostertag, E. M., Engleka, K. A., Seleme, M. C. & Kazazian, H. H., May 15 2004, In : Human molecular genetics. 13, 10, p. 1041-1048 8 p.

Research output: Contribution to journalArticle

Mobile Elements: Drivers of Genome Evolution

Kazazian, H. H., Mar 12 2004, In : Science. 303, 5664, p. 1626-1632 7 p.

Research output: Contribution to journalReview article

More active human L1 retrotransposons produce longer insertions

Farley, A. H., Luning Park, E. T. & Kazazian, H. H., 2004, In : Nucleic acids research. 32, 2, p. 502-510 9 p.

Research output: Contribution to journalArticle

Total correction of hemophilia A mice with canine FVIII using an AAV 8 serotype

Sarkar, R., Tetreault, R., Gao, G., Wang, L., Bell, P., Chandler, R., Wilson, J. M. & Kazazian, H. H., Feb 15 2004, In : Blood. 103, 4, p. 1253-1260 8 p.

Research output: Contribution to journalArticle

2003

A higher-impact Human Mutation launches web-based submission/peer review and Early View rapid publication

Cotton, R. G. H., Kazazian, H. H. & Paalman, M. H., 2003, In : Human mutation. 21, 1, p. 1 1 p.

Research output: Contribution to journalEditorial

Allelic Heterogeneity in LINE-1 Retrotransposition Activity

Lutz, S. M., Vincent, B. J., Kazazian, H. H., Batzer, M. A. & Moran, J. V., Dec 2003, In : American journal of human genetics. 73, 6, p. 1431-1437 7 p.

Research output: Contribution to journalArticle

An important role for RUNX3 in human L1 transcription and retrotransposition

Yang, N., Zhang, L., Zhang, Y. & Kazazian, H. H., Aug 15 2003, In : Nucleic acids research. 31, 16, p. 4929-4940 12 p.

Research output: Contribution to journalArticle

A single adeno-associated virus (AAV)-murine factor VIII vector partially corrects the hemophilia A phenotype

Sarkar, R., Xiaoy, W. & Kazazian, H. H., Feb 2003, In : Journal of Thrombosis and Haemostasis. 1, 2, p. 220-226 7 p.

Research output: Contribution to journalArticle

Dual vectors expressing murine factor VIII result in sustained correction of hemophilia a mice

Mah, C., Sarkar, R., Zolotukhin, I., Schleissing, M., Xiao, X., Kazazian, H. H. & Byrne, B. J., Jan 1 2003, In : Human gene therapy. 14, 2, p. 143-152 10 p.

Research output: Contribution to journalArticle

Hot L1s account for the bulk of retrotransposition in the human population

Brouha, B., Schustak, J., Badge, R. M., Lutz-Prigge, S., Farley, A. H., Morant, J. V. & Kazazian, H. H., Apr 29 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 9, p. 5280-5285 6 p.

Research output: Contribution to journalArticle

Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A

Hrachovinová, I., Cambien, B., Hafezi-Moghadam, A., Kappelmayer, J., Camphausen, R. T., Widom, A., Xia, L., Kazazian, H. H., Schaub, R. G., McEver, R. P. & Wagner, D. D., Aug 1 2003, In : Nature medicine. 9, 8, p. 1020-1025 6 p.

Research output: Contribution to journalArticle

Mobile elements and mammalian genome evolution

Deininger, P. L., Moran, J. V., Batzer, M. A. & Kazazian, H. H., Dec 2003, In : Current Opinion in Genetics and Development. 13, 6, p. 651-658 8 p.

Research output: Contribution to journalReview article

Phenotypic correction of a mouse model of hemophilia A using AAV2 vectors encoding the heavy and light chains of FVIII

Scallan, C. D., Liu, T., Parker, A. E., Patarroyo-White, S. L., Chen, H., Jiang, H., Vargas, J., Nagy, D., Powell, S. K., Wright, J. F., Sarkar, R., Kazazian, H. H., McClelland, A. & Couto, L. B., Dec 1 2003, In : Blood. 102, 12, p. 3919-3926 8 p.

Research output: Contribution to journalArticle

SVA Elements Are Nonautonomous Retrotransposons that Cause Disease in Humans

Ostertag, E. M., Goodier, J. L., Zhang, Y. & Kazazian, H. H., Dec 2003, In : American journal of human genetics. 73, 6, p. 1444-1451 8 p.

Research output: Contribution to journalArticle

Tracking an embryonic L1 retrotransposition event

Luning Prak, E. T., Dodson, A. W., Farkash, E. A. & Kazazian, H. H., Feb 18 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 4, p. 1832-1837 6 p.

Research output: Contribution to journalArticle

2002

A mouse model of human L1 retrotransposition

Ostertag, E. M., DeBerardinis, R. J., Goodier, J. L., Zhang, Y., Yang, N., Gerton, G. L. & Kazazian, H. H., Dec 1 2002, In : Nature genetics. 32, 4, p. 655-660 6 p.

Research output: Contribution to journalArticle

Evidence consistent with human L1 retrotransposition in maternal meiosis I

Brouha, B., Meischl, C., Ostertag, E., De Boer, M., Zhang, Y., Neijens, H., Roos, D. & Kazazian, H. H., 2002, In : American journal of human genetics. 71, 2, p. 327-336 10 p.

Research output: Contribution to journalArticle

Human mutation: The Official Journal of the Human Genome Variation Society (HGVS)

Cotton, R. G. H. & Kazazian, H. H., 2002, In : Human mutation. 19, 1, p. 1 1 p.

Research output: Contribution to journalEditorial

LINE drive: Retrotransposition and genome instability

Kazazian, H. H. & Goodier, J. L., Aug 9 2002, In : Cell. 110, 3, p. 277-280 4 p.

Research output: Contribution to journalReview article

2001

A novel active L1 retrotransposon subfamily in the mouse

Goodier, J. L., Ostertag, E. M., Du, K. & Kazazian, J., 2001, In : Genome research. 11, 10, p. 1677-1685 9 p.

Research output: Contribution to journalArticle

Biology of mammalian L1 retrotransposons

Ostertag, E. M. & Kazazian, J., Dec 1 2001, In : Annual review of genetics. 35, p. 501-538 38 p.

Research output: Contribution to journalReview article

Erratum: An actively retrotransposing, novel subfamily of mouse L1 elements (The EMBO Journal (1998) 17 (590-597))

Naas, T. P., DeBerardinis, R. J., Moran, J. V., Ostertag, E. M., Kingsmore, S. F., Seldin, M. F., Hayashizaki, Y., Martin, S. L. & Kazazian, J., May 15 2001, In : EMBO Journal. 20, 10, 1 p.

Research output: Contribution to journalComment/debate

Erratum: A novel active L1 retrotransposon subfamily in the mouse (Genome Research (2001) vol. 11 (1677-1685))

Goodier, J. L., Ostertag, E. M., Du, K. & Kazazian, J., Dec 11 2001, In : Genome research. 11, 11, 1 p.

Research output: Contribution to journalComment/debate

Human L1 retrotransposition: cis preference versus trans complementation

Wei, W., Gilbert, N., Ooi, S. L., Lawler, J. F., Ostertag, E. M., Kazazian, H. H., Boeke, J. D. & Moran, J. V., 2001, In : Molecular and cellular biology. 21, 4, p. 1429-1439 11 p.

Research output: Contribution to journalArticle

In memoriam

Kazazian, H. H. & Cotton, R. G. H., Dec 22 2001, In : Human mutation. 18, 6, 1 p.

Research output: Contribution to journalEditorial

Retrotransposon insertions in germ cells and somatic cells.

Kazazian, H. H., 2001, In : Developments in biologicals. 106, p. 307-313; discussion 313-314, 317-329

Research output: Contribution to journalArticle

Stable integration of transgenes delivered by a retrotransposon-adenovirus hybrid vector

Soifer, H., Higo, C., Kazazian, H. H., Moran, J. V., Mitani, K. & Kasahara, N., Jul 20 2001, In : Human gene therapy. 12, 11, p. 1417-1428 12 p.

Research output: Contribution to journalArticle

Subfamilies of CR1 non-LTR retrotransposons have different 5′UTR sequences but are otherwise conserved

Haas, N. B., Grabowski, J. M., North, J., Moran, J. V., Kazazian, H. H. & Burch, J. B. E., Mar 7 2001, In : Gene. 265, 1-2, p. 175-183 9 p.

Research output: Contribution to journalArticle

Twin priming: A proposed mechanism for the creation of inversions in L1 retrotransposition

Ostertag, E. M. & Kazazian, J., Dec 27 2001, In : Genome research. 11, 12, p. 2059-2065 7 p.

Research output: Contribution to journalArticle

2000

ACMG recommendations for standards for interpretation of sequence variations

Kazazian, J., Boehm, C. D. & Seltzer, W. K., Jan 1 2000, In : Genetics in Medicine. 2, 5, p. 302-303 2 p.

Research output: Contribution to journalComment/debate

Open Access

Correction of the coagulation defect in hemophilia A mice through factor VIII expression in skin

Fakharzadeh, S. S., Zhang, Y., Sarkar, R. & Kazazian, H. H., May 1 2000, In : Blood. 95, 9, p. 2799-2805 7 p.

Research output: Contribution to journalArticle

Correlation between factor VIII genotype and inhibitor development in hemophilia A

Fakharzadeh, S. S. & Kazazian, H. H., Jul 18 2000, In : Seminars in Thrombosis and Hemostasis. 26, 2, p. 167-171 5 p.

Research output: Contribution to journalReview article

Determination of L1 retrotransposition kinetics in cultured cells

Ostertag, E. M., Luning Prak, E. T., DeBerardinis, R. J., Moran, J. V. & Kazazian, H. H., Mar 15 2000, In : Nucleic acids research. 28, 6, p. 1418-1423 6 p.

Research output: Contribution to journalArticle

Open Access

Genetic heterogeneity in schizophrenia: Stratification of genome scan data using co-segregating related phenotypes

Pulver, A. E., Mulle, J., Nestadt, G., Swartz, K. L., Blouin, J. L., Dombroski, B., Liang, K. Y., Housman, D. E., Kazazian, H. H., Antonarakis, S. E., Lasseter, V. K., Wolyniec, P. S., Thornquist, M. H. & McGrath, J. A., Jan 1 2000, In : Molecular psychiatry. 5, 6, p. 650-653 4 p.

Research output: Contribution to journalArticle

Open Access

L1 retrotransposons shape the mammalian genome

Kazazian, J., Aug 18 2000, In : Science. 289, 5482, p. 1152-1153 2 p.

Research output: Contribution to journalReview article