Haig Kazazian

Professor

1965 …2020

Research output per year

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Research Output

2014 William Allan Award Introduction: Stuart Orkin1

Kazazian, H. H., Mar 5 2015, In : American journal of human genetics. 96, 3, p. 352-353 2 p.

Research output: Contribution to journalComment/debate

25 Years of Human Mutation

Cutting, G. R. & Kazazian, H., Jun 1 2016, In : Human Mutation. 37, 6, p. 503-504 2 p.

Research output: Contribution to journalArticle

Abnormal RNA processing due to the exon mutation of βE- globin gene

Orkin, S. H., Kazazian, H. H., Antonarakis, S. E., Ostrer, H., Goff, S. C. & Sexton, J. P., Dec 1 1982, In : Nature. 300, 5894, p. 768-769 2 p.

Research output: Contribution to journalArticle

Accuracy and limitations of pulsed field gel electrophoresis in sizing partial deletions of the factor VIII gene

Cutting, G. R., Antonarakis, S. E., Youssoufian, H. & Kazazian, H. H., Dec 1 1988, In : Molecular Biology and Medicine. 5, 3, p. 173-184 12 p.

Research output: Contribution to journalArticle

A cluster of cystic fibrosis mutations in the first nucleotide-binding fold of the cystic fibrosis conductance regulator protein

Cutting, G. R., Kasch, L. M., Rosenstein, B. J., Zielenski, J., Tsui, L. C., Antonarakis, S. E. & Kazazian, H. H., Jan 1 1990, In : Nature. 346, 6282, p. 366-369 4 p.

Research output: Contribution to journalArticle

ACMG recommendations for standards for interpretation of sequence variations

Kazazian, J., Boehm, C. D. & Seltzer, W. K., Jan 1 2000, In : Genetics in Medicine. 2, 5, p. 302-303 2 p.

Research output: Contribution to journalComment/debate

Open Access

A combined analysis of D22S278 marker alleles in affected sib-pairs: Support for a susceptibility locus for schizophrenia at chromosome 22q12

Gill, M., Vallada, H., Collier, D., Sham, P., Holmans, P., Murray, R., McGuffin, P., Nanko, S., Owen, M., Antonarakis, S., Housman, D., Kazazian, H., Nestadt, G., Pulver, A. E., Straub, R. E., MacLean, C. J., Walsh, D., Kendler, K. S. & DeLisi, L., 1996, In : American Journal of Medical Genetics - Neuropsychiatric Genetics. 67, 1, p. 40-45 6 p.

Research output: Contribution to journalArticle

Active human retrotransposons: Variation and disease

Hancks, D. C. & Kazazian, H. H., Jun 2012, In : Current Opinion in Genetics and Development. 22, 3, p. 191-203 13 p.

Research output: Contribution to journalReview article

Additional Support for Schizophrenia Linkage on Chromosomes 6 and 8: A Multicenter Study

Wildenauer, D. B., Schwab, S. G., Albus, M., Hallmayer, J., Lerer, B., Maier, W., Blackwood, D., Muir, W., St Clair, D., Morris, S., Moises, H. W., Yang, L., Kristbjarnarson, H., Helgason, T., Wiese, C., Collier, D. A., Holmans, P., Daniels, J., Rees, M., Asherson, P. & 107 others, Roberts, Q., Cardno, A., Arranz, M. J., Vallada, H., Ball, D., Kunugi, H., Murray, R. M., Powell, J. F., Nanko, S., Sham, P., Gill, M., McGuffin, P., Owen, M. J., Pulver, A. E., Antonarakis, S. E., Babb, R., Blouin, J. L., DeMarchi, N., Dombroski, B., Housman, D., Karayiorgou, M., Ott, J., Kasch, L., Kazazian, H., Lasseter, V. K., Loetscher, E., Luebbert, H., Nestadt, G., Ton, C., Wolyniec, P. S., Laurent, C., de Chaldee, M., Thibaut, F., Jay, M., Samolyk, D., Petit, M., Campion, D., Mallet, J., Straub, R. E., MacLean, C. J., Easter, S. M., O'Neill, F. A., Walsh, D., Kendler, K. S., Gejman, P. V., Cao, Q., Gershon, E., Badner, J., Beshah, E., Zhang, J., Riley, B. P., Rajagopalan, S., Mogudi-Carter, M., Jenkins, T., Williamson, R., DeLisi, L. E., Garner, C., Kelly, M., LeDuc, C., Cardon, L., Lichter, J., Harris, T., Loftus, J., Shields, G., Comasi, M., Vita, A., Smith, A., Dann, J., Joslyn, G., Gurling, H., Kalsi, G., Brynjolfsson, J., Curtis, D., Sigmundsson, T., Butler, R., Read, T., Murphy, P., Chen, A. C. H., Petursson, H., Byerley, B., Hoff, M., Holik, J., Coon, H., Levinson, D. F., Nancarrow, D. J., Crowe, R. R., Andreasen, N., Silverman, J. M., Mohs, R. C., Siever, L. J., Endicott, J., Sharpe, L., Walters, M. K., Lennon, D. P., Hayward, N. K., Sandkuijl, L. A., Mowry, B. J., Aschauer, H. N., Meszaros, K., Lenzinger, E., Fuchs, K., Yang, L., Heiden, A. M., Moises, H. W., Kruglyak, L., Daly, M. J. & Matise, T. C., 1996, In : American journal of medical genetics. 67, 6, p. 580-594 15 p.

Research output: Contribution to journalArticle

Adult hemoglobin synthesis by reticulocytes from the human fetus at midtrimester

Hollenberg, M. D., Kaback, M. M. & Kazazian, H. H., Jan 1 1971, In : Science. 174, 4010, p. 698-702 5 p.

Research output: Contribution to journalArticle

ADULT HEMOGLOBIN SYNTHESIS IN THE HUMAN FETUS

Kazazian, H. H. & Woodhead, A. P., Nov 1974, In : Annals of the New York Academy of Sciences. 241, 1, p. 691-698 8 p.

Research output: Contribution to journalArticle

Age at diagnosis as an indicator of eligibility for BRCA1 DNA testing in familial breast cancer

Giambona, A., Gioco, P. L., Marino, M., Abate, I., Di Marzo, R., Renda, M., Di Trapani, F., Messana, F., Siciliano, S., Rigano, P., Chehab, F. F., Kazazian, H. H. & Maggio, A., May 1 1995, In : Human genetics. 95, 5, p. 526-530 5 p.

Research output: Contribution to journalArticle

A geneticist's view of lung disease

Kazazian, H. H., Dec 1 1976, In : American Review of Respiratory Disease. 113, 3, p. 261-266 6 p.

Research output: Contribution to journalArticle

A higher-impact Human Mutation launches web-based submission/peer review and Early View rapid publication

Cotton, R. G. H., Kazazian, H. H. & Paalman, M. H., 2003, In : Human mutation. 21, 1, p. 1 1 p.

Research output: Contribution to journalEditorial

Aicardi-Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion

Li, P., Du, J., Goodier, J. L., Hou, J., Kang, J., Kazazian, H. H., Zhao, K. & Yu, X. F., 2017, In : Nucleic acids research. 45, 8, p. 4619-4631 13 p.

Research output: Contribution to journalArticle

A linkage map of three anonymous human DNA fragments and SOD-1 on chromosome 21.

Kittur, S. D., Antonarakis, S. E., Tanzi, R. E., Meyers, D. A., Chakravarti, A., Groner, Y., Phillips, J. A., Watkins, P. C., Gusella, J. F. & Kazazian, H. H., Sep 1985, In : The EMBO journal. 4, 9, p. 2257-2260 4 p.

Research output: Contribution to journalArticle

Allan Award Lecture: on jumping fields and "jumping genes".

Kazazian, H. H., Feb 2009, In : American journal of human genetics. 84, 2, p. 105-114 10 p.

Research output: Contribution to journalArticle

Allelic Heterogeneity in LINE-1 Retrotransposition Activity

Lutz, S. M., Vincent, B. J., Kazazian, H. H., Batzer, M. A. & Moran, J. V., Dec 2003, In : American journal of human genetics. 73, 6, p. 1431-1437 7 p.

Research output: Contribution to journalArticle

A molecular basis for hemoglobin-H disease in American blacks

Phillips, J. A., Scott, A. F., Smith, K. D., Young, K. E., Lightbody, K. L., Jiji, R. M. & Kazazian, H. H., Dec 1 1979, In : Blood. 54, 6, p. 1439-1445 7 p.

Research output: Contribution to journalArticle

A mouse model of human L1 retrotransposition

Ostertag, E. M., DeBerardinis, R. J., Goodier, J. L., Zhang, Y., Yang, N., Gerton, G. L. & Kazazian, H. H., Dec 1 2002, In : Nature genetics. 32, 4, p. 655-660 6 p.

Research output: Contribution to journalArticle

An actively retrotransposing, novel subfamily of mouse L1 elements

Naas, T. P., Deberardinis, R. J., Moran, J. V., Ostertag, E. M., Kingsmore, S. F., Seldin, M. F., Hayashizaki, Y., Martin, S. L. & Kazazian, H. H., Jan 15 1998, In : EMBO Journal. 17, 2, p. 590-597 8 p.

Research output: Contribution to journalArticle

Analysis of factor VIII gene inversion mutations in 166 unrelated haemophilia A families: Frequency and utility in genetic counselling

Vnencak-Jones, C. L., Phillips, J. A., Janco, R. L., Cohen, M. P., Dupont, W. D., Kazazian, H. H. & Rossiter, J. P., Jan 1 1996, In : Haemophilia. 2, 1, p. 18-23 6 p.

Research output: Contribution to journalArticle

Analysis of the promoter from an expanding mouse retrotransposon subfamily

Deberardinis, R. J. & Kazazian, H. H., Mar 15 1999, In : Genomics. 56, 3, p. 317-323 7 p.

Research output: Contribution to journalArticle

An estimated frequency of endogenous insertional mutations in humans [4]

Kazazian, J., 1999, In : Nature genetics. 22, 2, 1 p.

Research output: Contribution to journalLetter

A new mutation of IVS-1 of the human β globin gene causing β thalassemia due to abnormal splicing

Atweh, G. F., Wong, C., Reed, R., Antonarakis, S. E., Zhu, D., Ghosh, P. K., Maniatis, T., Forget, B. G. & Kazazian, H. H., Sep 23 1987, In : Blood. 70, 1, p. 147-151 5 p.

Research output: Contribution to journalArticle

A new retrotransposable human L1 element from the LRE2 locus on chromosome 1q produces a chimaeric insertion

Holmes, S. E., Dombroski, B. A., Krebs, C. M., Boehm, C. D. & Kazazian, H. H., Jun 1 1994, In : Nature genetics. 7, 2, p. 143-148 6 p.

Research output: Contribution to journalArticle

An important role for RUNX3 in human L1 transcription and retrotransposition

Yang, N., Zhang, L., Zhang, Y. & Kazazian, H. H., Aug 15 2003, In : Nucleic acids research. 31, 16, p. 4929-4940 12 p.

Research output: Contribution to journalArticle

An in vivo assay for the reverse transcriptase of human retrotransposon L1 in Saccharomyces cerevisiae

Dombroski, B. A., Feng, Q., Mathias, S. L., Sassaman, D. M., Scott, A. F., Kazazian, H. H. & Boeke, J. D., Jul 1994, In : Molecular and cellular biology. 14, 7, p. 4485-4492 8 p.

Research output: Contribution to journalArticle

Open Access

An Mspl polymorphism at the MX1 locus in 21q22.3

Mcginniss, M. J., Horisberger, M. A., Kazazian, H. H. & Antonarakis, S. E., Oct 11 1991, In : Nucleic acids research. 19, 19, 1 p.

Research output: Contribution to journalArticle

A novel active L1 retrotransposon subfamily in the mouse

Goodier, J. L., Ostertag, E. M., Du, K. & Kazazian, J., 2001, In : Genome research. 11, 10, p. 1677-1685 9 p.

Research output: Contribution to journalArticle

A novel testis ubiquitin-binding protein gene arose by exon shuffling in hominoids

Babushok, D. V., Ohshima, K., Ostertag, E. M., Chen, X., Wang, Y., Mandal, P. K., Okada, N., Abrams, C. S. & Kazazian, H. H., 2007, In : Genome research. 17, 8, p. 1129-1138 10 p.

Research output: Contribution to journalArticle

Antenatal Detection of Sickle-Cell Anemia

Kazazian, H. H., Jul 6 1972, In : New England Journal of Medicine. 287, 1, p. 41-42 2 p.

Research output: Contribution to journalEditorial

Anticipation and instability of IT-15 (CAG)(N) repeats in parent-offspring pairs with Huntington disease

Ranen, N. G., Stine, O. C., Abbott, M. H., Sherr, M., Codori, A. M., Franz, M. L., Chao, N. I., Chung, A. S., Pleasant, N., Callahan, C., Kasch, L. M., Ghaffari, M., Chase, G. A., Kazazian, H. H., Brandt, J., Folstein, S. E. & Ross, C. A., 1995, In : American journal of human genetics. 57, 3, p. 593-602 10 p.

Research output: Contribution to journalArticle

A potential role for the nucleous in L1 retrotransposition

Goodier, J. L., Ostertag, E. M., Engleka, K. A., Seleme, M. C. & Kazazian, H. H., May 15 2004, In : Human molecular genetics. 13, 10, p. 1041-1048 8 p.

Research output: Contribution to journalArticle

A rapid DNA method for first-trimester prenatal diagnosis.

Di Marzo, R., Maggio, A., D'Agostino, S., Dowling, C. E., Wong, C. & Kazazian, H. H., Dec 1 1988, In : British journal of haematology. 70, 4, p. 504-505 2 p.

Research output: Contribution to journalLetter

A single adeno-associated virus (AAV)-murine factor VIII vector partially corrects the hemophilia A phenotype

Sarkar, R., Xiaoy, W. & Kazazian, H. H., Feb 2003, In : Journal of Thrombosis and Haemostasis. 1, 2, p. 220-226 7 p.

Research output: Contribution to journalArticle

ATA box transcription mutation in β-thalassemia

Orkin, S. H., Sexton, J. P., Cheng, T. C., Goff, S. C., Giardina, P. J. V., Joseph, I. L. & Hazazian, H. H., Jul 25 1983, In : Nucleic acids research. 11, 14, p. 4727-4734 8 p.

Research output: Contribution to journalArticle

A transmission disequilibrium and linkage analysis of D22S278 marker alleles in 574 families: Further support for a susceptibility locus for schizophrenia at 22q12

Schizophrenia Collaborative Linkage Group for Chromosome 22, Jul 27 1998, In : Schizophrenia Research. 32, 2, p. 115-121 7 p.

Research output: Contribution to journalArticle

Base substitution at position -88 in a β-thalassemic globin gene. Further evidence for the role of distal promoter element ACACCC

Orkin, S. H., Antonarakis, S. E. & Kazazian, H. H., Jan 1 1984, In : Journal of Biological Chemistry. 259, 14, p. 8679-8681 3 p.

Research output: Contribution to journalArticle

Biology of mammalian L1 retrotransposons

Ostertag, E. M. & Kazazian, J., Dec 1 2001, In : Annual review of genetics. 35, p. 501-538 38 p.

Research output: Contribution to journalReview article

Changing erythrocyte populations in juvenile chronic myelocytic leukemia: evidence for disordered regulation

Dover, G. J., Boyer, S. H., Zinkham, W. H., Kazazian, H. H., Pinney, D. J. & Sigler, A., Jan 1 1977, In : Unknown Journal. 49, 3, p. 355-365 11 p.

Research output: Contribution to journalArticle

Open Access

Characterization of 5'-terminal methylation of human α- and β-globin mRNAs

Cho, S., Cheng, T. & Kazazian, H. H., Dec 1 1978, In : Journal of Biological Chemistry. 253, 16, p. 5558-5561 4 p.

Research output: Contribution to journalArticle

Characterization of a nondeleterious L1 insertion in an intron of the human factor VIII gene and further evidence of open reading frames in functional L1 elements

Woods-Samuels, P., Wong, C., Mathias, S. L., Scott, A. F., Kazazian, H. H. & Antonarakis, S. E., Apr 1989, In : Genomics. 4, 3, p. 290-296 7 p.

Research output: Contribution to journalArticle

Characterization of a spontaneous mutation to a β-thalassemia allele

Kazazian, H. H., Orkin, S. H., Boehm, C. D., Goff, S. C., Wong, C., Dowling, C. E., Newburger, P. E., Knowlton, R. G., Brown, V. & Donis-Keller, H., Nov 12 1986, In : American journal of human genetics. 38, 6, p. 860-867 8 p.

Research output: Contribution to journalArticle

Characterization of a thrombin cleavage site mutation (Arg 1689 to Cys) in the factor VIII gene of two unrelated patients with cross-reacting material-positive hemophilia A

Arai, M., Higuchi, M., Antonarakis, S. E., Kazazian, H. H., Phillips, J. A., Janco, R. L. & Hoyer l., W., 1990, In : Blood. 75, 2, p. 384-389 6 p.

Research output: Contribution to journalArticle

Characterization of five partial deletions of the factor VIII gene

Youssoufian, H., Antonarakis, S. E., Aronis, S., Tsiftis, G., Phillips, D. G. & Kazazian, H. H., Aug 14 1987, In : Proceedings of the National Academy of Sciences of the United States of America. 84, 11, p. 3772-3776 5 p.

Research output: Contribution to journalArticle

Characterization of mutations in the factor VIII gene by direct sequencing of amplified genomic DNA

Higuchi, M., Wong, C., Kochhan, L., Olek, K., Aronis, S., Kasper, C. K., Kazazian, H. H. & Antonarakis, S. E., Jan 1990, In : Genomics. 6, 1, p. 65-71 7 p.

Research output: Contribution to journalArticle

Characterization of β-thalassaemia mutations using direct genomic sequencing of amplified single copy DNA

Wong, C., Dowling, C. E., Saiki, R. K., Higuchi, R. G., Erlich, H. A. & Kazazian, H. H., Jan 1 1987, In : Nature. 330, 6146, p. 384-386 3 p.

Research output: Contribution to journalArticle