Haig Kazazian

Professor

1965 …2020

Research output per year

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Research Output

2020

Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

PCAWG Structural Variation Working Group & PCAWG Consortium, Mar 1 2020, In : Nature genetics. 52, 3, p. 306-319 14 p.

Research output: Contribution to journalArticle

Open Access
2019

Mobile DNA in Endocrinology: LINE-1 Retrotransposon Causing Partial Androgen Insensitivity Syndrome

Batista, R. L., Yamaguchi, K., Rodrigues, A. D. S., Nishi, M. Y., Goodier, J. L., Carvalho, L. R., Domenice, S., Costa, E. M. F., Kazazian, H. H. & Mendonca, B. B., Dec 1 2019, In : Journal of Clinical Endocrinology and Metabolism. 104, 12, p. 6385-6390 6 p.

Research output: Contribution to journalArticle

2018

Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis

Pereira, G. C., Sanchez, L., Schaughency, P. M., Rubio-Roldán, A., Choi, J. A., Planet, E., Batra, R., Turelli, P., Trono, D., Ostrow, L. W., Ravits, J., Kazazian, H. H., Wheelan, S. J., Heras, S. R., Mayer, J., García-Pérez, J. L. & Goodier, J. L., Dec 15 2018, In : Mobile DNA. 9, 1, 35.

Research output: Contribution to journalArticle

2017

Aicardi-Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion

Li, P., Du, J., Goodier, J. L., Hou, J., Kang, J., Kazazian, H. H., Zhao, K. & Yu, X. F., 2017, In : Nucleic acids research. 45, 8, p. 4619-4631 13 p.

Research output: Contribution to journalArticle

Fifty years in human genetics - A career retrospective

Kazazian, H., Sep 1 2017, In : FASEB Journal. 31, 9, p. 3712-3718 7 p.

Research output: Contribution to journalReview article

Heritable L1 retrotransposition in the mouse primordial germline and early embryo

Richardson, S. R., Gerdes, P., Gerhardt, D. J., Sanchez-Luque, F. J., Bodea, G. O., Muñoz-Lopez, M., Jesuadian, J. S., Kempen, M. J. H. C., Carreira, P. E., Jeddeloh, J. A., Garcia-Perez, J. L., Kazazian, H. H., Ewing, A. D. & Faulkner, G. J., Aug 2017, In : Genome research. 27, 8, p. 1395-1405 11 p.

Research output: Contribution to journalArticle

Mobile DNA in health and disease

Kazazian, H. & Moran, J. V., Jul 27 2017, In : New England Journal of Medicine. 377, 4, p. 361-370 10 p.

Research output: Contribution to journalReview article

Reading LINEs within the cocaine addicted brain

Doyle, G. A., Doucet-O'Hare, T. T., Hammond, M. J., Crist, R. C., Ewing, A. D., Ferraro, T. N., Mash, D. C., Kazazian, H. & Berrettini, W. H., May 1 2017, In : Brain and Behavior. 7, 5, e00678.

Research output: Contribution to journalArticle

Retrotransposon contribution to genomic plasticity

Doucet-O’Hare, T. T. & Kazazian, H., Jan 1 2017, Human Retrotransposons in Health and Disease. Springer International Publishing, p. 63-93 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

25 Years of Human Mutation

Cutting, G. R. & Kazazian, H., Jun 1 2016, In : Human Mutation. 37, 6, p. 503-504 2 p.

Research output: Contribution to journalArticle

Long interspersed element sequencing (L1-seq): A method to identify somatic LINE-1 insertions in the human genome

Doucet, T. T. & Kazazian, H. H., Jan 1 2016, Methods in Molecular Biology. Humana Press Inc., p. 79-93 15 p. (Methods in Molecular Biology; vol. 1400).

Research output: Chapter in Book/Report/Conference proceedingChapter

Purification of L1-ribonucleoprotein particles (L1-RNPs) from cultured human cells

Mandal, P. K. & Kazazian, H. H., Jan 1 2016, Methods in Molecular Biology. Humana Press Inc., p. 299-310 12 p. (Methods in Molecular Biology; vol. 1400).

Research output: Chapter in Book/Report/Conference proceedingChapter

Roles for retrotransposon insertions in human disease

Hancks, D. C. & Kazazian, H. H., May 6 2016, In : Mobile DNA. 7, 1, 65.

Research output: Contribution to journalReview article

Somatically Acquired LINE-1 Insertions in Normal Esophagus Undergo Clonal Expansion in Esophageal Squamous Cell Carcinoma

Doucet-O'Hare, T. T., Sharma, R., Rodić, N., Anders, R. A., Burns, K. & Kazazian, H., Sep 1 2016, In : Human Mutation. 37, 9, p. 942-954 13 p.

Research output: Contribution to journalArticle

2015

2014 William Allan Award Introduction: Stuart Orkin1

Kazazian, H. H., Mar 5 2015, In : American journal of human genetics. 96, 3, p. 352-353 2 p.

Research output: Contribution to journalComment/debate

In Memoriam: Richard G.H. Cotton (1940-2015)

Kazazian, H. H., Paalman, M. H. & Cutting, G. R., Aug 1 2015, In : Human Mutation. 36, 8, p. 741-742 2 p.

Research output: Contribution to journalArticle

LINE-1 expression and retrotransposition in Barrett's esophagus and esophageal carcinoma

Doucet-O'Hare, T. T., Rodić, N., Sharma, R., Darbari, I., Abril, G., Choi, J. A., Ahn, J. Y., Cheng, Y., Anders, R. A., Burns, K. H., Meltzer, S. J. & Kazazian, H. H., Sep 1 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 35, p. E4894-E4900

Research output: Contribution to journalArticle

The Broad-Spectrum Antiviral Protein ZAP Restricts Human Retrotransposition

Goodier, J. L., Pereira, G. C., Cheung, L. E., Rose, R. J. & Kazazian, H. H., May 1 2015, In : PLoS genetics. 11, 5, e1005252.

Research output: Contribution to journalArticle

Use of PCR in the diagnosis of monogenic disease

Kazazian, H., Dec 31 2015, PCR Technology: Principles and Applications for DNA Amplification. Palgrave Macmillan, p. 153-169 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution

Ewing, A. D., Gacita, A., Wood, L. D., Ma, F., Xing, D., Kim, M. S., Manda, S. S., Abril, G., Pereira, G., Makohon-Moore, A., Looijenga, L. H. J., Gillis, A. J. M., Hruban, R. H., Anders, R. A., Romans, K. E., Pandey, A., Iacobuzio-Donahue, C. A., Vogelstein, B., Kinzler, K. W., Kazazian, H. H. & 1 others, Solyom, S., Oct 1 2015, In : Genome research. 25, 10, p. 1536-1545 10 p.

Research output: Contribution to journalArticle

2014

Processed pseudogene insertions in somatic cells

Kazazian, H. H., Jul 2 2014, In : Mobile DNA. 5, 1, 20.

Research output: Contribution to journalReview article

2013

Enrichment of processed pseudogene transcripts in L1-ribonucleoprotein particles

Mandal, P. K., Ewing, A. D., Hancks, D. C. & Kazazian, H. H., Sep 1 2013, In : Human molecular genetics. 22, 18, p. 3730-3748 19 p., ddt225.

Research output: Contribution to journalArticle

In vitro screening for compounds that enhance human L1 mobilization.

Terasaki, N., Goodier, J. L., Cheung, L. E., Wang, Y. J., Kajikawa, M., Kazazian, H. H. & Okada, N., 2013, In : PloS one. 8, 9

Research output: Contribution to journalArticle

Open Access

Mapping the LINE1 ORF1 protein interactome reveals associated inhibitors of human retrotransposition

Goodier, J. L., Cheung, L. E. & Kazazian, H. H., Aug 2013, In : Nucleic acids research. 41, 15, p. 7401-7419 19 p.

Research output: Contribution to journalArticle

Modulation of LINE-1 and Alu/SVA Retrotransposition by Aicardi-Goutières Syndrome-Related SAMHD1

Zhao, K., Du, J., Han, X., Goodier, J. L., Li, P., Zhou, X., Wei, W., Evans, S. L., Li, L., Zhang, W., Cheung, L. E., Wang, G., Kazazian, H. H. & Yu, X. F., Sep 26 2013, In : Cell Reports. 4, 6, p. 1108-1115 8 p.

Research output: Contribution to journalArticle

2012

Active human retrotransposons: Variation and disease

Hancks, D. C. & Kazazian, H. H., Jun 2012, In : Current Opinion in Genetics and Development. 22, 3, p. 191-203 13 p.

Research output: Contribution to journalReview article

Extensive somatic L1 retrotransposition in colorectal tumors

Solyom, S., Ewing, A. D., Rahrmann, E. P., Doucet, T., Nelson, H. H., Burns, M. B., Harris, R. S., Sigmon, D. F., Casella, A., Erlanger, B., Wheelan, S., Upton, K. R., Shukla, R., Faulkner, G. J., Largaespada, D. A. & Kazazian, H. H., Dec 2012, In : Genome research. 22, 12, p. 2328-2338 11 p.

Research output: Contribution to journalArticle

Mobile elements in the human genome: Implications for disease

Solyom, S. & Kazazian, H. H., Feb 24 2012, In : Genome Medicine. 4, 2, 12.

Research output: Contribution to journalReview article

MOV10 RNA Helicase Is a Potent Inhibitor of Retrotransposition in Cells

Goodier, J. L., Cheung, L. E. & Kazazian, H. H., Oct 2012, In : PLoS genetics. 8, 10, e1002941.

Research output: Contribution to journalArticle

Pathogenic orphan transduction created by a nonreference LINE-1 retrotransposon

Solyom, S., Ewing, A. D., Hancks, D. C., Takeshima, Y., Awano, H., Matsuo, M. & Kazazian, H. H., Feb 2012, In : Human mutation. 33, 2, p. 369-371 3 p.

Research output: Contribution to journalArticle

The minimal active human SVA retrotransposon requires only the 5′-Hexamer and Alu-like domains

Hancks, D. C., Mandal, P. K., Cheung, L. E. & Kazazian, H. H., Nov 1 2012, In : Molecular and cellular biology. 32, 22, p. 4718-4726 9 p.

Research output: Contribution to journalArticle

2011

Efficacy and safety of long-term prophylaxis in severe hemophilia a dogs following liver gene therapy using AAV vectors

Sabatino, D. E., Lange, A. M., Altynova, E. S., Sarkar, R., Zhou, S., Merricks, E. P., Franck, H. G., Nichols, T. C., Arruda, V. R. & Kazazian Jr, H. H., Mar 2011, In : Molecular Therapy. 19, 3, p. 442-449 8 p.

Research output: Contribution to journalArticle

Mobile DNA transposition in somatic cells

Kazazian, H. H., Sep 29 2011, In : BMC Biology. 9, 62.

Research output: Contribution to journalComment/debate

Retrotransposition of marked SVA elements by human L1s in cultured cells

Hancks, D. C., Goodier, J. L., Mandal, P. K., Cheung, L. E. & Kazazian, H. H., Sep 2011, In : Human molecular genetics. 20, 17, p. 3386-3400 15 p., ddr245.

Research output: Contribution to journalArticle

Whole-genome resequencing allows detection of many rare LINE-1 insertion alleles in humans

Ewing, A. D. & Kazazian, H. H., Jun 1 2011, In : Genome research. 21, 6, p. 985-990 6 p.

Research output: Contribution to journalArticle

2010

Discrete subcellular partitioning of human retrotransposon RNAs despite a common mechanism of genome insertion

Goodier, J. L., Mandal, P. K., Zhang, L. & Kazazian, H. H., Feb 10 2010, In : Human molecular genetics. 19, 9, p. 1712-1725 14 p., ddq048.

Research output: Contribution to journalArticle

Eradication of neutralizing antibodies to factor VIII In canine hemophilia a after liver gene therapy

Finn, J. D., Ozelo, M. C., Sabatino, D. E., Franck, H. W. G., Merricks, E. P., Crudele, J. M., Zhou, S., Kazazian, H. H., Lillicrap, D., Nichols, T. C. & Arruda, V. R., Dec 23 2010, In : Blood. 116, 26, p. 5842-5848 7 p.

Research output: Contribution to journalArticle

High-throughput sequencing reveals extensive variation in human-specific L1 content in individual human genomes

Ewing, A. D. & Kazazian, H. H., Sep 1 2010, In : Genome research. 20, 9, p. 1262-1270 9 p.

Research output: Contribution to journalArticle

SVA retrotransposons: Evolution and genetic instability

Hancks, D. C. & Kazazian, H. H., Aug 2010, In : Seminars in Cancer Biology. 20, 4, p. 234-245 12 p.

Research output: Contribution to journalReview article

2009

Allan Award Lecture: on jumping fields and "jumping genes".

Kazazian, H. H., Feb 2009, In : American journal of human genetics. 84, 2, p. 105-114 10 p.

Research output: Contribution to journalArticle

Exon-trapping mediated by the human retrotransposon SVA

Hancks, D. C., Ewing, A. D., Chen, J. E., Tokunaga, K. & Kazazian, H. H., Nov 2009, In : Genome research. 19, 11, p. 1983-1991 9 p.

Research output: Contribution to journalArticle

L1 retrotransposition occurs mainly in embryogenesis and creates somatic mosaicism

Kano, H., Godoy, I., Courtney, C., Vetter, M. R., Gerton, G. L., Ostertag, E. M. & Kazazian, H. H., Jun 1 2009, In : Genes and Development. 23, 11, p. 1303-1312 10 p.

Research output: Contribution to journalArticle

Many LINE1 elements contribute to the transcriptome of human somatic cells

Rangwala, S. H., Zhang, L. & Kazazian, H. H., Sep 22 2009, In : Genome biology. 10, 9, R100.

Research output: Contribution to journalArticle

Recombinant canine B-domain-deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model

Sabatino, D. E., Freguia, C. F., Toso, R., Santos, A., Merricks, E. P., Kazazian, H. H., Nichols, T. C., Camire, R. M. & Arruda, V. R., Nov 12 2009, In : Blood. 114, 20, p. 4562-4565 4 p.

Research output: Contribution to journalArticle

The L1 retrotransposition assay: A retrospective and toolkit

Rangwala, S. H. & Kazazian, H. H., Nov 1 2009, In : Methods. 49, 3, p. 219-226 8 p.

Research output: Contribution to journalReview article

2008

In memoriam: Victor A. McKusick (1921-2008)

Cotton, R. G. H., Kazazian, H. H., Cutting, G. R. & Paalman, M. H., Oct 1 2008, In : Human mutation. 29, 10, p. 1169-1170 2 p.

Research output: Contribution to journalEditorial

Retrotransposons Revisited: The Restraint and Rehabilitation of Parasites

Goodier, J. L. & Kazazian, H. H., Oct 3 2008, In : Cell. 135, 1, p. 23-35 13 p.

Research output: Contribution to journalReview article

SnapShot: Vertebrate Transposons

Mandal, P. K. & Kazazian, H. H., Oct 3 2008, In : Cell. 135, 1, p. 192-192.e1

Research output: Contribution to journalShort survey

2007

A novel testis ubiquitin-binding protein gene arose by exon shuffling in hominoids

Babushok, D. V., Ohshima, K., Ostertag, E. M., Chen, X., Wang, Y., Mandal, P. K., Okada, N., Abrams, C. S. & Kazazian, H. H., 2007, In : Genome research. 17, 8, p. 1129-1138 10 p.

Research output: Contribution to journalArticle

Current topics in genome evolution: Molecular mechanisms of new gene formation

Babushok, D. V., Ostertag, E. M. & Kazazian, H. H., Mar 1 2007, In : Cellular and Molecular Life Sciences. 64, 5, p. 542-554 13 p.

Research output: Contribution to journalReview article