Gyanu Lamichhane

Associate Professor

20032019

Research output per year

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Research Output

2019

Identification of potent L,D-transpeptidase 5 inhibitors for Mycobacterium tuberculosis as potential anti-TB leads: virtual screening and molecular dynamics simulations

Sabe, V. T., Tolufashe, G. F., Ibeji, C. U., Maseko, S. B., Govender, T., Maguire, G. E. M., Lamichhane, G., Honarparvar, B. & Kruger, H. G., Nov 1 2019, In : Journal of Molecular Modeling. 25, 11, 328.

Research output: Contribution to journalArticle

Inhibition mechanism of L,D-transpeptidase 5 in presence of the β-lactams using ONIOM method

Tolufashe, G. F., Sabe, V. T., Ibeji, C. U., Lawal, M. M., Govender, T., Maguire, G. E. M., Lamichhane, G., Kruger, H. G. & Honarparvar, B., Mar 1 2019, In : Journal of Molecular Graphics and Modelling. 87, p. 204-210 7 p.

Research output: Contribution to journalArticle

N-Trifluoromethylthiolated Sulfonimidamides and Sulfoximines: Anti-microbial, Anti-mycobacterial, and Cytotoxic Activity

Thota, N., Makam, P., Rajbongshi, K. K., Nagiah, S., Abdul, N. S., Chuturgoon, A. A., Kaushik, A., Lamichhane, G., Somboro, A. M., Kruger, H. G., Govender, T., Naicker, T. & Arvidsson, P. I., Oct 10 2019, In : ACS Medicinal Chemistry Letters. 10, 10, p. 1457-1461 5 p.

Research output: Contribution to journalArticle

Select -Lactam Combinations Exhibit Synergy against Mycobacterium abscessus In Vitro

Story-Roller, E., Maggioncalda, E. C. & Lamichhane, G., Apr 1 2019, In : Antimicrobial agents and chemotherapy. e02613-18.

Research output: Contribution to journalArticle

Synergistic Efficacy of β-Lactam Combinations against Mycobacterium abscessus Pulmonary Infection in Mice

Story-Roller, E., Maggioncalda, E. C. & Lamichhane, G., Aug 1 2019, In : Antimicrobial agents and chemotherapy. 63, 8

Research output: Contribution to journalArticle

The Driving Force for the Acylation of β-Lactam Antibiotics by L,D-Transpeptidase 2: Quantum Mechanics/Molecular Mechanics (QM/MM) Study

Ibeji, C. U., Lawal, M. M., Tolufashe, G. F., Govender, T., Naicker, T., Maguire, G. E. M., Lamichhane, G., Kruger, H. G. & Honarparvar, B., Jan 1 2019, In : ChemPhysChem.

Research output: Contribution to journalArticle

2018

Activities of dual combinations of antibiotics against multidrug-resistant nontuberculous mycobacteria recovered from patients with cystic fibrosis

Schwartz, M., Fisher, S., Story-Roller, E., Lamichhane, G. & Parrish, N. M., Oct 1 2018, In : Microbial Drug Resistance. 24, 8, p. 1191-1197 7 p.

Research output: Contribution to journalArticle

Have we realized the full potential of β-lactams for treating drug-resistant TB?

Story-Roller, E. & Lamichhane, G., Sep 1 2018, In : IUBMB Life. 70, 9, p. 881-888 8 p.

Research output: Contribution to journalReview article

Inhibition of Mycobacterium tuberculosis L,D-Transpeptidase 5 by Carbapenems: MD and QM/MM Mechanistic Studies

Tolufashe, G. F., Halder, A. K., Ibeji, C. U., Lawal, M. M., Ntombela, T., Govender, T., Maguire, G. E. M., Lamichhane, G., Kruger, H. G. & Honarparvar, B., Dec 28 2018, In : ChemistrySelect. 3, 48, p. 13603-13612 10 p.

Research output: Contribution to journalArticle

Molecular insight on the non-covalent interactions between carbapenems and l,d-transpeptidase 2 from Mycobacterium tuberculosis: ONIOM study

Ntombela, T., Fakhar, Z., Ibeji, C. U., Govender, T., Maguire, G. E. M., Lamichhane, G., Kruger, H. G. & Honarparvar, B., May 29 2018, (Accepted/In press) In : Journal of Computer-Aided Molecular Design. p. 1-15 15 p.

Research output: Contribution to journalArticle

Mycobacterium abscessus and β-lactams: Emerging insights and potential opportunities

Story-Roller, E., Maggioncalda, E. C., Cohen, K. & Lamichhane, G., Sep 25 2018, In : Frontiers in Microbiology. 9, SEP, 2273.

Research output: Contribution to journalReview article

The catalytic role of water in the binding site of L,D-transpeptidase 2 within acylation mechanism: A QM/MM (ONIOM) modelling

Ibeji, C. U., Tolufashe, G. F., Ntombela, T., Govender, T., Maguire, G. E. M., Lamichhane, G., Kruger, H. G. & Honarparvar, B., Dec 1 2018, In : Tuberculosis. 113, p. 222-230 9 p.

Research output: Contribution to journalArticle

2017

Combinations of avibactam and carbapenems exhibit enhanced potencies against drug-resistant Mycobacterium abscessus

Kaushik, A., Gupta, C., Fisher, S., Story-Roller, E., Galanis, C., Parrish, N. M. & Lamichhane, G., May 1 2017, In : Future Microbiology. 12, 6, p. 473-480 8 p.

Research output: Contribution to journalArticle

Computational model for the acylation step of the β-lactam ring: Potential application for L,D-transpeptidase 2 in mycobacterium tuberculosis

Fakhar, Z., Govender, T., Lamichhane, G., Maguire, G. E. M., Kruger, H. G. & Honarparvar, B., Jan 15 2017, In : Journal of Molecular Structure. 1128, p. 94-102 9 p.

Research output: Contribution to journalArticle

Differential flap dynamics in l,d-transpeptidase2 from mycobacterium tuberculosis revealed by molecular dynamics

Fakhar, Z., Govender, T., Maguire, G. E. M., Lamichhane, G., Walker, R. C., Kruger, H. G. & Honarparvar, B., 2017, In : Molecular BioSystems. 13, 6, p. 1223-1234 12 p.

Research output: Contribution to journalArticle

Drug resistance mechanisms and novel drug targets for tuberculosis therapy

Islam, M. M., Hameed, H. M. A., Mugweru, J., Chhotaray, C., Wang, C., Tan, Y., Liu, J., Li, X., Tan, S., Ojima, I., Yew, W. W., Nuermberger, E., Lamichhane, G. & Zhang, T., Jan 20 2017, In : Journal of Genetics and Genomics. 44, 1, p. 21-37 17 p.

Research output: Contribution to journalReview article

Emerging therapies

Lamichhane, G. & Grosset, J. H., Mar 30 2017, Handbook of Tuberculosis. Springer International Publishing, p. 191-218 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Inhibition of innate immune cytosolic surveillance by an M.Tuberculosis phosphodiesterase

Dey, R. J., Dey, B., Zheng, Y., Cheung, L. S., Zhou, J., Sayre, D., Kumar, P., Guo, H., Lamichhane, G., Sintim, H. O. & Bishai, W. R., Feb 1 2017, In : Nature Chemical Biology. 13, 2, p. 210-217 8 p.

Research output: Contribution to journalArticle

In vitro and in vivo activity of biapenem against drug-susceptible and rifampicin-resistant Mycobacterium tuberculosis

Kaushik, A., Ammerman, N., Tasneen, R., Story-Roller, E., Dooley, K. E., Dorman, S. E., Nuermberger, E. & Lamichhane, G., Aug 1 2017, In : Journal of Antimicrobial Chemotherapy. 72, 8, p. 2320-2325 6 p., dkx152.

Research output: Contribution to journalArticle

LdtMav2, a nonclassical transpeptidase and susceptibility of Mycobacterium avium to carbapenems

Mattoo, R., Lloyd, E. P., Kaushik, A., Kumar, P., Brunelle, J. L., Townsend, C. A. & Lamichhane, G., Jun 1 2017, In : Future Microbiology. 12, 7, p. 595-607 13 p.

Research output: Contribution to journalArticle

Mutation in an unannotated protein confers carbapenem resistance in Mycobacterium tuberculosis

Kumar, P., Kaushik, A., Bell, D. T., Chauhan, V., Xia, F., Stevens, R. L. & Lamichhane, G., Mar 1 2017, In : Antimicrobial Agents and Chemotherapy. 61, 3, e02234.

Research output: Contribution to journalArticle

Mycobacterium abscessus L,D-transpeptidases are susceptible to inactivation by carbapenems and cephalosporins but not penicillins

Kumar, P., Chauhan, V., Silva, J. R. A., Lameira, J., D’Andrea, F. B., Li, S. G., Ginell, S. L., Freundlich, J. S., Alves, C. N., Bailey, S., Cohen, K. & Lamichhane, G., Oct 1 2017, In : Antimicrobial Agents and Chemotherapy. 61, 10, e00866.

Research output: Contribution to journalArticle

Pyrazinoic acid inhibits a bifunctional enzyme in Mycobacterium tuberculosis

Njire, M., Wang, N., Wang, B., Tan, Y., Cai, X., Liu, Y., Mugweru, J., Guo, J., Hameed, H. M. A., Tan, S., Liu, J., Yew, W. W., Nuermberger, E., Lamichhane, G., Liu, J. & Zhang, T., Jul 1 2017, In : Antimicrobial Agents and Chemotherapy. 61, 7, e00070-17.

Research output: Contribution to journalArticle

Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem

Bianchet, M. A., Pan, Y. H., Basta, L. A. B., Saavedra, H., Lloyd, E. P., Kumar, P., Mattoo, R., Townsend, C. A. & Lamichhane, G., May 25 2017, In : BMC Biochemistry. 18, 1, 8.

Research output: Contribution to journalArticle

Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery

Azzali, E., Machado, D., Kaushik, A., Vacondio, F., Flisi, S., Cabassi, C. S., Lamichhane, G., Viveiros, M., Costantino, G. & Pieroni, M., Aug 24 2017, In : Journal of Medicinal Chemistry. 60, 16, p. 7108-7122 15 p.

Research output: Contribution to journalArticle

2016

A comparative modeling and molecular docking study on Mycobacterium tuberculosis targets involved in peptidoglycan biosynthesis

Fakhar, Z., Naiker, S., Alves, C. N., Govender, T., Maguire, G. E. M., Lameira, J., Lamichhane, G., Kruger, H. G. & Honarparvar, B., Apr 3 2016, (Accepted/In press) In : Journal of Biomolecular Structure and Dynamics. p. 1-19 19 p.

Research output: Contribution to journalArticle

An evolved oxazolidinone with selective potency against Mycobacterium tuberculosis and gram positive bacteria

Kaushik, A., Heuer, A. M., Bell, D. T., Culhane, J. C., Ebner, D. C., Parrish, N. M., Ippoliti, J. T. & Lamichhane, G., Apr 19 2016, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

Carbapenems against Mycobacterium tuberculosis: A review of the evidence

Jaganath, D., Lamichhane, G. & Shah, M., Nov 1 2016, In : International Journal of Tuberculosis and Lung Disease. 20, 11, p. 1436-1447 12 p.

Research output: Contribution to journalReview article

Non-classical transpeptidases yield insight into new antibacterials

Kumar, P., Kaushik, A., Lloyd, E. P., Li, S. G., Mattoo, R., Ammerman, N., Bell, D. T., Perryman, A. L., Zandi, T. A., Ekins, S., Ginell, S. L., Townsend, C. A., Freundlich, J. S. & Lamichhane, G., Nov 7 2016, (Accepted/In press) In : Nature Chemical Biology.

Research output: Contribution to journalArticle

REMap: Operon map of M. tuberculosis based on RNA sequence data

Pelly, S., Winglee, K., Xia, F., Stevens, R. L., Bishai, W. R. & Lamichhane, G., Jul 1 2016, In : Tuberculosis. 99, p. 70-80 11 p.

Research output: Contribution to journalArticle

Role of the Cys154Arg substitution in ribosomal protein L3 in oxazolidinone resistance in Mycobacterium tuberculosis

Makafe, G. G., Cao, Y., Tan, Y., Julius, M., Liu, Z., Wang, C., Njire, M. M., Cai, X., Liu, T., Wang, B., Pang, W., Tan, S., Zhang, B., Yew, W. W., Lamichhane, G., Guo, J. & Zhang, T., May 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 5, p. 3202-3206 5 p.

Research output: Contribution to journalArticle

Targeting the cell wall of Mycobacterium tuberculosis: A molecular modeling investigation of the interaction of imipenem and meropenem with L,D-transpeptidase 2

Silva, J. R. A., Bishai, W. R., Govender, T., Lamichhane, G., Maguire, G. E. M., Kruger, H. G., Lameira, J. & Alves, C. N., 2016, In : Journal of Biomolecular Structure and Dynamics. 34, 2, p. 304-317 14 p.

Research output: Contribution to journalArticle

2015

Carbapenems and Rifampin exhibit synergy against Mycobacterium tuberculosis and Mycobacterium abscessus

Kaushik, A., Makkar, N., Pandey, P., Parrish, N. M., Singh, U. & Lamichhane, G., Oct 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 10, p. 6561-6567 7 p.

Research output: Contribution to journalArticle

Immunogenicity without efficacy of an adenoviral tuberculosis vaccine in a stringent mouse model for immunotherapy during treatment

Alyahya, S. A., Nolan, S. T., Smith, C. M. R., Bishai, W. R., Sadoff, J. & Lamichhane, G., May 21 2015, In : PLoS One. 10, 5, e0127907.

Research output: Contribution to journalArticle

Loss of a functionally and structurally distinct LD-transpeptidase, LdtMt5, compromises cell wall integrity in mycobacterium tuberculosis

Basta, L. A. B., Ghosh, A., Pan, Y., Jakoncic, J., Lloyd, E. P., Townsend, C. A., Lamichhane, G. & Bianchet, M. A., Oct 16 2015, In : Journal of Biological Chemistry. 290, 42, p. 25670-25685 16 p.

Research output: Contribution to journalArticle

Structural and functional features of enzymes of Mycobacterium tuberculosis peptidoglycan biosynthesis as targets for drug development

Moraes, G. L., Gomes, G. C., Monteiro De Sousa, P. R., Alves, C. N., Govender, T., Kruger, H. G., Maguire, G. E. M., Lamichhane, G. & Lameira, J., Mar 1 2015, In : Tuberculosis. 95, 2, p. 95-111 17 p.

Research output: Contribution to journalArticle

2014

Systems biology-based identification of Mycobacterium tuberculosis persistence genes in mouse lungs

Dutta, N., Bandyopadhyay, N., Veeramani, B., Lamichhane, G., Karakousis, P. & Bader, J. S., Feb 18 2014, In : mBio. 5, 1, e01066-13.

Research output: Contribution to journalArticle

2013

Definition and annotation of (myco)bacterial non-coding RNA

Lamichhane, G., Arnvig, K. B. & McDonough, K. A., Jan 2013, In : Tuberculosis. 93, 1, p. 26-29 4 p.

Research output: Contribution to journalArticle

2012

A screen for non-coding RNA in Mycobacterium tuberculosis reveals a cAMP-responsive RNA that is expressed during infection

Pelly, S., Bishai, W. R. & Lamichhane, G., May 25 2012, In : Gene. 500, 1, p. 85-92 8 p.

Research output: Contribution to journalArticle

Combining cheminformatics methods and pathway analysis to identify molecules with whole-cell activity against mycobacterium tuberculosis

Sarker, M., Talcott, C., Madrid, P., Chopra, S., Bunin, B. A., Lamichhane, G., Freundlich, J. S. & Ekins, S., Aug 2012, In : Pharmaceutical Research. 29, 8, p. 2115-2127 13 p.

Research output: Contribution to journalArticle

Targeting the cell wall of mycobacterium tuberculosis: Structure and mechanism of L,D-transpeptidase 2

Erdemli, S. B., Gupta, R., Bishai, W. R., Lamichhane, G., Amzel, M. L. & Bianchet, M. A., Dec 5 2012, In : Structure. 20, 12, p. 2103-2115 13 p.

Research output: Contribution to journalArticle

2011

Copper resistance is essential for virulence of Mycobacterium tuberculosis

Wolschendorf, F., Ackart, D., Shrestha, T. B., Hascall-Dove, L., Nolan, S., Lamichhane, G., Wang, Y., Bossmann, S. H., Basaraba, R. J. & Niederweis, M., Jan 25 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 4, p. 1621-1626 6 p.

Research output: Contribution to journalArticle

Essential metabolites of mycobacterium tuberculosis and their mimics

Lamichhane, G., Freundlich, J. S., Ekins, S., Wickramaratne, N., Nolan, S. T. & Bishai, W. R., Jan 2011, In : mBio. 2, 1

Research output: Contribution to journalArticle

Novel targets in M. tuberculosis: Search for new drugs

Lamichhane, G., Jan 2011, In : Trends in Molecular Medicine. 17, 1, p. 25-33 9 p.

Research output: Contribution to journalArticle

2010

Genetic requirements for the survival of tubercle bacilli in primates

Dutta, N., Mehra, S., Didier, P. J., Roy, C. J., Doyle, L. A., Alvarez, X., Ratterree, M., Be, N. A., Lamichhane, G., Jain, S., Lacey, M. R., Lackner, A. A. & Kaushal, D., Jun 1 2010, In : Journal of Infectious Diseases. 201, 11, p. 1743-1752 10 p.

Research output: Contribution to journalArticle

Methionine Aminopeptidases from Mycobacterium tuberculosis as Novel Antimycobacterial Targets

Olaleye, O., Raghunand, T. R., Bhat, S., He, J., Tyagi, S., Lamichhane, G., Gu, P., Zhou, J., Zhang, Y., Grosset, J., Bishai, W. R. & Liu, J., Jan 29 2010, In : Chemistry and Biology. 17, 1, p. 86-97 12 p.

Research output: Contribution to journalArticle

Protective efficacy of BCG overexpressing an L,D-transpeptidase against M. tuberculosisinfection

Nolan, S. T. & Lamichhane, G., 2010, In : PLoS One. 5, 10, e13773.

Research output: Contribution to journalArticle

The Impact of mouse passaging of Mycobacterium tuberculosis strains prior to virulence testing in the mouse and guinea pig aerosol models

Converse, P. J., Eisenach, K. D., Theus, S. A., Nuermberger, E., Tyagi, S., Ly, L. H., Geiman, D. E., Guo, H., Nolan, S. T., Akar, N. C., Klinkenberg, L. G., Gupta, R., Lun, S., Karakousis, P., Lamichhane, G., McMurray, D. N., Grosset, J. H. & Bishai, W. R., 2010, In : PLoS One. 5, 4, e10292.

Research output: Contribution to journalArticle