Guanshu Liu

Fac-Asst Prof- Staff

20012018
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Research Output 2001 2018

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Article
2018

MRI detection of bacterial brain abscesses and monitoring of antibiotic treatment using bacCEST

Liu, J., Bai, R., Li, Y., Staedtke, V., Zhang, S., van Zijl, P. C. M. & Liu, G. Jan 1 2018 (Accepted/In press) In : Magnetic resonance in medicine.

Research output: Contribution to journalArticle

Brain Abscess
Anti-Bacterial Agents
Bacterial Infections
Bacteria
Therapeutics

Phenols as Diamagnetic T2-Exchange Magnetic Resonance Imaging Contrast Agents

Zhang, J., Li, Y., Slania, S., Yadav, N. N., Liu, J., Wang, R., Zhang, J., Pomper, M. G., van Zijl, P. C., Yang, X. & Liu, G. Jan 26 2018 In : Chemistry - A European Journal. 24, 6, p. 1259-1263 5 p.

Research output: Contribution to journalArticle

Hole mobility
Chemical modification
Chemical shift
Enzyme activity
Magnetic resonance imaging
2017

A dextran-based probe for the targeted magnetic resonance imaging of tumours expressing prostate-specific membrane antigen

Liu, G., Banerjee, S. R., Yang, X., Yadav, N., Lisok, A., Jablonska, A., Xu, J., Li, Y., Pomper, M. G. & Van Zijl, P. Dec 1 2017 In : Nature Biomedical Engineering. 1, 12, p. 977-982 6 p.

Research output: Contribution to journalArticle

Dextran
Magnetic resonance
Antigens
Dextrans
Tumors

Characterization of tumor vascular permeability using natural dextrans and CEST MRI

Li, Y., Qiao, Y., Chen, H., Bai, R., Staedtke, V., Han, Z., Xu, J., Chan, K. W. Y., Yadav, N., Bulte, J. W. M., Zhou, S., van Zijl, P. C. M. & Liu, G. Jan 1 2017 (Accepted/In press) In : Magnetic Resonance in Medicine.

Research output: Contribution to journalArticle

Capillary Permeability
Dextrans
Neoplasms
Injections
Permeability

Detection and Quantification of Hydrogen Peroxide in Aqueous Solutions Using Chemical Exchange Saturation Transfer

Ryoo, D., Xu, X., Li, Y., Tang, J. A., Zhang, J., Van Zijl, P. C. M. & Liu, G. Jul 18 2017 In : Analytical Chemistry. 89, 14, p. 7758-7764 7 p.

Research output: Contribution to journalArticle

Saturation (materials composition)
Hydrogen Peroxide
Ion exchange
Nuclear magnetic resonance
Magnetic resonance

Detection of dynamic substrate binding using MRI

Yadav, N. N., Yang, X., Li, Y., Li, W., Liu, G. & Van Zijl, P. C. M. Dec 1 2017 In : Scientific Reports. 7, 1, 10138

Research output: Contribution to journalArticle

Protons
Magnetic Resonance Imaging
Water
Caffeine
Radio

GlucoCEST magnetic resonance imaging in vivo may be diagnostic of acute renal allograft rejection

Kentrup, D., Bovenkamp, P., Busch, A., Schuette-Nuetgen, K., Pawelski, H., Pavenstädt, H., Schlatter, E., Herrmann, K. H., Reichenbach, J. R., Löffler, B., Heitplatz, B., Van Marck, V., Yadav, N. N., Liu, G., van Zijl, P. C. M., Reuter, S. & Hoerr, V. Sep 1 2017 In : Kidney International. 92, 3, p. 757-764 8 p.

Research output: Contribution to journalArticle

Allografts
Magnetic Resonance Imaging
Kidney
Glucose
T-Lymphocytes

Monitoring tumor response to antivascular therapy using non-contrast intravoxel incoherent motion diffusion-weighted MRI

Shi, C., Liu, D., Xiao, Z., Zhang, D., Liu, G., Liu, G., Chen, H. & Luo, L. Jul 1 2017 In : Cancer Research. 77, 13, p. 3491-3501 11 p.

Research output: Contribution to journalArticle

Diffusion Magnetic Resonance Imaging
Neoplasms
Non-Small Cell Lung Carcinoma
Therapeutics
Perfusion

One-Component Supramolecular Filament Hydrogels as Theranostic Label-Free Magnetic Resonance Imaging Agents

Lock, L. L., Li, Y., Mao, X., Chen, H., Staedtke, V., Bai, R., Ma, W., Lin, R., Li, Y., Liu, G. & Cui, H. Jan 24 2017 In : ACS Nano. 11, 1, p. 797-805 9 p.

Research output: Contribution to journalArticle

Hydrogels
Magnetic resonance
Pemetrexed
magnetic resonance
Labels
2016

CEST-MRI detects metabolite levels altered by breast cancer cell aggressiveness and chemotherapy response

Chan, K. W. Y., Jiang, L., Cheng, M., Wijnen, J. P., Liu, G., Huang, P., van Zijl, P. C. M., Mcmahon, M. T. & Glunde, K. 2016 (Accepted/In press) In : NMR in Biomedicine.

Research output: Contribution to journalArticle

Chemotherapy
Metabolites
Magnetic resonance imaging
Cells
Breast Neoplasms

CEST theranostics: Label-free MR imaging of anticancer drugs

Li, Y., Chen, H., Xu, J., Yadav, N. N., Chan, K. W. Y., Luo, L., McMahon, M. T., Vogelstein, B., Van Zijl, P. C. M., Zhou, S. & Liu, G. 2016 In : Oncotarget. 7, 6, p. 6369-6378 10 p.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
gemcitabine
Folic Acid Antagonists
Neoplasms
Liposomes

Developing imidazoles as CEST MRI pH sensors

Yang, X., Song, X., Ray Banerjee, S., Li, Y., Byun, Y., Liu, G., Bhujwalla, Z. M., Pomper, M. G. & McMahon, M. T. Jul 1 2016 In : Contrast Media and Molecular Imaging. 11, 4, p. 304-312 9 p.

Research output: Contribution to journalArticle

Imidazoles
Magnetic Resonance Imaging
Heterocyclic Compounds
Intravenous Administration
Hydrogen

Imaging the DNA alkylator melphalan by CEST MRI: An advanced approach to theranostics

Ngen, E. J., Bar-Shir, A., Jablonska, A., Liu, G., Song, X., Ansari, R., Bulte, J. W. M., Janowski, M., Pearl, M., Walczak, P. & Gilad, A. A. Sep 6 2016 In : Molecular Pharmaceutics. 13, 9, p. 3043-3053 11 p.

Research output: Contribution to journalArticle

Melphalan
Alkylating Agents
Magnetic Resonance Imaging
DNA
Brain Neoplasms

Intravoxel incoherent motion diffusion weighted imaging in the assessment of the renal functional alternation in contrast-induced acute kidney injury models

Zhang, B., Chen, W., Liang, L., Liu, G., Chan, K. W. Y., Li, Y., Zheng, J., Liang, C. & Zhang, S. Mar 10 2016 In : Chinese Journal of Radiology (China). 50, 3, p. 180-185 6 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Kidney
Injections
Diatrizoate Meglumine
Vasodilator Agents

Label-free CEST MRI detection of citicoline-liposome drug delivery in ischemic stroke

Liu, H., Jablonska, A., Li, Y., Cao, S., Liu, D., Chen, H., Van Zijl, P. C. M., Bulte, J. W. M., Janowski, M., Walczak, P. & Liu, G. 2016 In : Theranostics. 6, 10, p. 1588-1600 13 p.

Research output: Contribution to journalArticle

Cytidine Diphosphate Choline
Liposomes
Stroke
Pharmaceutical Preparations
Ischemia

On-resonance variable delay multipulse scheme for imaging of fast-exchanging protons and semisolid macromolecules

Xu, J., Chan, K. W. Y., Xu, X., Yadav, N., Liu, G. & van Zijl, P. C. M. 2016 (Accepted/In press) In : Magnetic Resonance in Medicine.

Research output: Contribution to journalArticle

Protons
Creatine
Water
Brain
Inositol
2015
Blood Volume
Blood-Brain Barrier
Brain Neoplasms
Glucose
Area Under Curve

Establishing the lysine-rich protein CEST reporter gene as a CEST MR imaging detector for oncolytic virotherapy

Farrar, C. T., Buhrman, J. S., Liu, G., Kleijn, A., Lamfers, M. L. M., McMahon, M. T., Gilad, A. A. & Fulci, G. Jun 1 2015 In : Radiology. 275, 3, p. 746-754 9 p.

Research output: Contribution to journalArticle

Oncolytic Virotherapy
Reporter Genes
Lysine
Magnetic Resonance Imaging
Proteins

Label-free in vivo molecular imaging of underglycosylated mucin-1 expression in tumour cells

Song, X., Airan, R. D., Arifin, D. R., Bar-Shir, A., Kadayakkara, D. K., Liu, G., Gilad, A. A., Van Zijl, P. C. M., McMahon, M. T. & Bulte, J. W. M. Mar 30 2015 In : Nature Communications. 6, 6719

Research output: Contribution to journalArticle

Molecular imaging
Mucin-1
Molecular Imaging
Labels
Tumors

To evaluate the damage of renal function in CIAKI rats at 3T: Using ASL and BOLD MRI

Chen, W. B., Liang, L., Zhang, B., Liu, C. L., Liu, H. J., Luo, H. Y., Zeng, Q. X., Liang, C. H., Liu, G. S. & Zhang, S. X. 2015 In : BioMed Research International. 2015, 593060

Research output: Contribution to journalArticle

Acute Kidney Injury
Magnetic resonance imaging
Labeling
Rats
Blood

Using intravoxel incoherent motion MR imaging to study the renal pathophysiological process of contrast-induced acute kidney injury in rats: Comparison with conventional DWI and arterial spin labelling

Liang, L., Chen, W. B., Chan, K. W. Y., Li, Y. G., Zhang, B., Liang, C. H., Liu, G. S. & Zhang, S. X. Sep 15 2015 (Accepted/In press) In : European Radiology.

Research output: Contribution to journalArticle

Acute Kidney Injury
Kidney
Renal Circulation
Perfusion
Creatinine
2014

A diaCEST MRI approach for monitoring liposomal accumulation in tumors

Chan, K. W. Y., Yu, T., Qiao, Y., Liu, Q., Yang, M., Patel, H., Liu, G., Kinzler, K. W., Vogelstein, B., Bulte, J. W. M., Van Zijl, P. C. M., Hanes, J., Zhou, S. & McMahon, M. T. Apr 28 2014 In : Journal of Controlled Release. 180, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

Liposomes
Tumor Necrosis Factor-alpha
Neoplasms
Nanomedicine
Capillary Permeability

Human protamine-1 as an mri reporter gene based on chemical exchange

Bar-Shir, A., Liu, G., Chan, K. W. Y., Oskolkov, N., Song, X., Yadav, N. N., Walczak, P., McMahon, M. T., Van Zijl, P. C. M., Bulte, J. W. M. & Gilad, A. A. Jan 17 2014 In : ACS Chemical Biology. 9, 1, p. 134-138 5 p.

Research output: Contribution to journalArticle

Protamines
Reporter Genes
Genes
Magnetic resonance imaging
Arginine
Alginate
Adaptive Immunity
Innate Immunity
Magnetic resonance imaging
Capsules

Multiwalled nanotubes formed by catanionic mixtures of drug amphiphiles

Lin, Y. A., Cheetham, A. G., Zhang, P., Ou, Y. C., Li, Y., Liu, G., Hermida-Merino, D., Hamley, I. W. & Cui, H. Dec 23 2014 In : ACS Nano. 8, 12, p. 12690-12700 11 p.

Research output: Contribution to journalArticle

Amphiphiles
Nanotubes
nanotubes
drugs
Pharmaceutical Preparations

Non-invasive temperature mapping using temperature-responsive water saturation shift referencing (T-WASSR) MRI

Liu, G., Qin, Q., Chan, K. W. Y., Li, Y., Bulte, J. W. M., Mcmahon, M. T., Van Zijl, P. C. M. & Gilad, A. A. Mar 2014 In : NMR in Biomedicine. 27, 3, p. 320-331 12 p.

Research output: Contribution to journalArticle

Magnetic resonance imaging
Temperature
Water
Protons
Fats

Vaginal Delivery of Paclitaxel via Nanoparticles with Non-Mucoadhesive Surfaces Suppresses Cervical Tumor Growth

Yang, M., Yu, T., Wang, Y. Y., Lai, S. K., Zeng, Q., Miao, B., Tang, B. C., Simons, B. W., Ensign, L. M., Liu, G., Chan, K. W. Y., Juang, C. Y., Mert, O., Wood, J., Fu, J., Mcmahon, M. T., Wu, T. C., Hung, C. F. & Hanes, J. 2014 In : Advanced healthcare materials. 3, 7, p. 1044-1052 9 p.

Research output: Contribution to journalArticle

Paclitaxel
Nanoparticles
Mucus
Tumors
Growth
2013

Metal ion sensing using ion chemical exchange saturation transfer 19F magnetic resonance imaging

Bar-Shir, A., Gilad, A. A., Chan, K. W. Y., Liu, G., Van Zijl, P. C. M., Bulte, J. W. M. & McMahon, M. T. Aug 21 2013 In : Journal of the American Chemical Society. 135, 33, p. 12164-12167 4 p.

Research output: Contribution to journalArticle

Ion Exchange
Chemical shift
Magnetic resonance
Metal ions
Ion exchange

MRI-detectable pH nanosensors incorporated into hydrogels for in vivo sensing of transplanted-cell viability

Chan, K. W. Y., Liu, G., Song, X., Kim, H., Yu, T., Arifin, D. R., Gilad, A. A., Hanes, J., Walczak, P., Van Zijl, P. C. M., Bulte, J. W. M. & McMahon, M. T. Mar 2013 In : Nature Materials. 12, 3, p. 268-275 8 p.

Research output: Contribution to journalArticle

Nanosensors
Hydrogels
Magnetic resonance
viability
magnetic resonance
Germination
Clostridium
Bacteria
Bacterial Spores
Infection

NOrmalized MAgnetization Ratio (NOMAR) filtering for creation of tissue selective contrast maps

Liu, G., Chan, K. W. Y., Song, X., Zhang, J., Gilad, A. A., Bulte, J. W. M., Van Zijl, P. C. M. & McMahon, M. T. Feb 2013 In : Magnetic Resonance in Medicine. 69, 2, p. 516-523 8 p.

Research output: Contribution to journalArticle

Bovine Serum Albumin
Liposomes
Artifacts
Contrast Media
Cerebrospinal Fluid

Nuts and bolts of chemical exchange saturation transfer MRI

Liu, G., Song, X., Chan, K. W. Y. & Mcmahon, M. T. Jul 2013 In : NMR in Biomedicine. 26, 7, p. 810-828 19 p.

Research output: Contribution to journalArticle

Magnetic resonance imaging
Technology Transfer
Imaging techniques
Molecular Imaging
Magnetic Fields
Salicylic acid
Salicylic Acid
Magnetic resonance imaging
Contrast Media
Protons

Synthesis of a probe for monitoring HSV1-tk reporter gene expression using chemical exchange saturation transfer MRI

Bar-Shir, A., Liu, G., Greenberg, M. M., Bulte, J. W. M. & Gilad, A. A. 2013 In : Nature Protocols. 8, 12, p. 2380-2391 12 p.

Research output: Contribution to journalArticle

Thymidine Kinase
Human Herpesvirus 1
Reporter Genes
Viruses
Gene expression

Synthesis of a probe for monitoring HSV1-tk reporter gene expression using chemical exchange saturation transfer MRI

Bar-Shir, A., Liu, G., Greenberg, M. M., Bulte, J. W. M. & Gilad, A. A. Jan 1 2013 In : Nature protocols. 8, 12, p. 2380-2391 12 p.

Research output: Contribution to journalArticle

Thymidine Kinase
Human Herpesvirus 1
Reporter Genes
Gene Expression
Genetically Modified Animals

Transforming thymidine into a magnetic resonance imaging probe for monitoring gene expression

Bar-Shir, A., Liu, G., Liang, Y., Yadav, N. N., McMahon, M. T., Walczak, P., Nimmagadda, S., Pomper, M. G., Tallman, K. A., Greenberg, M. M., Van Zijl, P. C. M., Bulte, J. W. M. & Gilad, A. A. Jan 30 2013 In : Journal of the American Chemical Society. 135, 4, p. 1617-1624 8 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
Magnetic resonance
Gene expression
Thymidine
Protons
2012

CEST phase mapping using a length and offset varied saturation (LOVARS) scheme

Song, X., Gilad, A. A., Joel, S., Liu, G., Bar-Shir, A., Liang, Y., Gorelik, M., Pekar, J. J., Van Zijl, P. C. M., Bulte, J. W. M. & McMahon, M. T. Oct 2012 In : Magnetic Resonance in Medicine. 68, 4, p. 1074-1086 13 p.

Research output: Contribution to journalArticle

Noise
Gliosarcoma
Contrast Sensitivity
Molecular Imaging
Gadolinium

Imaging in vivo extracellular pH with a single paramagnetic chemical exchange saturation transfer magnetic resonance imaging contrast agent

Liu, G., Li, Y., Sheth, V. R. & Pagel, M. D. Jan 2012 In : Molecular Imaging. 11, 1, p. 47-57 11 p.

Research output: Contribution to journalArticle

Magnetic resonance
Contrast Media
magnetic resonance
Magnetic Resonance Imaging
saturation

Improved pH measurements with a single PARACEST MRI contrast agent

Sheth, V. R., Liu, G., Li, Y. & Pagel, M. D. Jan 2012 In : Contrast Media and Molecular Imaging. 7, 1, p. 26-34 9 p.

Research output: Contribution to journalArticle

Contrast Media
Temperature
Therapeutic Uses
Magnetic Fields
Amides

In vivo multicolor molecular MR imaging using diamagnetic chemical exchange saturation transfer liposomes

Liu, G., Moake, M., Har-El, Y. E., Long, C. M., Chan, K. W. Y., Cardona, A., Jamil, M., Walczak, P., Gilad, A. A., Sgouros, G., Van Zijl, P. C. M., Bulte, J. W. M. & McMahon, M. T. Apr 2012 In : Magnetic Resonance in Medicine. 67, 4, p. 1106-1113 8 p.

Research output: Contribution to journalArticle

Molecular Imaging
Liposomes
Contrast Media
Glycogen
Lysine

MRI biosensor for protein kinase A encoded by a single synthetic gene

Airan, R. D., Bar-Shir, A., Liu, G., Pelled, G., McMahon, M. T., Van Zijl, P. C. M., Bulte, J. W. M. & Gilad, A. A. Dec 2012 In : Magnetic Resonance in Medicine. 68, 6, p. 1919-1923 5 p.

Research output: Contribution to journalArticle

Synthetic Genes
Biosensing Techniques
Cyclic AMP-Dependent Protein Kinases
Protein Kinases
Phosphorylation

Natural D -glucose as a biodegradable MRI contrast agent for detecting cancer

Chan, K. W. Y., McMahon, M. T., Kato, Y., Liu, G., Bulte, J. W. M., Bhujwalla, Z. M., Artemov, D. & Van Zijl, P. C. M. Dec 2012 In : Magnetic Resonance in Medicine. 68, 6, p. 1764-1773 10 p.

Research output: Contribution to journalArticle

Contrast Media
Hydroxyl Radical
Glucose
Iodine Radioisotopes
Protons
2011

A self-calibrating PARACEST MRI contrast agent that detects esterase enzyme activity

Li, Y., Sheth, V. R., Liu, G. & Pagel, M. D. Jul 2011 In : Contrast Media and Molecular Imaging. 6, 4, p. 219-228 10 p.

Research output: Contribution to journalArticle

Esterases
Contrast Media
Biomarkers
Enzymes
Temperature

Monitoring enzyme activity using a diamagnetic chemical exchange saturation transfer magnetic resonance imaging contrast agent

Liu, G., Liang, Y., Bar-Shir, A., Chan, K. W. Y., Galpoththawela, C. S., Bernard, S. M., Tse, T., Yadav, N. N., Walczak, P., McMahon, M. T., Bulte, J. W. M., Van Zijl, P. C. M. & Gilad, A. A. Oct 19 2011 In : Journal of the American Chemical Society. 133, 41, p. 16326-16329 4 p.

Research output: Contribution to journalArticle

Cytosine Deaminase
Enzyme activity
Magnetic resonance
Contrast Media
Magnetic Resonance Imaging

Multimodal imaging of sustained drug release from 3-D poly(propylene fumarate) (PPF) scaffolds

Choi, J., Kim, K., Kim, T., Liu, G., Bar-Shir, A., Hyeon, T., McMahon, M. T., Bulte, J. W. M., Fisher, J. P. & Gilad, A. A. Dec 10 2011 In : Journal of Controlled Release. 156, 2, p. 239-245 7 p.

Research output: Contribution to journalArticle

Multimodal Imaging
Fumarates
Protamines
Pharmaceutical Preparations
Optical Imaging
2010
Contrast Media
Plastics
Water
High-Throughput Screening Assays
Magnetic Fields
2009

Paracest mri with improved temporal resolution

Liu, G., Ali, M. M., Yoo, B., Griswold, M. A., Tkach, J. A. & Pagel, M. D. Feb 2009 In : Magnetic Resonance in Medicine. 61, 2, p. 399-408 10 p.

Research output: Contribution to journalArticle

Molecular Imaging
Contrast Media
In Vitro Techniques

Using two chemical exchange saturation transfer magnetic resonance imaging contrast agents for molecular imaging studies

Ali, M. M., Liu, G., Shah, T., Flask, C. A. & Pagel, M. D. Jul 21 2009 In : Accounts of Chemical Research. 42, 7, p. 915-924 10 p.

Research output: Contribution to journalArticle

Experimental Mammary Neoplasms
Magnetics
Imaging Phantoms
Organometallic Compounds
Lanthanoid Series Elements
2007

Design and characterization of a new irreversible responsive PARACEST MRI contrast agent that detects nitric oxide

Liu, G., Li, Y. & Pagel, M. D. Dec 2007 In : Magnetic Resonance in Medicine. 58, 6, p. 1249-1256 8 p.

Research output: Contribution to journalArticle

Contrast Media
Nitric Oxide
Molecular Imaging
Amides
Amines
2004

Recent developments in the determination of urinary cancer biomarkers by capillary electrophoresis

Ma, Y., Liu, G., Du, M. & Stayton, I. Jun 2004 In : Electrophoresis. 25, 10-11, p. 1473-1484 12 p.

Research output: Contribution to journalArticle

Capillary electrophoresis
Capillary Electrophoresis
Tumor Biomarkers
Biomarkers
Cerebrospinal fluid