Gregg L Semenza

Professor

1984 …2020

Research output per year

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Research Output

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Reversible inhibition of hypoxia-inducible factor 1 activation by exposure of hypoxic cells to the volatile anesthetic halothane

Itoh, T., Namba, T., Fukuda, K., Semenza, G. L. & Hirota, K., Dec 7 2001, In : FEBS Letters. 509, 2, p. 225-229 5 p.

Research output: Contribution to journalArticle

Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain

Bergeron, M., Gidday, J. M., Aimee, Y. Y., Semenza, G. L., Ferriero, D. M. & Sharp, F. R., Sep 18 2000, In : Annals of neurology. 48, 3, p. 285-296 12 p.

Research output: Contribution to journalArticle

Role of hypoxia-inducible factor 1α in gastric cancer cell growth, angiogenesis, and vessel maturation

Stoeltzing, O., McCarty, M. F., Wey, J. S., Fan, F., Liu, W., Belcheva, A., Bucana, C. D., Semenza, G. L. & Ellis, L. M., Jun 16 2004, In : Journal of the National Cancer Institute. 96, 12, p. 946-956 11 p.

Research output: Contribution to journalArticle

Open Access

SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1α ubiquitination and degradation

Tan, M., Gu, Q., He, H., Pamarthy, D., Semenza, G. L. & Sun, Y., Feb 28 2008, In : Oncogene. 27, 10, p. 1404-1411 8 p.

Research output: Contribution to journalArticle

Science signaling podcast: 12 February 2013

Semenza, G. L., Hubbi, M. E. & VanHook, A. M., Feb 12 2013, In : Science signaling. 6, 262, pc5.

Research output: Contribution to journalArticle

Segregation of a familial balanced (12;10) insertion resulting in dup(10)(q21.2q22.1) and Del(10)(q21.2q22.1) in First cousins

Doheny, K. F., Rasmussen, S. A., Rutberg, J., Semenza, G. L., Stamberg, J., Schwartz, M., Batista, D. A. S., Stetten, G. & Thomas, G. H., Mar 17 1997, In : American journal of medical genetics. 69, 2, p. 188-193 6 p.

Research output: Contribution to journalArticle

Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways

Siddiq, A., Aminova, L. R., Troy, C. M., Suh, K., Messer, Z., Semenza, G. L. & Ratan, R. R., Jul 8 2009, In : Journal of Neuroscience. 29, 27, p. 8828-8838 11 p.

Research output: Contribution to journalArticle

Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer

Kizaka-Kondoh, S., Itasaka, S., Zeng, L., Tanaka, S., Zhao, T., Takahashi, Y., Shibuya, K., Hirota, K., Semenza, G. L. & Hiraoka, M., May 15 2009, In : Clinical Cancer Research. 15, 10, p. 3433-3441 9 p.

Research output: Contribution to journalArticle

Signal transduction to hypoxia-inducible factor 1

Semenza, G. L., Sep 1 2002, In : Biochemical Pharmacology. 64, 5-6, p. 993-998 6 p.

Research output: Contribution to journalArticle

Sirtuin-7 inhibits the activity of hypoxia-inducible factors

Hubbi, M. E., Hu, H., Kshitiz, Gilkes, D. M. & Semenza, G. L., Jul 19 2013, In : Journal of Biological Chemistry. 288, 29, p. 20768-20775 8 p.

Research output: Contribution to journalArticle

Spermidine/spermine N1-acetyltransferase-1 binds to hypoxia-inducible factor-1α (HIF-1α) and RACK1 and promotes ubiquitination and degradation of HIF-1α

Baek, J. H., Liu, Y. V., McDonald, K. R., Wesley, J. B., Zhang, H. & Semenza, G. L., Nov 16 2007, In : Journal of Biological Chemistry. 282, 46, p. 33358-33366 9 p.

Research output: Contribution to journalArticle

Spermidine/Spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1α

Jin, H. B., Liu, Y. V., McDonald, K. R., Wesley, J. B., Hubbi, M. E., Byun, H. & Semenza, G. L., Aug 10 2007, In : Journal of Biological Chemistry. 282, 32, p. 23572-23580 9 p.

Research output: Contribution to journalArticle

Spontaneous transformation of cultured mouse bone marrow-derived stromal cells

Yi, F. Z., Bosch-Marce, M., Okuyama, H., Krishnamachary, B., Kimura, H., Zhang, L., Huso, D. L. & Semenza, G. L., Nov 15 2006, In : Cancer Research. 66, 22, p. 10849-10854 6 p.

Research output: Contribution to journalArticle

Stromal cell-derived factor-1α and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: Von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor

Zagzag, D., Krishnamachary, B., Yee, H., Okuyama, H., Chiriboga, L., Ali, M. A., Melamed, J. & Semenza, G. L., Jul 15 2005, In : Cancer Research. 65, 14, p. 6178-6188 11 p.

Research output: Contribution to journalArticle

Structural and functional analysis of hypoxia-inducible factor 1

Semenza, G. L., Agani, F., Booth, G., Forsythe, J., Iyer, N., Jiang, B. H., Leung, S., Roe, R., Wiener, C. & Yu, A., Jan 1 1997, In : Kidney international. 51, 2, p. 553-555 3 p.

Research output: Contribution to journalArticle

Open Access

Sustained delivery of a HIF-1 antagonist for ocular neovascularization

Iwase, T., Fu, J., Yoshida, T., Muramatsu, D., Miki, A., Hashida, N., Lu, L., Oveson, B., Lima E Silva, R., Seidel, C., Yang, M., Connelly, S., Shen, J., Han, B., Wu, M., Semenza, G. L., Hanes, J. & Campochiaro, P. A., Nov 13 2013, In : Journal of Controlled Release. 172, 3, p. 625-633 9 p.

Research output: Contribution to journalArticle

Synergistic effect of HIF-1α gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia

Rey, S., Lee, K. A., Wang, C. J., Gupta, K., Chen, S., McMillan, A., Bhise, N., Levchenko, A. & Semenza, G. L., Dec 1 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 48, p. 20399-20404 6 p.

Research output: Contribution to journalArticle

Systemic delivery of microencapsulated 3-bromopyruvate for the therapy of pancreatic cancer

Chapiro, J., Sur, S., Savic, L. J., Ganapathy-Kanniappan, S., Reyes, J., Duran, R., Thiruganasambandam, S. C., Moats, C. R., Lin, M. D., Luo, W., Tran, P. T., Herman, J. M., Semenza, G. L., Ewald, A. J., Vogelstein, B. & Geschwind, J. F., Dec 15 2014, In : Clinical Cancer Research. 20, 24, p. 6406-6417 12 p.

Research output: Contribution to journalArticle

Systems biology of oxygen homeostasis

Samanta, D., Prabhakar, N. R. & Semenza, G. L., 2017, (Accepted/In press) In : Wiley Interdisciplinary Reviews: Systems Biology and Medicine.

Research output: Contribution to journalArticle

Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

Xu, Q., Briggs, J., Park, S., Niu, G., Kortylewski, M., Zhang, S., Gritsko, T., Turkson, J., Kay, H., Semenza, G. L., Cheng, J. Q., Jove, R. & Yu, H., Aug 25 2005, In : Oncogene. 24, 36, p. 5552-5560 9 p.

Research output: Contribution to journalArticle

T-cell activation under hypoxic conditions enhances IFN-γ secretion

Roman, J., Rangasamy, T., Guo, J., Sugunan, S., Meednu, N., Packirisamy, G., Shimoda, L. A., Golding, A., Semenza, G. & Georas, S. N., Jan 1 2010, In : American journal of respiratory cell and molecular biology. 42, 1, p. 123-128 6 p.

Research output: Contribution to journalArticle

Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung

Yu, A. Y., Frid, M. G., Shimoda, L. A., Wiener, C. M., Stenmark, K. & Semenza, G. L., Nov 9 1998, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 275, 4 19-4, p. L818-L826

Research output: Contribution to journalArticle

The expanding universe of hypoxia

Zhang, H. & Semenza, G. L., Jul 1 2008, In : Journal of Molecular Medicine. 86, 7, p. 739-746 8 p.

Research output: Contribution to journalArticle

The HIF-1 antagonist acriflavine: visualization in retina and suppression of ocular neovascularization

Zeng, M., Shen, J., Liu, Y., Lu, L. Y., Ding, K., Fortmann, S. D., Khan, M., Wang, J., Hackett, S. F., Semenza, G. L. & Campochiaro, P. A., Dec 21 2016, (Accepted/In press) In : Journal of Molecular Medicine. p. 1-13 13 p.

Research output: Contribution to journalArticle

The human hypoxia-inducible factor 1α gene: HIF1A structure and evolutionary conservation

Iyer, N. V., Leung, S. W. & Semenza, G. L., Sep 1 1998, In : Genomics. 52, 2, p. 159-165 7 p.

Research output: Contribution to journalArticle

The inhibitory effect of sodium nitroprusside on HIF-1 activation is not dependent on nitric oxide-soluble guanylyl cyclase pathway

Takabuchi, S., Hirota, K., Nishi, K., Oda, S., Oda, T., Shingu, K., Takabayashi, A., Adachi, T., Semenza, G. L. & Fukuda, K., Nov 5 2004, In : Biochemical and Biophysical Research Communications. 324, 1, p. 417-423 7 p.

Research output: Contribution to journalArticle

The intravenous anesthetic propofol inhibits hypoxia-inducible factor 1 activity in an oxygen tension-dependent manner

Takabuchi, S., Hirota, K., Nishi, K., Oda, S., Oda, T., Shingu, K., Takabayashi, A., Adachi, T., Semenza, G. L. & Fukuda, K., Nov 19 2004, In : FEBS Letters. 577, 3, p. 434-438 5 p.

Research output: Contribution to journalArticle

'The metabolism of tumours': 70 years later

Semenza, G. L., Artemov, D., Bedi, A., Bhujwalla, Z., Chiles, K., Feldser, D., Laughner, E., Ravi, R., Simons, J., Taghavi, P. & Zhong, H., Dec 1 2001, In : Novartis Foundation Symposium. 240, p. 251-260 10 p.

Research output: Contribution to journalArticle

The role of hypoxia-inducible factors in carotid body (patho) physiology

Semenza, G. L. & Prabhakar, N. R., Jan 1 2018, (Accepted/In press) In : Journal of Physiology.

Research output: Contribution to journalArticle

The silent carrier allele: β thalassemia without a mutation in the β-globin gene or its immediate flanking regions

Semenza, G. L., Delgrosso, K., Poncz, M., Malladi, P., Schwartz, E. & Surrey, S., Nov 1984, In : Cell. 39, 1, p. 123-128 6 p.

Research output: Contribution to journalArticle

The ubiquitin ligase stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3

Chen, Z., Barbi, J., Bu, S., Yang, H. Y., Li, Z., Gao, Y., Jinasena, D., Fu, J., Lin, F., Chen, C., Zhang, J., Yu, N., Li, X., Shan, Z., Nie, J., Gao, Z., Tian, H., Li, Y., Yao, Z., Zheng, Y. & 16 others, Park, B. V., Pan, Z., Zhang, J., Dang, E., Li, Z., Wang, H., Luo, W., Li, L., Semenza, G. L., Zheng, S. G., Loser, K., Tsun, A., Greene, M. I., Pardoll, D. M., Pan, F. & Li, B., Aug 22 2013, In : Immunity. 39, 2, p. 272-285 14 p.

Research output: Contribution to journalArticle

The use of in situ hybridization to study erythropoietin gene expression in murine kidney and liver

Koury, S. T., Bondurant, M. C., Semenza, G. L. & Koury, M. J., May 1 1993, In : Microscopy Research and Technique. 25, 1, p. 29-39 11 p.

Research output: Contribution to journalArticle

Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells

Sarkar, K., Rey, S., Zhang, X., Sebastian, R., Marti, G. P., Fox-Talbot, K., Cardona, A. V., Du, J., Tan, Y. S., Liu, L., Lay, F., Gonzalez, F. J., Harmon, J. W. & Semenza, G. L., Jan 1 2012, In : Cardiovascular research. 93, 1, p. 162-169 8 p.

Research output: Contribution to journalArticle

Tie2-dependent VHL knockdown promotes airway microvascular regeneration and attenuates invasive growth of Aspergillus fumigatus

Jiang, X., Hsu, J. L., Tian, W., Yuan, K., Olcholski, M., De Jesus Perez, V., Semenza, G. L. & Nicolls, M. R., Sep 1 2013, In : Journal of Molecular Medicine. 91, 9, p. 1081-1093 13 p.

Research output: Contribution to journalArticle

Transactivation and inhibitory domains of Hypoxia-inducible factor 1α: Modulation of transcriptional activity by oxygen tension

Jiang, B. H., Zheng, J. Z., Leung, S. W., Roe, R. & Semenza, G. L., Aug 1 1997, In : Journal of Biological Chemistry. 272, 31, p. 19253-19260 8 p.

Research output: Contribution to journalArticle

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1

Semenza, G. L., Roth, P. H., Fang, H. M. & Wang, G. L., Sep 23 1994, In : Journal of Biological Chemistry. 269, 38, p. 23757-23763 7 p.

Research output: Contribution to journalArticle

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1

Manalo, D. J., Rowan, A., Lavoie, T., Natarajan, L., Kelly, B. D., Ye, S. Q., Garcia, J. G. N. & Semenza, G. L., Jan 15 2005, In : Blood. 105, 2, p. 659-669 11 p.

Research output: Contribution to journalArticle

Up-regualtion of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor I (HIF-I)

Greijer, A. E., van der Groep, P., Kemming, D., Shvarts, A., Semenza, G. L., Meijer, G. A., van de Wiel, M. A., Belien, J. A. M., van Diest, P. J. & van der Wall, E., Jul 1 2005, In : Journal of Pathology. 206, 3, p. 291-304 14 p.

Research output: Contribution to journalArticle

Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia: HIF-1-independent mechanisms

Dong, Z., Venkatachalam, M. A., Wang, J., Patel, Y., Saikumar, P., Semenza, G. L., Force, T. & Nishiyama, J., Jun 1 2001, In : Journal of Biological Chemistry. 276, 22, p. 18702-18709 8 p.

Research output: Contribution to journalArticle

Up-regulation of hypoxia-inducible factor 1α is an early event in prostate carcinogenesis

Zhong, H., Semenza, G. L., Simons, J. W. & De Marzo, A. M., Apr 20 2004, In : Cancer detection and prevention. 28, 2, p. 88-93 6 p.

Research output: Contribution to journalArticle

Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1

Fukuda, R., Kelly, B. & Semenza, G. L., May 1 2003, In : Cancer Research. 63, 9, p. 2330-2334 5 p.

Research output: Contribution to journalArticle

VEGF secreted by hypoxic Müller cells induces MMP-2 expression and activity in endothelial cells to promote retinal neovascularization in proliferative diabetic retinopathy

Rodrigues, M., Xin, X., Jee, K., Babapoor-Farrokhran, S., Kashiwabuchi, F., Ma, T., Bhutto, I., Hassan, S. J., Daoud, Y., Baranano, D., Solomon, S., Lutty, G., Semenza, G. L., Montaner, S. & Sodhi, A., Nov 1 2013, In : Diabetes. 62, 11, p. 3863-3873 11 p.

Research output: Contribution to journalArticle

β-Arrestin mediates the Frank-Starling mechanism of cardiac contractility

Abraham, D. M., Davis, R. T., Warren, C. M., Mao, L., Wolska, B. M., Solaro, R. J., Rockman, H. A. & Semenza, G. L., Dec 13 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 50, p. 14426-14431 6 p.

Research output: Contribution to journalArticle