Gregg L Semenza

Professor

1984 …2020

Research output per year

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Research Output

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2015

Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy

Babapoor-Farrokhran, S., Jee, K., Puchner, B., Hassan, S. J., Xin, X., Rodrigues, M., Kashiwabuchi, F., Ma, T., Hu, K., Deshpande, M., Daoud, Y., Solomon, S., Wenick, A., Lutty, G. A., Semenza, G. L., Montaner, S. & Sodhi, A., Jun 9 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 23, p. E3030-E3039

Research output: Contribution to journalArticle

HIF-1α activation by intermittent hypoxia requires NADPH oxidase stimulation by xanthine oxidase

Nanduri, J., Vaddi, D. R., Khan, S. A., Wang, N., Makarenko, V., Semenza, G. L. & Prabhakar, N. R., Mar 9 2015, In : PloS one. 10, 3, e0119762.

Research output: Contribution to journalArticle

HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells

Xiang, L., Gilkes, D. M., Hu, H., Luo, W., Bullen, J. W., Liang, H. & Semenza, G. L., Jan 1 2015, In : Oncotarget. 6, 14, p. 11768-11778 11 p.

Research output: Contribution to journalArticle

Open Access

Hypoxia inducible factor-1-dependent up-regulation of BMP4 mediates hypoxia-induced increase of TRPC expression in PASMCs

Wang, J., Fu, X., Yang, K., Jiang, Q., Chen, Y., Jia, J., Duan, X., Wang, E. W., He, J., Ran, P., Zhong, N., Semenza, G. L. & Lu, W., Jul 1 2015, In : Cardiovascular research. 107, 1, p. 108-118 11 p.

Research output: Contribution to journalArticle

KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi’s sarcoma

Ma, T., Patel, H., Babapoor-Farrokhran, S., Franklin, R., Semenza, G. L., Sodhi, A. & Montaner, S., Oct 1 2015, In : Angiogenesis. 18, 4, p. 477-488 12 p.

Research output: Contribution to journalArticle

Protein kinase G-regulated production of H2S governs oxygen sensing

Yuan, G., Vasavda, C., Peng, Y. J., Makarenko, V. V., Raghuraman, G., Nanduri, J., Gadalla, M. M., Semenza, G. L., Kumar, G. K., Snyder, S. H. & Prabhakar, N. R., Apr 21 2015, In : Science signaling. 8, 373, ra37.

Research output: Contribution to journalArticle

2016

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

Elgogary, A., Xu, Q., Poore, B., Alt, J., Zimmermann, S. C., Zhao, L., Fu, J., Chen, B., Xia, S., Liu, Y., Neisser, M., Nguyen, C., Lee, R., Park, J. K., Reyes, J., Hartung, T., Rojas, C., Rais, R., Tsukamoto, T., Semenza, G. L. & 3 others, Hanes, J., Slusher, B. S. & Le, A., Sep 6 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 36, p. E5328-E5336

Research output: Contribution to journalArticle

Epigenetic regulation of redox state mediates persistent cardiorespiratory abnormalities after long-term intermittent hypoxia

Nanduri, J., Peng, Y. J., Wang, N., Khan, S. A., Semenza, G. L., Kumar, G. K. & Prabhakar, N. R., 2016, (Accepted/In press) In : Journal of Physiology.

Research output: Contribution to journalArticle

Expression pattern of HIF-1α and VEGF supports circumferential application of scatter laser for proliferative sickle retinopathy

Rodrigues, M., Kashiwabuchi, F., Deshpande, M., Jee, K., Goldberg, M. F., Lutty, G., Semenza, G. L., Montaner, S. & Sodhi, A., Dec 2016, In : Investigative Ophthalmology and Visual Science. 57, 15, p. 6739-6746 8 p.

Research output: Contribution to journalArticle

H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea

Yuan, G., Peng, Y. J., Khan, S. A., Nanduri, J., Singh, A., Vasavda, C., Semenza, G. L., Kumar, G. K., Snyder, S. H. & Prabhakar, N. R., Aug 16 2016, In : Science Signaling. 9, 441, ra80.

Research output: Contribution to journalArticle

Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma

Hu, K., Babapoor-Farrokhran, S., Rodrigues, M., Deshpande, M., Puchner, B., Kashiwabuchi, F., Hassan, S. J., Asnaghi, L., Handa, J. T., Merbs, S., Eberhart, C. G., Semenza, G. L., Montaner, S. & Sodhi, A., 2016, In : Oncotarget. 7, 7, p. 7816-7828 13 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1α Is a Critical Downstream Mediator for Hypoxia-Induced Mitogenic Factor (FIZZ1/RELMα)-Induced Pulmonary Hypertension

Johns, R. A., Takimoto, E., Meuchel, L. W., Elsaigh, E., Zhang, A., Heller, N. M., Semenza, G. L. & Yamaji-Kegan, K., Jan 1 2016, In : Arteriosclerosis, thrombosis, and vascular biology. 36, 1, p. 134-144 11 p.

Research output: Contribution to journalArticle

Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217-and ALKBH5-mediated modulation of RNA methylation in breast cancer cells

Zhang, C., Zhi, W. I., Lu, H., Samanta, D., Chen, I., Gabrielson, E. & Semenza, G. L., Jan 1 2016, In : Oncotarget. 7, 40, p. 64527-64542 16 p.

Research output: Contribution to journalArticle

PHGDH expression is required for mitochondrial redox homeostasis, breast cancer stem cell maintenance, and lung metastasis

Samanta, D., Park, Y., Andrabi, S. A., Shelton, L. M., Gilkes, D. & Semenza, G. L., Aug 1 2016, In : Cancer Research. 76, 15, p. 4430-4442 13 p.

Research output: Contribution to journalArticle

PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia

Luo, W., Chen, I., Chen, Y., Alkam, D., Wang, Y. & Semenza, G. L., Jan 1 2016, In : Oncotarget. 7, 6, p. 6379-6397 19 p.

Research output: Contribution to journalArticle

Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor

Bullen, J. W., Tchernyshyov, I., Holewinski, R. J., Devine, L., Wu, F., Venkatraman, V., Kass, D. A., Cole, R. N., Van Eyk, J. & Semenza, G. L., May 31 2016, In : Science Signaling. 9, 430, RA56.

Research output: Contribution to journalArticle

The HIF-1 antagonist acriflavine: visualization in retina and suppression of ocular neovascularization

Zeng, M., Shen, J., Liu, Y., Lu, L. Y., Ding, K., Fortmann, S. D., Khan, M., Wang, J., Hackett, S. F., Semenza, G. L. & Campochiaro, P. A., Dec 21 2016, (Accepted/In press) In : Journal of Molecular Medicine. p. 1-13 13 p.

Research output: Contribution to journalArticle

β-Arrestin mediates the Frank-Starling mechanism of cardiac contractility

Abraham, D. M., Davis, R. T., Warren, C. M., Mao, L., Wolska, B. M., Solaro, R. J., Rockman, H. A. & Semenza, G. L., Dec 13 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 50, p. 14426-14431 6 p.

Research output: Contribution to journalArticle

2017

A compendium of proteins that interact with HIF-1α

Semenza, G. L., Jul 15 2017, In : Experimental cell research. 356, 2, p. 128-135 8 p.

Research output: Contribution to journalArticle

Anthracyclines suppress pheochromocytoma cell characteristics, including metastasis, through inhibition of the hypoxia signaling pathway

Pang, Y., Yang, C., Schovanek, J., Wang, H., Bullova, P., Caisova, V., Gupta, G., Wolf, K. I., Semenza, G. L., Zhuang, Z. & Pacak, K., 2017, In : Oncotarget. 8, 14, p. 22313-22324 12 p.

Research output: Contribution to journalArticle

Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment

Lu, H., Chen, I., Shimoda, L., Park, Y., Zhang, C., Tran, L., Zhang, H. & Semenza, G. L., Feb 21 2017, In : Cell Reports. 18, 8, p. 1946-1957 12 p.

Research output: Contribution to journalArticle

Complementary roles of gasotransmitters CO and H2S in sleep apnea

Peng, Y. J., Zhang, X., Gridina, A., Chupikova, I., Mccormick, D. L., Thomas, R. J., Scammell, T. E., Kim, G., Vasavda, C., Nanduri, J., Kumar, G. K., Semenza, G. L., Snyder, S. H. & Prabhakar, N. R., Feb 7 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 6, p. 1413-1418 6 p.

Research output: Contribution to journalArticle

Expression of the angiogenic mediator, angiopoietin-like 4, in the eyes of patients with proliferative sickle retinopathy

Jee, K., Rodrigues, M., Kashiwabuchi, F., Applewhite, B. P., Han, I., Lutty, G., Goldberg, M. F., Semenza, G. L., Montaner, S. & Sodhi, A., Aug 2017, In : PloS one. 12, 8, e0183320.

Research output: Contribution to journalArticle

Hypoxia-inducible factor-dependent expression of angiopoietin-like 4 by conjunctival epithelial cells promotes the angiogenic phenotype of pterygia

Meng, Q., Qin, Y., Deshpande, M., Kashiwabuchi, F., Rodrigues, M., Lu, Q., Ren, H., Elisseeff, J. H., Semenza, G. L., Montaner, S. V. & Sodhi, A., Sep 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 11, p. 4514-4523 10 p.

Research output: Contribution to journalArticle

Hypoxia Selectively Enhances Integrin α5β1 receptor expression in breast cancer to promote metastasis

Ju, J. A., Godet, I., Ye, I. C., Byun, J., Jayatilaka, H., Lee, S. J., Xiang, L., Samanta, D., Lee, M. H., Wu, P. H., Wirtz, D., Semenza, G. L. & Gilkes, D., Jun 1 2017, In : Molecular Cancer Research. 15, 6, p. 723-734 12 p.

Research output: Contribution to journalArticle

Lack of Evidence for Vasoactive and Inflammatory Mediators in the Promotion of Macular Edema Associated with Epiretinal Membranes

Applewhite, B. P., Babapoor-Farrokhran, S., Poon, D., Hassan, S. J., Wellmann, E., Ying, H. S., Semenza, G. L., Montaner, S. & Sodhi, A., Dec 1 2017, In : Scientific Reports. 7, 1, 10608.

Research output: Contribution to journalArticle

Systems biology of oxygen homeostasis

Samanta, D., Prabhakar, N. R. & Semenza, G. L., 2017, (Accepted/In press) In : Wiley Interdisciplinary Reviews: Systems Biology and Medicine.

Research output: Contribution to journalArticle

2018

DNA methylation in the central and efferent limbs of the chemoreflex requires carotid body neural activity

Nanduri, J., Peng, Y. J., Wang, N., Khan, S. A., Semenza, G. L. & Prabhakar, N. R., Jan 1 2018, (Accepted/In press) In : Journal of Physiology.

Research output: Contribution to journalArticle

Inositol polyphosphate multikinase inhibits angiogenesis via inositol pentakisphosphate-induced HIF-1α degradation

Fu, C., Tyagi, R., Chin, A. C., Rojas, T., Li, R. J., Guha, P., Bernstein, I. A., Rao, F., Xu, R., Cha, J., Xu, J., Snowman, A. M., Semenza, G. L. & Snyder, S. H., Feb 2 2018, In : Circulation Research. 122, 3, p. 457-472 16 p.

Research output: Contribution to journalArticle

Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration

Bao, L., Chen, Y., Lai, H. T., Wu, S. Y., Wang, J. E., Hatanpaa, K. J., Raisanen, J. M., Fontenot, M., Lega, B., Chiang, C. M., Semenza, G. L., Wang, Y. & Luo, W., 2018, In : Nucleic acids research. 46, 13, p. 6576-6591 16 p.

Research output: Contribution to journalArticle

Reciprocal regulation of DUSP9 and DUSP16 expression by HIF1 controls ERK and p38 MAP kinase activity and mediates chemotherapy-induced breast cancer stem cell enrichment

Lu, H., Tran, L., Park, Y., Chen, I., Lan, J., Xie, Y. & Semenza, G. L., Aug 1 2018, In : Cancer Research. 78, 15, p. 4191-4202 12 p.

Research output: Contribution to journalArticle

The role of hypoxia-inducible factors in carotid body (patho) physiology

Semenza, G. L. & Prabhakar, N. R., Jan 1 2018, (Accepted/In press) In : Journal of Physiology.

Research output: Contribution to journalArticle

2019

A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension

Dabral, S., Muecke, C., Valasarajan, C., Schmoranzer, M., Wietelmann, A., Semenza, G. L., Meister, M., Muley, T., Seeger-Nukpezah, T., Samakovlis, C., Weissmann, N., Grimminger, F., Seeger, W., Savai, R. & Pullamsetti, S. S., Dec 1 2019, In : Nature communications. 10, 1, 2130.

Research output: Contribution to journalArticle

Open Access

Endothelial Hypoxia-Inducible Factor-2 Is Required for the Maintenance of Airway Microvasculature

Jiang, X., Tian, W., Tu, A. B., Pasupneti, S., Shuffle, E., Dahms, P., Zhang, P., Cai, H., Dinh, T. T., Liu, B., Cain, C., Giaccia, A. J., Butcher, E. C., Simon, M. C., Semenza, G. L. & Nicolls, M. R., Jan 22 2019, In : Circulation. 139, 4, p. 502-517 16 p.

Research output: Contribution to journalArticle

Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization

Xiang, L., Mou, J., Shao, B., Wei, Y., Liang, H., Takano, N., Semenza, G. L. & Xie, G., Jan 1 2019, In : Cell Death and Disease. 10, 2, 40.

Research output: Contribution to journalArticle

HIF-1α is required for development of the sympathetic nervous system

Bohuslavova, R., Cerychova, R., Papousek, F., Olejnickova, V., Bartos, M., Görlach, A., Kolar, F., Sedmera, D., Semenza, G. L. & Pavlinkova, G., 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 27, p. 13414-13423 10 p.

Research output: Contribution to journalArticle

Open Access