Gregg L Semenza

Professor

1984 …2020

Research output per year

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Research Output

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2003

Regulation of hypoxia-inducible factor-1α, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer

Stoeltzing, O., Liu, W., Reinmuth, N., Fan, F., Parikh, A. A., Bucana, C. D., Evans, D. B., Semenza, G. L. & Ellis, L. M., Sep 1 2003, In : American Journal of Pathology. 163, 3, p. 1001-1011 11 p.

Research output: Contribution to journalArticle

Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1

Fukuda, R., Kelly, B. & Semenza, G. L., May 1 2003, In : Cancer Research. 63, 9, p. 2330-2334 5 p.

Research output: Contribution to journalArticle

2002

Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice

Kojima, H., Gu, H., Nomura, S., Caldwell, C. C., Kobata, T., Carmeliet, P., Semenza, G. L. & Sitkovsky, M. V., Feb 19 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 4, p. 2170-2174 5 p.

Research output: Contribution to journalArticle

Biologic correlates of 18fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography

Bos, R., Van der Hoeven, J. J. M., Van der Wall, E., Van der Groep, P., Van Diest, P. J., Comans, E. F. I., Joshi, U., Semenza, G. L., Hoekstra, O. S., Lammertsma, A. A. & Molthoff, C. F. M., Jan 15 2002, In : Journal of Clinical Oncology. 20, 2, p. 379-387 9 p.

Research output: Contribution to journalArticle

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

Ang, S. O., Chen, H., Hirota, K., Gordeuk, V. R., Jelinek, J., Guan, Y., Liu, E., Sergueeva, A. I., Miasnikova, G. Y., Mole, D., Maxwell, P. H., Stockton, D. W., Semenza, G. L. & Prchal, J. T., Dec 1 2002, In : Nature genetics. 32, 4, p. 614-621 8 p.

Research output: Contribution to journalArticle

HIF-1α, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors

Janssen, H. L. K., Haustermans, K. M. G., Sprong, D., Blommestijn, G., Hofland, I., Hoebers, F. J., Blijweert, E., Raleigh, J. A., Semenza, G. L., Varia, M. A., Balm, A. J., Van Velthuysen, M. L. F., Delaere, P., Sciot, R. & Begg, A. C., Dec 1 2002, In : International Journal of Radiation Oncology Biology Physics. 54, 5, p. 1537-1549 13 p.

Research output: Contribution to journalArticle

Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway

Treins, C., Giorgetti-Peraldi, S., Murdaca, J., Semenza, G. L. & Van Obberghen, E., Aug 2 2002, In : Journal of Biological Chemistry. 277, 31, p. 27975-27981 7 p.

Research output: Contribution to journalArticle

Involvement of hypoxia-inducible factor 1 in human cancer

Semenza, G. L., Jan 1 2002, In : Internal Medicine. 41, 2, p. 79-83 5 p.

Research output: Contribution to journalArticle

Open Access

Molecular cytogenetic characterization of a subtle interstitial del(3)(p25.3p26.2) in a patient with deletion 3p syndrome

Cargile, C. B., Goh, D. L. M., Goodman, B. K., Chen, X. N., Korenberg, J. R., Semenza, G. L. & Thomas, G. H., Apr 22 2002, In : American journal of medical genetics. 109, 2, p. 133-138 6 p.

Research output: Contribution to journalArticle

Signal transduction to hypoxia-inducible factor 1

Semenza, G. L., Sep 1 2002, In : Biochemical Pharmacology. 64, 5-6, p. 993-998 6 p.

Research output: Contribution to journalArticle

2001

Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: Evidence for a process of disordered angiogenesis

Tuder, R. M., Chacon, M., Alger, L., Wang, J., Taraseviciene-Stewart, L., Kasahara, Y., Cool, C. D., Bishop, A. E., Geraci, M., Semenza, G. L., Yacoub, M., Polak, J. M. & Voelkel, N. F., Nov 7 2001, In : Journal of Pathology. 195, 3, p. 367-374 8 p.

Research output: Contribution to journalArticle

Expression of hypoxia-inducible factor-1α: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer

Aebersold, D. M., Burri, P., Beer, K. T., Laissue, J., Djonov, V., Greiner, R. H. & Semenza, G. L., Apr 1 2001, In : Cancer Research. 61, 7, p. 2911-2916 6 p.

Research output: Contribution to journalArticle

FIH-1: A novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

Mahon, P. C., Hirota, K. & Semenza, G. L., Oct 15 2001, In : Genes and Development. 15, 20, p. 2675-2686 12 p.

Research output: Contribution to journalArticle

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

Laughner, E., Taghavi, P., Chiles, K., Mahon, P. C. & Semenza, G. L., Jun 1 2001, In : Molecular and cellular biology. 21, 12, p. 3995-4004 10 p.

Research output: Contribution to journalArticle

Hypoxia Inhibits G1/S Transition through Regulation of p27 Expression

Gardner, L. B., Li, Q., Park, M. S., Flanagan, W. M., Semenza, G. L. & Dang, C. V., Mar 16 2001, In : Journal of Biological Chemistry. 276, 11, p. 7919-7926 8 p.

Research output: Contribution to journalArticle

Intrasubthalamic injection of 6-hydroxydopamine induces changes in the firing rate and pattern of subthalamic nucleus neurons in the rat

Cargile, C. B., Goh, D. L. M., Goodman, B. K., Chen, X. N., Korenberg, J. R., Semenza, G. L. & Thomas, G. H., Apr 5 2001, In : Synapse. 40, 2, p. 145-153 9 p.

Research output: Contribution to journalArticle

Levels of hypoxia-inducible factor-1α during breast carcinogenesis

Bos, R., Zhong, H., Hanrahan, C. F., Mommers, E. C. M., Semenza, G. L., Pinedo, H. M., Abeloff, M. D., Simons, J. W., Van Diest, P. J. & Van Der Wall, E., Feb 21 2001, In : Journal of the National Cancer Institute. 93, 4, p. 309-314 6 p.

Research output: Contribution to journalArticle

Open Access

Rac1 Activity is Required for the Activation of Hypoxia-inducible Factor 1

Hirota, K. & Semenza, G. L., Jun 15 2001, In : Journal of Biological Chemistry. 276, 24, p. 21166-21172 7 p.

Research output: Contribution to journalArticle

Reversible inhibition of hypoxia-inducible factor 1 activation by exposure of hypoxic cells to the volatile anesthetic halothane

Itoh, T., Namba, T., Fukuda, K., Semenza, G. L. & Hirota, K., Dec 7 2001, In : FEBS Letters. 509, 2, p. 225-229 5 p.

Research output: Contribution to journalArticle

'The metabolism of tumours': 70 years later

Semenza, G. L., Artemov, D., Bedi, A., Bhujwalla, Z., Chiles, K., Feldser, D., Laughner, E., Ravi, R., Simons, J., Taghavi, P. & Zhong, H., Dec 1 2001, In : Novartis Foundation Symposium. 240, p. 251-260 10 p.

Research output: Contribution to journalArticle

Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia: HIF-1-independent mechanisms

Dong, Z., Venkatachalam, M. A., Wang, J., Patel, Y., Saikumar, P., Semenza, G. L., Force, T. & Nishiyama, J., Jun 1 2001, In : Journal of Biological Chemistry. 276, 22, p. 18702-18709 8 p.

Research output: Contribution to journalArticle

2000

Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity

Rivard, A., Berthou-Soulie, L., Principe, N., Kearney, M., Curry, C., Branellec, D., Semenza, G. L. & Isner, J. M., Sep 22 2000, In : Journal of Biological Chemistry. 275, 38, p. 29643-29647 5 p.

Research output: Contribution to journalArticle

Chairman's summary: Mechanisms of oxygen homeostasis, circa 1999

Semenza, G. L., Dec 1 2000, In : Advances in experimental medicine and biology. 475, p. 303-310 8 p.

Research output: Contribution to journalArticle

Expression of hypoxia-inducible factor 1: Mechanisms and consequences

Semenza, G. L., Jan 1 2000, In : Biochemical Pharmacology. 59, 1, p. 47-53 7 p.

Research output: Contribution to journalArticle

Expression of hypoxia-inducible factor 1α in brain tumors: Association with angiogenesis, invasion, and progression

Zagzag, D., Zhong, H., Scalzitti, J. M., Laughner, E., Simons, J. W. & Semenza, G. L., Jun 1 2000, In : Cancer. 88, 11, p. 2606-2618 13 p.

Research output: Contribution to journalArticle

Hypoxia, HIF-1, and the pathophysiology of common human diseases

Semenza, G. L., Agani, F., Feldser, D., Iyer, N., Kotch, L., Laughner, E. & Yu, A., Dec 1 2000, In : Advances in experimental medicine and biology. 475, p. 123-130 8 p.

Research output: Contribution to journalArticle

Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics

Zhong, H., Chiles, K., Feldser, D., Laughner, E., Hanrahan, C., Georgescu, M. M., Simons, J. W. & Semenza, G. L., Mar 15 2000, In : Cancer Research. 60, 6, p. 1541-1545 5 p.

Research output: Contribution to journalArticle

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia- inducible factor 1α

Ravi, R., Mookerjee, B., Bhujwalla, Z. M., Sutter, C. H., Artemov, D., Zeng, Q., Dillehay, L. E., Madan, A., Semenza, G. L. & Bedi, A., Jan 1 2000, In : Genes and Development. 14, 1, p. 34-44 11 p.

Research output: Contribution to journalArticle

Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain

Bergeron, M., Gidday, J. M., Aimee, Y. Y., Semenza, G. L., Ferriero, D. M. & Sharp, F. R., Sep 18 2000, In : Annals of neurology. 48, 3, p. 285-296 12 p.

Research output: Contribution to journalArticle

1999

Defective vascularization of HIF-1α-null embryos is not associated with VEGF deficiency but with mesenchymal cell death

Kotch, L. E., Iyer, N. V., Laughner, E. & Semenza, G. L., May 15 1999, In : Developmental biology. 209, 2, p. 254-267 14 p.

Research output: Contribution to journalArticle

Differential regulation of vascular endothelial growth factor during ventilated pulmonary ischemia

Yu, A., Alcasabas, A., Semenza, G. & Becker, P., Jul 29 1999, In : CHEST. 116, SUPPL., p. 32S

Research output: Contribution to journalArticle

Hypoxia inducible factor-1α is increased in ischemic retina: Temporal and spatial correlation with VEGF expression

Ozaki, H., Yu, A. Y., Della, N., Ozaki, K., Luna, J. D., Yamada, H., Hackett, S. F., Okamoto, N., Zack, D. J., Semenza, G. L. & Campochiaro, P. A., Jan 20 1999, In : Investigative Ophthalmology and Visual Science. 40, 1, p. 182-189 8 p.

Research output: Contribution to journalArticle

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α

Yu, A. Y., Shimoda, L. A., Iyer, N. V., Huso, D. L., Sun, X., McWilliams, R., Beaty, T., Sham, J. S. K., Wiener, C. M., Sylvester, J. T. & Semenza, G. L., Mar 1999, In : Journal of Clinical Investigation. 103, 5, p. 691-696 6 p.

Research output: Contribution to journalArticle

Open Access

Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain

Bergeron, M., Yu, A. Y., Solway, K. E., Semenza, G. L. & Sharp, F. R., Dec 1 1999, In : European Journal of Neuroscience. 11, 12, p. 4159-4170 12 p.

Research output: Contribution to journalArticle

Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases

Zhong, H., De Marzo, A. M., Laughner, E., Lim, M., Hilton, D. A., Zagzag, D., Buechler, P., Isaacs, W. B., Semenza, G. L. & Simons, J. W., Nov 15 1999, In : Cancer Research. 59, 22, p. 5830-5835 6 p.

Research output: Contribution to journalArticle

Perspectives on oxygen sensing

Semenza, G. L., Aug 6 1999, In : Cell. 98, 3, p. 281-284 4 p.

Research output: Contribution to journalArticle

Reciprocal positive regulation of hypoxia-inducible factor 1α and insulin-like growth factor 2

Feldser, D., Agani, F., Iyer, N. V., Pak, B., Ferreira, G. & Semenza, G. L., Aug 15 1999, In : Cancer Research. 59, 16, p. 3915-3918 4 p.

Research output: Contribution to journalArticle

Regulation of cardiovascular development and physiology by hypoxia-inducible factor 1

Semenza, G. L., Agani, F., Iyer, N., Kotch, L., Laughner, E., Leung, S. & Yu, A., Jan 1 1999, In : Annals of the New York Academy of Sciences. 874, p. 262-268 7 p.

Research output: Contribution to journalArticle

1998

Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5' enhancer

Liu, Y., Christou, H., Morita, T., Laughner, E., Semenza, G. L. & Kourembanas, S., Jun 12 1998, In : Journal of Biological Chemistry. 273, 24, p. 15257-15262 6 p.

Research output: Contribution to journalArticle

Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1

Martin, C., Yu, A. Y., Jiang, B. H., Davis, L., Kimberly, D., Hohimer, A. R. & Semenza, G. L., Jan 1 1998, In : American journal of obstetrics and gynecology. 178, 3, p. 527-534 8 p.

Research output: Contribution to journalArticle

Cellular and developmental control of O2 homeostasis by hypoxia- inducible factor 1α

Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y. & Semenza, G. L., Jan 15 1998, In : Genes and Development. 12, 2, p. 149-162 14 p.

Research output: Contribution to journalArticle

Open Access

Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1

Palmer, L. A., Semenza, G. L., Stoler, M. H. & Johns, R. A., Apr 8 1998, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 274, 2 18-2, p. L212-L219

Research output: Contribution to journalArticle

Hypoxia-inducible factor 1: Master regulator of O2 homeostasis

Semenza, G. L., Oct 1998, In : Current Opinion in Genetics and Development. 8, 5, p. 588-594 7 p.

Research output: Contribution to journalArticle

Hypoxia-inducible factor 1: From molecular biology to cardiopulmonary physiology

Semenza, G. L., Agani, F., Iyer, N., Jiang, B. H., Leung, S., Wiener, C. & Yu, A., Jul 1998, In : CHEST. 114, 1 SUPPL., p. 40S-45S

Research output: Contribution to journalArticle