Gregg L Semenza

Professor

1984 …2020

Research output per year

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Research Output

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2007

HIF-1 Inhibits Mitochondrial Biogenesis and Cellular Respiration in VHL-Deficient Renal Cell Carcinoma by Repression of C-MYC Activity

Zhang, H., Gao, P., Fukuda, R., Kumar, G., Krishnamachary, B., Zeller, K. I., Dang, CV. V. & Semenza, G. L., May 8 2007, In : Cancer cell. 11, 5, p. 407-420 14 p.

Research output: Contribution to journalArticle

HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells

Fukuda, R., Zhang, H., Kim, J. W., Shimoda, L., Dang, C. V. & Semenza, GL. L., Apr 6 2007, In : Cell. 129, 1, p. 111-122 12 p.

Research output: Contribution to journalArticle

HIF-Dependent Antitumorigenic Effect of Antioxidants In Vivo

Gao, P., Zhang, H., Dinavahi, R., Li, F., Xiang, Y., Raman, V., Bhujwalla, Z. M., Felsher, D. W., Cheng, L., Pevsner, J., Lee, L. A., Semenza, G. L. & Dang, C. V., Sep 11 2007, In : Cancer cell. 12, 3, p. 230-238 9 p.

Research output: Contribution to journalArticle

Partial rescue of defects in Cited2-deficient embryos by HIF-1α heterozygosity

Xu, B., Doughman, Y., Turakhia, M., Jiang, W., Landsettle, C. E., Agani, F. H., Semenza, G. L., Watanabe, M. & Yang, Y. C., Jan 1 2007, In : Developmental biology. 301, 1, p. 130-140 11 p.

Research output: Contribution to journalArticle

RACK1 Competes with HSP90 for Binding to HIF-1α and Is Required for O2-Independent and HSP90 Inhibitor-Induced Degradation of HIF-1α

Liu, Y. V., Baek, J. H., Zhang, H., Diez, R., Cole, R. N. & Semenza, G. L., Jan 26 2007, In : Molecular cell. 25, 2, p. 207-217 11 p.

Research output: Contribution to journalArticle

Regulation of tissue perfusion in mammals by hypoxia-inducible factor 1

Semenza, G. L., Nov 2007, In : Experimental Physiology. 92, 6, p. 988-991 4 p.

Research output: Contribution to journalArticle

Spermidine/spermine N1-acetyltransferase-1 binds to hypoxia-inducible factor-1α (HIF-1α) and RACK1 and promotes ubiquitination and degradation of HIF-1α

Baek, J. H., Liu, Y. V., McDonald, K. R., Wesley, J. B., Zhang, H. & Semenza, G. L., Nov 16 2007, In : Journal of Biological Chemistry. 282, 46, p. 33358-33366 9 p.

Research output: Contribution to journalArticle

Spermidine/Spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1α

Jin, H. B., Liu, Y. V., McDonald, K. R., Wesley, J. B., Hubbi, M. E., Byun, H. & Semenza, G. L., Aug 10 2007, In : Journal of Biological Chemistry. 282, 32, p. 23572-23580 9 p.

Research output: Contribution to journalArticle

2006

Activation of hypoxia-inducible factor 1 during macrophage differentiation

Oda, T., Hirota, K., Nishi, K., Takabuchi, S., Oda, S., Yamada, H., Arai, T., Fukuda, K., Kita, T., Adachi, T., Semenza, G. L. & Nohara, R., Jul 12 2006, In : American Journal of Physiology - Cell Physiology. 291, 1, p. C104-C113

Research output: Contribution to journalArticle

Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1α

Li, J., Bosch-Marce, M., Nanayakkara, A., Savransky, V., Fried, S. K., Semenza, G. L. & Polotsky, V. Y., May 16 2006, In : Physiological Genomics. 25, 3, p. 450-457 8 p.

Research output: Contribution to journalArticle

Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1

Okuyama, H., Krishnamachary, B., Zhou, Y. F., Nagasawa, H., Bosch-Marce, M. & Semenza, G. L., Jun 2 2006, In : Journal of Biological Chemistry. 281, 22, p. 15554-15563 10 p.

Research output: Contribution to journalArticle

Heterozygous HIF-1α deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia

Peng, Y. J., Yuan, G., Ramakrishnan, D., Sharma, S. D., Bosch-Marce, M., Kumar, G. K., Semenza, G. L. & Prabhakar, N. R., Dec 1 2006, In : Journal of Physiology. 577, 2, p. 705-716 12 p.

Research output: Contribution to journalArticle

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Kim, J. W., Tchernyshyov, I., Semenza, G. L. & Dang, C. V., Mar 1 2006, In : Cell Metabolism. 3, 3, p. 177-185 9 p.

Research output: Contribution to journalArticle

Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy

Arbeit, J. M., Brown, J. M., Chao, K. S. C., Chapman, J. D., Eckelman, W. C., Fyles, A. W., Giaccia, A. J., Hill, R. P., Koch, C. J., Krishna, M. C., Krohn, K. A., Lewis, J. S., Mason, R. P., Melillo, G., Padhani, A. R., Powis, G., Rajendran, J. G., Reba, R., Robinson, S. P., Semenza, G. L. & 4 others, Swartz, H. M., Vaupel, P., Yang, D. & Tatum, J. L., Oct 1 2006, In : International journal of radiation biology. 82, 10, p. 699-757 59 p.

Research output: Contribution to journalArticle

Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development

Yoon, D., Pastore, Y. D., Divoky, V., Liu, E., Mlodnicka, A. E., Rainey, K., Ponka, P., Semenza, G. L., Schumacher, A. & Prchal, J. T., Sep 1 2006, In : Journal of Biological Chemistry. 281, 35, p. 25703-25711 9 p.

Research output: Contribution to journalArticle

Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B

Krishnamachary, B., Zagzag, D., Nagasawa, H., Rainey, K., Okuyama, H., Baek, J. H. & Semenza, G. L., Mar 1 2006, In : Cancer Research. 66, 5, p. 2725-2731 7 p.

Research output: Contribution to journalArticle

Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca 2+ in pulmonary arterial smooth muscle cells

Wang, J., Weigand, L., Lu, W., Sylvester, J. T., Semenza, G. L. & Shimoda, L. A., Jun 1 2006, In : Circulation research. 98, 12, p. 1528-1537 10 p.

Research output: Contribution to journalArticle

Meeting report: Exploiting the tumor microenvironment for therapeutics

Melillo, G. & Semenza, G. L., May 1 2006, In : Cancer Research. 66, 9, p. 4558-4560 3 p.

Research output: Contribution to journalArticle

Ocular versus extraocular neovascularization: Mirror images or vague resemblances

Campochiaro, P. A., Alani, R., Alitalo, K., Brooks, P., Caldwell, R., Carmeliet, P., Claudio, P. P., D'Amato, R., Das, A., De Martin, R., Detmar, M., Ferrara, N., Frank, R. N., Fruttiger, M., Giordano, A., Grant, M., Hammes, H. P., Hellstrom, M., Hinton, D., Keshet, E. & 16 others, Koch, A., Lang, R., McDonald, D., Nathans, J., Neri, D., Neufeld, G., Plouet, J., Semenza, G., Sheibani, N., Shima, D., Thorpe, P., Tuder, R., Volpert, O., Wagner, E., Weber, B. & Wiegand, S., Feb 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 2, p. 462-474 13 p.

Research output: Contribution to journalArticle

Spontaneous transformation of cultured mouse bone marrow-derived stromal cells

Yi, F. Z., Bosch-Marce, M., Okuyama, H., Krishnamachary, B., Kimura, H., Zhang, L., Huso, D. L. & Semenza, G. L., Nov 15 2006, In : Cancer Research. 66, 22, p. 10849-10854 6 p.

Research output: Contribution to journalArticle

2005

Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia

Yuan, G., Nanduri, J., Bhasker, C. R., Semenza, G. L. & Prabhakar, N. R., Feb 11 2005, In : Journal of Biological Chemistry. 280, 6, p. 4321-4328 8 p.

Research output: Contribution to journalArticle

Constitutively active HIF-1α improves perfusion and arterial remodeling in an endovascular model of limb ischemia

Patel, T. H., Kimura, H., Weiss, C. R., Semenza, G. L. & Hofmann, L. V., Oct 1 2005, In : Cardiovascular research. 68, 1, p. 144-154 11 p.

Research output: Contribution to journalArticle

HIF-1α, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas

Gray, M. J., Zhang, J., Ellis, L. M., Semenza, G. L., Evans, D. B., Watowich, S. S. & Gallick, G. E., Apr 28 2005, In : Oncogene. 24, 19, p. 3110-3120 11 p.

Research output: Contribution to journalArticle

HIF-1α-targeted pathways are activated by heat acclimation and contribute to acclimation-ischemic cross-tolerance in the heart

Maloyan, A., Eli-Berchoer, L., Semenza, G. L., Gerstenblith, G., Stern, M. D. & Horowitz, M., Sep 21 2005, In : Physiological Genomics. 23, 1, p. 79-88 10 p.

Research output: Contribution to journalArticle

Hypoxia-inducible factor 1α polymorphism and coronary collaterals in patients with ischemic heart disease

Resar, J. R., Roguin, A., Voner, J., Nasir, K., Hennebry, T. A., Miller, J. M., Ingersoll, R., Kasch, L. M. & Semenza, G. L., Aug 2005, In : CHEST. 128, 2, p. 787-791 5 p.

Research output: Contribution to journalArticle

Involvement of hypoxia-inducible factor 1 in pulmonary pathophysiology

Semenza, G. L., Dec 2005, In : CHEST. 128, 6 SUPPL., p. 592S-594S

Research output: Contribution to journalArticle

OS-9 interacts with hypoxia-inducible factor 1α and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1α

Baek, J. H., Mahon, P. C., Oh, J., Kelly, B., Krishnamachary, B., Pearson, M., Chan, D. A., Giaccia, A. J. & Semenza, G. L., Feb 18 2005, In : Molecular cell. 17, 4, p. 503-512 10 p.

Research output: Contribution to journalArticle

PTEN activity is modulated during ischemia and reperfusion: Involvement in the induction and decay of preconditioning

Cai, Z. & Semenza, G. L., Dec 1 2005, In : Circulation research. 97, 12, p. 1351-1359 9 p.

Research output: Contribution to journalArticle

Stromal cell-derived factor-1α and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: Von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor

Zagzag, D., Krishnamachary, B., Yee, H., Okuyama, H., Chiriboga, L., Ali, M. A., Melamed, J. & Semenza, G. L., Jul 15 2005, In : Cancer Research. 65, 14, p. 6178-6188 11 p.

Research output: Contribution to journalArticle

Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

Xu, Q., Briggs, J., Park, S., Niu, G., Kortylewski, M., Zhang, S., Gritsko, T., Turkson, J., Kay, H., Semenza, G. L., Cheng, J. Q., Jove, R. & Yu, H., Aug 25 2005, In : Oncogene. 24, 36, p. 5552-5560 9 p.

Research output: Contribution to journalArticle

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1

Manalo, D. J., Rowan, A., Lavoie, T., Natarajan, L., Kelly, B. D., Ye, S. Q., Garcia, J. G. N. & Semenza, G. L., Jan 15 2005, In : Blood. 105, 2, p. 659-669 11 p.

Research output: Contribution to journalArticle

Up-regualtion of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor I (HIF-I)

Greijer, A. E., van der Groep, P., Kemming, D., Shvarts, A., Semenza, G. L., Meijer, G. A., van de Wiel, M. A., Belien, J. A. M., van Diest, P. J. & van der Wall, E., Jul 1 2005, In : Journal of Pathology. 206, 3, p. 291-304 14 p.

Research output: Contribution to journalArticle

Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling

Hirota, K., Fukuda, R., Takabuchi, S., Kizaka-Kondoh, S., Adachi, T., Fukuda, K. & Semenza, G. L., Oct 1 2004, In : Journal of Biological Chemistry. 279, 40, p. 41521-41528 8 p.

Research output: Contribution to journalArticle

Nitric Oxide Induces Hypoxia-inducible Factor 1 Activation That Is Dependent on MAPK and Phosphatidylinositol 3-Kinase Signaling

Kasuno, K., Takabuchi, S., Fukuda, K., Kizaka-Kondoh, S., Yodoi, J., Adachi, T., Semenza, G. L. & Hirota, K., Jan 23 2004, In : Journal of Biological Chemistry. 279, 4, p. 2550-2558 9 p.

Research output: Contribution to journalArticle

Proceedings of the Oxygen Homeostasis/Hypoxia Meeting

Kaufman, B., Scharf, O., Arbeit, J., Ashcroft, M., Brown, J. M., Bruick, R. K., Chapman, J. D., Evans, S. M., Giaccia, A. J., Harris, A. L., Huang, E., Johnson, R., Kaelin, W., Koch, C. J., Maxwell, P., Mitchell, J., Neckers, L., Powis, G., Rajendran, J., Semenza, G. L. & 6 others, Simons, J., Storkebaum, E., Welch, M. J., Whitelaw, M., Melillo, G. & Ivy, S. P., May 1 2004, In : Cancer Research. 64, 9, p. 3350-3356 7 p.

Research output: Contribution to journalArticle

Role of hypoxia-inducible factor 1α in gastric cancer cell growth, angiogenesis, and vessel maturation

Stoeltzing, O., McCarty, M. F., Wey, J. S., Fan, F., Liu, W., Belcheva, A., Bucana, C. D., Semenza, G. L. & Ellis, L. M., Jun 16 2004, In : Journal of the National Cancer Institute. 96, 12, p. 946-956 11 p.

Research output: Contribution to journalArticle

Open Access

The inhibitory effect of sodium nitroprusside on HIF-1 activation is not dependent on nitric oxide-soluble guanylyl cyclase pathway

Takabuchi, S., Hirota, K., Nishi, K., Oda, S., Oda, T., Shingu, K., Takabayashi, A., Adachi, T., Semenza, G. L. & Fukuda, K., Nov 5 2004, In : Biochemical and Biophysical Research Communications. 324, 1, p. 417-423 7 p.

Research output: Contribution to journalArticle

The intravenous anesthetic propofol inhibits hypoxia-inducible factor 1 activity in an oxygen tension-dependent manner

Takabuchi, S., Hirota, K., Nishi, K., Oda, S., Oda, T., Shingu, K., Takabayashi, A., Adachi, T., Semenza, G. L. & Fukuda, K., Nov 19 2004, In : FEBS Letters. 577, 3, p. 434-438 5 p.

Research output: Contribution to journalArticle

Up-regulation of hypoxia-inducible factor 1α is an early event in prostate carcinogenesis

Zhong, H., Semenza, G. L., Simons, J. W. & De Marzo, A. M., Apr 20 2004, In : Cancer detection and prevention. 28, 2, p. 88-93 6 p.

Research output: Contribution to journalArticle

2003

Cell Type-Specific Regulation of Angiogenic Growth Factor Gene Expression and Induction of Angiogenesis in Nonischemic Tissue by a Constitutively Active Form of Hypoxia-Inducible Factor 1

Kelly, B. D., Hackett, S. F., Hirota, K., Oshima, Y., Cai, Z., Berg-Dixon, S., Rowan, A., Yan, Z., Campochiaro, P. A. & Semenza, G. L., Nov 28 2003, In : Circulation research. 93, 11, p. 1074-1081 8 p.

Research output: Contribution to journalArticle

Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury

Cai, Z., Manalo, D. J., Wei, G., Rodriguez, E. R., Fox-Talbot, K., Lu, H., Zweier, J. L. & Semenza, G. L., Jul 8 2003, In : Circulation. 108, 1, p. 79-85 7 p.

Research output: Contribution to journalArticle

Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer

Büchler, P., Reber, H. A., Büchler, M., Shrinkante, S., Büchler, M. W., Friess, H., Semenza, G. L. & Hines, O. J., Jan 1 2003, In : Pancreas. 26, 1, p. 56-64 9 p.

Research output: Contribution to journalArticle

Levels of hypoxia-inducible factor-1α independently predict prognosis in patients with lymph node negative breast carcinoma

Bos, R., Van der Groep, P., Greijer, A. E., Shvarts, A., Meijer, S., Pinedo, H. M., Semenza, G. L., Van Diest, P. J. & Van der Wall, E., Mar 15 2003, In : Cancer. 97, 6, p. 1573-1581 9 p.

Research output: Contribution to journalArticle

Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1

Krishnamachary, B., Berg-Dixon, S., Kelly, B., Agani, F., Feldser, D., Ferreira, G., Iyer, N., LaRusch, J., Pak, B., Taghavi, P. & Semenza, G. L., Mar 1 2003, In : Cancer Research. 63, 5, p. 1138-1143 6 p.

Research output: Contribution to journalArticle