Gregg L Semenza

Professor

1984 …2020

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2011

Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension

Peng, Y. J., Nanduri, J., Khan, S. A., Yuan, G., Wang, N., Kinsman, B., Vaddi, D. R., Kumar, G. K., Garcia, J. A., Semenza, G. L. & Prabhakar, N. R., Feb 15 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 7, p. 3065-3070 6 p.

Research output: Contribution to journalArticle

Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury

Kannan, K. B., Colorado, I., Reino, D., Palange, D., Lu, Q., Qin, X., Abungu, B., Watkins, A., Caputo, F. J., Xu, D. Z., Semenza, G. L., Deitch, E. A. & Feinman, R., May 1 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 5, p. G853-G861

Research output: Contribution to journalArticle

Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis

Hattori, H., Okuda, K., Murase, T., Shigetsura, Y., Narise, K., Semenza, G. L. & Nagasawa, H., Sep 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 18, p. 5392-5401 10 p.

Research output: Contribution to journalArticle

MCM Proteins Are Negative Regulators of Hypoxia-Inducible Factor 1

Hubbi, M. E., Luo, W., Baek, J. H. & Semenza, G. L., Jun 10 2011, In : Molecular cell. 42, 5, p. 700-712 13 p.

Research output: Contribution to journalArticle

Metabolic reprogramming by HIF-1 promotes the survival of bone marrow-derived angiogenic cells in ischemic tissue

Rey, S., Luo, W., Shimoda, L. A. & Semenza, G. L., May 5 2011, In : Blood. 117, 18, p. 4988-4998 11 p.

Research output: Contribution to journalArticle

Nitric oxide prevents axonal degeneration by inducing HIF-1-dependent expression of erythropoietin

Keswani, S. C., Bosch-Marcé, M., Reed, N., Fischer, A., Semenza, G. L. & Höke, A., Mar 22 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 12, p. 4986-4990 5 p.

Research output: Contribution to journalArticle

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

Luo, W., Hu, H., Chang, R., Zhong, J., Knabel, M., O'Meally, R., Cole, R. N., Pandey, A. & Semenza, G. L., May 27 2011, In : Cell. 145, 5, p. 732-744 13 p.

Research output: Contribution to journalArticle

Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells

Luo, W. & Semenza, G. L., Jul 2011, In : Oncotarget. 2, 7, p. 551-556 6 p.

Research output: Contribution to journalArticle

Open Access

Regulation of metabolism by hypoxia-inducible factor 1

Semenza, G. L., Dec 1 2011, In : Cold Spring Harbor symposia on quantitative biology. 76, p. 347-353 7 p.

Research output: Contribution to journalArticle

2010

Association of increasing burn severity in mice with delayed mobilization of circulating angiogenic cells

Zhang, X., Wei, X., Liu, L., Marti, G. P., Ghanamah, M. S., Arshad, M. J., Strom, L., Spence, R., Jeng, J., Milner, S., Harmon, J. W. & Semenza, G. L., Mar 1 2010, In : Archives of surgery. 145, 3, p. 259-266 8 p.

Research output: Contribution to journalArticle

Differentiation stage-specific requirement in hypoxia-inducible factor-1α-regulated glycolytic pathway during murine B cell development in bone marrow

Kojima, H., Kobayashi, A., Sakurai, D., Kanno, Y., Hase, H., Takahashi, R., Totsuka, Y., Semenza, G. L., Sitkovsky, M. V. & Kobata, T., Jan 1 2010, In : Journal of Immunology. 184, 1, p. 154-163 10 p.

Research output: Contribution to journalArticle

Digoxin inhibits retinal ischemia-induced HIF-1α expression and ocular neovascularization

Yoshida, T., Zhang, H., Iwase, T., Shen, J., Semenza, G. L. & Campochiaro, P. A., Jun 1 2010, In : FASEB Journal. 24, 6, p. 1759-1767 9 p.

Research output: Contribution to journalArticle

G-rich oligonucleotides inhibit HIF-1α and HIF-2α and block tumor growth

Guan, Y., Ramasamy Reddy, K., Zhu, Q., Li, Y., Lee, K., Weerasinghe, P., Prchal, J., Semenza, G. L. & Jing, N., Jan 1 2010, In : Molecular Therapy. 18, 1, p. 188-197 10 p.

Research output: Contribution to journalArticle

HIF-1beta determines ABCA1 expression under hypoxia in human macrophages

Ugocsai, P., Hohenstatt, A., Paragh, G., Liebisch, G., Langmann, T., Wolf, Z., Weiss, T., Groitl, P., Dobner, T., Kasprzak, P., Göbölös, L., Falkert, A., Seelbach-Goebel, B., Gellhaus, A., Winterhager, E., Schmidt, M., Semenza, G. L. & Schmitz, G., Feb 1 2010, In : International Journal of Biochemistry and Cell Biology. 42, 2, p. 241-252 12 p.

Research output: Contribution to journalArticle

HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury

Feinman, R., Deitch, E. A., Watkins, A. C., Abungu, B., Colorado, I., Kannan, K. B., Sheth, S. U., Caputo, F. J., Lu, Q., Ramanathan, M., Attan, S., Badami, C. D., Doucet, D., Barlos, D., Bosch-Marce, M., Semenza, G. L. & Xu, D. Z., Oct 1 2010, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 299, 4, p. G833-G843

Research output: Contribution to journalArticle

Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1α but not HIF-2α

Luo, W., Zhong, J., Chang, R., Hu, H., Pandey, A. & Semenza, G. L., Feb 5 2010, In : Journal of Biological Chemistry. 285, 6, p. 3651-3663 13 p.

Research output: Contribution to journalArticle

Impaired angiogenesis and mobilization of circulating angiogenic cells in HIF-1α heterozygous-null mice after burn wounding

Zhang, X., Liu, L., Wei, X., Tan, Y. S., Tong, L., Chang, R., Ghanamah, M. S., Reinblatt, M., Marti, G. P., Harmon, J. W. & Semenza, G. L., Mar 1 2010, In : Wound Repair and Regeneration. 18, 2, p. 193-201 9 p.

Research output: Contribution to journalArticle

Increased size of solid organs in patients with Chuvash polycythemia and in mice with altered expression of HIF-1α and HIF-2α

Yoon, D., Okhotin, D. V., Kim, B., Okhotina, Y., Okhotin, D. J., Miasnikova, G. Y., Sergueeva, A. I., Polyakova, L. A., Maslow, A., Lee, Y., Semenza, G. L., Prchal, J. T. & Gordeuk, V. R., May 1 2010, In : Journal of Molecular Medicine. 88, 5, p. 523-530 8 p.

Research output: Contribution to journalArticle

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

Le, A., Cooper, C. R., Gouw, A. M., Dinavahi, R., Maitra, A., Deck, L. M., Royer, R. E., Vander Jagt, D. L., Semenza, G. L. & Dang, C. V., Feb 2 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 5, p. 2037-2042 6 p.

Research output: Contribution to journalArticle

Negative Regulation of Hypoxic Responses via Induced Reptin Methylation

Lee, J. S., Kim, Y., Kim, I. S., Kim, B., Choi, H. J., Lee, J. M., Shin, H. J. R., Kim, J. H., Kim, J. Y., Seo, S. B., Lee, H., Binda, O., Gozani, O., Semenza, G. L., Kim, M., Kim, K. I., Hwang, D. & Baek, S. H., Jul 1 2010, In : Molecular cell. 39, 1, p. 71-85 15 p.

Research output: Contribution to journalArticle

T-cell activation under hypoxic conditions enhances IFN-γ secretion

Roman, J., Rangasamy, T., Guo, J., Sugunan, S., Meednu, N., Packirisamy, G., Shimoda, L. A., Golding, A., Semenza, G. & Georas, S. N., Jan 1 2010, In : American journal of respiratory cell and molecular biology. 42, 1, p. 123-128 6 p.

Research output: Contribution to journalArticle

2009

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

Lee, K. A., Zhang, H., Qian, D. Z., Rey, S., Liu, J. O. & Semenza, G. L., Oct 20 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 42, p. 17910-17915 6 p.

Research output: Contribution to journalArticle

Adenoviral transfer of HIF-1α enhances vascular responses to critical limb ischemia in diabetic mice

Sarkar, K., Fox-Talbot, K., Steenbergen, C., Bosch-Marcë, M. & Semenza, G. L., Nov 3 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 44, p. 18769-18774 6 p.

Research output: Contribution to journalArticle

Altered hypoxia-inducible factor-1 alpha expression levels correlate with coronary vessel anomalies.

Wikenheiser, J., Wolfram, J. A., Gargesha, M., Yang, K., Karunamuni, G., Wilson, D. L., Semenza, G. L., Agani, F., Fisher, S. A., Ward, N. & Watanabe, M., Oct 2009, In : Developmental dynamics : an official publication of the American Association of Anatomists. 238, 10, p. 2688-2700 13 p.

Research output: Contribution to journalArticle

Identification of chemical compounds that induce HIF-1α activity

Xia, M., Huang, R., Sun, Y., Semenza, G. L., Aldred, S. F., Witt, K. L., Inglese, J., Tice, R. R. & Austin, C. P., Nov 16 2009, In : Toxicological Sciences. 112, 1, p. 153-163 11 p.

Research output: Contribution to journalArticle

Regulation of oxygen homeostasis by hypoxia-Inducible factor 1

Semenza, G. L., Apr 2009, In : Physiology. 24, 2, p. 97-106 10 p.

Research output: Contribution to journalArticle

Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways

Siddiq, A., Aminova, L. R., Troy, C. M., Suh, K., Messer, Z., Semenza, G. L. & Ratan, R. R., Jul 8 2009, In : Journal of Neuroscience. 29, 27, p. 8828-8838 11 p.

Research output: Contribution to journalArticle

Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer

Kizaka-Kondoh, S., Itasaka, S., Zeng, L., Tanaka, S., Zhao, T., Takahashi, Y., Shibuya, K., Hirota, K., Semenza, G. L. & Hiraoka, M., May 15 2009, In : Clinical Cancer Research. 15, 10, p. 3433-3441 9 p.

Research output: Contribution to journalArticle

Synergistic effect of HIF-1α gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia

Rey, S., Lee, K. A., Wang, C. J., Gupta, K., Chen, S., McMillan, A., Bhise, N., Levchenko, A. & Semenza, G. L., Dec 1 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 48, p. 20399-20404 6 p.

Research output: Contribution to journalArticle

2008

Age-dependent impairment of HIF-1α expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells

Liu, L., Marti, G. P., Wei, X., Zhang, X., Zhang, H., Liu, Y. V., Nastai, M., Semenza, G. L. & Harmon, J. W., Nov 1 2008, In : Journal of Cellular Physiology. 217, 2, p. 319-327 9 p.

Research output: Contribution to journalArticle

A new weapon for attacking tumor blood vessels

Semenza, G. L., May 8 2008, In : New England Journal of Medicine. 358, 19, 1 p.

Research output: Contribution to journalArticle

Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1α

Cai, Z., Zhong, H., Bosch-Marce, M., Fox-Talbot, K., Wang, L., Wei, C., Trush, M. A. & Semenza, G. L., Feb 1 2008, In : Cardiovascular research. 77, 3, p. 463-470 8 p.

Research output: Contribution to journalArticle

Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth

Zhang, H., Qian, D. Z., Tan, Y. S., Lee, K. A., Gao, P., Ren, Y. R., Rey, S., Hammers, H., Chang, D., Pili, R., Dang, C. V., Liu, J. O. & Semenza, G. L., Dec 16 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 50, p. 19579-19586 8 p.

Research output: Contribution to journalArticle

Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K + channel expression in pulmonary arterial myocytes

Whitman, E. M., Pisarcik, S., Luke, T., Fallon, M., Wang, J., Sylvester, J. T., Semenza, G. L. & Shimoda, L. A., Feb 1 2008, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 294, 2, p. L309-L318

Research output: Contribution to journalArticle

Hypoxia-induced resistance to anticancer drugs is associated with decreased senescence and requires hypoxia-inducible factor-1 activity

Sullivan, R., Paré, G. C., Frederiksen, L. J., Semenza, G. L. & Graham, C. H., Oct 15 2008, In : Molecular cancer therapeutics. 7, 7, p. 1961-1973 13 p.

Research output: Contribution to journalArticle

Induction of HIF-1α expression by intermittent hypoxia: Involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR

Yuan, G., Nanduri, J., Khan, S., Semenza, G. L. & Prabhakar, N. R., Dec 1 2008, In : Journal of Cellular Physiology. 217, 3, p. 674-685 12 p.

Research output: Contribution to journalArticle

LPS induces hypoxia-inducible factor 1 activation in macrophage- differentiated cells in a reactive oxygen species-dependent manner

Nishi, K., Oda, T., Takabuchi, S., Oda, S., Fukuda, K., Adachi, T., Semenza, G. L., Shingu, K. & Hirota, K., May 1 2008, In : Antioxidants and Redox Signaling. 10, 5, p. 983-995 13 p.

Research output: Contribution to journalArticle

Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner

Oda, S., Oda, T., Nishi, K., Takabuchi, S., Wakamatsu, T., Tanaka, T., Adachi, T., Fukuda, K., Semenza, G. L. & Hirota, K., May 21 2008, In : PloS one. 3, 5, e2215.

Research output: Contribution to journalArticle

Mitochondrial autophagy: Life and breath of the cell

Semenza, G. L., May 16 2008, In : Autophagy. 4, 4, p. 534-536 3 p.

Research output: Contribution to journalArticle

Open Access

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

Zhang, H., Bosch-Marce, M., Shimoda, L. A., Yee, S. T., Jin, H. B., Wesley, J. B., Gonzalez, F. J. & Semenza, G. L., Apr 18 2008, In : Journal of Biological Chemistry. 283, 16, p. 10892-10903 12 p.

Research output: Contribution to journalArticle

n-Propyl gallate activates hypoxia-inducible factor 1 by modulating intracellular oxygen-sensing systems

Kimura, M., Takabuchi, S., Tanaka, T., Murata, M., Nishi, K., Oda, S., Oda, T., Kanai, M., Fukuda, K., Kizaka-Kondoh, S., Adachi, T., Takabayashi, A., Semenza, G. L. & Hirota, K., Apr 1 2008, In : Biochemical Journal. 411, 1, p. 97-105 9 p.

Research output: Contribution to journalArticle

SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1α ubiquitination and degradation

Tan, M., Gu, Q., He, H., Pamarthy, D., Semenza, G. L. & Sun, Y., Feb 28 2008, In : Oncogene. 27, 10, p. 1404-1411 8 p.

Research output: Contribution to journalArticle

The expanding universe of hypoxia

Zhang, H. & Semenza, G. L., Jul 1 2008, In : Journal of Molecular Medicine. 86, 7, p. 739-746 8 p.

Research output: Contribution to journalArticle

2007

Activation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cells

Tomita, M., Semenza, G. L., Michiels, C., Matsuda, T., Uchihara, J. N., Okudaira, T., Tanaka, Y., Taira, N., Ohshiro, K. & Mori, N., Sep 1 2007, In : Biochemical Journal. 406, 2, p. 317-323 7 p.

Research output: Contribution to journalArticle

Calcineurin promotes hypoxia-inducible factor 1α expression by dephosphorylating RACK1 and blocking RACK1 dimerization

Liu, Y. V., Hubbi, M. E., Pan, F., McDonald, K. R., Mansharamani, M., Cole, R. N., Liu, J. O. & Semenza, G. L., Dec 21 2007, In : Journal of Biological Chemistry. 282, 51, p. 37064-37073 10 p.

Research output: Contribution to journalArticle

Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia

Bosch-Marce, M., Okuyama, H., Wesley, J. B., Sarkar, K., Kimura, H., Liu, Y. V., Zhang, H., Strazza, M., Rey, S., Savino, L., Zhou, Y. F., McDonald, K. R., Na, Y., Vandiver, S., Rabi, A., Shaked, Y., Kerbel, R., LaVallee, T. & Semenza, G. L., Dec 1 2007, In : Circulation research. 101, 12, p. 1310-1318 9 p.

Research output: Contribution to journalArticle

Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1α deficiency

Komatsu, D. E., Bosch-Marce, M., Semenza, G. L. & Hadjiargyrou, M., Mar 1 2007, In : Journal of Bone and Mineral Research. 22, 3, p. 366-374 9 p.

Research output: Contribution to journalArticle

HIF-1 Inhibits Mitochondrial Biogenesis and Cellular Respiration in VHL-Deficient Renal Cell Carcinoma by Repression of C-MYC Activity

Zhang, H., Gao, P., Fukuda, R., Kumar, G., Krishnamachary, B., Zeller, K. I., Dang, CV. V. & Semenza, G. L., May 8 2007, In : Cancer cell. 11, 5, p. 407-420 14 p.

Research output: Contribution to journalArticle