Gregg L Semenza

Professor

1984 …2020

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2014

Hypoxia-inducible factor 1 and cardiovascular disease

Semenza, G. L., Feb 1 2014, In : Annual review of physiology. 76, p. 39-56 18 p.

Research output: Contribution to journalArticle

Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype

Xiang, L., Gilkes, D. M., Hu, H., Takano, N., Luo, W., Lu, H., Bullen, J. W., Samanta, D., Liang, H. & Semenza, G. L., Jan 1 2014, In : Oncotarget. 5, 24, p. 12509-12527 19 p.

Research output: Contribution to journalArticle

Open Access

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

Wang, T., Gilkes, D. M., Takano, N., Xiang, L., Luo, W., Bishop, C. J., Chaturvedi, P., Green, J. J. & Semenza, G. L., Aug 5 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 31, p. E3234-E3242

Research output: Contribution to journalArticle

Hypoxia-inducible factors enhance glutamate signaling in cancer cells

Hu, H., Takano, N., Xiang, L., Gilkes, D. M., Luo, W. & Semenza, G. L., Jan 1 2014, In : Oncotarget. 5, 19, p. 8853-8868 16 p.

Research output: Contribution to journalArticle

Open Access

Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells

Gilkes, D. M., Xiang, L., Lee, S. J., Chaturvedi, P., Hubbi, M. E., Wirtz, D. & Semenza, G. L., Jan 21 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 3, p. E384-E393

Research output: Contribution to journalArticle

Open Access

Hypoxia-inducible factors regulate human and rat cystathionine â-synthase gene expression

Takano, N., Peng, Y. J., Kumar, G. K., Luo, W., Hu, H., Shimoda, L. A., Suematsu, M., Prabhakar, N. R. & Semenza, G. L., Mar 1 2014, In : Biochemical Journal. 458, 2, p. 203-211 9 p.

Research output: Contribution to journalArticle

PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility

Luo, W., Lin, B., Wang, Y., Zhong, J., O'Meally, R., Cole, R. N., Pandey, A., Levchenko, A. & Semenza, G. L., Sep 15 2014, In : Molecular biology of the cell. 25, 18, p. 2788-2796 9 p.

Research output: Contribution to journalArticle

Open Access

Promotion of airway anastomotic microvascular regeneration and alleviation of airway ischemia by deferoxamine nanoparticles

Jiang, X., Malkovskiy, A. V., Tian, W., Sung, Y. K., Sun, W., Hsu, J. L., Manickam, S., Wagh, D., Joubert, L. M., Semenza, G. L., Rajadas, J. & Nicolls, M. R., Jan 1 2014, In : Biomaterials. 35, 2, p. 803-813 11 p.

Research output: Contribution to journalArticle

Regulation of hypoxia-inducible factor-α isoforms and redox state by carotid body neural activity in rats

Peng, Y. J., Yuan, G., Khan, S., Nanduri, J., Makarenko, V. V., Reddy, V. D., Vasavda, C., Kumar, G. K., Semenza, G. L. & Prabhakar, N. R., Sep 1 2014, In : Journal of Physiology. 592, 17, p. 3841-3858 18 p.

Research output: Contribution to journalArticle

Systemic delivery of microencapsulated 3-bromopyruvate for the therapy of pancreatic cancer

Chapiro, J., Sur, S., Savic, L. J., Ganapathy-Kanniappan, S., Reyes, J., Duran, R., Thiruganasambandam, S. C., Moats, C. R., Lin, M. D., Luo, W., Tran, P. T., Herman, J. M., Semenza, G. L., Ewald, A. J., Vogelstein, B. & Geschwind, J. F., Dec 15 2014, In : Clinical Cancer Research. 20, 24, p. 6406-6417 12 p.

Research output: Contribution to journalArticle

2013

Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1

Pisarcik, S., Maylor, J., Lu, W., Yun, X., Undem, C., Sylvester, J. T., Semenza, G. L. & Shimoda, L. A., Jun 11 2013, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 304, 8, p. L549-L561

Research output: Contribution to journalArticle

A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication

Hubbi, M. E., Kshitiz, Gilkes, D. M., Rey, S., Wong, C. C., Luo, W., Kim, D. H., Dang, C. V., Levchenko, A. & Semenza, G. L., Feb 12 2013, In : Science signaling. 6, 262, ra10.

Research output: Contribution to journalArticle

A physical sciences network characterization of non-tumorigenic and metastatic cells

Agus, D. B., Alexander, J. F., Arap, W., Ashili, S., Aslan, J. E., Austin, R. H., Backman, V., Bethel, K. J., Bonneau, R., Chen, W. C., Chen-Tanyolac, C., Choi, N. C., Curley, S. A., Dallas, M., Damania, D., Davies, P. C. W., Decuzzi, P., Dickinson, L., Estevez-Salmeron, L., Estrella, V. & 75 others, Ferrari, M., Fischbach, C., Foo, J., Fraley, S. I., Frantz, C., Fuhrmann, A., Gascard, P., Gatenby, R. A., Geng, Y., Gerecht, S., Gillies, R. J., Godin, B., Grady, W. M., Greenfield, A., Hemphill, C., Hempstead, B. L., Hielscher, A., Hillis, W. D., Holland, E. C., Ibrahim-Hashim, A., Jacks, T., Johnson, R. H., Joo, A., Katz, J. E., Kelbauskas, L., Kesselman, C., King, M. R., Konstantopoulos, K., Kraning-Rush, C. M., Kuhn, P., Kung, K., Kwee, B., Lakins, J. N., Lambert, G., Liao, D., Licht, J. D., Liphardt, J. T., Liu, L., Lloyd, M. C., Lyubimova, A., Mallick, P., Marko, J., McCarty, O. J. T., Meldrum, D. R., Michor, F., Mumenthaler, S. M., Nandakumar, V., O'Halloran, T. V., Oh, S., Pasqualini, R., Paszek, M. J., Philips, K. G., Poultney, C. S., Rana, K., Reinhart-King, C. A., Ros, R., Semenza, G. L., Senechal, P., Shuler, M. L., Srinivasan, S., Staunton, J. R., Stypula, Y., Subramanian, H., Tlsty, T. D., Tormoen, G. W., Tseng, Y., Van Oudenaarden, A., Verbridge, S. S., Wan, J. C., Weaver, V. M., Widom, J., Will, C., Wirtz, D., Wojtkowiak, J. & Wu, P. H., Jul 4 2013, In : Scientific reports. 3, 1449.

Research output: Contribution to journalArticle

Chaperone-mediated autophagy targets hypoxia-inducible factor-1β(HIF- 1β) for lysosomal degradation

Hubbi, M. E., Hu, H., Kshitiz, Ahmed, I., Levchenko, A. & Semenza, G. L., Apr 12 2013, In : Journal of Biological Chemistry. 288, 15, p. 10703-10714 12 p.

Research output: Contribution to journalArticle

Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4

Drager, L. F., Yao, Q., Hernandez, K. L., Shin, M. K., Bevans-Fonti, S., Gay, J., Sussan, T. E., Jun, J. C., Myers, A. C., Olivecrona, G., Schwartz, A. R., Halberg, N., Scherer, P. E., Semenza, G. L., Powell, D. R. & Polotsky, V. Y., Jul 15 2013, In : American journal of respiratory and critical care medicine. 188, 2, p. 240-248 9 p.

Research output: Contribution to journalArticle

Collagen prolyl hydroxylases are essential for breast cancer metastasis

Gilkes, D. M., Chaturvedi, P., Bajpai, S., Wong, C. C., Wei, H., Pitcairn, S., Hubbi, M. E., Wirtz, D. & Semenza, G. L., Jun 1 2013, In : Cancer Research. 73, 11, p. 3285-3296 12 p.

Research output: Contribution to journalArticle

Combination of HIF-1α gene transfection and HIF-1-Activated bone marrow-derived angiogenic cell infusion improves burn wound healing in aged mice

Du, J., Liu, L., Lay, F., Wang, Q., Dou, C., Zhang, X., Hosseini, S. M., Simon, A., Rees, D. J., Ahmed, A. K., Sebastian, R., Sarkar, K., Milner, S., Marti, G. P., Semenza, G. L. & Harmon, J. W., Nov 1 2013, In : Gene Therapy. 20, 11, p. 1070-1076 7 p.

Research output: Contribution to journalArticle

Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart

Cai, Z., Luo, W., Zhan, H. & Semenza, G. L., Oct 22 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 43, p. 17462-17467 6 p.

Research output: Contribution to journalArticle

Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis

Chaturvedi, P., Gilkes, D. M., Wong, C. C. L., Kshitiz, Luo, W., Zhang, H., Wei, H., Takano, N., Schito, L., Levchenko, A. & Semenza, G. L., Jan 2 2013, In : Journal of Clinical Investigation. 123, 1, p. 189-205 17 p.

Research output: Contribution to journalArticle

Hypoxic retinal Müller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4

Xin, X., Rodrigues, M., Umapathi, M., Kashiwabuchi, F., Ma, T., Babapoor-Farrokhran, S., Wang, S., Hu, J., Bhutto, I., Welsbie, D. S., Duh, E. J., Handa, J. T., Eberhart, C. G., Lutty, G., Semenza, G. L., Montaner, S. & Sodhi, A., Sep 3 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 36, p. E3425-E3434

Research output: Contribution to journalArticle

Increased susceptibility of HIF-1α heterozygous-null mice to cardiovascular malformations associated with maternal diabetes

Bohuslavova, R., Skvorova, L., Sedmera, D., Semenza, G. L. & Pavlinkova, G., Jul 1 2013, In : Journal of Molecular and Cellular Cardiology. 60, 1, p. 129-141 13 p.

Research output: Contribution to journalArticle

Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis

Yuan, G., Peng, Y. J., Reddy, V. D., Makarenko, V. V., Nanduri, J., Khan, S. A., Garcia, J. A., Kumar, G. K., Semenza, G. L. & Prabhakar, N. R., May 7 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 19, p. E1788-E1796

Research output: Contribution to journalArticle

Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis

Gilkes, D. M., Bajpai, S., Wong, C. C., Chaturvedi, P., Hubbi, M. E., Wirtz, D. & Semenza, G. L., May 1 2013, In : Molecular Cancer Research. 11, 5, p. 456-466 11 p.

Research output: Contribution to journalArticle

Science signaling podcast: 12 February 2013

Semenza, G. L., Hubbi, M. E. & VanHook, A. M., Feb 12 2013, In : Science signaling. 6, 262, pc5.

Research output: Contribution to journalArticle

Sirtuin-7 inhibits the activity of hypoxia-inducible factors

Hubbi, M. E., Hu, H., Kshitiz, Gilkes, D. M. & Semenza, G. L., Jul 19 2013, In : Journal of Biological Chemistry. 288, 29, p. 20768-20775 8 p.

Research output: Contribution to journalArticle

Sustained delivery of a HIF-1 antagonist for ocular neovascularization

Iwase, T., Fu, J., Yoshida, T., Muramatsu, D., Miki, A., Hashida, N., Lu, L., Oveson, B., Lima E Silva, R., Seidel, C., Yang, M., Connelly, S., Shen, J., Han, B., Wu, M., Semenza, G. L., Hanes, J. & Campochiaro, P. A., Nov 13 2013, In : Journal of Controlled Release. 172, 3, p. 625-633 9 p.

Research output: Contribution to journalArticle

The ubiquitin ligase stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3

Chen, Z., Barbi, J., Bu, S., Yang, H. Y., Li, Z., Gao, Y., Jinasena, D., Fu, J., Lin, F., Chen, C., Zhang, J., Yu, N., Li, X., Shan, Z., Nie, J., Gao, Z., Tian, H., Li, Y., Yao, Z., Zheng, Y. & 16 others, Park, B. V., Pan, Z., Zhang, J., Dang, E., Li, Z., Wang, H., Luo, W., Li, L., Semenza, G. L., Zheng, S. G., Loser, K., Tsun, A., Greene, M. I., Pardoll, D. M., Pan, F. & Li, B., Aug 22 2013, In : Immunity. 39, 2, p. 272-285 14 p.

Research output: Contribution to journalArticle

Tie2-dependent VHL knockdown promotes airway microvascular regeneration and attenuates invasive growth of Aspergillus fumigatus

Jiang, X., Hsu, J. L., Tian, W., Yuan, K., Olcholski, M., De Jesus Perez, V., Semenza, G. L. & Nicolls, M. R., Sep 1 2013, In : Journal of Molecular Medicine. 91, 9, p. 1081-1093 13 p.

Research output: Contribution to journalArticle

VEGF secreted by hypoxic Müller cells induces MMP-2 expression and activity in endothelial cells to promote retinal neovascularization in proliferative diabetic retinopathy

Rodrigues, M., Xin, X., Jee, K., Babapoor-Farrokhran, S., Kashiwabuchi, F., Ma, T., Bhutto, I., Hassan, S. J., Daoud, Y., Baranano, D., Solomon, S., Lutty, G., Semenza, G. L., Montaner, S. & Sodhi, A., Nov 1 2013, In : Diabetes. 62, 11, p. 3863-3873 11 p.

Research output: Contribution to journalArticle

2012

Digoxin inhibits development of hypoxic pulmonary hypertension in mice

Abud, E. M., Maylor, J., Undem, C., Punjabi, A., Zaiman, A. L., Myers, A. C., Sylvester, J. T., Semenza, G. L. & Shimoda, L. A., Jan 24 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 4, p. 1239-1244 6 p.

Research output: Contribution to journalArticle

Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis

Nanduri, J., Makarenko, V., Reddy, V. D., Yuan, G., Pawar, A., Wang, N., Khan, S. A., Zhang, X., Kinsman, B., Peng, Y. J., Kumar, G. K., Fox, A. P., Godley, L. A., Semenza, G. L. & Prabhakar, N. R., Feb 14 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 7, p. 2515-2520 6 p.

Research output: Contribution to journalArticle

Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1

Hubbi, M. E., Gilkes, D. M., Baek, J. H. & Semenza, G. L., Feb 24 2012, In : Journal of Biological Chemistry. 287, 9, p. 6139-6149 11 p.

Research output: Contribution to journalArticle

HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

Zhang, H., Wong, C. C. L., Wei, H., Gilkes, D. M., Korangath, P., Chaturvedi, P., Schito, L., Chen, J., Krishnamachary, B., Winnard, P. T., Raman, V., Zhen, L., Mitzner, W. A., Sukumar, S. & Semenza, G. L., Apr 5 2012, In : Oncogene. 31, 14, p. 1757-1770 14 p.

Research output: Contribution to journalArticle

Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells

Schito, L., Rey, S., Tafani, M., Zhang, H., Wong, C. C. L., Russo, A., Russo, M. A. & Semenza, G. L., Oct 2 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 40, p. E2707-E2716

Research output: Contribution to journalArticle

Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning

Sarkar, K., Cai, Z., Gupta, R., Parajuli, N., Fox-Talbot, K., Darshan, M. S., Gonzalez, F. J. & Semenza, G. L., Jun 26 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 26, p. 10504-10509 6 p.

Research output: Contribution to journalArticle

Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis

Wong, C. C. L., Zhang, H., Gilkes, D. M., Chen, J., Wei, H., Chaturvedi, P., Hubbi, M. E. & Semenza, G. L., Jul 1 2012, In : Journal of Molecular Medicine. 90, 7, p. 803-815 13 p.

Research output: Contribution to journalArticle

Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors

Kshitiz, Hubbi, M. E., Ahn, E. H., Downey, J., Afzal, J., Kim, D. H., Rey, S., Chang, C., Kundu, A., Semenza, G. L., Abraham, R. M. & Levchenko, A., Jun 5 2012, In : Science signaling. 5, 227, ra41.

Research output: Contribution to journalArticle

Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells

Sarkar, K., Rey, S., Zhang, X., Sebastian, R., Marti, G. P., Fox-Talbot, K., Cardona, A. V., Du, J., Tan, Y. S., Liu, L., Lay, F., Gonzalez, F. J., Harmon, J. W. & Semenza, G. L., Jan 1 2012, In : Cardiovascular research. 93, 1, p. 162-169 8 p.

Research output: Contribution to journalArticle

2011

Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection

Jiang, X., Khan, M. A., Tian, W., Beilke, J., Natarajan, R., Kosek, J., Yoder, M. C., Semenza, G. L. & Nicolls, M. R., Jun 1 2011, In : Journal of Clinical Investigation. 121, 6, p. 2336-2349 14 p.

Research output: Contribution to journalArticle

Aging impairs the mobilization and homing of bone marrow-derived angiogenic cells to burn wounds

Zhang, X., Sarkar, K., Rey, S., Sebastian, R., Andrikopoulou, E., Marti, G. P., Fox-Talbot, K., Semenza, G. L. & Harmon, J. W., Oct 1 2011, In : Journal of Molecular Medicine. 89, 10, p. 985-995 11 p.

Research output: Contribution to journalArticle

Control of TH17/Treg balance by hypoxia-inducible factor 1

Dang, E. V., Barbi, J., Yang, H. Y., Jinasena, D., Yu, H., Zheng, Y., Bordman, Z., Fu, J., Kim, Y., Yen, H. R., Luo, W., Zeller, K., Shimoda, L., Topalian, S. L., Semenza, G. L., Dang, C. V., Pardoll, D. M. & Pan, F., Sep 2 2011, In : Cell. 146, 5, p. 772-784 13 p.

Research output: Contribution to journalArticle

Hypoxia. cross talk between oxygen sensing and the cell cycle machinery

Semenza, G. L., Sep 1 2011, In : American Journal of Physiology - Cell Physiology. 301, 3, p. C550-C552

Research output: Contribution to journalArticle

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

Wong, C. C. L., Gilkes, D. M., Zhang, H., Chen, J., Wei, H., Chaturvedi, P., Fraley, S. I., Wong, C. M., Khoo, U. S., Ng, I. O. L., Wirtz, D. & Semenza, G. L., Sep 27 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 39, p. 16369-16374 6 p.

Research output: Contribution to journalArticle

Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia

Yuan, G., Khan, S. A., Luo, W., Nanduri, J., Semenza, G. L. & Prabhakar, N. R., Nov 1 2011, In : Journal of Cellular Physiology. 226, 11, p. 2925-2933 9 p.

Research output: Contribution to journalArticle