Gregg L Semenza

Professor

1984 …2020

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[16]Identification and characterization of transcription factors from mammalian cells

Wang, G. L. & Semenza, G. L., Dec 1 1996, In : Methods in Molecular Genetics. 8, C, p. 298-320 23 p.

Research output: Contribution to journalArticle

Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice

Kojima, H., Gu, H., Nomura, S., Caldwell, C. C., Kobata, T., Carmeliet, P., Semenza, G. L. & Sitkovsky, M. V., Feb 19 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 4, p. 2170-2174 5 p.

Research output: Contribution to journalArticle

A compendium of proteins that interact with HIF-1α

Semenza, G. L., Mar 15 2017, (Accepted/In press) In : Experimental Cell Research.

Research output: Contribution to journalArticle

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

Lee, K. A., Zhang, H., Qian, D. Z., Rey, S., Liu, J. O. & Semenza, G. L., Oct 20 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 42, p. 17910-17915 6 p.

Research output: Contribution to journalArticle

Activation of hypoxia-inducible factor 1 during macrophage differentiation

Oda, T., Hirota, K., Nishi, K., Takabuchi, S., Oda, S., Yamada, H., Arai, T., Fukuda, K., Kita, T., Adachi, T., Semenza, G. L. & Nohara, R., Jul 12 2006, In : American Journal of Physiology - Cell Physiology. 291, 1, p. C104-C113

Research output: Contribution to journalArticle

Activation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cells

Tomita, M., Semenza, G. L., Michiels, C., Matsuda, T., Uchihara, J. N., Okudaira, T., Tanaka, Y., Taira, N., Ohshiro, K. & Mori, N., Sep 1 2007, In : Biochemical Journal. 406, 2, p. 317-323 7 p.

Research output: Contribution to journalArticle

Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1

Pisarcik, S., Maylor, J., Lu, W., Yun, X., Undem, C., Sylvester, J. T., Semenza, G. L. & Shimoda, L. A., Jun 11 2013, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 304, 8, p. L549-L561

Research output: Contribution to journalArticle

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

Forsythe, J. A., Jiang, B. H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D. & Semenza, G. L., Jan 1 1996, In : Molecular and cellular biology. 16, 9, p. 4604-4613 10 p.

Research output: Contribution to journalArticle

Open Access

Adenoviral transfer of HIF-1α enhances vascular responses to critical limb ischemia in diabetic mice

Sarkar, K., Fox-Talbot, K., Steenbergen, C., Bosch-Marcë, M. & Semenza, G. L., Nov 3 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 44, p. 18769-18774 6 p.

Research output: Contribution to journalArticle

Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection

Jiang, X., Khan, M. A., Tian, W., Beilke, J., Natarajan, R., Kosek, J., Yoder, M. C., Semenza, G. L. & Nicolls, M. R., Jun 1 2011, In : Journal of Clinical Investigation. 121, 6, p. 2336-2349 14 p.

Research output: Contribution to journalArticle

Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity

Rivard, A., Berthou-Soulie, L., Principe, N., Kearney, M., Curry, C., Branellec, D., Semenza, G. L. & Isner, J. M., Sep 22 2000, In : Journal of Biological Chemistry. 275, 38, p. 29643-29647 5 p.

Research output: Contribution to journalArticle

Age-dependent impairment of HIF-1α expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells

Liu, L., Marti, G. P., Wei, X., Zhang, X., Zhang, H., Liu, Y. V., Nastai, M., Semenza, G. L. & Harmon, J. W., Nov 1 2008, In : Journal of Cellular Physiology. 217, 2, p. 319-327 9 p.

Research output: Contribution to journalArticle

A genetic mechanism for Tibetan high-altitude adaptation

Lorenzo, F. R., Huff, C., Myllymäki, M., Olenchock, B., Swierczek, S., Tashi, T., Gordeuk, V., Wuren, T., Ge, R. L., McClain, D. A., Khan, T. M., Koul, P. A., Guchhait, P., Salama, M. E., Xing, J., Semenza, G. L., Liberzon, E., Wilson, A., Simonson, T. S., Jorde, L. B. & 3 others, Kaelin, W. G., Koivunen, P. & Prchal, J. T., Jan 1 2014, In : Nature genetics. 46, 9, p. 951-956 6 p.

Research output: Contribution to journalArticle

Aging impairs the mobilization and homing of bone marrow-derived angiogenic cells to burn wounds

Zhang, X., Sarkar, K., Rey, S., Sebastian, R., Andrikopoulou, E., Marti, G. P., Fox-Talbot, K., Semenza, G. L. & Harmon, J. W., Oct 1 2011, In : Journal of Molecular Medicine. 89, 10, p. 985-995 11 p.

Research output: Contribution to journalArticle

Altered hypoxia-inducible factor-1 alpha expression levels correlate with coronary vessel anomalies.

Wikenheiser, J., Wolfram, J. A., Gargesha, M., Yang, K., Karunamuni, G., Wilson, D. L., Semenza, G. L., Agani, F., Fisher, S. A., Ward, N. & Watanabe, M., Oct 2009, In : Developmental dynamics : an official publication of the American Association of Anatomists. 238, 10, p. 2688-2700 13 p.

Research output: Contribution to journalArticle

Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1α

Li, J., Bosch-Marce, M., Nanayakkara, A., Savransky, V., Fried, S. K., Semenza, G. L. & Polotsky, V. Y., May 16 2006, In : Physiological Genomics. 25, 3, p. 450-457 8 p.

Research output: Contribution to journalArticle

An essential role for chaperone-mediated autophagy in cell cycle progression

Hubbi, M. E. & Semenza, G. L., Jan 1 2015, In : Autophagy. 11, 5, p. 850-851 2 p.

Research output: Contribution to journalArticle

A new weapon for attacking tumor blood vessels

Semenza, G. L., May 8 2008, In : New England Journal of Medicine. 358, 19, 1 p.

Research output: Contribution to journalArticle

Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy

Babapoor-Farrokhran, S., Jee, K., Puchner, B., Hassan, S. J., Xin, X., Rodrigues, M., Kashiwabuchi, F., Ma, T., Hu, K., Deshpande, M., Daoud, Y., Solomon, S., Wenick, A., Lutty, G. A., Semenza, G. L., Montaner, S. & Sodhi, A., Jun 9 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 23, p. E3030-E3039

Research output: Contribution to journalArticle

A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication

Hubbi, M. E., Kshitiz, Gilkes, D. M., Rey, S., Wong, C. C., Luo, W., Kim, D. H., Dang, C. V., Levchenko, A. & Semenza, G. L., Feb 12 2013, In : Science signaling. 6, 262, ra10.

Research output: Contribution to journalArticle

Anthracyclines suppress pheochromocytoma cell characteristics, including metastasis, through inhibition of the hypoxia signaling pathway

Pang, Y., Yang, C., Schovanek, J., Wang, H., Bullova, P., Caisova, V., Gupta, G., Wolf, K. I., Semenza, G. L., Zhuang, Z. & Pacak, K., Jan 1 2017, In : Oncotarget. 8, 14, p. 22313-22324 12 p.

Research output: Contribution to journalArticle

Open Access

An Xba I polymorphism 3′ to the human erythropoietin (EPO) gene

Semenza, G. L., Ladias, J. A. A. & Antonarakis, S. E., Aug 25 1987, In : Nucleic acids research. 15, 16, 1 p.

Research output: Contribution to journalArticle

A physical sciences network characterization of non-tumorigenic and metastatic cells

Agus, D. B., Alexander, J. F., Arap, W., Ashili, S., Aslan, J. E., Austin, R. H., Backman, V., Bethel, K. J., Bonneau, R., Chen, W. C., Chen-Tanyolac, C., Choi, N. C., Curley, S. A., Dallas, M., Damania, D., Davies, P. C. W., Decuzzi, P., Dickinson, L., Estevez-Salmeron, L., Estrella, V. & 75 others, Ferrari, M., Fischbach, C., Foo, J., Fraley, S. I., Frantz, C., Fuhrmann, A., Gascard, P., Gatenby, R. A., Geng, Y., Gerecht, S., Gillies, R. J., Godin, B., Grady, W. M., Greenfield, A., Hemphill, C., Hempstead, B. L., Hielscher, A., Hillis, W. D., Holland, E. C., Ibrahim-Hashim, A., Jacks, T., Johnson, R. H., Joo, A., Katz, J. E., Kelbauskas, L., Kesselman, C., King, M. R., Konstantopoulos, K., Kraning-Rush, C. M., Kuhn, P., Kung, K., Kwee, B., Lakins, J. N., Lambert, G., Liao, D., Licht, J. D., Liphardt, J. T., Liu, L., Lloyd, M. C., Lyubimova, A., Mallick, P., Marko, J., McCarty, O. J. T., Meldrum, D. R., Michor, F., Mumenthaler, S. M., Nandakumar, V., O'Halloran, T. V., Oh, S., Pasqualini, R., Paszek, M. J., Philips, K. G., Poultney, C. S., Rana, K., Reinhart-King, C. A., Ros, R., Semenza, G. L., Senechal, P., Shuler, M. L., Srinivasan, S., Staunton, J. R., Stypula, Y., Subramanian, H., Tlsty, T. D., Tormoen, G. W., Tseng, Y., Van Oudenaarden, A., Verbridge, S. S., Wan, J. C., Weaver, V. M., Widom, J., Will, C., Wirtz, D., Wojtkowiak, J. & Wu, P. H., Jul 4 2013, In : Scientific reports. 3, 1449.

Research output: Contribution to journalArticle

A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension

Dabral, S., Muecke, C., Valasarajan, C., Schmoranzer, M., Wietelmann, A., Semenza, G. L., Meister, M., Muley, T., Seeger-Nukpezah, T., Samakovlis, C., Weissmann, N., Grimminger, F., Seeger, W., Savai, R. & Pullamsetti, S. S., Dec 1 2019, In : Nature communications. 10, 1, 2130.

Research output: Contribution to journalArticle

Open Access

Assignment of the hypoxia-inducible factor 1α gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q

Semenza, G. L., Rue, E. A., Iyer, N. V., Pang, M. G. & Kearns, W. G., Jun 15 1996, In : Genomics. 34, 3, p. 437-439 3 p.

Research output: Contribution to journalArticle

Association of increasing burn severity in mice with delayed mobilization of circulating angiogenic cells

Zhang, X., Wei, X., Liu, L., Marti, G. P., Ghanamah, M. S., Arshad, M. J., Strom, L., Spence, R., Jeng, J., Milner, S., Harmon, J. W. & Semenza, G. L., Mar 1 2010, In : Archives of surgery. 145, 3, p. 259-266 8 p.

Research output: Contribution to journalArticle

Biologic correlates of 18fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography

Bos, R., Van der Hoeven, J. J. M., Van der Wall, E., Van der Groep, P., Van Diest, P. J., Comans, E. F. I., Joshi, U., Semenza, G. L., Hoekstra, O. S., Lammertsma, A. A. & Molthoff, C. F. M., Jan 15 2002, In : Journal of Clinical Oncology. 20, 2, p. 379-387 9 p.

Research output: Contribution to journalArticle

Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia

Yuan, G., Nanduri, J., Bhasker, C. R., Semenza, G. L. & Prabhakar, N. R., Feb 11 2005, In : Journal of Biological Chemistry. 280, 6, p. 4321-4328 8 p.

Research output: Contribution to journalArticle

Calcineurin promotes hypoxia-inducible factor 1α expression by dephosphorylating RACK1 and blocking RACK1 dimerization

Liu, Y. V., Hubbi, M. E., Pan, F., McDonald, K. R., Mansharamani, M., Cole, R. N., Liu, J. O. & Semenza, G. L., Dec 21 2007, In : Journal of Biological Chemistry. 282, 51, p. 37064-37073 10 p.

Research output: Contribution to journalArticle

Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5' enhancer

Liu, Y., Christou, H., Morita, T., Laughner, E., Semenza, G. L. & Kourembanas, S., Jun 12 1998, In : Journal of Biological Chemistry. 273, 24, p. 15257-15262 6 p.

Research output: Contribution to journalArticle

Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1

Martin, C., Yu, A. Y., Jiang, B. H., Davis, L., Kimberly, D., Hohimer, A. R. & Semenza, G. L., Jan 1 1998, In : American journal of obstetrics and gynecology. 178, 3, p. 527-534 8 p.

Research output: Contribution to journalArticle

Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice

Semenza, G. L., Koury, S. T., Nejfelt, M. K., Gearhart, J. D. & Antonarakis, S. E., Oct 24 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 19, p. 8725-8729 5 p.

Research output: Contribution to journalArticle

Open Access

Cell Type-Specific Regulation of Angiogenic Growth Factor Gene Expression and Induction of Angiogenesis in Nonischemic Tissue by a Constitutively Active Form of Hypoxia-Inducible Factor 1

Kelly, B. D., Hackett, S. F., Hirota, K., Oshima, Y., Cai, Z., Berg-Dixon, S., Rowan, A., Yan, Z., Campochiaro, P. A. & Semenza, G. L., Nov 28 2003, In : Circulation research. 93, 11, p. 1074-1081 8 p.

Research output: Contribution to journalArticle

Cellular and developmental control of O2 homeostasis by hypoxia- inducible factor 1α

Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y. & Semenza, G. L., Jan 15 1998, In : Genes and Development. 12, 2, p. 149-162 14 p.

Research output: Contribution to journalArticle

Open Access

Chairman's summary: Mechanisms of oxygen homeostasis, circa 1999

Semenza, G. L., Dec 1 2000, In : Advances in experimental medicine and biology. 475, p. 303-310 8 p.

Research output: Contribution to journalArticle

Chaperone-mediated autophagy targets hypoxia-inducible factor-1β(HIF- 1β) for lysosomal degradation

Hubbi, M. E., Hu, H., Kshitiz, Ahmed, I., Levchenko, A. & Semenza, G. L., Apr 12 2013, In : Journal of Biological Chemistry. 288, 15, p. 10703-10714 12 p.

Research output: Contribution to journalArticle

Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia

Wang, G. L. & Semenza, G. L., Jan 1 1993, In : Journal of Biological Chemistry. 268, 29, p. 21513-21518 6 p.

Research output: Contribution to journalArticle

Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment

Lu, H., Chen, I., Shimoda, L., Park, Y., Zhang, C., Tran, L., Zhang, H. & Semenza, G. L., Feb 21 2017, In : Cell Reports. 18, 8, p. 1946-1957 12 p.

Research output: Contribution to journalArticle

Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4

Drager, L. F., Yao, Q., Hernandez, K. L., Shin, M. K., Bevans-Fonti, S., Gay, J., Sussan, T. E., Jun, J. C., Myers, A. C., Olivecrona, G., Schwartz, A. R., Halberg, N., Scherer, P. E., Semenza, G. L., Powell, D. R. & Polotsky, V. Y., Jul 15 2013, In : American journal of respiratory and critical care medicine. 188, 2, p. 240-248 9 p.

Research output: Contribution to journalArticle

Collagen prolyl hydroxylases are essential for breast cancer metastasis

Gilkes, D. M., Chaturvedi, P., Bajpai, S., Wong, C. C., Wei, H., Pitcairn, S., Hubbi, M. E., Wirtz, D. & Semenza, G. L., Jun 1 2013, In : Cancer Research. 73, 11, p. 3285-3296 12 p.

Research output: Contribution to journalArticle

Combination of HIF-1α gene transfection and HIF-1-Activated bone marrow-derived angiogenic cell infusion improves burn wound healing in aged mice

Du, J., Liu, L., Lay, F., Wang, Q., Dou, C., Zhang, X., Hosseini, S. M., Simon, A., Rees, D. J., Ahmed, A. K., Sebastian, R., Sarkar, K., Milner, S., Marti, G. P., Semenza, G. L. & Harmon, J. W., Nov 1 2013, In : Gene Therapy. 20, 11, p. 1070-1076 7 p.

Research output: Contribution to journalArticle

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

Elgogary, A., Xu, Q., Poore, B., Alt, J., Zimmermann, S. C., Zhao, L., Fu, J., Chen, B., Xia, S., Liu, Y., Neisser, M., Nguyen, C., Lee, R., Park, J. K., Reyes, J., Hartung, T., Rojas, C., Rais, R., Tsukamoto, T., Semenza, G. L. & 3 others, Hanes, J. S., Slusher, B. & Le Thi, Q. H., Sep 6 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 36, p. E5328-E5336

Research output: Contribution to journalArticle

Complementary roles of gasotransmitters CO and H2S in sleep apnea

Peng, Y. J., Zhang, X., Gridina, A., Chupikova, I., Mccormick, D. L., Thomas, R. J., Scammell, T. E., Kim, G., Vasavda, C., Nanduri, J., Kumar, G. K., Semenza, G. L., Snyder, S. H. & Prabhakar, N. R., Feb 7 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 6, p. 1413-1418 6 p.

Research output: Contribution to journalArticle

Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1α

Cai, Z., Zhong, H., Bosch-Marce, M., Fox-Talbot, K., Wang, L., Wei, C., Trush, M. A. & Semenza, G. L., Feb 1 2008, In : Cardiovascular research. 77, 3, p. 463-470 8 p.

Research output: Contribution to journalArticle

Constitutively active HIF-1α improves perfusion and arterial remodeling in an endovascular model of limb ischemia

Patel, T. H., Kimura, H., Weiss, C. R., Semenza, G. L. & Hofmann, L. V., Oct 1 2005, In : Cardiovascular research. 68, 1, p. 144-154 11 p.

Research output: Contribution to journalArticle