Gregg L Semenza

Professor

1984 …2020

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1984

Detection of a novel DNA polymorphism in the β-globin gene cluster

Semenza, G. L., Malladi, P., Surrey, S., Delgrosso, K., Poncz, M. & Schwartz, E., Jul 19 1984, In : Journal of Biological Chemistry. 259, 10, p. 6045-6048 4 p.

Research output: Contribution to journalArticle

The silent carrier allele: β thalassemia without a mutation in the β-globin gene or its immediate flanking regions

Semenza, G. L., Delgrosso, K., Poncz, M., Malladi, P., Schwartz, E. & Surrey, S., Nov 1984, In : Cell. 39, 1, p. 123-128 6 p.

Research output: Contribution to journalArticle

1987

An Xba I polymorphism 3′ to the human erythropoietin (EPO) gene

Semenza, G. L., Ladias, J. A. A. & Antonarakis, S. E., Aug 25 1987, In : Nucleic acids research. 15, 16, 1 p.

Research output: Contribution to journalArticle

1988

Respiratory complications of mucopolysaccharide storage disorders

Semenza, G. L. & Pyeritz, R. E., Jul 1988, In : Medicine (United States). 67, 4, p. 209-219 11 p.

Research output: Contribution to journalArticle

1989

Polycythemia in transgenic mice expressing the human erythropoietin gene

Semenza, G. L., Traystman, M. D., Gearhart, J. D. & Antonarakis, S. E., Jan 1 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 7, p. 2301-2305 5 p.

Research output: Contribution to journalArticle

Open Access
1990

Human erythropoietin gene expression in transgenic mice: multiple transcription initiation sites and cis-acting regulatory elements

Semenza, G. L., Dureza, R. C., Traystman, M. D., Gearhart, J. D. & Antonarakis, S. E., Jan 1 1990, In : Molecular and cellular biology. 10, 3, p. 930-938 9 p.

Research output: Contribution to journalArticle

Open Access
1991

Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice

Semenza, G. L., Koury, S. T., Nejfelt, M. K., Gearhart, J. D. & Antonarakis, S. E., Oct 24 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 19, p. 8725-8729 5 p.

Research output: Contribution to journalArticle

Open Access

Erythropoietin ontogeny and organ distribution in mice

Bondurant, M. C., Koury, M. J., Koury, S. T. & Semenza, G., Jul 1 1991, In : Seminars in Hematology. 28, 3 SUPPL. 3, p. 20-27 8 p.

Research output: Contribution to journalArticle

Hypoxia-inducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene

Semenza, G. L., Nejfelt, M. K., Chi, S. M. & Antonarakis, S. E., Jul 1 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 13, p. 5680-5684 5 p.

Research output: Contribution to journalArticle

Open Access

Localization of cells producing erythropoietin in murine liver by in situ hybridization

Koury, S. T., Bondurant, M. C., Koury, M. J. & Semenza, G. L., Jan 1 1991, In : Blood. 77, 11, p. 2497-2503 7 p.

Research output: Contribution to journalArticle

1992
Open Access
1993

Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia

Wang, G. L. & Semenza, G. L., Jan 1 1993, In : Journal of Biological Chemistry. 268, 29, p. 21513-21518 6 p.

Research output: Contribution to journalArticle

Open Access

The use of in situ hybridization to study erythropoietin gene expression in murine kidney and liver

Koury, S. T., Bondurant, M. C., Semenza, G. L. & Koury, M. J., May 1 1993, In : Microscopy Research and Technique. 25, 1, p. 29-39 11 p.

Research output: Contribution to journalArticle

1994

Erythropoietin Gene Expression in Transgenic Mice and Human Hepatoma Cells

SEMENZA, GREGG. L., Apr 1994, In : Annals of the New York Academy of Sciences. 718, 1, p. 41-49 9 p.

Research output: Contribution to journalArticle

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1

Semenza, G. L., Roth, P. H., Fang, H. M. & Wang, G. L., Sep 23 1994, In : Journal of Biological Chemistry. 269, 38, p. 23757-23763 7 p.

Research output: Contribution to journalArticle

1995

DNA binding and transcriptional properties of wild-type and mutant forms of the homeodomain protein Msx2

Semenza, G. L., Wang, G. L. & Kundu, R., Apr 6 1995, In : Biochemical and Biophysical Research Communications. 209, 1, p. 257-262 6 p.

Research output: Contribution to journalArticle

Effect of altered redox states on expression and DNA-binding activity of hypoxia-inducible factor 1

Wang, G. L., Jiang, B. H. & Semenza, G. L., Jul 17 1995, In : Biochemical and Biophysical Research Communications. 212, 2, p. 550-556 7 p.

Research output: Contribution to journalArticle

Effect of protein kinase and phosphatase inhibitors on expression of hypoxia inducible factor 1

Wang, G. L., Jiang, B. H. & Semenza, G. L., Jan 1 1995, In : Biochemical and Biophysical Research Communications. 216, 2, p. 669-675 7 p.

Research output: Contribution to journalArticle

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

Wang, G. L., Jiang, B. H., Rue, E. A. & Semenza, G. L., Jun 6 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 12, p. 5510-5514 5 p.

Research output: Contribution to journalArticle

Primary familial polycythemia: A frameshift mutation in the erythropoietin receptor gene and increased sensitivity of erythroid progenitors to erythropoietin

Sokol, L., Luhovy, M., Guan, Y., Prchal, J. F., Semenza, G. L. & Prchal, J. T., Jan 1 1995, In : Blood. 86, 1, p. 15-22 8 p.

Research output: Contribution to journalArticle

Purification and characterization of hypoxia-inducible factor

Wang, G. L. & Semenza, G. L., Jan 20 1995, In : Journal of Biological Chemistry. 270, 3, p. 1230-1237 8 p.

Research output: Contribution to journalArticle

Open Access
1996

[16]Identification and characterization of transcription factors from mammalian cells

Wang, G. L. & Semenza, G. L., Dec 1 1996, In : Methods in Molecular Genetics. 8, C, p. 298-320 23 p.

Research output: Contribution to journalArticle

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

Forsythe, J. A., Jiang, B. H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D. & Semenza, G. L., Jan 1 1996, In : Molecular and cellular biology. 16, 9, p. 4604-4613 10 p.

Research output: Contribution to journalArticle

Open Access

Assignment of the hypoxia-inducible factor 1α gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q

Semenza, G. L., Rue, E. A., Iyer, N. V., Pang, M. G. & Kearns, W. G., Jun 15 1996, In : Genomics. 34, 3, p. 437-439 3 p.

Research output: Contribution to journalArticle

Dimerization, DNA binding, and transactivation properties of hypoxia- inducible factor 1

Jiang, B. H., Rue, E., Wang, G. L., Roe, R. & Semenza, G. L., Aug 10 1996, In : Journal of Biological Chemistry. 271, 30, p. 17771-17778 8 p.

Research output: Contribution to journalArticle

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O 2 tension

Jiang, B. H., Semenza, G. L., Bauer, C. & Marti, H. H., Oct 1 1996, In : American Journal of Physiology - Cell Physiology. 271, 4 40-4, p. C1172-C1180

Research output: Contribution to journalArticle

Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase a gene promoters contain essential binding sites for hypoxia-inducible factor 1

Semenza, G. L., Jiang, B. H., Leung, S. W., Passantino, R., Concordat, J. P., Maire, P. & Giallongo, A., Jan 1 1996, In : Journal of Biological Chemistry. 271, 51, p. 32529-32537 9 p.

Research output: Contribution to journalArticle

Open Access

In vivo expression of mRNAs encoding hypoxia-inducible factor 1

Wiener, C. M., Booth, G. & Semenza, G. L., Aug 14 1996, In : Biochemical and Biophysical Research Communications. 225, 2, p. 485-488 4 p.

Research output: Contribution to journalArticle

Oxygen sensing and response to hypoxia by mammalian cells

Wang, G. L. & Semenza, G. L., Jan 1 1996, In : Redox Report. 2, 2, p. 89-96 8 p.

Research output: Contribution to journalArticle

Regulation of type II nitric oxide synthase (NOS) expression by hypoxia

Palmer, L. A., Semenza, G. L. & Johns, R. A., Dec 1 1996, In : FASEB Journal. 10, 3, p. A436

Research output: Contribution to journalArticle

1997

Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia

Lee, P. J., Jiang, B. H., Chin, B. Y., Iyer, N. V., Alam, J., Semenza, G. L. & Choi, A. M. K., Feb 28 1997, In : Journal of Biological Chemistry. 272, 9, p. 5375-5381 7 p.

Research output: Contribution to journalArticle

Increased vascularization VEGF and HIF-1 expression in myocardium of chronically anemic fetal sheep

Davis, L., Yu, A., Hohimer, A. R., Jiang, B., Kimberly, D., Martin, C. & Semenza, G., Dec 1 1997, In : FASEB Journal. 11, 3, p. A256

Research output: Contribution to journalArticle

p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene

Agani, F., Kirsch, D. G., Friedman, S. L., Kastan, M. B. & Semenza, G. L., Oct 15 1997, In : Cancer Research. 57, 20, p. 4474-4477 4 p.

Research output: Contribution to journalArticle

Perinatal lethality and multiple craniofacial malformations in MSX2 transgenic mice

Winograd, J., Reilly, M. P., Roe, R., Lutz, J., Laughner, E., Xu, X., Hu, L., Asakura, T., Kolk, C. V., Strandberg, J. D. & Semenza, G. L., Mar 1 1997, In : Human molecular genetics. 6, 3, p. 369-379 11 p.

Research output: Contribution to journalArticle

Segregation of a familial balanced (12;10) insertion resulting in dup(10)(q21.2q22.1) and Del(10)(q21.2q22.1) in First cousins

Doheny, K. F., Rasmussen, S. A., Rutberg, J., Semenza, G. L., Stamberg, J., Schwartz, M., Batista, D. A. S., Stetten, G. & Thomas, G. H., Mar 17 1997, In : American journal of medical genetics. 69, 2, p. 188-193 6 p.

Research output: Contribution to journalArticle

Structural and functional analysis of hypoxia-inducible factor 1

Semenza, G. L., Agani, F., Booth, G., Forsythe, J., Iyer, N., Jiang, B. H., Leung, S., Roe, R., Wiener, C. & Yu, A., Jan 1 1997, In : Kidney international. 51, 2, p. 553-555 3 p.

Research output: Contribution to journalArticle

Open Access

Transactivation and inhibitory domains of Hypoxia-inducible factor 1α: Modulation of transcriptional activity by oxygen tension

Jiang, B. H., Zheng, J. Z., Leung, S. W., Roe, R. & Semenza, G. L., Aug 1 1997, In : Journal of Biological Chemistry. 272, 31, p. 19253-19260 8 p.

Research output: Contribution to journalArticle

1998

Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5' enhancer

Liu, Y., Christou, H., Morita, T., Laughner, E., Semenza, G. L. & Kourembanas, S., Jun 12 1998, In : Journal of Biological Chemistry. 273, 24, p. 15257-15262 6 p.

Research output: Contribution to journalArticle

Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1

Martin, C., Yu, A. Y., Jiang, B. H., Davis, L., Kimberly, D., Hohimer, A. R. & Semenza, G. L., Jan 1 1998, In : American journal of obstetrics and gynecology. 178, 3, p. 527-534 8 p.

Research output: Contribution to journalArticle

Cellular and developmental control of O2 homeostasis by hypoxia- inducible factor 1α

Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y. & Semenza, G. L., Jan 15 1998, In : Genes and Development. 12, 2, p. 149-162 14 p.

Research output: Contribution to journalArticle

Open Access

Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1

Palmer, L. A., Semenza, G. L., Stoler, M. H. & Johns, R. A., Apr 8 1998, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 274, 2 18-2, p. L212-L219

Research output: Contribution to journalArticle

Hypoxia-inducible factor 1: Master regulator of O2 homeostasis

Semenza, G. L., Oct 1998, In : Current Opinion in Genetics and Development. 8, 5, p. 588-594 7 p.

Research output: Contribution to journalArticle

Hypoxia-inducible factor 1: From molecular biology to cardiopulmonary physiology

Semenza, G. L., Agani, F., Iyer, N., Jiang, B. H., Leung, S., Wiener, C. & Yu, A., Jul 1998, In : CHEST. 114, 1 SUPPL., p. 40S-45S

Research output: Contribution to journalArticle

Increased expression of hypoxia inducible factor-1α in rat and human prostate cancer

Zhong, H., Agani, F., Baccala, A. A., Laughner, E., Rioseco-Camacho, N., Isaacs, W. B., Simons, J. W. & Semenza, G. L., Dec 1 1998, In : Cancer Research. 58, 23, p. 5280-5284 5 p.

Research output: Contribution to journalArticle

Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung

Yu, A. Y., Frid, M. G., Shimoda, L. A., Wiener, C. M., Stenmark, K. & Semenza, G. L., Nov 9 1998, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 275, 4 19-4, p. L818-L826

Research output: Contribution to journalArticle

The human hypoxia-inducible factor 1α gene: HIF1A structure and evolutionary conservation

Iyer, N. V., Leung, S. W. & Semenza, G. L., Sep 1 1998, In : Genomics. 52, 2, p. 159-165 7 p.

Research output: Contribution to journalArticle