Research output per year
Research output per year
- 1 - 50 out of 493 results
Search results
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2024
Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes
Lyu, Y., Yang, Y., Talwar, V., Lu, H., Chen, C., Salman, S., Wicks, E. E., Huang, T. Y. T., Drehmer, D., Wang, Y., Zuo, Q., Datan, E., Jackson, W., Dordai, D., Wang, R. & Semenza, G. L., Apr 23 2024, In: Cell Reports. 43, 4, 113972.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Erratum: Withdrawal: Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia (Journal of Biological Chemistry (2008) 283(16) (10892–10903), (S0021925820620579), (10.1074/jbc.M800102200))
Zhang, H., Bosch-Marce, M., Shimoda, L. A., Tan, Y. S., Baek, J. H., Wesley, J. B., Gonzalez, F. J. & Semenza, G. L., Aug 2023, In: Journal of Biological Chemistry. 299, 8, 105125.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Hypoxia-inducible factors: roles in cardiovascular disease progression, prevention, and treatment
Semenza, G. L., Feb 1 2023, In: Cardiovascular research. 119, 2, p. 371-380 10 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
On either side of homeostasis: EPAS1 gain- and loss-of-function mutations
Prchal, J. T. & Semenza, G. L., Oct 2023, In: Haematologica. 108, 10, p. 2564-2565 2 p.Research output: Contribution to journal › Editorial › peer-review
Open Access -
Plexin-B3 expression stimulates MET signaling, breast cancer stem cell specification, and lung metastasis
Zuo, Q., Yang, Y., Lyu, Y., Yang, C., Chen, C., Salman, S., Huang, T. Y. T., Wicks, E. E., Jackson, W., Datan, E., Qin, W. & Semenza, G. L., Mar 28 2023, In: Cell Reports. 42, 3, 112164.Research output: Contribution to journal › Article › peer-review
Open Access -
Regulation of Erythropoiesis by the Hypoxia-Inducible Factor Pathway: Effects of Genetic and Pharmacological Perturbations
Semenza, G. L., Jan 27 2023, In: Annual review of medicine. 74, p. 307-319 13 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Retraction: Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization (Proc. Natl. Acad. Sci. U.S.A. (2009) 106 (17910–17915) DOI: 10.1073/pnas.0909353106)
Qian, D. Z., Rey, S., Liu, J. O. & Semenza, G. L., May 2 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 118, e2305537120.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Retraction Note: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs (Oncogene, (2012), 31, 14, (1757-1770), 10.1038/onc.2011.365)
Zhang, H., Wong, C. C. L., Wei, H., Gilkes, D. M., Korangath, P., Chaturvedi, P., Schito, L., Chen, J., Krishnamachary, B., Winnard, P. T., Raman, V., Zhen, L., Mitzner, W. A., Sukumar, S. & Semenza, G. L., Jul 7 2023, In: Oncogene. 42, 28, p. 2234 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Targeting hypoxia-inducible factors with 32-134D safely and effectively treats diabetic eye disease in mice
Zhang, J., Sharma, D., Dinabandhu, A., Sanchez, J., Applewhite, B., Jee, K., Deshpande, M., Flores-Bellver, M., Hu, M. W., Guo, C., Salman, S., Hwang, Y., Anders, N. M., Rudek, M. A., Qian, J., Canto-Soler, M. V., Semenza, G. L., Montaner, S. & Sodhi, A., Jul 3 2023, In: Journal of Clinical Investigation. 133, 13, e163290.Research output: Contribution to journal › Article › peer-review
Open Access -
Targeting intratumoral hypoxia to enhance anti-tumor immunity
Semenza, G. L., Nov 2023, In: Seminars in Cancer Biology. 96, p. 5-10 6 p.Research output: Contribution to journal › Review article › peer-review
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Withdrawal: Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts (Journal of Biological Chemistry (2013) 288(15) (10819–10829), (S0021925820673045), (10.1074/jbc.M112.442939))
Gilkes, D. M., Bajpai, S., Chaturvedi, P., Wirtz, D. & Semenza, G. L., Sep 2023, In: Journal of Biological Chemistry. 299, 9, 105144.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia signaling to promote cancer aggressiveness
Koyasu, S., Horita, S., Saito, K., Kobayashi, M., Ishikita, H., Chow, C. C. T., Kambe, G., Nishikawa, S., Menju, T., Morinibu, A., Okochi, Y., Tabuchi, Y., Onodera, Y., Takeda, N., Date, H., Semenza, G. L., Hammond, E. M. & Harada, H., Jan 9 2023, In: EMBO Reports. 24, 1, e54042.Research output: Contribution to journal › Article › peer-review
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2022
ANGPTL4 influences the therapeutic response of patients with neovascular age-related macular degeneration by promoting choroidal neovascularization
Qin, Y., Dinabandhu, A., Cao, X., Sanchez, J. C., Jee, K., Rodrigues, M., Guo, C., Zhang, J., Vancel, J., Menon, D., Khan, N. S., Ma, T., Tzeng, S. Y., Daoud, Y., Green, J. J., Semenza, G. L., Montaner, S. & Sodhi, A., Jul 8 2022, In: JCI Insight. 7, 13, e157896.Research output: Contribution to journal › Article › peer-review
Open Access -
Breakthrough science: hypoxia-inducible factors, oxygen sensing, and disorders of hematopoiesis
Semenza, G. L., Apr 21 2022, In: Blood. 139, 16, p. 2441-2449 9 p.Research output: Contribution to journal › Review article › peer-review
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Correction: PHGDH expression is required for mitochondrial redox homeostasis, breast cancer stem cell maintenance, and lung metastasis (Cancer Research (2016) 76 (4430-4442) DOI: 10.1158/0008-5472.CAN-16-0530)
Samanta, D., Park, Y., Andrabi, S. A., Shelton, L. M., Gilkes, D. M. & Semenza, G. L., Mar 15 2022, In: Cancer Research. 82, 6, p. 1153 1 p.Research output: Contribution to journal › Comment/debate › peer-review
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Disruption of the HIF-1 pathway in individuals with Ollier disease and Maffucci syndrome
Poll, S. R., Martin, R., Wohler, E., Partan, E. S., Walek, E., Salman, S., Groepper, D., Kratz, L., Cernach, M., Jesus-Garcia, R., Haldeman-Englert, C., Choi, Y. J., Morris, C. D., Cohen, B., Hoover-Fong, J., Valle, D., Semenza, G. L. & Sobreira, N. L. M., Dec 8 2022, In: PLoS genetics. 18, 12, p. 1DUMMARY e1010504.Research output: Contribution to journal › Article › peer-review
Open Access -
Erratum: Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis (Cancer Res (2013) 73 (3285–3296) DOI: 10.1158/0008-5472.CAN-12-3963)
Gilkes, D. M., Chaturvedi, P., Bajpai, S., Wong, C. C., Wei, H., Pitcairn, S., Hubbi, M. E., Wirtz, D. & Semenza, G. L., Mar 1 2022, In: Cancer Research. 82, 5, p. 943 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Erratum: Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis (Proc. Natl. Acad. Sci. U.S.A. (2013) 110 (E1788–E1796) DOI: 10.1073/pnas.1305961110)
Yuan, G., Peng, Y. J., Reddy, V. D., Makarenko, V. V., Nanduri, J., Khan, S. A., Garcia, J. A., Kumar, G. K., Semenza, G. L. & Prabhakar, N. R., Sep 20 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 38, e2213287119.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia
Yang, Y., Lu, H., Chen, C., Lyu, Y., Cole, R. N. & Semenza, G. L., Dec 2022, In: Nature communications. 13, 1, 316.Research output: Contribution to journal › Article › peer-review
Open Access -
HIF inhibitor 32-134D eradicates murine hepatocellular carcinoma in combination with anti-PD1 therapy
Salman, S., Meyers, D. J., Wicks, E. E., Lee, S. N., Datan, E., Thomas, A. M., Anders, N., Hwang, Y., Lyu, Y., Yang, Y., Jackson, W., Dordai, D., Rudek, M. & Semenza, G. L., May 2 2022, In: Journal of Clinical Investigation. 132, 9, e156774.Research output: Contribution to journal › Article › peer-review
Open Access -
Hypoxia and Hypoxia-Inducible Factors in Lymphedema
Jiang, X., Tian, W., Kim, D., McQuiston, A. S., Vinh, R., Rockson, S. G., Semenza, G. L. & Nicolls, M. R., Mar 28 2022, In: Frontiers in Pharmacology. 13, 851057.Research output: Contribution to journal › Review article › peer-review
Open Access -
Hypoxia-inducible factors: cancer progression and clinical translation
Wicks, E. E. & Semenza, G. L., Jun 1 2022, In: Journal of Clinical Investigation. 132, 11, e159839.Research output: Contribution to journal › Review article › peer-review
Open Access -
NARF is a hypoxia-induced coactivator for OCT4-mediated breast cancer stem cell specification
Yang, Y., Chen, C., Zuo, Q., Lu, H., Salman, S., Lyu, Y., Huang, T. Y. T., Wicks, E. E., Jackson, W., Datan, E., Wang, R., Wang, Y., Le, N., Zhu, Y., Qin, W. & Semenza, G. L., 2022, In: Science Advances. 8, 49, abo5000.Research output: Contribution to journal › Article › peer-review
Open Access -
Retraction: Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells (Proceedings of the National Academy of Sciences of the United States of America (2013) 111 (E384-E393) DOI: 10.1073/pnas.1321510111)
Xiang, L., Chaturvedi, P., Wirtz, D. & Semenza, G. L., Sep 20 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 38, e2213288119.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Retraction: Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells (Proceedings of the National Academy of Sciences of the United States of America (2009) 106 (2353-2358) DOI: 10.1073/pnas.0812801106)
Qian, D. Z., Rey, S., Liu, J. O. & Semenza, G. L., Sep 20 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 38, e2213285119.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
2021
Correction: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs (Oncogene, (2012), 31, 14, (1757-1770), 10.1038/onc.2011.365)
Zhang, H., Wong, C. C. L., Wei, H., Gilkes, D. M., Korangath, P., Chaturvedi, P., Schito, L., Chen, J., Krishnamachary, B., Winnard, P. T., Raman, V., Zhen, L., Mitzner, W. A., Sukumar, S. & Semenza, G. L., Feb 25 2021, In: Oncogene. 40, 8, p. 1552-1553 2 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Erratum: Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment (Chemotherapy-Induced Ca^2^+ Release Stimulates Breast Cancer Stem Cell Enrichment (2017) 18(8) (1946–1957), (S2211124717301651), (10.1016/j.celrep.2017.02.001))
Lu, H., Chen, I., Shimoda, L. A., Park, Y., Zhang, C., Tran, L., Zhang, H. & Semenza, G. L., Jan 5 2021, In: Cell Reports. 34, 1, 108605.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Erratum: Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma (Oncotarget (2016) 7 (7816–7828) Doi:10.18632/oncotarget.6868)
Hu, K., Babapoor-Farrokhran, S., Rodrigues, M., Deshpande, M., Puchner, B., Kashiwabuchi, F., Hassan, S. J., Asnaghi, L., Handa, J. T., Merbs, S. L., Eberhart, C. G., Semenza, G. L., Montaner, S. & Sodhi, A., Mar 2 2021, In: Oncotarget. 12, 5, p. 519-520 2 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Erratum: Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells (Cardiovascular Research (2012) 93:1 (162-169) DOI: 10.1093/cvr/cvr282)
Sarkar, K., Rey, S., Zhang, X., Sebastian, R., Marti, G. P., Fox-Talbot, K., Cardona, A. V., Du, J., Tan, Y. S., Liu, L., Lay, F., Gonzalez, F. J., Harmon, J. & Semenza, G. L., Apr 1 2021, In: Cardiovascular research. 117, 4, p. 1231 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Heritable disorders of oxygen sensing
Semenza, G. L., Aug 2021, In: American Journal of Medical Genetics, Part A. 185, 8, p. 2576-2581 6 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Heritable disorders of oxygen sensing
Semenza, G. L., Nov 1 2021, In: American journal of medical genetics. Part A. 185, 11, p. 3334-3339 6 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
HIF-1 recruits NANOG as a coactivator for TERT gene transcription in hypoxic breast cancer stem cells
Lu, H., Lyu, Y., Tran, L., Lan, J., Xie, Y., Yang, Y., Murugan, N. L., Wang, Y. J. & Semenza, G. L., Sep 28 2021, In: Cell Reports. 36, 13, 109757.Research output: Contribution to journal › Article › peer-review
Open Access -
HIF-1-regulated expression of calreticulin promotes breast tumorigenesis and progression through Wnt/β-catenin pathway activation
Liu, X., Xie, P., Hao, N., Zhang, M., Liu, Y., Liu, P., Semenza, G. L., He, J. & Zhang, H., Nov 2 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 44, e2109144118.Research output: Contribution to journal › Article › peer-review
Open Access -
HIF-1α and HIF-2α redundantly promote retinal neovascularization in patients with ischemic retinal disease
Zhang, J., Qin, Y., Martinez, M., Flores-Bellver, M., Rodrigues, M., Dinabandhu, A., Cao, X., Deshpande, M., Qin, Y., Aparicio-Domingo, S., Rui, Y., Tzeng, S. Y., Salman, S., Yuan, J., Scott, A. W., Green, J. J., Valeria Canto-Soler, M., Semenza, G. L., Montaner, S. & Sodhi, A., Jun 2021, In: Journal of Clinical Investigation. 131, 12, e139202.Research output: Contribution to journal › Article › peer-review
Open Access -
Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization
Wang, Y., Lyu, Y., Tu, K., Xu, Q., Yang, Y., Salman, S., Le, N., Lu, H., Chen, C., Zhu, Y., Wang, R., Liu, Q. & Semenza, G. L., Aug 2021, In: Science Advances. 7, 35, eabe3771.Research output: Contribution to journal › Article › peer-review
Open Access -
Hypoxia-induced suppression of alternative splicing of MBD2 promotes breast cancer metastasis via activation of FZD1
Liu, Z., Sun, L., Cai, Y., Shen, S., Zhang, T., Wang, N., Wu, G., Ma, W., Li, S. T., Suo, C., Hao, Y., Jia, W. D., Semenza, G. L., Gao, P. & Zhang, H., Mar 1 2021, In: Cancer Research. 81, 5, p. 1265-1278 14 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis
Wang, R., Godet, I., Yang, Y., Salman, S., Lu, H., Lyu, Y., Zuo, Q., Wang, Y., Zhu, Y., Chen, C., He, J., Gilkes, D. M. & Semenza, G. L., May 11 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 19, e2020490118.Research output: Contribution to journal › Article › peer-review
Open Access -
Intratumoral hypoxia and mechanisms of immune evasion mediated by hypoxia- inducible factors
Semenza, G. L., 2021, In: Physiology. 36, 2, p. 73-83 11 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
The Journal of Clinical Investigation in the time of COVID-19
Casadevall, A., Jackson, S., Semenza, G. L., Tomaselli, G. F. & Ahima, R. S., Dec 1 2021, In: Journal of Clinical Investigation. 131, 24, e156409.Research output: Contribution to journal › Review article › peer-review
Open Access -
2020
BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy Efficacy
Samanta, D., Huang, T. Y. T., Shah, R., Yang, Y., Pan, F. & Semenza, G. L., Aug 25 2020, In: Cell Reports. 32, 8, 108073.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Changing the editorial process at JCI and JCI Insight in response to the COVID-19 pandemic
Ahima, R. S., Jackson, S., Casadevall, A., Semenza, G. L., Tomaselli, G., Collins, K. L., Lieberman, A. P., Martin, D. M. & Reddy, P., May 1 2020, In: Journal of Clinical Investigation. 130, 5, p. 2147 1 p.Research output: Contribution to journal › Editorial › peer-review
Open Access4 Scopus citations -
Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness
Lu, H., Xie, Y., Tran, L., Lan, J., Yang, Y., Murugan, N. L., Wang, R., Wang, Y. J. & Semenza, G. L., Sep 1 2020, In: Journal of Clinical Investigation. 130, 9, p. 4607-4623 17 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Decreased lymphatic HIF-2α accentuates lymphatic remodeling in lymphedema
Jiang, X., Tian, W., Granucci, E. J., Tu, A. B., Kim, D., Dahms, P., Pasupneti, S., Peng, G., Kim, Y., Lim, A. H., Hernan Espinoza, F., Cribb, M., Brandon Dixon, J., Rockson, S. G., Semenza, G. L. & Nicolls, M. R., Oct 1 2020, In: Journal of Clinical Investigation. 130, 10, p. 5562-5575 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Endothelial HIF-2a as a key endogenous mediator preventing emphysema
Pasupneti, S., Tian, W., Tu, A. B., Dahms, P., Granucci, E., Gandjeva, A., Xiang, M., Butcher, E. C., Semenza, G. L., Tuder, R. M., Jiang, X. & Nicolls, M. R., Oct 1 2020, In: American journal of respiratory and critical care medicine. 202, 7, p. 983-995 13 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Erratum: Activation of hypoxia-inducible factor 1 during macrophage differentiation (American Journal of Physiology - Cell Physiology (2006) 291 (C104-C113) DOI: 10.1152/ajpcell.00614.2005)
Oda, T., Hirota, K., Nishi, K., Takabuchi, S., Oda, S., Yamada, H., Arai, T., Fukuda, K., Kita, T., Adachi, T., Semenza, G. L. & Nohara, R., Apr 2020, In: American Journal of Physiology - Cell Physiology. 320, 4, p. C666-C667Research output: Contribution to journal › Comment/debate › peer-review
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Hypoxia-inducible factor-1 mediates pancreatic b-cell dysfunction by intermittent hypoxia
Wang, N., Shi, X. F., Khan, S. A., Wang, B., Semenza, G. L., Prabhakar, N. R. & Nanduri, J., Nov 2020, In: American Journal of Physiology - Cell Physiology. 319, 5, p. C922-C932Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
The genomics and genetics of oxygen homeostasis
Semenza, G. L., Aug 31 2020, In: Annual Review of Genomics and Human Genetics. 21, p. 183-204 22 p.Research output: Contribution to journal › Review article › peer-review
10 Scopus citations -
2019
A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension
Dabral, S., Muecke, C., Valasarajan, C., Schmoranzer, M., Wietelmann, A., Semenza, G. L., Meister, M., Muley, T., Seeger-Nukpezah, T., Samakovlis, C., Weissmann, N., Grimminger, F., Seeger, W., Savai, R. & Pullamsetti, S. S., Dec 1 2019, In: Nature communications. 10, 1, 2130.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
Editorial overview: Hypoxia
Sadek, H. A. & Semenza, G. L., Feb 2019, In: Current Opinion in Physiology. 7, p. iii-vResearch output: Contribution to journal › Editorial › peer-review
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Endothelial Hypoxia-Inducible Factor-2 Is Required for the Maintenance of Airway Microvasculature
Jiang, X., Tian, W., Tu, A. B., Pasupneti, S., Shuffle, E., Dahms, P., Zhang, P., Cai, H., Dinh, T. T., Liu, B., Cain, C., Giaccia, A. J., Butcher, E. C., Simon, M. C., Semenza, G. L. & Nicolls, M. R., Jan 22 2019, In: Circulation. 139, 4, p. 502-517 16 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations