Godfree Mlambo

Research Associate

20032019
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Research Output 2003 2019

2019

Generation of Transmission-Competent Human Malaria Parasites with Chromosomally-Integrated Fluorescent Reporters

McLean, K. J., Straimer, J., Hopp, C. S., Vega-Rodriguez, J., Small-Saunders, J. L., Kanatani, S., Tripathi, A., Mlambo, G., Dumoulin, P. C., Harris, C. T., Tong, X., Shears, M. J., Ankarklev, J., Kafsack, B. F. C., Fidock, D. A. & Sinnis, P., Sep 11 2019, In : Scientific reports. 9, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Plasmodium falciparum
Malaria
Parasites
Life Cycle Stages
Culicidae
2018

A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission

Schleicher, T. R., Yang, J., Freudzon, M., Rembisz, A., Craft, S., Hamilton, M., Graham, M., Mlambo, G., Tripathi, A., Li, Y., Cresswell, P., Sinnis, P., Dimopoulos, G. & Fikrig, E., Dec 1 2018, In : Nature Communications. 9, 1, 2908.

Research output: Contribution to journalArticle

Salivary Proteins and Peptides
saliva
salivary glands
Sporozoites
Plasmodium
Aquaglyceroporins
Merozoites
Malaria
Parasites
Liver

Immunization with AgTRIO, a Protein in Anopheles Saliva, Contributes to Protection against Plasmodium Infection in Mice

Dragovic, S. M., Agunbiade, T. A., Freudzon, M., Yang, J., Hastings, A. K., Schleicher, T. R., Zhou, X., Craft, S., Chuang, Y. M., Gonzalez, F., Li, Y., Hrebikova, G., Tripathi, A., Mlambo, G., Almeras, L., Ploss, A., Dimopoulos, G. & Fikrig, E., Apr 11 2018, In : Cell Host and Microbe. 23, 4, p. 523-535.e5

Research output: Contribution to journalArticle

Anopheles gambiae
Anopheles
Culicidae
Saliva
Malaria

Long-acting injectable atovaquone nanomedicines for malaria prophylaxis

Bakshi, R., Tatham, L. M., Savage, A. C., Tripathi, A., Mlambo, G., Ippolito, M., Nenortas, E., Rannard, S. P., Owen, A. & Shapiro, T. A., Dec 1 2018, In : Nature Communications. 9, 1, 315.

Research output: Contribution to journalArticle

prophylaxis
Atovaquone
Nanomedicine
Medical nanotechnology
Malaria

Transcriptome analysis based detection of Plasmodium falciparum development in Anopheles stephensi mosquitoes

Oakley, M. S., Verma, N., Myers, T. G., Zheng, H., Locke, E., Morin, M. J., Tripathi, A., Mlambo, G. & Kumar, S., Dec 1 2018, In : Scientific Reports. 8, 1, 11568.

Research output: Contribution to journalArticle

Anopheles
Gene Expression Profiling
Plasmodium falciparum
Culicidae
Oocysts
2017

A no film slot blot for the detection of developing P. Falciparum oocysts in mosquitoes

Grabias, B., Verma, N., Zheng, H., Tripathi, A., Mlambo, G., Morin, M. J., Locke, E. & Kumar, S., Apr 1 2017, In : PLoS One. 12, 4, 0174229.

Research output: Contribution to journalArticle

Oocysts
Culicidae
oocysts
Assays
Autoradiography

A Novel Gametocyte Biomarker for Superior Molecular Detection of the Plasmodium falciparum Infectious Reservoirs

Essuman, E., Grabias, B., Verma, N., Chorazeczewski, J. K., Tripathi, A., Mlambo, G., Addison, E. A., Amoah, A. G. B., Quakyi, I., Oakley, M. S. & Kumar, S., Dec 5 2017, In : The Journal of infectious diseases. 216, 10, p. 1264-1272 9 p.

Research output: Contribution to journalArticle

Plasmodium falciparum
Biomarkers
Parasites
Culicidae
Transcriptome

Functional characterization of malaria parasites deficient in the K+ channel Kch2

Ellekvist, P., Mlambo, G., Kumar, N. & Klaerke, D. A., 2017, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

Malaria
Parasites
Culicidae
Gene Knockout Techniques
Anopheles

Immune regulation of plasmodium is anopheles species specific and infection intensity dependent

Simoes, M. L., Mlambo, G., Tripathi, A., Dong, Y. & Dimopoulos, G., Sep 1 2017, In : mBio. 8, 5, e01631-17.

Research output: Contribution to journalArticle

Anopheles
Plasmodium
Parasites
Culicidae
Malaria
2016

Functional genomic analyses of Enterobacter, Anopheles and Plasmodium reciprocal interactions that impact vector competence

Dennison, N. J., Saraiva, R. G., Cirimotich, C. M., Mlambo, G., Mongodin, E. F. & Dimopoulos, G., Aug 22 2016, In : Malaria Journal. 15, 1, 1468.

Research output: Contribution to journalArticle

Enterobacter
Anopheles
Plasmodium
Culicidae
Mental Competency

Molecular markers of radiation induced attenuation in intrahepatic plasmodium falciparum parasites

Oakley, M. S., Verma, N., Zheng, H., Anantharaman, V., Takeda, K., Gao, Y., Myers, T. G., Pham, P. T., Mahajan, B., Kumar, N., Sangweme, D., Tripathi, A., Mlambo, G., Aravind, L. & Kumar, S., Dec 1 2016, In : PLoS One. 11, 12, e0166814.

Research output: Contribution to journalArticle

Plasmodium falciparum
Sporozoites
sporozoites
Parasites
Liver

Overexpression of Plasmodium berghei ATG8 by liver forms leads to cumulative defects in organelle dynamics and to generation of noninfectious merozoites

Voss, C., Ehrenman, K., Mlambo, G., Mishra, S., Kumar, K. A., Sacci, J. B., Sinnis, P. & Coppens, I., 2016, In : mBio. 7, 3, e00682-16.

Research output: Contribution to journalArticle

Merozoites
Plasmodium berghei
Organelles
Apicoplasts
Parasites
2015
Anopheles
Plasmodium falciparum
Culicidae
Enzyme-Linked Immunosorbent Assay
Malaria
2014

Chromobacterium Csp_P Reduces Malaria and Dengue Infection in Vector Mosquitoes and Has Entomopathogenic and In Vitro Anti-pathogen Activities

Ramirez, J. L., Short, S. M., Bahia, A. C., Saraiva, R. G., Dong, Y., Kang, S., Tripathi, A., Mlambo, G. & Dimopoulos, G., Oct 1 2014, In : PLoS Pathogens. 10, 10

Research output: Contribution to journalArticle

Chromobacterium
Dengue
Culicidae
Malaria
Bacteria

Exploring Anopheles gut bacteria for Plasmodium blocking activity

Bahia, A. C., Dong, Y., Blumberg, B. J., Mlambo, G., Tripathi, A., Benmarzouk-Hidalgo, O. J., Chandra, R. & Dimopoulos, G., 2014, In : Environmental Microbiology. 16, 9, p. 2980-2994 15 p.

Research output: Contribution to journalArticle

Anopheles
Plasmodium
Culicidae
mosquito
digestive system
Plasmodium falciparum
Assays
Malaria
Parasites
assays
2013

Functional evaluation of malaria Pfs25 DNA vaccine by in vivo electroporation in olive baboons

Kumar, R., Nyakundi, R., Kariuki, T., Ozwara, H., Nyamongo, O., Mlambo, G., Ellefsen, B., Hannaman, D. & Kumar, N., Jun 28 2013, In : Vaccine. 31, 31, p. 3140-3147 8 p.

Research output: Contribution to journalArticle

Papio anubis
DNA Vaccines
Electroporation
electroporation
recombinant vaccines
2012

Aberrant Sporogonic Development of Dmc1 (a Meiotic Recombinase) Deficient Plasmodium berghei Parasites

Mlambo, G., Coppens, I. & Kumar, N., Dec 21 2012, In : PLoS One. 7, 12, e52480.

Research output: Contribution to journalArticle

Plasmodium berghei
Recombinases
Parasites
Oocysts
oocysts
2011

A proteogenomic analysis of Anopheles gambiae using high-resolution Fourier transform mass spectrometry

Chaerkady, R., Kelkar, D. S., Muthusamy, B., Kandasamy, K., Dwivedi, S. B., Sahasrabuddhe, N. A., Kim, M. S., Renuse, S., Pinto, S. M., Sharma, R., Pawar, H., Sekhar, N. R., Mohanty, A. K., Getnet, D., Yang, Y., Zhong, J., Dash, A. P., MacCallum, R. M., Delanghe, B., Mlambo, G. & 5 others, Kumar, A., Prasad, T. S. K., Okulate, M., Kumar, N. & Pandey, A., Nov 2011, In : Genome Research. 21, 11, p. 1872-1881 10 p.

Research output: Contribution to journalArticle

Anopheles gambiae
Fourier Analysis
Mass Spectrometry
Genome
Genes
2010

Functional immunogenicity of baculovirus expressing Pfs25, a human malaria transmission-blocking vaccine candidate antigen

Mlambo, G., Kumar, N. & Yoshida, S., Oct 8 2010, In : Vaccine. 28, 43, p. 7025-7029 5 p.

Research output: Contribution to journalArticle

Baculoviridae
malaria
Malaria
Vaccines
immune response
2008

Critical role of a K+ channel in Plasmodium berghei transmission revealed by targeted gene disruption

Ellekvist, P., Maciel, J., Mlambo, G., Ricke, C. H., Colding, H., Klaerke, D. A. & Kumar, N., Apr 29 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 17, p. 6398-6402 5 p.

Research output: Contribution to journalArticle

Plasmodium berghei
Parasites
Genes
Plasmodium falciparum
Culicidae
Plasmodium berghei
Plasmodium falciparum
Culicidae
Parasites
Vaccines
Plasmodium falciparum
Reverse Transcription
Polymerase Chain Reaction
Malaria
Blood Preservation
Protozoan Antibodies
Protozoan Antigens
Malaria Vaccines
Animal Disease Models
Plasmodium berghei
2007

A modified Plasmodium falciparum growth inhibition assay (GIA) to assess activity of plasma from malaria endemic areas

Mlambo, G. & Kumar, N., Feb 2007, In : Experimental Parasitology. 115, 2, p. 211-214 4 p.

Research output: Contribution to journalArticle

Plasmodium falciparum
Malaria
Growth
Pharmaceutical Preparations
Chloroquine

Analysis of genetic polymorphism in select vaccine candidate antigens and microsatellite loci in Plasmodium falciparum from endemic areas at varying altitudes

Mlambo, G., Sullivan, D. J., Mutambu, S. L., Soko, W., Mbedzi, J., Chivenga, J., Jaenisch, T., Gemperli, A. & Kumar, N., Jun 2007, In : Acta Tropica. 102, 3, p. 201-205 5 p.

Research output: Contribution to journalArticle

Plasmodium falciparum
Genetic Polymorphisms
Microsatellite Repeats
Parasites
Vaccines

High prevalence of molecular markers for resistance to chloroquine and pyrimethamine in Plasmodium falciparum from Zimbabwe

Mlambo, G., Sullivan, D. J., Mutambu, S. L., Soko, W., Mbedzi, J., Chivenga, J., Gemperli, A. & Kumar, N., Sep 2007, In : Parasitology Research. 101, 4, p. 1147-1151 5 p.

Research output: Contribution to journalArticle

pyrimethamine
Zimbabwe
chloroquine
Pyrimethamine
Chloroquine
2006

Antibody responses to Plasmodium falciparum vaccine candidate antigens in three areas distinct with respect to altitude

Mlambo, G., Mutambu, S. L., Mduluza, T., Soko, W., Mbedzi, J., Chivenga, J., Lanar, D. E., Singh, S., Carucci, D., Gemperli, A. & Kumar, N., Nov 2006, In : Acta Tropica. 100, 1-2, p. 70-78 9 p.

Research output: Contribution to journalArticle

Plasmodium falciparum
Antibody Formation
Vaccines
vaccines
antigens
2003
Zymosan
Rifampin
Nitrites
Phagocytosis
Dexamethasone