Gianluca Ursini

Instructor

20082019
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Research Output 2008 2019

2019

Brain-derived neurotrophic factor and schizophrenia

Di Carlo, P., Punzi, G. & Ursini, G., Oct 1 2019, In : Psychiatric genetics. 29, 5, p. 200-210 11 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Schizophrenia
Neuronal Plasticity
Long-Term Potentiation
Genome-Wide Association Study
2018

Association of a Noncoding RNA Postmortem With Suicide by Violent Means and In Vivo With Aggressive Phenotypes

Punzi, G., Ursini, G., Viscanti, G., Radulescu, E., Shin, J. H., Quarto, T., Catanesi, R., Blasi, G., Jaffe, A., Deep-Soboslay, A., Hyde, T., Kleinman, J., Bertolino, A. & Weinberger, D., Jan 1 2018, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to journalArticle

Untranslated RNA
Suicide
Phenotype
Long Noncoding RNA
Gene Regulatory Networks

Convergence of placenta biology and genetic risk for schizophrenia article

Ursini, G., Punzi, G., Chen, Q., Marenco, S., Robinson, J. F., Porcelli, A., Hamilton, E. G., Mitjans, M., Maddalena, G., Begemann, M., Seidel, J., Yanamori, H., Jaffe, A., Berman, K. F., Egan, M. F., Straub, R. E., Colantuoni, C., Blasi, G., Hashimoto, R., Rujescu, D. & 3 others, Ehrenreich, H., Bertolino, A. & Weinberger, D., Jun 1 2018, In : Nature Medicine. 24, 6, p. 792-801 10 p.

Research output: Contribution to journalArticle

Placenta
Schizophrenia
Genes
Germany
Biological Phenomena

Genetic vulnerability to DUSP22 promoter hypermethylation is involved in the relation between in utero famine exposure and schizophrenia

Boks, M. P., Houtepen, L. C., Xu, Z., He, Y., Ursini, G., Maihofer, A. X., Rajarajan, P., Yu, Q., Xu, H., Wu, Y., Wang, S., Shi, J. P., Hulshoff Pol, H. E., Strengman, E., Rutten, B. P. F., Jaffe, A., Kleinman, J., Baker, D. G., Hol, E. M., Akbarian, S. & 6 others, Nievergelt, C. M., De Witte, L. D., Vinkers, C. H., Weinberger, D., Yu, J. & Kahn, R. S., Dec 1 2018, In : npj Schizophrenia. 4, 1, 16.

Research output: Contribution to journalArticle

Dual-Specificity Phosphatases
Starvation
Schizophrenia
Methylation
DNA Methylation

Interaction of childhood urbanicity and variation in dopamine genes alters adult prefrontal function as measured by functional magnetic resonance imaging (fMRI)

Reed, J. L., D’Ambrosio, E., Marenco, S., Ursini, G., Zheutlin, A. B., Blasi, G., Spencer, B. E., Romano, R., Hochheiser, J., Reifman, A., Sturm, J., Berman, K. F., Bertolino, A., Weinberger, D. & Callicott, J. H., Apr 1 2018, In : PLoS One. 13, 4, e0195189.

Research output: Contribution to journalArticle

dopamine
magnetic resonance imaging
childhood
Dopamine
Genes

Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder

Rutten, B. P. F., Vermetten, E., Vinkers, C. H., Ursini, G., Daskalakis, N. P., Pishva, E., De Nijs, L., Houtepen, L. C., Eijssen, L., Jaffe, A., Kenis, G., Viechtbauer, W., Van Den Hove, D., Schraut, K. G., Lesch, K. P., Kleinman, J., Hyde, T., Weinberger, D., Schalkwyk, L., Lunnon, K. & 8 others, Mill, J., Cohen, H., Yehuda, R., Baker, D. G., Maihofer, A. X., Nievergelt, C. M., Geuze, E. & Boks, M. P. M., May 1 2018, In : Molecular Psychiatry. 23, 5, p. 1145-1156 12 p.

Research output: Contribution to journalArticle

Post-Traumatic Stress Disorders
DNA Methylation
DNA
Military Personnel
Wounds and Injuries

Neuroepigenetics of Schizophrenia

Punzi, G., Bharadwaj, R. & Ursini, G., Jan 1 2018, (Accepted/In press) In : Progress in Molecular Biology and Translational Science.

Research output: Contribution to journalArticle

Schizophrenia
Epigenomics
Brain
Chromatin
Genes

Schizophrenia polygenic risk score predicts mnemonic hippocampal activity

Chen, Q., Ursini, G., Romer, A. L., Knodt, A. R., Mezeivtch, K., Xiao, E., Pergola, G., Blasi, G., Straub, R. E., Callicott, J. H., Berman, K. F., Hariri, A. R., Bertolino, A., Mattay, V. & Weinberger, D., Apr 1 2018, In : Brain. 141, 4, p. 1218-1228 11 p.

Research output: Contribution to journalArticle

Schizophrenia
Healthy Volunteers
Genome-Wide Association Study
Masks
Alleles
2017

A Polygenic Risk Score of glutamatergic SNPs associated with schizophrenia predicts attentional behavior and related brain activity in healthy humans

Rampino, A., Taurisano, P., Fanelli, G., Attrotto, M., Torretta, S., Antonucci, L. A., Miccolis, G., Pergola, G., Ursini, G., Maddalena, G., Romano, R., Masellis, R., Di Carlo, P., Pignataro, P., Blasi, G. & Bertolino, A., Sep 1 2017, In : European Neuropsychopharmacology. 27, 9, p. 928-939 12 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Schizophrenia
Brain
Short-Term Memory
Healthy Volunteers

Association of functional genetic variation in PP2A with prefrontal working memory processing

Rampino, A., Di Carlo, P., Fazio, L., Ursini, G., Pergola, G., De Virgilio, C., Gadaleta, G., Giordano, G. M., Bertolino, A. & Blasi, G., Jan 1 2017, In : Behavioural Brain Research. 316, p. 125-130 6 p.

Research output: Contribution to journalArticle

Protein Phosphatase 2
Prefrontal Cortex
Short-Term Memory
Single Nucleotide Polymorphism
Cyclic AMP Receptors
2016

BDNF rs6265 methylation and genotype interact on risk for schizophrenia

Ursini, G., Cavalleri, T., Fazio, L., Angrisano, T., Iacovelli, L., Porcelli, A., Maddalena, G., Punzi, G., Mancini, M., Gelao, B., Romano, R., Masellis, R., Calabrese, F., Rampino, A., Taurisano, P., Giorgio, A. D., Keller, S., Tarantini, L., Sinibaldi, L., Quarto, T. & 8 others, Popolizio, T., Caforio, G., Blasi, G., Riva, M. A., De Blasi, A., Chiariotti, L., Bollati, V. & Bertolino, A., Jan 2 2016, In : Epigenetics. 11, 1, p. 11-23 13 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Methylation
Schizophrenia
Genotype
Phenotype
2015

DEGS2 polymorphism associated with cognition in schizophrenia is associated with gene expression in brain

Ohi, K., Ursini, G., Li, M., Shin, J. H., Ye, T., Chen, Q., Tao, R., Kleinman, J., Hyde, T., Hashimoto, R. & Weinberger, D., May 26 2015, In : Translational Psychiatry. 5, 4, e550.

Research output: Contribution to journalArticle

Cognition
Schizophrenia
Genome-Wide Association Study
Gene Expression
Single Nucleotide Polymorphism

Erratum: Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity (Cell Stem Cell (2014) 15 (79-91))

Yoon, K. J., Nguyen, H. N., Ursini, G., Zhang, F., Kim, N. S., Wen, Z., Makri, G., Nauen, D., Shin, J. H., Park, Y., Chung, R., Pekle, E., Zhang, C., Towe, M., Hussaini, S. M. Q., Lee, Y., Rujescu, D., St. Clair, D., Kleinman, J. E., Hyde, T. M. & 6 others, Krauss, G., Christian, K. M., Rapoport, J. L., Weinberger, D. R., Song, H. & Ming, G. L., Mar 5 2015, In : Cell Stem Cell. 16, 3, p. 339 1 p.

Research output: Contribution to journalArticle

Adherens Junctions
Cell Polarity
Neural Stem Cells
Schizophrenia
Stem Cells

Functional genetic variation of the cannabinoid receptor 1 and cannabis use interact on prefrontal connectivity and related working memory behavior

Colizzi, M., Fazio, L., Ferranti, L., Porcelli, A., Masellis, R., Marvulli, D., Bonvino, A., Ursini, G., Blasi, G. & Bertolino, A., Jan 1 2015, In : Neuropsychopharmacology. 40, 3, p. 640-649 10 p.

Research output: Contribution to journalArticle

Cannabinoid Receptors
Cannabis
Short-Term Memory
Cannabinoids
Messenger RNA

Interaction between functional genetic variation of DRD2 and cannabis use on risk of psychosis

Colizzi, M., Iyegbe, C., Powell, J., Ursini, G., Porcelli, A., Bonvino, A., Taurisano, P., Romano, R., Masellis, R., Blasi, G., Morgan, C., Aitchison, K., Mondelli, V., Luzi, S., Kolliakou, A., David, A., Murray, R. M., Bertolino, A. & Di Forti, M., Jan 1 2015, In : Schizophrenia Bulletin. 41, 5, p. 1171-1182 12 p.

Research output: Contribution to journalArticle

Cannabis
Psychotic Disorders
Healthy Volunteers
Short-Term Memory
Case-Control Studies
Joint Instability
Connective Tissue
Psychology
Compulsive Personality Disorder
Anxiety
2014

Differential effects of common variants in SCN2A on general cognitive ability, brain physiology, and messenger RNA expression in schizophrenia cases and control individuals

Dickinson, D., Straub, R. E., Trampush, J. W., Gao, Y., Feng, N., Xie, B., Shin, J. H., Lim, H. K., Ursini, G., Bigos, K., Kolachana, B., Hashimoto, R., Takeda, M., Baum, G. L., Rujescu, D., Callicott, J. H., Hyde, T., Berman, K. F., Kleinman, J. & Weinberger, D., 2014, In : JAMA Psychiatry. 71, 6, p. 647-656 10 p.

Research output: Contribution to journalArticle

Aptitude
Schizophrenia
Messenger RNA
Brain
Genotype

DRD2 genotype predicts prefrontal activity during working memory after stimulation of D2 receptors with bromocriptine

Gelao, B., Fazio, L., Selvaggi, P., Di Giorgio, A., Taurisano, P., Quarto, T., Romano, R., Porcelli, A., Mancini, M., Masellis, R., Ursini, G., De Simeis, G., Caforio, G., Ferranti, L., Lo Bianco, L., Rampino, A., Todarello, O., Popolizio, T., Blasi, G. & Bertolino, A., Jan 1 2014, In : Psychopharmacology. 231, 11, p. 2361-2370 10 p.

Research output: Contribution to journalArticle

Bromocriptine
Short-Term Memory
Genotype
Magnetic Resonance Imaging
Placebos

Expression of DISC1-interactome members correlates with cognitive phenotypes related to schizophrenia

Rampino, A., Walker, R. M., Torrance, H. S., Anderson, S. M., Fazio, L., Di Giorgio, A., Taurisano, P., Gelao, B., Romano, R., Masellis, R., Ursini, G., Caforio, G., Blasi, G., Millar, J. K., Porteous, D. J., Thomson, P. A., Bertolino, A. & Evans, K. L., Jun 18 2014, In : PLoS One. 9, 6, e99892.

Research output: Contribution to journalArticle

Schizophrenia
Phenotype
phenotype
Genes
cognition

Modeling a genetic risk for schizophrenia in iPSCs and Mice reveals neural stem cell deficits associated with adherens junctions and polarity

Yoon, K. J., Nguyen, H. N., Ursini, G., Zhang, F., Kim, N. S., Wen, Z., Makri, G., Nauen, D., Shin, J. H., Park, Y., Chung, R., Pekle, E., Zhang, C., Towe, M., Hussaini, S. M. Q., Lee, Y., Rujescu, D., St. Clair, D., Kleinman, J., Hyde, T. & 6 others, Krauss, G., Christian, K. M., Rapoport, J. L., Weinberger, D., Song, H. & Ming, G. L., Jul 3 2014, In : Cell Stem Cell. 15, 1, p. 79-91 13 p.

Research output: Contribution to journalArticle

Adherens Junctions
Neural Stem Cells
Schizophrenia
Ependymoglial Cells
Haploinsufficiency

Prefronto-striatal physiology is associated with schizotypy and is modulated by a functional variant of DRD2

Taurisano, P., Romano, R., Mancini, M., Di Giorgio, A., Antonucci, L. A., Fazio, L., Rampino, A., Quarto, T., Gelao, B., Porcelli, A., Papazacharias, A., Ursini, G., Caforio, G., Masellis, R., Niccoli-Asabella, A., Todarello, O., Popolizio, T., Rubini, G., Blasi, G. & Bertolino, A., Jul 9 2014, In : Frontiers in Behavioral Neuroscience. 8, JULY, 235.

Research output: Contribution to journalArticle

Corpus Striatum
Schizophrenia
Personality
Dopamine
Genotype
2013

Association of GSK-3β genetic variation with GSK-3β expression, prefrontal cortical thickness, prefrontal physiology, and schizophrenia

Blasi, G., Napolitano, F., Ursini, G., Di Giorgio, A., Caforio, G., Taurisano, P., Fazio, L., Gelao, B., Attrotto, M. T., Colagiorgio, L., Todarello, G., Piva, F., Papazacharias, A., Masellis, R., Mancini, M., Porcelli, A., Romano, R., Rampino, A., Quarto, T., Giulietti, M. & 6 others, Lipska, B. K., Kleinman, J., Popolizio, T., Weinberger, D., Usiello, A. & Bertolino, A., Aug 1 2013, In : American Journal of Psychiatry. 170, 8, p. 868-876 9 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Schizophrenia
Catenins
Genotype
Prefrontal Cortex

Converging evidence for the association of functional genetic variation in the serotonin receptor 2a gene with prefrontal function and olanzapine treatment

Blasi, G., De Virgilio, C., Papazacharias, A., Taurisano, P., Gelao, B., Fazio, L., Ursini, G., Sinibaldi, L., Andriola, I., Masellis, R., Romano, R., Rampino, A., Di Giorgio, A., Lo Bianco, L., Caforio, G., Piva, F., Popolizio, T., Bellantuono, C., Todarello, O., Kleinman, J. & 3 others, Gadaleta, G., Weinberger, D. & Bertolino, A., 2013, In : JAMA Psychiatry. 70, 9, p. 921-930 10 p.

Research output: Contribution to journalArticle

olanzapine
Receptor, Serotonin, 5-HT2A
Schizophrenia
Short-Term Memory
Genes

DAT by perceived MC interaction on human prefrontal activity and connectivity during emotion processing

Taurisano, P., Blasi, G., Romano, R., Sambataro, F., Fazio, L., Gelao, B., Ursini, G., Lo Bianco, L., Di Giorgio, A., Ferrante, F., Papazacharias, A., Porcelli, A., Sinibaldi, L., Popolizio, T. & Bertolino, A., Dec 1 2013, In : Social Cognitive and Affective Neuroscience. 8, 8, p. 855-862 8 p., nss084.

Research output: Contribution to journalArticle

Dopamine Plasma Membrane Transport Proteins
Human Activities
Emotions
Mothers
Prefrontal Cortex

DRD2 genotype-based variation of default mode network activity and of its relationship with striatal DAT binding

Sambataro, F., Fazio, L., Taurisano, P., Gelao, B., Porcelli, A., Mancini, M., Sinibaldi, L., Ursini, G., Masellis, R., Caforio, G., Di Giorgio, A., Niccoli-Asabella, A., Popolizio, T., Blasi, G. & Bertolino, A., Jan 1 2013, In : Schizophrenia Bulletin. 39, 1, p. 206-216 11 p.

Research output: Contribution to journalArticle

Corpus Striatum
Dopamine Plasma Membrane Transport Proteins
Genotype
Dopamine
Gyrus Cinguli

Interaction between catechol-O-methyltransferase (COMT) Val 158Met genotype and genetic vulnerability to schizophrenia during explicit processing of aversive facial stimuli

Lo Bianco, L., Blasi, G., Taurisano, P., Di Giorgio, A., Ferrante, F., Ursini, G., Fazio, L., Gelao, B., Romano, R., Papazacharias, A., Caforio, G., Sinibaldi, L., Popolizio, T., Bellantuono, C. & Bertolino, A., Feb 1 2013, In : Psychological Medicine. 43, 2, p. 279-292 14 p.

Research output: Contribution to journalArticle

Catechol O-Methyltransferase
Schizophrenia
Genotype
Emotions
Siblings

Mirtazapine add-on improves olanzapine effect on negative symptoms of schizophrenia

Caforio, G., Di Giorgio, A., Rampino, A., Rizzo, M., Romano, R., Taurisano, P., Fazio, L., De Simeis, G., Ursini, G., Blasi, G., Nardini, M., Mancini, M. & Bertolino, A., Dec 1 2013, In : Journal of Clinical Psychopharmacology. 33, 6, p. 810-812 3 p.

Research output: Contribution to journalLetter

Schizophrenic Psychology
olanzapine
Mianserin
Tricyclic Antidepressive Agents
Combination Drug Therapy
2011

Catechol-O-methyltransferase Val158Met association with parahippocampal physiology during memory encoding in schizophrenia

Di Giorgio, A., Caforio, G., Blasi, G., Taurisano, P., Fazio, L., Romano, R., Ursini, G., Gelao, B., Bianco, L. L., Papazacharias, A., Sinibaldi, L., Popolizio, T., Bellomo, A. & Bertolino, A., Aug 1 2011, In : Psychological Medicine. 41, 8, p. 1721-1731 11 p.

Research output: Contribution to journalArticle

Catechol O-Methyltransferase
Schizophrenia
Healthy Volunteers
Genotype
Dopamine

D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans

Fazio, L., Blasi, G., Taurisano, P., Papazacharias, A., Romano, R., Gelao, B., Ursini, G., Quarto, T., Lo Bianco, L., Di Giorgio, A., Mancini, M., Popolizio, T., Rubini, G. & Bertolino, A., Feb 14 2011, In : NeuroImage. 54, 4, p. 2915-2921 7 p.

Research output: Contribution to journalArticle

Corpus Striatum
Dopamine
Motor Activity
Genotype
Motor Cortex

DRD2/AKT1 interaction on D2 c-AMP independent signaling, attentional processing, and response to olanzapine treatment in schizophrenia

Blasi, G., Napolitano, F., Ursini, G., Taurisano, P., Romano, R., Caforio, G., Fazio, L., Gelao, B., Di Giorgio, A., Iacovelli, L., Sinibaldi, L., Popolizio, T., Usiello, A. & Bertolino, A., Jan 18 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 3, p. 1158-1163 6 p.

Research output: Contribution to journalArticle

olanzapine
Adenosine Monophosphate
Glycogen Synthase Kinase 3
Schizophrenia
Alleles

Stress-related methylation of the catechol-O-methyltransferase val158 allele predicts human prefrontal cognition and activity

Ursini, G., Bollati, V., Fazio, L., Porcelli, A., Iacovelli, L., Catalani, A., Sinibaldi, L., Gelao, B., Romano, R., Rampino, A., Taurisano, P., Mancini, M., di Giorgio, A., Popolizio, T., Baccarelli, A., de Blasi, A., Blasi, G. & Bertolino, A., May 4 2011, In : Journal of Neuroscience. 31, 18, p. 6692-6698 7 p.

Research output: Contribution to journalArticle

Catechol O-Methyltransferase
Cognition
Methylation
Short-Term Memory
Alleles
2010

Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance

Bertolino, A., Taurisano, P., Pisciotta, N. M., Blasi, G., Fazio, L., Romano, R., Gelao, B., Lo Bianco, L., Lozupone, M., Di Giorgio, A., Caforio, G., Sambataro, F., Niccoli-Asabella, A., Papp, A., Ursini, G., Sinibaldi, L., Popolizio, T., Sadee, W. & Rubini, G., Feb 22 2010, In : PLoS One. 5, 2, e9348.

Research output: Contribution to journalArticle

Corpus Striatum
Short-Term Memory
dopamine
Data storage equipment
receptors
2009

Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans

Blasi, G., Lo Bianco, L., Taurisano, P., Gelao, B., Romano, R., Fazio, L., Papazacharias, A., Di Giorgio, A., Caforio, G., Rampino, A., Masellis, R., Papp, A., Ursini, G., Sinibaldi, L., Popolizio, T., Sadee, W. & Bertolino, A., Nov 25 2009, In : Journal of Neuroscience. 29, 47, p. 14812-14819 8 p.

Research output: Contribution to journalArticle

Dopamine D2 Receptors
Amygdala
Emotions
Prefrontal Cortex
Genotype

Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and volume in humans

Bertolino, A., Fazio, L., Di Giorgio, A., Blasi, G., Romano, R., Taurisano, P., Caforio, G., Sinibaldi, L., Ursini, G., Popolizio, T., Tirotta, E., Papp, A., Dallapiccola, B., Borrelli, E. & Sadee, W., Jan 28 2009, In : Journal of Neuroscience. 29, 4, p. 1224-1234 11 p.

Research output: Contribution to journalArticle

Corpus Striatum
Dopamine Plasma Membrane Transport Proteins
Dopamine D2 Receptors
Dopamine
Prefrontal Cortex
2008

Interazioni geni-ambiente nella schizofrenia

Translated title of the contribution: Gene-environment interactions in schizophreniaUrsini, G., di Giorgio, A., Fazio, L., de Simeis, G., Sinibaldi, L., Latorre, V., Caforio, G., Rizzo, M., Rampino, A., Douzgou, S., Castellana, C., Romano, R., Taurisano, P., Gambi, F., Papazacharias, A., Aquilino, S., Lobianco, L., Popolizio, T., Blasi, G., Dallapiccola, B. & 2 others, Nardinil, M. & Bertolino, A., Dec 1 2008, In : Quaderni Italiani di Psichiatria. 27, 4, p. 133-135 3 p.

Research output: Contribution to journalArticle

Gene-Environment Interaction
Schizophrenia
Genes
Obstetrics
Genotype