George Umanah

Assistant Professor

20082018
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Research Output 2008 2018

A homozygous ATAD1 mutation impairs postsynaptic AMPA receptor trafficking and causes a lethal encephalopathy

Piard, J., Umanah, G., Harms, F. L., Abalde-Atristain, L., Amram, D., Chang, M., Chen, R., Alawi, M., Salpietro, V., Rees, M. I., Chung, S. K., Houlden, H., Verloes, A., Dawson, T. M., Dawson, V., Van Maldergem, L. & Kutsche, K., Mar 1 2018, In : Brain. 141, 3, p. 651-661 11 p.

Research output: Contribution to journalArticle

AMPA Receptors
Brain Diseases
Mutation
Adenosine Triphosphatases
Arthrogryposis

GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers

Kim, S., Yun, S. P., Lee, S., Umanah, G., Bandaru, V. V. R., Yin, X., Rhee, P., Karuppagounder, S., Kwon, S. H., Lee, H., Mao, X., Kim, D., Pandey, A., Lee, G., Dawson, V., Dawson, T. M. & Ko, H. S., Jan 23 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. 798-803 6 p.

Research output: Contribution to journalArticle

Gaucher Disease
alpha-Synuclein
Glucosylceramidase
Glycosphingolipids
Dopaminergic Neurons

Poly(ADP-ribose) drives pathologic a-synuclein neurodegeneration in Parkinson’s disease

Kam, T. I., Mao, X., Park, H., Chou, S. C., Karuppagounder, S., Umanah, G., Yun, S. P., Brahmachari, S., Panicker, N., Chen, R., Andrabi, S. A., Qi, C., Poirier, G. G., Pletnikova, O., Troncoso, J. C., Bekris, L. M., Leverenz, J. B., Pantelyat, A., Ko, H. S., Rosenthal, L. I. S. & 2 othersDawson, T. M. & Dawson, V., Nov 2 2018, In : Science. 362, 6414, eaat8407.

Research output: Contribution to journalArticle

Synucleins
Poly Adenosine Diphosphate Ribose
Parkinson Disease
Adenosine Diphosphate Ribose
Poisons

Reply: ATAD1 encephalopathy and stiff baby syndrome: A recognizable clinical presentation

Piard, J., Umanah, G., Harms, F. L., Abalde-Atristain, L., Amram, D., Chang, M., Chen, R., Alawi, M., Salpietro, V., Rees, M. I., Chung, S. K., Houlden, H., Verloes, A., Dawson, T. M., Dawson, V., Van Maldergem, L. & Kutsche, K., Jun 1 2018, In : Brain. 141, 6, p. e50

Research output: Contribution to journalLetter

Brain Diseases
Hyperexplexia hereditary

The AAA + ATPase Thorase is neuroprotective against ischemic injury

Zhang, J., Yang, J., Wang, H., Sherbini, O., Keuss, M. J., Umanah, G., Pai, E. L. L., Chi, Z., Paldanius, K. M. A., He, W., Wang, H., Andrabi, S. A., Dawson, T. M. & Dawson, V., Jan 1 2018, (Accepted/In press) In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticle

Adenosine Triphosphatases
Wounds and Injuries
Stroke
Glutamic Acid
Oxygen