Frederick Lenz

Professor

1976 …2018
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Research Output 1976 2018

2003

Attenuation of cerebellar tremor with implantation of an intrathecal baclofen pump: The role of γ-aminobutyric acidergic pathways - Case report

Weiss, N., North, R. B., Ohara, S. & Lenz, F., Oct 1 2003, In : Journal of Neurosurgery. 99, 4, p. 768-771 4 p.

Research output: Contribution to journalArticle

Baclofen
Tremor
Upper Extremity
Lower Extremity
Therapeutics

Dipole source analysis of laser-evoked subdural potentials recorded from parasylvian cortex in humans

Vogel, H., Port, J. D., Lenz, F., Solaiyappan, M., Krauss, G. & Treede, R. D., Jun 1 2003, In : Journal of Neurophysiology. 89, 6, p. 3051-3060 10 p.

Research output: Contribution to journalArticle

Auditory Evoked Potentials
Scalp
Electrodes
Hot Temperature
Posterior Thalamic Nuclei

ET-1- and NO-mediated signal transduction pathway in human brain capillary endothelial cells

Chen, Y., McCarron, R. M., Golech, S., Bembry, J., Ford, B., Lenz, F., Azzam, N. & Spatz, M., Feb 1 2003, In : American Journal of Physiology - Cell Physiology. 284, 2 53-2

Research output: Contribution to journalArticle

Signal transduction
Endothelial cells
Endothelin-1
Signal Transduction
Brain

Medial lateral extent of thermal and pain sensations evoked by microstimulation in somatic sensory nuclei of human thalamus

Ohara, S. & Lenz, F., Oct 1 2003, In : Journal of Neurophysiology. 90, 4, p. 2367-2377 11 p.

Research output: Contribution to journalArticle

Thalamus
Hot Temperature
Pain
Ventral Thalamic Nuclei
Tremor

Physiological changes in primate somatosensory thalamus induced by deafferentation are dependent on the spinal funiculi that are sectioned and time following injury

Weng, H. R., Lenz, F., Vierck, C. & Dougherty, P. M., Feb 28 2003, In : Neuroscience. 116, 4, p. 1149-1160 12 p.

Research output: Contribution to journalArticle

Thalamus
Primates
Neurons
Wounds and Injuries
Survival
2002

Attention, novelty, and pain

Lenz, F. & Treede, R. D., Sep 2002, In : Pain. 99, 1-2, p. 1-3 3 p.

Research output: Contribution to journalArticle

Pain
Cerebellar Diseases
Neurophysiology
Tremor
Thalamus
Neurons

Experiential phenomenon on cortical stimulation [5] (multiple letters)

Lehman, R. M., Lenz, F., Moriarity, J. L., Storm, P. B., Krauss, G. & Boatman, D. F., 2002, In : Journal of Neurology Neurosurgery and Psychiatry. 72, 6, p. 823 1 p.

Research output: Contribution to journalArticle

Temporal Lobe
Amygdala
Electric Stimulation
Seizures
Recurrence
Ventral Thalamic Nuclei
Microelectrodes
Tremor
Essential Tremor
Thalamic Nuclei

Single-neuron analysis of human thalamus in patients with intention tremor and other clinical signs of cerebellar disease

Lenz, F., Jaeger, C. J., Seike, M. S., Lin, Y. C. & Reich, S. G., 2002, In : Journal of Neurophysiology. 87, 4, p. 2084-2094 11 p.

Research output: Contribution to journalArticle

Cerebellar Diseases
Tremor
Thalamus
Neurons
Cerebellar Nuclei

Surgery of the motor thalamus: Problems with the present nomenclatures

Krack, P., Dostrovsky, J., Ilinsky, I., Kultas-Ilinsky, K., Lenz, F., Lozano, A. & Vitek, J., 2002, In : Movement disorders : official journal of the Movement Disorder Society. 17, SUPPL. 3

Research output: Contribution to journalArticle

Thalamus
Terminology
Haplorhini
Thalamic Nuclei
Atlases
2001

Deep brain stimulation for the control of pain

Garonzik, I., Samdani, A., Ohara, S. & Lenz, F., 2001, In : Epilepsy and Behavior. 2, 3 SUPPL. 3

Research output: Contribution to journalArticle

Deep Brain Stimulation
Periaqueductal Gray
Pain
Spinothalamic Tracts
Nociceptive Pain
Temporal Lobe
Seizures
Anterior Temporal Lobectomy
Sclerosis
Electrodes

Reorganization of somatic sensory function in the human thalamus after stroke

Ohara, S. & Lenz, F., 2001, In : Annals of Neurology. 50, 6, p. 800-803 4 p.

Research output: Contribution to journalArticle

Thalamus
Stroke
Anterior Thalamic Nuclei
Essential Tremor
Microelectrodes
2000

Adrenergic mediation of TNF alpha-stimulated ICAM-1 expression on human brain microvascular endothelial cells.

Ohara, Y., McCarron, R. M., Hoffman, T. T., Sugano, H., Bembry, J., Lenz, F. & Spatz, M., 2000, In : Acta Neurochirurgica, Supplement. 76, p. 117-120 4 p.

Research output: Contribution to journalArticle

Intercellular Adhesion Molecule-1
Adrenergic Agents
Endothelial Cells
Tumor Necrosis Factor-alpha
Adrenergic beta-2 Receptor Antagonists

Cortical representation of pain: Functional characterization of nociceptive areas near the lateral sulcus

Treede, R. D., Apkarian, A. V., Bromm, B., Greenspan, J. D. & Lenz, F., Aug 1 2000, In : Pain. 87, 2, p. 113-119 7 p.

Research output: Contribution to journalArticle

Somatosensory Cortex
Lasers
Nociceptors
Touch
Scalp

Different generators in human temporal-parasylvian cortex account for subdural laser-evoked potentials, auditory-evoked potentials, and event- related potentials

Lenz, F., Krauss, G., Treede, R. D., Lee, J. I., Boatman, D. F., Crone, N. E., Minahan, R., Port, J. & Rios, M., Feb 4 2000, In : Neuroscience Letters. 279, 3, p. 153-156 4 p.

Research output: Contribution to journalArticle

Auditory Evoked Potentials
Temporal Lobe
Evoked Potentials
Lasers
P300 Event-Related Potentials

Endothelin-1 and nitric oxide affect human cerebromicrovascular endothelial responses and signal transduction.

Chen, Y., McCarron, R. M., Azzam, N., Bembry, J., Reutzler, C., Lenz, F. & Spatz, M., 2000, In : Acta Neurochirurgica, Supplement. 76, p. 131-135 5 p.

Research output: Contribution to journalArticle

Endothelin-1
Signal Transduction
Nitric Oxide
Blood-Brain Barrier
Actin Cytoskeleton

Functional plasticity in primate somatosensory thalamus following chronic lesion of the ventral lateral spinal cord

Weng, H. R., Lee, J. I., Lenz, F., Schwartz, A., Vierck, C., Rowland, L. & Dougherty, P. M., Nov 7 2000, In : Neuroscience. 101, 2, p. 393-401 9 p.

Research output: Contribution to journalArticle

Thalamus
Primates
Spinal Cord
Spinothalamic Tracts
Ventral Thalamic Nuclei

Human brain capillary endothelium: 2-Arachidonoglycerol (endocannabinoid) interacts with endothelin-1

Chen, Y., McCarron, R. M., Ohara, Y., Bembry, J., Azzam, N., Lenz, F., Shohami, E., Mechoulam, R. & Spatz, M., Aug 18 2000, In : Circulation Research. 87, 4, p. 323-327 5 p.

Research output: Contribution to journalArticle

Endocannabinoids
Vascular Endothelium
Endothelin-1
Brain
Cytoskeleton

Microelectrode studies of normal organization and plasticity of human somatosensory thalamus

Hua, S. E., Garonzik, I., Lee, J. I. & Lenz, F., 2000, In : Journal of Clinical Neurophysiology. 17, 6, p. 559-574 16 p.

Research output: Contribution to journalArticle

Microelectrodes
Thalamus
Pain
Dystonia
Amputation

Plasticity of pain-related neuronal activity in the human thalamus

Lenz, F., Lee, J. I., Garonzik, I., Rowland, L. H., Dougherty, P. M. & Hua, S. E., 2000, In : Progress in Brain Research. 129, p. 259-273 15 p.

Research output: Contribution to journalArticle

Thalamus
Human Activities
Pain

Right Hemisphere Language Dominance in a Right-Handed Patient with Late-Onset Seizures

Boatman, D. F., Alidoost, M., Bergey, G. K., Gordon, B., Crone, N. E., Hart, J. & Lenz, F., Aug 2000, In : Epilepsy and Behavior. 1, 4, p. 281-286 6 p.

Research output: Contribution to journalArticle

Patient Rights
Seizures
Language
Speech-Language Pathology
Amobarbital

Scientific position paper of the movement disorder society evaluation of surgery for Parkinson's disease

Hallett, M., Litvan, I., Lenz, F., Ahlskog, E., Grossman, R., Jankovic, J., Narabayashi, H., Tasker, R., Lozano, A. M., Delong, M., Lang, A. E., Obeso, J. A., Waters, C., Koller, W. C., Benabid, A. L., Caparros-Lefebvre, D., Nutt, J. G., Pollak, P., Siegfried, J., Goetz, C. & 2 others, Defer, G. L. & Lopez-Lozano, J. J., 2000, In : Movement disorders : official journal of the Movement Disorder Society. 15, 3, p. 436-438 3 p.

Research output: Contribution to journalArticle

Brain Tissue Transplantation
Outcome and Process Assessment (Health Care)
Fetal Tissue Transplantation
Stereotaxic Techniques
Cerebral Dominance

Transcortical sensory aphasia: Revisited and revised

Boatman, D. F., Gordon, B., Hart, J., Selnes, O., Miglioretti, D. & Lenz, F., Aug 2000, In : Brain. 123, 8, p. 1634-1642 9 p.

Research output: Contribution to journalArticle

Wernicke Aphasia
Language
Amobarbital
Phonetics
Semantics
1999

Ablative surgery and deep brain stimulation for Parkinson's disease [1]

Lee, J. I., Hua, S., Clatterbuck, R. E., Moriarity, J., Dougherty, P. M., Lenz, F. & Laitinen, L. V., 1999, In : Neurosurgery. 45, 2, p. 417-418 2 p.

Research output: Contribution to journalArticle

HIV-associated primary CNS lymorbidity and utility of brain biopsy

Skolasky, R., Dal Pan, G. J., Olivi, A., Lenz, F., Abrams, R. A. & McArthur, J. C., Feb 1 1999, In : Journal of the Neurological Sciences. 163, 1, p. 32-38 7 p.

Research output: Contribution to journalArticle

Lymphoma
Central Nervous System
HIV
Biopsy
Brain

Meningioma with meningioangiomatosis: A condition mimicking invasive meningiomas in children and young adults: Report of two cases and review of the literature

Giangaspero, F., Guiducci, A., Lenz, F., Mastronardi, L. & Burger, P. C., Aug 1999, In : American Journal of Surgical Pathology. 23, 8, p. 872-875 4 p.

Research output: Contribution to journalArticle

Meningioma
Young Adult
Neurofibromatosis 2
Brain
Islands

Nitric oxide modulates endothelin 1-induced Ca2+ mobilization and cytoskeletal F-actin filaments in human cerebromicrovascular endothelial cells

Chen, Y., McCarron, R. M., Bembry, J., Ruetzler, C., Azzam, N., Lenz, F. & Spatz, M., 1999, In : Journal of Cerebral Blood Flow and Metabolism. 19, 2, p. 133-138 6 p.

Research output: Contribution to journalArticle

Endothelin-1
Actin Cytoskeleton
Cyclic GMP-Dependent Protein Kinases
Actins
Nitric Oxide

Pain-related evoked potentials from parasylvian cortex in humans.

Treede, R. D., Vogel, H., Rios, M., Krauss, G., Lesser, R. P. & Lenz, F., 1999, In : Electroencephalography and clinical neurophysiology. Supplement. 49, p. 250-254 5 p.

Research output: Contribution to journalArticle

Somatosensory Cortex
Somatosensory Evoked Potentials
Evoked Potentials
Pain

Pain sensitivity alterations as a function of lesion location in the parasylvian cortex

Greenspan, J. D., Lee, R. R. & Lenz, F., Jun 1 1999, In : Pain. 81, 3, p. 273-282 10 p.

Research output: Contribution to journalArticle

Pain Threshold
Pain
Cerebral Cortex
Hand
Hot Temperature
Dystonia
Skin
Essential Tremor
Human Body
Thalamus

Responses of neurons in the region of human thalamic principal somatic sensory nucleus to mechanical and thermal stimuli graded into the painful range

Lee, J. I., Dougherty, P. M., Antezana, D. & Lenz, F., Aug 9 1999, In : Journal of Comparative Neurology. 410, 4, p. 541-555 15 p.

Research output: Contribution to journalArticle

Hot Temperature
Neurons
Ventral Thalamic Nuclei
Movement Disorders
Skin

Responses of primate spinomesencephalic tract cells to intradermal capsaicin

Dougherty, P. M., Schwartz, A. & Lenz, F., Jun 1999, In : Neuroscience. 90, 4, p. 1377-1392 16 p.

Research output: Contribution to journalArticle

Capsaicin
Primates
Periaqueductal Gray
Excitatory Amino Acids
Injections

Somatosensory stimulus entrains spindle oscillations in the thalamic VPL nucleus in barbiturate anesthetized rats

Muthuswamy, J., Tran, P., Rangarajan, R., Lenz, F., Hanley, D. F. & Thakor, N. V., Mar 12 1999, In : Neuroscience Letters. 262, 3, p. 191-194 4 p.

Research output: Contribution to journalArticle

Ventral Thalamic Nuclei
Thalamus
Evoked Potentials
barbituric acid

Stereotactic ablative and stimulation procedures for treatment of movement disorders

Vitek, J. L., Lozano, A. M. & Lenz, F., Jun 1999, In : Neurosurgery Quarterly. 9, 2, p. 103-119 17 p.

Research output: Contribution to journalArticle

Movement Disorders
Deep Brain Stimulation
Tremor
Pallidotomy
Parkinson Disease

Stereotactic thalamotomy in the treatment of essential tremor of the upper extremity: Reassessment including a blinded measure of outcome

Zirh, A., Reich, S. G., Dougherty, P. M. & Lenz, F., Jun 1999, In : Journal of Neurology Neurosurgery and Psychiatry. 66, 6, p. 772-775 4 p.

Research output: Contribution to journalArticle

Essential Tremor
Handwriting
Upper Extremity
Tremor
Outcome Assessment (Health Care)

Thalamic single neuron activity in patients with dystonia: Dystonia- related activity and somatic sensory reorganization

Lenz, F., Jaeger, C. J., Seike, M. S., Lin, Y. C., Reich, S. G., DeLong, M. R. & Vitek, J. L., 1999, In : Journal of Neurophysiology. 82, 5, p. 2372-2392 21 p.

Research output: Contribution to journalArticle

Dystonia
Neurons
Muscles
Joints
Muscle Contraction

Tremor-frequency (3-6 Hz) activity in the sensorimotor arm representation of the internal segment of the globus pallidus in patients with Parkinson's disease

Lemstra, A. W., Verhagen Metman, L., Lee, J. I., Dougherty, P. M. & Lenz, F., May 28 1999, In : Neuroscience Letters. 267, 2, p. 129-132 4 p.

Research output: Contribution to journalArticle

Globus Pallidus
Tremor
Parkinson Disease
Arm
Neurons
1998

Ablative therapy for movement disorders: Thalamotomy for Parkinson's disease

Perry, V. L. & Lenz, F., 1998, In : Neurosurgery Clinics of North America. 9, 2, p. 317-323 7 p.

Research output: Contribution to journalArticle

Movement Disorders
Parkinson Disease
Stereotaxic Techniques
Safety
Tremor

A new version of the thalamic disinhibition hypothesis of central pain

Craig, A. D., Bowsher, D., Tasker, R. R., Lenz, F., Dougherty, P. M. & Wiesenfeld- Hallin, Z., 1998, In : Pain Forum. 7, 1, p. 1-28 28 p.

Research output: Contribution to journalArticle

Pain
Hot Temperature
Brain
Inhibition (Psychology)

Distribution of cardiovascular related cells within the human thalamus

Oppenheimer, S. M., Kulshreshtha, N., Lenz, F., Zhang, Z., Rowland, L. H. & Dougherty, P. M., 1998, In : Clinical Autonomic Research. 8, 3, p. 173-179 7 p.

Research output: Contribution to journalArticle

Thalamus
Fatal Familial Insomnia
Ventral Thalamic Nuclei
Neurosurgical Procedures
Pain

Facilitation of responses to AMPA but not kainate by cyclothiazide in primate somatosensory thalamus

Dougherty, P. M., Mittman, S. H. & Lenz, F., Apr 17 1998, In : Neuroscience Letters. 246, 1, p. 17-20 4 p.

Research output: Contribution to journalArticle

Kainic Acid
Thalamus
Primates
Ventral Thalamic Nuclei
Glutamate Receptors

Hemispatial somatosensory and motor extinction after stereotactic thalamic lesions

Hillis-Trupe, A., Lenz, F., Zirh, T. A., Dougherty, P. M., Eckel, T. S. & Jackson, K., 1998, In : Neurocase. 4, 1, p. 21-33 13 p.

Research output: Contribution to journalArticle

Perceptual Disorders
Thalamus
Cerebrovascular Circulation
Psychological Extinction
Extinction

Human brain capillary endothelium: Modulation of K+ efflux and K+, Ca2+ uptake by endothelin

Spatz, M., Kawai, N., Bembry, J., Lenz, F. & McCarron, R. M., 1998, In : Neurochemical Research. 23, 8, p. 1125-1132 8 p.

Research output: Contribution to journalArticle

Endothelins
Vascular Endothelium
Protein Kinase C
Brain
Modulation

Neuronal activity in the region of the thalamic principal sensory nucleus (ventralis caudalis) in patients with pain following amputations

Lenz, F., Garonzik, I., Zirh, T. A. & Dougherty, P. M., Jun 18 1998, In : Neuroscience. 86, 4, p. 1065-1081 17 p.

Research output: Contribution to journalArticle

Amputation
Pain
Calcium Signaling
Movement Disorders
Extremities

Neurons in the human thalamic somatosensory nucleus (ventralis caudalis) respond to innocuous cool and mechanical stimuli

Lenz, F. & Dougherty, P. M., Apr 1998, In : Journal of Neurophysiology. 79, 4, p. 2227-2230 4 p.

Research output: Contribution to journalArticle

Thalamic Nuclei
Neurons
Thalamus
Human Body
Population

Painful stimuli evoke potentials recorded from the parasylvian cortex in humans

Lenz, F., Rios, M., Chau, D., Krauss, G., Zirh, T. A. & Lesser, R. P., Oct 1998, In : Journal of Neurophysiology. 80, 4, p. 2077-2088 12 p.

Research output: Contribution to journalArticle

Scalp
Hand
Evoked Potentials
Implanted Electrodes
Gas Lasers

Painful stimuli evoke potentials recorded over the human anterior cingulate gyrus

Lenz, F., Rios, Zirh, Chau, Krauss, G. & Lesser, R. P., 1998, In : Journal of Neurophysiology. 79, 4, p. 2231-2234 4 p.

Research output: Contribution to journalArticle

Gyrus Cinguli
Gas Lasers
Motor Cortex
Prefrontal Cortex
Scalp

Pallidal activity during dystonia: Somatosensory reorganisation and changes with severity

Lenz, F., Suarez, J., Metman, L. V., Reich, S. G., Karp, B. I., Hallett, M., Rowland, L. H. & Dougherty, P. M., 1998, In : Journal of Neurology Neurosurgery and Psychiatry. 65, 5, p. 767-770 4 p.

Research output: Contribution to journalArticle

Dystonia
Globus Pallidus
Dyskinesias
Pallidotomy
Upper Extremity