Frederick Lenz

Professor

1976 …2018
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Research Output 1976 2018

2010

Thalamotomy

von Coelln, R., Kobayashi, K., Kim, J. H., Anderson, W. S., Winberry, J. & Lenz, F. A., Jan 1 2010, Encyclopedia of Movement Disorders. Elsevier Inc., p. 226-229 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tremor
Ventral Thalamic Nuclei
Essential Tremor
Deep Brain Stimulation
Microelectrodes

The human pain system: Experimental and clinical perspectives

Lenz, F., Casey, K. L., Jones, E. G. & Willis, W. D., Oct 1 2010, Cambridge University Press. 638 p.

Research output: Book/ReportBook

Pain
Primates
Rodentia
Anatomy
Pharmacology
2009

A painful cutaneous laser stimulus evokes responses from single neurons in the human thalamic principal somatic sensory nucleus ventral caudal (Vc)

Kobayashi, K., Winberry, J., Liu, C. C., Treede, R. D. & Lenz, F., May 2009, In : Journal of Neurophysiology. 101, 5, p. 2210-2217 8 p.

Research output: Contribution to journalArticle

Lasers
Neurons
Skin
Thalamus
Afferent Pathways

Lesioning and stimulation as surgical treatments for psychiatric disorders

Anderson, W. S. & Lenz, F., Jun 2009, In : Neurosurgery Quarterly. 19, 2, p. 132-143 12 p.

Research output: Contribution to journalArticle

Psychiatry
Psychosurgery
Tourette Syndrome
Deep Brain Stimulation
Obsessive-Compulsive Disorder

Mental arithmetic leads to multiple discrete changes from baseline in the firing patterns of human thalamic neurons

Kim, J. H., Ohara, S. & Lenz, F., Apr 2009, In : Journal of Neurophysiology. 101, 4, p. 2107-2119 13 p.

Research output: Contribution to journalArticle

Wakefulness
Neurons
Aminobutyrates
Inhibitory Postsynaptic Potentials
Tremor

Neurosurgical treatment of cancer pain

Hurley, R. W. & Lenz, F., Jan 1 2009, Cancer Pain: Assessment and Management, Second Edition. Cambridge University Press, p. 329-340 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pain
Opiate Alkaloids
Therapeutics
Nervous System Trauma
Nociceptive Pain

The human thalamic somatic sensory nucleus [Ventral caudal (Vc)] shows neuronal mechanoreceptor-like responses to optimal stimuli for peripheral mechanoreceptors

Weiss, N., Ohara, S., Johnson, K. O. & Lenz, F., Feb 2009, In : Journal of Neurophysiology. 101, 2, p. 1033-1042 10 p.

Research output: Contribution to journalArticle

Mechanoreceptors
Pacinian Corpuscles
Neurons
Vibration
Skin

What can neuroimaging tell us about central pain?

Veldhuijzen, D. S., Lenz, F., Lagraize, S. C. & Greenspan, J. D., Jan 1 2009, Translational Pain Research: From Mouse to Man. CRC Press, p. 315-328 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neuroimaging
Neurology
Pain
Central Nervous System
2008
Pain Perception
Pain
Electrodes
Gyrus Cinguli
Implanted Electrodes

Cold stimuli evoke potentials that can be recorded directly from parasylvian cortex in humans

Greenspan, J. D., Ohara, S., Franaszczuk, P., Veldhuijzen, D. S. & Lenz, F., Oct 2008, In : Journal of Neurophysiology. 100, 4, p. 2282-2286 5 p.

Research output: Contribution to journalArticle

Evoked Potentials
Implanted Electrodes
Electrodes
Seizures

Irregularity distinguishes limb tremor in cervical dystonia from essential tremor

Shaikh, A. G., Jinnah, H. A., Tripp, R. M., Optican, L. M., Ramat, S., Lenz, F. & Zee, D. S., Feb 2008, In : Journal of Neurology Neurosurgery and Psychiatry. 79, 2, p. 187-189 3 p.

Research output: Contribution to journalArticle

Essential Tremor
Torticollis
Tremor
Ion Channels

Neural activities of tactile cross-modal working memory in humans: an event-related potential study

Ohara, S., Wang, L., Ku, Y., Lenz, F., Hsiao, S. S., Hong, B. & Zhou, Y. D., Mar 27 2008, In : Neuroscience. 152, 3, p. 692-702 11 p.

Research output: Contribution to journalArticle

Touch
Short-Term Memory
Evoked Potentials
Scalp
Fingers

Quantitative somatic sensory testing and functional imaging of the response to painful stimuli before and after cingulotomy for obsessive-compulsive disorder (OCD)

Greenspan, J. D., Coghill, R. C., Gilron, I., Sarlani, E., Veldhuijzen, D. S. & Lenz, F., Nov 2008, In : European Journal of Pain (United Kingdom). 12, 8, p. 990-999 10 p.

Research output: Contribution to journalArticle

Obsessive-Compulsive Disorder
Gyrus Cinguli
Acute Pain
Pain
Hot Temperature
Torticollis
Superficial Back Muscles
Denervation
Muscles
Therapeutics
2007

Ablative surgery for the treatment of Parkinson's disease

Lenz, F., 2007, In : Handbook of Clinical Neurology. 84

Research output: Contribution to journalArticle

Parkinson Disease

Imaging central pain syndromes

Veldhuijzen, D. S., Greenspan, J. D., Kim, J. H., Coghill, R. C., Treede, R. D., Ohara, S. & Lenz, F. A., Jun 2007, In : Current Pain and Headache Reports. 11, 3, p. 183-189 7 p.

Research output: Contribution to journalArticle

Pain
Functional Neuroimaging
Magnetic Resonance Spectroscopy
Central Nervous System
Wounds and Injuries

Internal pallidal neuronal activity during mild drug-related dyskinesias in Parkinson's disease: Decreased firing rates and altered firing patterns

Lee, J. I., Verhagen Metman, L., Ohara, S., Dougherty, P. M., Kim, J. H. & Lenz, F., Apr 2007, In : Journal of Neurophysiology. 97, 4, p. 2627-2641 15 p.

Research output: Contribution to journalArticle

Dyskinesias
Parkinson Disease
Apomorphine
Pharmaceutical Preparations
Neurons

Lesions limited to the human thalamic principal somatosensory nucleus (ventral caudal) are associated with loss of cold sensations and central pain

Kim, J. H., Greenspan, J. D., Coghill, R. C., Ohara, S. & Lenz, F., May 2 2007, In : Journal of Neuroscience. 27, 18, p. 4995-5005 11 p.

Research output: Contribution to journalArticle

Ventral Thalamic Nuclei
Pain
Thalamus
Hand
Stroke

Prefrontal cortex and somatosensory cortex in tactile crossmodal association: An independent component analysis of ERP recordings

Ku, Y., Ohara, S., Wang, L., Lenz, F., Hsiao, S. S., Bodner, M., Hong, B. & Zhou, Y. D., Aug 22 2007, In : PLoS One. 2, 8, e771.

Research output: Contribution to journalArticle

Neurophysiology
Somatosensory Cortex
Independent component analysis
Touch
Prefrontal Cortex

Spatial neglect during electrocortical stimulation mapping in the right hemisphere

Kleinman, J. T., Sepkuty, J. P., Hillis-Trupe, A., Lenz, F., Heidler-Gary, J., Gingis, L. & Crone, N. E., Dec 2007, In : Epilepsia. 48, 12, p. 2365-2368 4 p.

Research output: Contribution to journalArticle

Perceptual Disorders
Parietal Lobe
Temporal Lobe
Epilepsy
Electrodes

Spontaneous low threshold spike bursting in awake humans is different in different lateral thalamic nuclei

Ohara, S., Taghva, A., Kim, J. H. & Lenz, F., Jun 2007, In : Experimental Brain Research. 180, 2, p. 281-288 8 p.

Research output: Contribution to journalArticle

Lateral Thalamic Nuclei
Calcium Signaling
Neurons
Thalamic Diseases
Essential Tremor

Statistical modeling and analysis of laser-evoked potentials of electrocorticogram recordings from awake humans

Chen, Z., Ohara, S., Cao, J., Vialatte, F., Lenz, F. & Cichocki, A., 2007, In : Computational Intelligence and Neuroscience. 2007, 10479.

Research output: Contribution to journalArticle

Statistical Modeling
Bioelectric potentials
Statistical Analysis
Laser
Wavelet Analysis
2006
Pain
Frontal Lobe
Lasers
Nociceptors
Implanted Electrodes

Chapter 21 Plasticity of pain-related neuronal activity in the human thalamus

Anderson, W. S., Ohara, S., Lawson, H. C., Treede, R. D. & Lenz, F., 2006, In : Progress in Brain Research. 157, p. 353-364 12 p.

Research output: Contribution to journalArticle

Thalamus
Human Activities
Neuronal Plasticity
Pain
Wounds and Injuries

Chapter 59 Neurosurgical treatment of pain

Lenz, F., 2006, Handbook of Clinical Neurology. Vol. 81. p. 869-885 17 p. (Handbook of Clinical Neurology; vol. 81).

Research output: Chapter in Book/Report/Conference proceedingChapter

Pain
Therapeutics

Effects of human cerebellar thalamus disruption on adaptive control of reaching

Chen, H., Hua, S. E., Smith, M. A., Lenz, F. & Shadmehr, R., Oct 2006, In : Cerebral Cortex. 16, 10, p. 1462-1473 12 p.

Research output: Contribution to journalArticle

Thalamus
Essential Tremor
Deep Brain Stimulation
Tremor
Cerebellum

Endogenous and exogenous modulators of potentials evoked by a painful cutaneous laser (LEPs)

Ohara, S., Anderson, W. S., Lawson, H. C., Lee, H. T. & Lenz, F., Jan 1 2006, Advances in Functional and Reparative Neurosurgery. 99 ed. Springer-Verlag Wien, p. 77-79 3 p. (Acta Neurochirurgica, Supplementum; no. 99).

Research output: Chapter in Book/Report/Conference proceedingChapter

Evoked Potentials
Lasers
Pain
Skin
Gyrus Cinguli

Fractal characteristics of human parkinsonian neuronal spike trains

Rasouli, G., Rasouli, M., Lenz, F., Verhagen, L., Borrett, D. S. & Kwan, H. C., 2006, In : Neuroscience. 139, 3, p. 1153-1158 6 p.

Research output: Contribution to journalArticle

Fractals
Apomorphine
Globus Pallidus
Neurons
Dopamine Agonists

Modulation of somatosensory event-related potential components in a tactile-visual cross-modal task

Ohara, S., Lenz, F. & Zhou, Y. D., 2006, In : Neuroscience. 138, 4, p. 1387-1395 9 p.

Research output: Contribution to journalArticle

Touch
Evoked Potentials
Scalp

Passing lanes and slow lanes into the nociceptive network of the human brain

Treede, R. D. & Lenz, F., Aug 2006, In : Pain. 123, 3, p. 223-225 3 p.

Research output: Contribution to journalArticle

Neural Pathways
Nociceptors
Brain

Psychophysical elements of place and modality specificity in the thalamic somatic sensory nucleus (ventral caudal, Vc) of awake humans

Patel, S., Ohara, S., Dougherty, P. M., Gracely, R. H. & Lenz, F., Feb 2006, In : Journal of Neurophysiology. 95, 2, p. 646-659 14 p.

Research output: Contribution to journalArticle

Thalamus
Human Body
Movement Disorders
Haplorhini

Psychophysics of CNS pain-related activity: Binary and analog channels and memory encoding

Bagley, C. A., Ohara, S., Lawson, H. C. & Lenz, F., Feb 2006, In : Neuroscientist. 12, 1, p. 29-42 14 p.

Research output: Contribution to journalArticle

Psychophysics
Spinothalamic Tracts
Pain
Afferent Pathways
Prosencephalon

Sequential neural processes of tactile-visual crossmodal working memory

Ohara, S., Lenz, F. & Zhou, Y. D., 2006, In : Neuroscience. 139, 1, p. 299-309 11 p.

Research output: Contribution to journalArticle

Touch
Short-Term Memory
Evoked Potentials
Scalp
Cognition

Speech recognition impairments in patients with intractable right temporal lobe epilepsy

Boatman, D. F., Lesser, R. P., Crone, N. E., Krauss, G., Lenz, F. & Miglioretti, D. L., Aug 2006, In : Epilepsia. 47, 8, p. 1397-1401 5 p.

Research output: Contribution to journalArticle

Temporal Lobe Epilepsy
Amobarbital
Partial Epilepsy
Patient Rights
Temporal Lobe

Surgery insight: Deep brain stimulation for movement disorders

Anderson, W. S. & Lenz, F., Jun 2006, In : Nature Clinical Practice Neurology. 2, 6, p. 310-320 11 p.

Research output: Contribution to journalArticle

Deep Brain Stimulation
Movement Disorders
Parkinson Disease
Essential Tremor
Tourette Syndrome
2005

Electrocorticographic high gamma activity versus electrical cortical stimulation mapping of naming

Sinai, A., Bowers, C. W., Crainiceanu, C. M., Boatman, D. F., Gordon, B., Lesser, R. P., Lenz, F. & Crone, N. E., Jul 2005, In : Brain. 128, 7, p. 1556-1570 15 p.

Research output: Contribution to journalArticle

Electric Stimulation
Mouth
Electrodes
Epilepsy
Sensitivity and Specificity

Pain and temperature encoding in the human thalamic somatic sensory nucleus (ventral caudal): Inhibition-related bursting mediates sensations evoked by somatic stimuli

Kim, J. H., Veldhuijzen, D., Anderson, W. S., Lee, J. I., Lee, H. T., Ohara, S. & Lenz, F., Dec 2005, In : Thalamus and Related Systems. 3, 4, p. 305-314 10 p.

Research output: Contribution to journalArticle

Pain
Temperature
Ventral Thalamic Nuclei
Hot Temperature
Skin

Pain and temperature encoding in the human thalamic somatic sensory nucleus (ventral caudal): Inhibition-related bursting evoked by somatic stimuli

Lee, J. I., Ohara, S., Dougherty, P. M. & Lenz, F., Sep 2005, In : Journal of Neurophysiology. 94, 3, p. 1676-1687 12 p.

Research output: Contribution to journalArticle

Calcium Signaling
Neurons
Pain
Temperature
Hot Temperature

Posture-related oscillations in human cerebellar thalamus in essential tremor are enabled by voluntary motor circuits

Hua, S. E. & Lenz, F., Jan 2005, In : Journal of Neurophysiology. 93, 1, p. 117-127 11 p.

Research output: Contribution to journalArticle

Essential Tremor
Tremor
Posture
Thalamus
Neurons

Studies of the human ascending pain pathways

Weiss, N., Lawson, H. C., Greenspan, J. D., Ohara, S. & Lenz, F., Mar 2005, In : Thalamus and Related Systems. 3, 1, p. 71-86 16 p.

Research output: Contribution to journalArticle

Chronic Pain
Primates
Pain Clinics
Pain
Nociception

Transient unilateral hearing loss induced by electrocortical stimulation

Sinha, S. R., Crone, N. E., Fotta, R., Lenz, F. & Boatman, D. F., Jan 25 2005, In : Neurology. 64, 2, p. 383-385 3 p.

Research output: Contribution to journalArticle

Unilateral Hearing Loss
Temporal Lobe
Hearing
Ear
Seizures
2004

Allodynia in patients with post-stroke central pain (CPSP) studied by statistical quantitative sensory testing within individuals

Greenspan, J. D., Ohara, S., Sarlani, E. & Lenz, F., Jun 2004, In : Pain. 109, 3, p. 357-366 10 p.

Research output: Contribution to journalArticle

Hyperalgesia
Stroke
Pain
Hypesthesia
Touch

Amplitudes of laser evoked potential recorded from primary somatosensory, parasylvian and medial frontal cortex are graded with stimulus intensity

Ohara, S., Crone, N. E., Weiss, N., Treede, R. D. & Lenz, F., Jul 2004, In : Pain. 110, 1-2, p. 318-328 11 p.

Research output: Contribution to journalArticle

Frontal Lobe
Lasers
Pain
Implanted Electrodes
Brain

Attention to a painful cutaneous laser stimulus modulates electrocorticographic event-related desynchronization in humans

Ohara, S., Crone, N. E., Weiss, N. & Lenz, F., Jul 2004, In : Clinical Neurophysiology. 115, 7, p. 1641-1652 12 p.

Research output: Contribution to journalArticle

Lasers
Skin
Cortical Synchronization
Pain
Somatosensory Cortex

Attention to pain is processed at multiple cortical sites in man

Ohara, S., Crone, N. E., Weiss, N., Vogel, H., Treede, R. D. & Lenz, F., Jun 2004, In : Experimental Brain Research. 156, 4, p. 513-517 5 p.

Research output: Contribution to journalArticle

Pain
Frontal Lobe
Reading
Epilepsy
Electrodes

Chapter 6 The role of the thalamus in pain

Lenz, F., Weiss, N., Ohara, S., Lawson, C. & Greenspan, J. D., 2004, In : Supplements to Clinical Neurophysiology. 57, C, p. 50-61 12 p.

Research output: Contribution to journalArticle

Physical Stimulation
Brain Mapping
Neural Pathways
Nociceptors
Pain Threshold

Cutaneous painful laser stimuli evoke responses recorded directly from primary somatosensory cortex in awake humans

Ohara, S., Crone, N. E., Weiss, N., Treede, R. D. & Lenz, F., Jun 2004, In : Journal of Neurophysiology. 91, 6, p. 2734-2746 13 p.

Research output: Contribution to journalArticle

Somatosensory Cortex
Lasers
Skin
Fingers
Motor Cortex

Human brain endothelium: Coexpression and function of vanilloid and endocannabinoid receptors

Golech, S. A., McCarron, R. M., Chen, Y., Bembry, J., Lenz, F., Mechoulam, R., Shohami, E. & Spatz, M., Dec 6 2004, In : Molecular Brain Research. 132, 1, p. 87-92 6 p.

Research output: Contribution to journalArticle

TRPV Cation Channels
Endocannabinoids
Endothelium
Brain
rimonabant
Touch
Vibration
Kinesthesis
Pressure
Mechanoreceptors

Pain encoding in the human forebrain: Binary and analog exteroceptive channels

Lenz, F., Ohara, S., Gracely, R. H., Dougherty, P. M. & Patel, S. H., Jul 21 2004, In : Journal of Neuroscience. 24, 29, p. 6540-6544 5 p.

Research output: Contribution to journalArticle

Prosencephalon
Spinothalamic Tracts
Pain
Brain
Emotions