Fred Bunz

Associate Professor

1993 …2019
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Research Output 1993 2019

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2019

Increased uptake of doxorubicin by cells undergoing heat stress does not explain its synergistic cytotoxicity with hyperthermia

Sharma, A., Özayral, S., Caserto, J. S., Ten Cate, R., Anders, N., Barnett, J. D., Kandala, S. K., Henderson, E., Stewart, J., Liapi, E. A., Rudek-Renaut, M., Franken, N. A. P., Oei, A. L., Korangath, P., Bunz, F. & Ivkov, R., Jan 1 2019, In : International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 36, 1, p. 712-720 9 p.

Research output: Contribution to journalArticle

Open Access
Doxorubicin
Fever
Hot Temperature
HCT116 Cells
Heating
2018

Seamless assembly of recombinant adenoviral genomes from high-copy plasmids

Miciak, J. J., Hirshberg, J. & Bunz, F., Jun 1 2018, In : PLoS One. 13, 6, e0199563.

Research output: Contribution to journalArticle

Adenoviridae
Viruses
plasmids
Plasmids
Genes
2017

Tumor-associated APE1 variant exhibits reduced complementation efficiency but does not promote cancer cell phenotypes

Illuzzi, J. L., McNeill, D. R., Bastian, P., Brenerman, B., Wersto, R., Russell, H. R., Bunz, F., McKinnon, P. J., Becker, K. G. & Wilson, D. M., Mar 1 2017, In : Environmental and Molecular Mutagenesis. 58, 2, p. 84-98 15 p.

Research output: Contribution to journalArticle

Endonucleases
Phenotype
Neoplasms
DNA Repair
DNA Damage
2016

Long story short: p53 mediates innate immunity

Miciak, J. & Bunz, F., Apr 1 2016, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1865, 2, p. 220-227 8 p.

Research output: Contribution to journalArticle

Innate Immunity
Neoplasms
Virus Diseases
Homeostasis
Proteins
2015

Effective treatment of diverse medulloblastoma models with mebendazole and its impact on tumor angiogenesis

Bai, R., Staedtke, V., Rudin, C. M., Bunz, F. & Riggins, G. J., 2015, In : Neuro-Oncology. 17, 4, p. 545-554 10 p.

Research output: Contribution to journalArticle

Mebendazole
Medulloblastoma
Vascular Endothelial Growth Factor Receptor-2
HhAntag691
Phosphotransferases

Pathways to chromothripsis

Ivkov, R. & Bunz, F., 2015, In : Cell cycle (Georgetown, Tex.). 14, 18, p. 2886-2890 5 p.

Research output: Contribution to journalArticle

Chromosomal Instability
Medulloblastoma
Chromosomes
Genome
DNA

Repurposing the antihelmintic mebendazole as a hedgehog inhibitor

Larsen, A. R., Bai, R., Chung, J. H., Borodovsky, A., Rudin, C. M., Riggins, G. J. & Bunz, F., Jan 1 2015, In : Molecular Cancer Therapeutics. 14, 1, p. 3-13 11 p.

Research output: Contribution to journalArticle

Mebendazole
Anthelmintics
HhAntag691
Microtubules
Antiparasitic Agents
2014

A PTCH1 homolog transcriptionally activated by p53 suppresses hedgehog signaling

Chung, J. H., Larsen, A. R., Chen, E. & Bunz, F., Nov 21 2014, In : Journal of Biological Chemistry. 289, 47, p. 33020-33031 12 p.

Research output: Contribution to journalArticle

Transcription
Tumors
Genes
Tissue
Neoplasms

A recombinant reporter system for monitoring reactivation of an endogenously DNA hypermethylated gene

Cui, Y., Hausheer, F., Beaty, R., Zahnow, C., Issa, J. P., Bunz, F. & Baylin, S. B., Jul 15 2014, In : Cancer Research. 74, 14, p. 3834-3843 10 p.

Research output: Contribution to journalArticle

DNA
Gene Silencing
Genes
Neoplasms
Histone Deacetylase Inhibitors

Polo-like kinase 2 activates an antioxidant pathway to promote the survival of cells with mitochondrial dysfunction

Li, J., Ma, W., Wang, P. Y., Hurley, P., Bunz, F. & Hwang, P. M., 2014, In : Free Radical Biology and Medicine. 73, p. 270-277 8 p.

Research output: Contribution to journalArticle

Cell Survival
Phosphotransferases
Antioxidants
Cells
Neurodegenerative diseases

Transcriptomes and shRNA suppressors in a TP53 allele-specific model of early-onset colon cancer in African Americans

Weige, C. C., Birtwistle, M. R., Mallick, H., Yi, N., Berrong, Z., Cloessner, E., Duff, K., Tidwell, J., Clendenning, M., Wilkerson, B., Farrell, C., Bunz, F., Ji, H., Shtutman, M., Creek, K. E., Banister, C. E. & Buckhaults, P. J., 2014, In : Molecular Cancer Research. 12, 7, p. 1029-1041 13 p.

Research output: Contribution to journalArticle

Transcriptome
African Americans
Colonic Neoplasms
Small Interfering RNA
Alleles
2013

A loss-of-function mutation in PTCH1 suggests a role for autocrine hedgehog signaling in colorectal tumorigenesis

Chung, J. H. & Bunz, F., Dec 2013, In : Oncotarget. 4, 12, p. 2208-2211 4 p.

Research output: Contribution to journalArticle

Autocrine Communication
Colorectal Neoplasms
Carcinogenesis
Mutation
Ligands
2012

Chk1 suppresses bypass of mitosis and tetraploidization in p53-deficient cancer cells

Wilsker, D., Chung, J. H. & Bunz, F., Apr 15 2012, In : Cell cycle (Georgetown, Tex.). 11, 8, p. 1564-1572 9 p.

Research output: Contribution to journalArticle

Mitosis
Diploidy
Neoplasms
Cell Cycle
Endoreduplication

Genetic disruption of USP9X sensitizes colorectal cancer cells to 5-fluorouracil

Harris, D. R., Mims, A. & Bunz, F., Nov 2012, In : Cancer Biology and Therapy. 13, 13, p. 1319-1324 6 p.

Research output: Contribution to journalArticle

Fluorouracil
Colorectal Neoplasms
Neoplasms
Homologous Recombination
Disease Progression

Targeted mutations in the ATR pathway define agent- Specific requirements for cancer cell growth and survival

Wilsker, D., Chung, J. H., Pradilla, I., Petermann, E., Helleday, T. & Bunz, F., Jan 2012, In : Molecular Cancer Therapeutics. 11, 1, p. 98-107 10 p.

Research output: Contribution to journalArticle

Cell Survival
Mutation
Growth
Ataxia Telangiectasia Mutated Proteins
Pharmaceutical Preparations
2011

ATR mediates cisplatin resistance in a p53 genotype-specific manner

Sangster-Guity, N., Conrad, B. H., Papadopoulos, N. & Bunz, F., Jun 2 2011, In : Oncogene. 30, 22, p. 2526-2533 8 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Cisplatin
Genotype
DNA
Pharmaceutical Preparations

DNA damage signaling downstream of ATM

Bunz, F., 2011, In : Current Cancer Research. 19, p. 35-52 18 p.

Research output: Contribution to journalArticle

Protein Kinases
DNA Damage
Phosphatidylinositol 3-Kinase
Double-Stranded DNA Breaks
DNA Repair

Inhibition of ataxia telangiectasia- and Rad3-related function abrogates the in vitro and in vivo tumorigenicity of human colon cancer cells through depletion of the CD133+ tumor-initiating cell fraction

Gallmeier, E., Hermann, P. C., Mueller, M. T., Machado, J. G., Ziesch, A., De Toni, E. N., Palagyi, A., Eisen, C., Ellwart, J. W., Rivera, J., Rubio-Viqueira, B., Hidalgo, M., Bunz, F., Göke, B. & Christopher, H., Mar 2011, In : Stem Cells. 29, 3, p. 418-429 12 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Neoplastic Stem Cells
Colonic Neoplasms
1-Phosphatidylinositol 4-Kinase
Phosphotransferases
2010

Cdk2 is required for p53-independent G2/M checkpoint control

Chung, J. H. & Bunz, F., Feb 2010, In : PLoS Genetics. 6, 2, e1000863.

Research output: Contribution to journalArticle

cyclin-dependent kinase
Cyclin-Dependent Kinases
S Phase
DNA
protein

Checkpoint bypass and cell viability

Chung, J. H., Zhang, Y. & Bunz, F., Jun 1 2010, In : Cell cycle (Georgetown, Tex.). 9, 11, p. 2102-2107 6 p.

Research output: Contribution to journalArticle

Cell Survival
DNA Damage
Neoplasms
Chromosome Segregation
DNA Replication

Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance

Singh, A., Bodas, M., Wakabayashi, N., Bunz, F. & Biswal, S., Dec 1 2010, In : Antioxidants and Redox Signaling. 13, 11, p. 1627-1637 11 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Antioxidants
Cells
Ionizing Radiation
Glutathione

Mitochondrial respiration protects against oxygen-associated DNA damage

Sung, H. J., Ma, W., Wang, P. Y., Hynes, J., O'Riordan, T. C., Combs, C. A., McCoy, J. P., Bunz, F., Kang, J. G. & Hwang, P. M., 2010, In : Nature Communications. 1, 1

Research output: Contribution to journalArticle

respiration
DNA Damage
Respiration
deoxyribonucleic acid
Oxygen

Protein phosphatases and the dynamics of the DNA damage response

Harris, D. R. & Bunz, F., Mar 1 2010, In : Cell cycle (Georgetown, Tex.). 9, 5, p. 861 1 p.

Research output: Contribution to journalArticle

2009

Ancient drugs, modern targets

Bunz, F., Nov 1 2009, In : Cancer Biology and Therapy. 8, 21, p. 2063-2064 2 p.

Research output: Contribution to journalArticle

Alkylating Antineoplastic Agents
ADAM Proteins
Phenanthrenes
Chinese Herbal Drugs
Amyloid Precursor Protein Secretases
p53 Genes
Neoplasms
Homologous Recombination
Gene Expression Profiling
Ionizing Radiation

Chk1 phosphorylation during mitosis: A new role for a master regulator

Wilsker, D. & Bunz, F., Apr 15 2009, In : Cell cycle (Georgetown, Tex.). 8, 8, p. 1161-1163 3 p.

Research output: Contribution to journalArticle

Mitosis
Phosphorylation
DNA Damage
Proteins
Phosphotransferases
2008

Deficiency of Bloom syndrome helicase activity is radiomimetic

Horowitz, D. P., Topaloglu, O., Zhang, Y. & Bunz, F., 2008, In : Cancer Biology and Therapy. 7, 11, p. 1783-1786 4 p.

Research output: Contribution to journalArticle

Bloom Syndrome
RecQ Helicases
DNA Helicases
Neoplasms
Sister Chromatid Exchange

Epitope tagging of endogenous genes in diverse human cell lines

Kim, J. S., Bonifant, C., Bunz, F., Lane, W. S. & Waldman, T., 2008, In : Nucleic Acids Research. 36, 19, e127.

Research output: Contribution to journalArticle

Epitopes
Cell Line
Genes
Homologous Recombination
Proteins

Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control

Wilsker, D., Petermann, E., Helleday, T. & Bunz, F., Dec 30 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 52, p. 20752-20757 6 p.

Research output: Contribution to journalArticle

DNA Replication
DNA Damage
Phosphorylation
Centrosome
Gene Targeting

RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy

Singh, A., Boldin-Adamsky, S., Thimmulappa, R. K., Rath, S. K., Ashush, H., Coulter, J., Blackford, A., Goodman, S. N., Bunz, F., Watson, W. H., Gabrielson, E., Feinstein, E. & Biswal, S., Oct 1 2008, In : Cancer Research. 68, 19, p. 7975-7984 10 p.

Research output: Contribution to journalArticle

RNA Interference
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Gene Expression
Drug Therapy

Thymidylate synthase and 5-fluorouracil: A cautionary tale

Bunz, F., Jul 2008, In : Cancer Biology and Therapy. 7, 7, p. 995-996 2 p.

Research output: Contribution to journalArticle

Neoplastic Gene Expression Regulation
Antineoplastic Antimetabolites
Neoplasm Drug Resistance
Thymidylate Synthase
Biological Models
2007

ATM and ATR: Components of an integrated circuit

Hurley, P. & Bunz, F., Feb 15 2007, In : Cell cycle (Georgetown, Tex.). 6, 4, p. 414-417 4 p.

Research output: Contribution to journalArticle

Automatic teller machines
DNA Damage
Integrated circuits
DNA
Phosphatidylinositol 3-Kinase

Gene-specific selection against experimental fanconi anemia gene inactivation in human cancer

Gallmeier, E., Hucl, T., Calhoun, E. S., Cunningham, S. C., Bunz, F., Brody, J. R. & Kern, S. E., May 2007, In : Cancer Biology and Therapy. 6, 5, p. 654-660 7 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Gene Silencing
Genes
Neoplasms
Fanconi Anemia Complementation Group D2 Protein

Genetic knockouts and knockins in human somatic cells.

Rago, C., Vogelstein, B. & Bunz, F., 2007, In : Nature Protocols. 2, 11, p. 2734-2746 13 p.

Research output: Contribution to journalArticle

Dependovirus
Viruses
Genes
Gene Targeting
Alleles

Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation

Hurley, P., Wilsker, D. & Bunz, F., Apr 19 2007, In : Oncogene. 26, 18, p. 2535-2542 8 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Ionizing Radiation
Cell Cycle
S Phase
Neoplasms
Ataxia Telangiectasia
Cell Survival
Pharmaceutical Preparations
Neoplasms
Antimetabolites
2006

Hypoxia-inducible factor-1α promotes nonhypoxia-mediated proliferation in colon cancer cells and xenografts

Dang, D. T., Chen, F., Gardner, L. B., Cummins, J. M., Rago, C., Bunz, F., Kantsevoy, S. V. & Dang, L. H., Feb 1 2006, In : Cancer Research. 66, 3, p. 1684-1693 10 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Heterografts
Colonic Neoplasms
Cell Proliferation
Neoplasms

p53 regulates mitochondrial respiration

Matoba, S., Kang, J. G., Patino, W. D., Wragg, A., Boehm, M., Gavrilova, O., Hurley, P., Bunz, F. & Hwang, P. M., Jun 16 2006, In : Science. 312, 5780, p. 1650-1653 4 p.

Research output: Contribution to journalArticle

Electron Transport Complex IV
Respiration
Glycolysis
Neoplasms
Neoplasm Genes
2005

Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development

Zambidis, E., Peault, B., Park, T. S., Bunz, F. & Civin, C. I., Aug 1 2005, In : Blood. 106, 3, p. 860-870 11 p.

Research output: Contribution to journalArticle

Yolk Sac
Hematopoiesis
Stem cells
Macrophages
Embryoid Bodies

Improved methods for the generation of human gene knockout and knockin cell lines

Topaloglu, O., Hurley, P., Yildirim, O., Civin, C. I. & Bunz, F., 2005, In : Nucleic Acids Research. 33, 18, p. 1-7 7 p.

Research output: Contribution to journalArticle

Gene Knockout Techniques
Exons
Cell Line
Plasmids
Catenins

Regulation of cancer cell growth and death: Evaluating new anticancer targets

Bunz, F., 2005, In : Drug Discovery Today: Disease Mechanisms. 2, 3, p. 383-387 5 p.

Research output: Contribution to journalArticle

Cell Death
Gene Knock-In Techniques
Growth
Genes
Neoplasms
2004

Digital HLA allelotyping

Topaloglu, O., Civin, C. I. & Bunz, F., Sep 2004, In : Cancer Biology and Therapy. 3, 9, p. 899-902 4 p.

Research output: Contribution to journalArticle

HLA Antigens
Alleles
Tissue Donors
Stem Cell Transplantation
Graft vs Host Disease
X-Linked Inhibitor of Apoptosis Protein
Tumor Necrosis Factor-alpha
Apoptosis
Inhibitor of Apoptosis Proteins
Ligands
2003

Haploinsufficiency of hTERT leads to telomere dysfunction and radiosensitivity in human cancer cells

Hauguel, T. & Bunz, F., Nov 2003, In : Cancer Biology and Therapy. 2, 6, p. 679-684 6 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Radiation Tolerance
Telomere
Telomerase
Neoplasms

Overcoming the hypoxic barrier to radiation therapy with anaerobic bacteria

Bettegowda, C., Dang, L. H., Abrams, R., Huso, D. L., Dillehay, L., Cheong, I., Agrawal, N., Borzillary, S., McCaffery, J. M., Watson, E. L., Lin, K. S., Bunz, F., Baidoo, K., Pomper, M. G., Kinzler, K. W., Vogelstein, B. & Zhou, S., Dec 9 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 25, p. 15083-15088 6 p.

Research output: Contribution to journalArticle

Anaerobic Bacteria
Radiotherapy
Spores
Radiation
Radioimmunotherapy

The Chk2 tumor suppressor is not required for p53 responses in human cancer cells

Jallepalli, P. V., Lengauer, C., Vogelstein, B. & Bunz, F., Jun 6 2003, In : Journal of Biological Chemistry. 278, 23, p. 20475-20479 5 p.

Research output: Contribution to journalArticle

Tumors
Cells
Neoplasms
Checkpoint Kinase 2
Genes
2002

High-throughput sequencing and cancer genetics.

Bunz, F., Sep 2002, In : Cell cycle (Georgetown, Tex.). 1, 5, p. 320-321 2 p.

Research output: Contribution to journalArticle

DNA Mutational Analysis
ras Genes
Mutation
Neoplasms

Human cell knockouts

Bunz, F., 2002, In : Current Opinion in Oncology. 14, 1, p. 73-78 6 p.

Research output: Contribution to journalArticle

Gene Targeting
Genes
Neoplasms
Cell Cycle
Theoretical Models

Targeted inactivation of p53 in human cells does not result in aneuploidy

Bunz, F., Kinzler, K. W., Vogelstein, B., Dutriaux, A., Sedivy, J. M., Kinzler, K. W., Vogelstein, B. & Lengauer, C., 2002, In : Cancer Research. 62, 4, p. 1129-1133 5 p.

Research output: Contribution to journalArticle

Aneuploidy
Homologous Recombination
Chromosomal Instability
Sister Chromatid Exchange
Diploidy
2001

Cell death and cancer therapy

Bunz, F., Aug 1 2001, In : Current Opinion in Pharmacology. 1, 4, p. 337-341 5 p.

Research output: Contribution to journalArticle

Cell Death
Neoplasms
Inhibitor of Apoptosis Proteins
bcl-2 Genes
Therapeutics