Research Output 2005 2017

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2016

Interference with nuclear factor kappaB signaling pathway by pathogen-encoded proteases: Global and selective inhibition

Hodgson, A. & Wan, F. Feb 1 2016 In : Molecular Microbiology. 99, 3, p. 439-452 14 p.

Research output: Research - peer-reviewArticle

Peptide Hydrolases
Genes
Virulence Factors
Protein Transport
Infection

Sam68/KHDRBS1-dependent NF-κB activation confers radioprotection to the colon epithelium in γ-irradiated mice

Fu, K., Sun, X., Wier, E. M., Hodgson, A., Hobbs, R. P. & Wan, F. Dec 20 2016 In : eLife. 5, DECEMBER2016, e21957

Research output: Research - peer-reviewArticle

Colon
Epithelium
Chemical activation
DNA Damage
Irradiation

Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation

Fu, K., Sun, X., Wier, E. M., Hodgson, A., Liu, Y., Sears, C. L. & Wan, F. Jul 25 2016 In : eLife. 5, 2016JULY, e15018

Research output: Research - peer-reviewArticle

Chemical activation
DNA
DNA Damage
Colon
Carcinogenesis

Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation

Sun, X., Fu, K., Hodgson, A., Wier, E. M., Wen, M. G., Kamenyeva, O., Xia, X., Koo, L. Y. & Wan, F. Sep 16 2016 In : PLoS Biology. 14, 9, e1002543

Research output: Research - peer-reviewArticle

adenosine diphosphate
DNA damage
Adenosine Diphosphate
DNA Damage
DNA

Ultrasound imaging of splenomegaly as a proxy to monitor colon tumor development in Apcmin716/+ mice

Hodgson, A., Wier, E. M., Fu, K., Sun, X. & Wan, F. Sep 1 2016 In : Cancer Medicine. 5, 9, p. 2469-2476 8 p.

Research output: Research - peer-reviewArticle

Splenomegaly
Proxy
Ultrasonography
Colon
Neoplasms
2015

Caspase-3 cleaved p65 fragment dampens NF-κB-mediated anti-apoptotic transcription by interfering with the p65/RPS3 interaction

Wier, E. M., Fu, K., Hodgson, A., Sun, X. & Wan, F. Nov 30 2015 In : FEBS Letters. 589, 23, p. 3581-3587 7 p.

Research output: Research - peer-reviewArticle

Transcription
Caspase 3
ribosomal protein S3
Apoptosis
Transcriptional Activation

Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes

Hobbs, R. P., Depianto, D. J., Jacob, J. T., Han, M. C., Chung, B. M., Batazzi, A. S., Poll, B. G., Guo, Y., Han, J., Ong, S., Zheng, W., Taube, J. M., Ciháková, D., Wan, F. & Coulombe, P. A. Aug 30 2015 In : Nature Genetics. 47, 8, p. 933-938 6 p.

Research output: Research - peer-reviewArticle

Keratin-17
Regulator Genes
Keratins
Keratinocytes
Gene Expression

Metalloprotease NleC Suppresses Host NF-κB/Inflammatory Responses by Cleaving p65 and Interfering with the p65/RPS3 Interaction

Hodgson, A., Wier, E. M., Fu, K., Sun, X., Yu, H., Zheng, W., Sham, H. P., Johnson, K., Bailey, S., Vallance, B. A. & Wan, F. Mar 1 2015 In : PLoS Pathogens. 11, 3, p. 1-23 23 p., e1004705

Research output: Research - peer-reviewArticle

Metalloproteases
ribosomal protein S3
Citrobacter rodentium
Foodborne Diseases
Infection

TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis

Gao, L., Li, D., Ma, K., Zhang, W., Xu, T., Fu, C., Jing, C., Jia, X., Wu, S., Sun, X., Dong, M., Deng, M., Chen, Y., Zhu, W., Peng, J., Wan, F., Zhou, Y., Zon, L. I. & Pan, W. Jul 1 2015 In : PLoS Genetics. 11, 7, e1005346

Research output: Research - peer-reviewArticle

DNA topoisomerase (ATP-hydrolysing)
hematopoiesis
Danio rerio
cell viability
stem cells
2014

Microbiota organization is a distinct feature of proximal colorectal cancers

Dejea, C. M. , Wick, E. C. , Hechenbleikner, E. M. , White, J. R. , Mark Welch, J. L. , Rossettid, B. J. , Peterson, S. N. , Snesrud, E. C. , Borisy, G. G. , Lazarev, M. , Stein, E. , Vadivelu, J. , Roslani, A. C. , Malik, A. A. , Wanyiri, J. W. , Goh, K. L. , Thevambiga, I. , Fu, K. , Wan, F. , Llosa, N. & 9 others Housseau, F., Romans, K., Wu, X., McAllister, F. M., Wu, S., Vogelstein, B., Kinzler, K. W., Pardoll, D. M. & Sears, C. L. Dec 23 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 51, p. 18321-18326 6 p.

Research output: Research - peer-reviewArticle

Microbiota
Colorectal Neoplasms
Neoplasms
Biofilms
Mucous Membrane
2013

Sam68 modulates the promoter specificity of NF-κB and mediates expression of CD25 in activated T cells

Fu, K., Sun, X., Zheng, W., Wier, E. M., Hodgson, A., Tran, D. Q., Richard, S. & Wan, F. 2013 In : Nature Communications. 4, 1909

Research output: Research - peer-reviewArticle

T-Lymphocytes
T-cells
Transcription
nuclei
Interleukin-2 Receptor alpha Subunit
2012

Functional differences and interactions between the escherichia coli type III secretion system effectors NleH1 and NleH2

Pham, T. H., Gao, X., Tsai, K., Olsen, R., Wan, F. & Hardwidge, P. R. Jun 2012 In : Infection and Immunity. 80, 6, p. 2133-2140 8 p.

Research output: Research - peer-reviewArticle

Escherichia coli
Type III Secretion Systems
Citrobacter
Enterohemorrhagic Escherichia coli
Enteropathogenic Escherichia coli

Identification of an N-terminal truncation of the NF-κB p65 subunit that specifically modulates ribosomal protein S3-dependent NF-κB gene expression

Wier, E. M., Neighoff, J., Sun, X., Fu, K. & Wan, F. Dec 14 2012 In : Journal of Biological Chemistry. 287, 51, p. 43019-43029 11 p.

Research output: Research - peer-reviewArticle

Gene expression
ribosomal protein S3
Gene Expression
Genes
Transcription
2011

IKKβ 2 phosphorylation regulates RPS3 nuclear translocation and NF-κ B function during infection with Escherichia coli strain O157: H7

Wan, F., Weaver, A., Gao, X., Bern, M., Hardwidge, P. R. & Lenardo, M. J. Apr 2011 In : Nature Immunology. 12, 4, p. 335-344 10 p.

Research output: Research - peer-reviewArticle

Escherichia coli O157
NF-kappa B
Phosphorylation
Infection
ribosomal protein S3
2010

Protein kinase A phosphorylation activates Vpr-induced cell cycle arrest during human immunodeficiency virus type 1 infection

Barnitz, R. A., Wan, F., Tripuraneni, V., Bolton, D. L. & Lenardo, M. J. Jul 2010 In : Journal of Virology. 84, 13, p. 6410-6424 15 p.

Research output: Research - peer-reviewArticle

Virus Diseases
Cyclic AMP-Dependent Protein Kinases
Cell Cycle Checkpoints
Serine
HIV-1

Termination of autophagy and reformation of lysosomes regulated by mTOR

Yu, L., McPhee, C. K., Zheng, L., Mardones, G. A., Rong, Y., Peng, J., Mi, N., Zhao, Y., Liu, Z., Wan, F., Hailey, D. W., Oorschot, V., Klumperman, J., Baehrecke, E. H. & Lenardo, M. J. Jun 17 2010 In : Nature. 465, 7300, p. 942-946 5 p.

Research output: Research - peer-reviewArticle

Autophagy
Lysosomes
Food
Starvation
Autophagosomes

The nuclear signaling of NF-κB: Current knowledge, new insights, and future perspectives

Wan, F. & Lenardo, M. J. Jan 2010 In : Cell Research. 20, 1, p. 24-33 10 p.

Research output: Research - peer-reviewArticle

Transcription Factors
NF-kappa B
Adaptive Immunity
Innate Immunity
Signal Transduction
2009

Bacterial effector binding to ribosomal protein S3 subverts NF-κB function

Gao, X., Wan, F., Mateo, K., Callegari, E., Wang, D., Deng, W., Puente, J., Li, F., Chaussee, M. S., Finlay, B. B., Lenardo, M. J. & Hardwidge, P. R. Dec 2009 In : PLoS Pathogens. 5, 12, e1000708

Research output: Research - peer-reviewArticle

ribosomal protein S3
NF-kappa B
Enterohemorrhagic Escherichia coli
Escherichia coli O157
Proteins

Casein kinase 1α governs antigen-receptor-induced NF-κB activation and human lymphoma cell survival

Bidère, N., Ngo, V. N., Lee, J., Collins, C., Zheng, L., Wan, F., Davis, R. E., Lenz, G., Anderson, D. E., Arnoult, D., Vazquez, A., Sakai, K., Zhang, J., Meng, Z., Veenstra, T. D., Staudt, L. M. & Lenardo, M. J. Mar 5 2009 In : Nature. 458, 7234, p. 92-96 5 p.

Research output: Research - peer-reviewArticle

Casein Kinases
Antigen Receptors
Lymphoma
Cell Survival
Lymphoma, Large B-Cell, Diffuse

NF-κB activity marks cells engaged in receptor editing

Cadera, E. J., Wan, F., Amin, R. H., Nolla, H., Lenardo, M. J. & Schlissel, M. S. Aug 3 2009 In : Journal of Experimental Medicine. 206, 8, p. 1803-1816 14 p.

Research output: Research - peer-reviewArticle

B-Lymphoid Precursor Cells
Complementary DNA
Autoantigens
B-Lymphocytes
Immunoglobulin Genes

Specification of DNA binding activity of NF-kappaB proteins.

Wan, F. & Lenardo, M. J. Oct 2009 In : Cold Spring Harbor perspectives in biology. 1, 4

Research output: Research - peer-reviewArticle

Specifications
DNA
Proteins
Cell proliferation
Cell death
2007

Ribosomal Protein S3: A KH Domain Subunit in NF-κB Complexes that Mediates Selective Gene Regulation

Wan, F., Anderson, D. E., Barnitz, R. A., Snow, A., Bidere, N., Zheng, L., Hegde, V., Lam, L. T., Staudt, L. M., Levens, D., Deutsch, W. A. & Lenardo, M. J. Nov 30 2007 In : Cell. 131, 5, p. 927-939 13 p.

Research output: Research - peer-reviewArticle

Gene expression
Genes
ribosomal protein S3
DNA
Proteins
2006

Autophagic programmed cell death by selective catalase degradation

Yu, L., Wan, F., Dutta, S., Welsh, S., Liu, Z., Freundt, E., Baehrecke, E. H. & Lenardo, M. Mar 28 2006 In : Proceedings of the National Academy of Sciences of the United States of America. 103, 13, p. 4952-4957 6 p.

Research output: Research - peer-reviewArticle

Autophagy
Catalase
Reactive Oxygen Species
Cell Death
Caspases
2005

Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition

Yang, J. K., Wang, L., Zheng, L., Wan, F., Ahmed, M., Lenardo, M. J. & Wu, H. Dec 22 2005 In : Molecular Cell. 20, 6, p. 939-949 11 p.

Research output: Research - peer-reviewArticle

Death Domain Receptor Signaling Adaptor Proteins
Caspase 8
Proteins
Death Domain
Caspase 10