Felipe Andrade

2024

A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection

Gour, N., Yong, H. M., Magesh, A., Atakkatan, A., Andrade, F., Lajoie, S. & Dong, X., Feb 13 2024, In: Immunity. 57, 2, p. 333-348.e6

Research output: Contribution to journal › Article › peer-review

Open Access

Anti-Gephyrin Antibodies: A Novel Specificity in Patients With Systemic Sclerosis and Lower Bowel Dysfunction

McMahan, Z. H., Kulkarni, S., Andrade, F., Perin, J., Zhang, C., Hooper, J. E., Wigley, F. M., Rosen, A., Pasricha, P. J. & Casciola-Rosen, L., Jan 2024, In: Arthritis and Rheumatology. 76, 1, p. 92-99 8 p.

Research output: Contribution to journal › Article › peer-review

2023

Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus

Gomez-Bañuelos, E., Yu, Y., Li, J., Cashman, K. S., Paz, M., Trejo-Zambrano, M. I., Bugrovsky, R., Wang, Y., Chida, A. S., Sherman-Baust, C. A., Ferris, D. P., Goldman, D. W., Darrah, E., Petri, M., Sanz, I. & Andrade, F., Dec 2023, In: Nature communications. 14, 1, 1388.

Research output: Contribution to journal › Article › peer-review

Open Access

An update on autoantibodies in systemic lupus erythematosus

Gómez-Bañuelos, E., Fava, A. & Andrade, F., Mar 1 2023, In: Current opinion in rheumatology. 35, 2, p. 61-67 7 p.

Research output: Contribution to journal › Review article › peer-review

2022

Alternative exon usage in TRIM21 determines the antigenicity of Ro52/TRIM21 in systemic lupus erythematosus

Gomez-Bañuelos, E., Wahadat, M. J., Li, J., Paz, M., Antiochos, B., Celia, A. I., Andrade, V., Ferris, D. P., Goldman, D. W., Darrah, E., Petri, M. & Andrade, F., Oct 10 2022, In: JCI Insight. 7, 19, e163795.

Research output: Contribution to journal › Article › peer-review

Open Access

Autoantibodies targeting LINE-1-encoded ORF1p are associated with systemic lupus erythematosus diagnosis but not with disease activity

Antiochos, B., Paz, M., Li, J., Goldman, D. W., Petri, M., Darrah, E., Cashman, K., Sanz, I., Burns, K. H., Ardeljan, D., Andrade, F. & Rosen, A., Sep 2022, In: Clinical and experimental rheumatology. 40, 9, p. 1636-1641 6 p.

Research output: Contribution to journal › Article › peer-review

Heavy Chain Constant Region Usage in Antibodies to Peptidylarginine Deiminase 4 as a Marker of Disease Subsets in Rheumatoid Arthritis

Gómez-Bañuelos, E., Shi, J., Wang, H., Danila, M. I., Bridges, S. L., Giles, J. T., Sims, G. P., Andrade, F. & Darrah, E. D., Nov 2022, In: Arthritis and Rheumatology. 74, 11, p. 1746-1754 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function

Casciola-Rosen, L., Thiemann, D. R., Andrade, F., Trejo-Zambrano, M. I., Leonard, E. K., Spangler, J. B., Skinner, N. E., Bailey, J., Yegnasubramanian, S., Wang, R., Vaghasia, A. M., Gupta, A., Cox, A. L., Ray, S. C., Linville, R. M., Guo, Z., Searson, P. C., Machamer, C. E., Desiderio, S., Sauer, L., & 18 othersLaeyendecker, O. B., Garibaldi, B. T., Gao, L., Damarla, M., Hassoun, P. M., Hooper, J., Mecoli, C. A., Christopher-Stine, L., Gutierrez-Alamillo, L., Yang, Q., Hines, D., Clarke, W. A., Rothman, R. E., Pekosz, A., Fenstermacher, K. Z. J., Wang, Z., Zeger, S. L. & Rosen, A., May 9 2022, In: JCI Insight. 7, 9, e158362.

Research output: Contribution to journal › Article › peer-review

Open Access

Intersection Between Large Granular Lymphocyte Leukemia and Rheumatoid Arthritis

Moosic, K. B., Ananth, K., Andrade, F., Feith, D. J., Darrah, E. & Loughran, T. P., May 13 2022, In: Frontiers in Oncology. 12, 869205.

Research output: Contribution to journal › Review article › peer-review

Open Access

Microbial pathways to subvert host immunity generate citrullinated neoantigens targeted in rheumatoid arthritis

Gómez-Bañuelos, E., Konig, M. F. & Andrade, F., Aug 2022, In: Current Opinion in Structural Biology. 75, 102423.

Research output: Contribution to journal › Review article › peer-review

Open Access

Redox-Mediated Carbamylation As a Hapten Model Applied to the Origin of Antibodies to Modified Proteins in Rheumatoid Arthritis

Trejo-Zambrano, M. I., Gómez-Bañuelos, E. & Andrade, F., Mar 2022, In: Antioxidants and Redox Signaling. 36, 7-9, p. 389-409 21 p.

Research output: Contribution to journal › Review article › peer-review

2021

Associations of Antibodies Targeting Periodontal Pathogens With Subclinical Coronary, Carotid, and Peripheral Arterial Atherosclerosis in Rheumatoid Arthritis

Giles, J. T., Reinholdt, J., Andrade, F. & Konig, M. F., Apr 2021, In: Arthritis and Rheumatology. 73, 4, p. 568-575 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Granzyme B induces IRF-3 phosphorylation through a perforin-independent proteolysis-dependent signaling cascade without inducing cell death

Gapud, E. J., Trejo-Zambrano, M. I., Gomez-Banuelos, E., Tiniakou, E., Antiochos, B., Granville, D. J., Andrade, F., Casciola-Rosen, L. & Rosen, A., Jan 15 2021, In: Journal of Immunology. 206, 2, p. 335-344 10 p.

Research output: Contribution to journal › Article › peer-review

2020

Citrulline Not a Major Determinant in the Recognition of Peptidylarginine Deiminase 2 and 4 by Autoantibodies in Rheumatoid Arthritis

Darrah, E., Davis, R. L., Curran, A. M., Naik, P., Chen, R., Na, C. H., Giles, J. T. & Andrade, F., Sep 1 2020, In: Arthritis and Rheumatology. 72, 9, p. 1476-1482 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Exposure to aggregatibacter actinomycetemcomitans before symptom onset and the risk of evolving to rheumatoid arthritis

Gomez‐Bañuelos, E., Johansson, L., Konig, M. F., Lundquist, A., Paz, M., Buhlin, K., Johansson, A., Rantapää‐Dahlqvist, S. & Andrade, F., Jun 2 2020, In: Journal of Clinical Medicine. 9, 6, p. 1-11 11 p., 1906.

Research output: Contribution to journal › Article › peer-review

Open Access

Generation of Distinct Patterns of Rheumatoid Arthritis Autoantigens by Peptidylarginine Deiminase Types 2 and 4 During Perforin-Induced Cell Damage

Romero, V., Darrah, E. & Andrade, F., Jun 1 2020, In: Arthritis and Rheumatology. 72, 6, p. 912-918 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Insights into the study and origin of the citrullinome in rheumatoid arthritis

Fert-Bober, J., Darrah, E. & Andrade, F., Mar 1 2020, In: Immunological reviews. 294, 1, p. 133-147 15 p.

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

2019

Individuals at risk of seropositive rheumatoid arthritis: the evolving story

Rantapää Dahlqvist, S. & Andrade, F., Dec 1 2019, In: Journal of Internal Medicine. 286, 6, p. 627-643 17 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

6 Scopus citations

Rheumatoid arthritis-associated mechanisms of porphyromonas gingivalis and aggregatibacter actinomycetemcomitans

Gómez-Bañuelos, E., Mukherjee, A., Darrah, E. & Andrade, F., Sep 2019, In: Journal of Clinical Medicine. 8, 9, 1309.

Research output: Contribution to journal › Review article › peer-review

Open Access

To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps

Boeltz, S., Amini, P., Anders, H. J., Andrade, F., Bilyy, R., Chatfield, S., Cichon, I., Clancy, D. M., Desai, J., Dumych, T., Dwivedi, N., Gordon, R. A., Hahn, J., Hidalgo, A., Hoffmann, M. H., Kaplan, M. J., Knight, J. S., Kolaczkowska, E., Kubes, P., Leppkes, M., & 29 othersManfredi, A. A., Martin, S. J., Maueröder, C., Maugeri, N., Mitroulis, I., Munoz, L. E., Nakazawa, D., Neeli, I., Nizet, V., Pieterse, E., Radic, M. Z., Reinwald, C., Ritis, K., Rovere-Querini, P., Santocki, M., Schauer, C., Schett, G., Shlomchik, M. J., Simon, H. U., Skendros, P., Stojkov, D., Vandenabeele, P., Berghe, T. V., van der Vlag, J., Vitkov, L., von Köckritz-Blickwede, M., Yousefi, S., Zarbock, A. & Herrmann, M., Mar 1 2019, In: Cell death and differentiation. 26, 3, p. 395-408 14 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

117 Scopus citations

2018

Affinity maturation shapes the function of agonistic antibodies to peptidylarginine deiminase type 4 in rheumatoid arthritis

Shi, J., Darrah, E., Sims, G. P., Mustelin, T., Sampson, K., Konig, M. F., Bingham, C. O., Rosen, A. & Andrade, F., Jan 2018, In: Annals of the rheumatic diseases. 77, 1, p. 141-148 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Autoantibodies to peptidylarginine deiminase 2 are associated with less severe disease in rheumatoid arthritis

Darrah, E. D., Giles, J. T., Davis, R. L., Naik, P., Wang, H., Konig, M. F., Cappelli, L. C., Bingham, C. O., Danoff, S. K. & Andrade, F., Nov 20 2018, In: Frontiers in immunology. 9, NOV, 2696.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Comment on “Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis”

Shi, J. & Andrade, F., 2018, In: Science Immunology. 3, 21, eaao6234.

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Response to comment on “Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis”

Konig, M. F., Giles, J. T., Teles, R. P., Moutsopoulos, N. M. & Andrade, F., Mar 21 2018, In: Science translational medicine. 10, 433, 3031.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Rheumatoid arthritis and citrullination

Darrah, E. & Andrade, F., Jan 1 2018, In: Current opinion in rheumatology. 30, 1, p. 72-78 7 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

60 Scopus citations

Rheumatoid arthritis-associated autoimmunity due to Aggregatibacter actinomycetemcomitans and its resolution with antibiotic therapy

Mukherjee, A., Jantsch, V., Khan, R., Hartung, W., Fischer, R., Jantsch, J., Ehrenstein, B., Konig, M. F. & Andrade, F., Oct 16 2018, In: Frontiers in immunology. 9, OCT, 2352.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2017

Spontaneous secretion of the citrullination enzyme PAD2 and cell surface exposure of PAD4 by neutrophils

Zhou, Y., Chen, B., Mittereder, N., Chaerkady, R., Strain, M., An, L. L., Rahman, S., Ma, W., Low, C. P., Chan, D., Neal, F., Bingham, C. O., Sampson, K., Darrah, E., Siegel, R. M., Hasni, S., Andrade, F., Vousden, K. A., Mustelin, T. & Sims, G. P., Sep 25 2017, In: Frontiers in immunology. 8, SEP, 1200.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

2016

A critical reappraisal of neutrophil extracellular traps and NETosis mimics based on differential requirements for protein citrullination

Konig, M. F. & Andrade, F., Nov 4 2016, In: Frontiers in immunology. 7, NOV, 461.

Research output: Contribution to journal › Article › peer-review

Open Access

112 Scopus citations

Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis

Konig, M. F., Abusleme, L., Reinholdt, J., Palmer, R. J., Teles, R. P., Sampson, K., Rosen, A., Nigrovic, P. A., Sokolove, J., Giles, J. T., Moutsopoulos, N. M. & Andrade, F., Dec 14 2016, In: Science translational medicine. 8, 369, 369ra176.

Research output: Contribution to journal › Article › peer-review

Open Access

208 Scopus citations

Antibodies to native and citrullinated RA33 (hnRNP A2/B1) challenge citrullination as the inciting principle underlying loss of tolerance in rheumatoid arthritis

Konig, M. F., Giles, J. T., Nigrovic, P. A. & Andrade, F., Nov 1 2016, In: Annals of the rheumatic diseases. 75, 11, p. 2022-2028 7 p.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Autoantibodies in Rheumatoid Arthritis

Andrade, F., Darrah, E. D. & Rosen, A., Jan 1 2016, Kelley and Firestein's Textbook of Rheumatology: Volumes 1-2, Tenth Edition. Elsevier, Vol. 1. p. 831-845.e5

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2015

Citrullination of myofilament proteins in heart failure

Fert-Bober, J., Giles, J. T., Holewinski, R. J., Kirk, J. A., Uhrigshardt, H., Crowgey, E. L., Andrade, F., Bingham, C. O., Park, J. K., Halushka, M. K., Kass, D. A., Bathon, J. M. & Van Eyk, J. E., Jan 7 2015, In: Cardiovascular research. 108, 2, p. 232-242 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

Defining the role of Porphyromonas gingivalis peptidylarginine deiminase (PPAD) in rheumatoid arthritis through the study of PPAD biology

Konig, M. F., Paracha, A. S., Moni, M., Bingham, C. O. & Andrade, F., Nov 1 2015, In: Annals of the rheumatic diseases. 74, 11, p. 2054-2061 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

58 Scopus citations

Development of autoantibodies against musclespecific FHL1 in severe inflammatory myopathies

Albrecht, I., Wick, C., Hallgren, A., Tjärnlund, A., Nagaraju, K., Andrade, F., Thompson, K., Coley, W., Phadke, A., Diaz-Gallo, L. M., Bottai, M., Nennesmo, I., Chemin, K., Herrath, J., Johansson, K., Wikberg, A., Jimmy Ytterberg, A., Zubarev, R. A., Danielsson, O., Krystufkova, O., & 6 othersVencovsky, J., Landegren, N., Wahren-Herlenius, M., Padyukov, L., Kämpe, O. & Lundberg, I. E., Dec 2015, In: Journal of Clinical Investigation. 125, 12, p. 4612-4624 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Editorial: Citrullination, and carbamylation, and malondialdehyde-acetaldehyde! oh my! entering the forest of autoantigen modifications in rheumatoid arthritis

Darrah, E. & Andrade, F., Mar 1 2015, In: Arthritis and Rheumatology. 67, 3, p. 604-608 5 p.

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

PPAD is not targeted as a citrullinated protein in rheumatoid arthritis, but remains a candidate for inducing autoimmunity

Konig, M. F., Bingham, C. O. & Andrade, F., Jan 1 2015, In: Annals of the rheumatic diseases. 74, 1

Research output: Contribution to journal › Letter › peer-review

Open Access

6 Scopus citations

2014

Association of cross-reactive antibodies targeting peptidyl-arginine deiminase 3 and 4 with rheumatoid arthritis-associated interstitial lung disease

Giles, J. T., Darrah, E., Danoff, S., Johnson, C., Andrade, F., Rosen, A. & Bathon, J. M., Jun 5 2014, In: PloS one. 9, 6, e98794.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

Insights into the significance of peptidylarginine deiminase 4 and antibodies against citrullinated antigens in the absence of "true ACPAs" in an experimental model of arthritis: Comment on the article by Shelef et al

Konig, M. F., Darrah, E. & Andrade, F., Sep 2014, In: Arthritis and Rheumatology. 66, 9, p. 2642-2644 3 p.

Research output: Contribution to journal › Letter › peer-review

4 Scopus citations

2013

Erosive rheumatoid arthritis is associated with antibodies that activate PAD4 by increasing calcium sensitivity

Darrah, E., Giles, J. T., Ols, M. L., Bull, H. G., Andrade, F. & Rosen, A., May 22 2013, In: Science translational medicine. 5, 186, 186ra65.

Research output: Contribution to journal › Article › peer-review

Open Access

92 Scopus citations

Granzyme H

Andrade, F. & Jenne, D. E., Aug 29 2013, Handbook of Proteolytic Enzymes. Elsevier Ltd, Vol. 3. p. 2721-2724 4 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis

Romero, V., Fert-Bober, J., Nigrovic, P. A., Darrah, E., Haque, U. J., Lee, D. M., Van Eyk, J., Rosen, A. & Andrade, F., Oct 30 2013, In: Science translational medicine. 5, 209, 209ra150.

Research output: Contribution to journal › Article › peer-review

Open Access

137 Scopus citations

2012

Autoantibodies in Rheumatoid Arthritis

Andrade, F., Darrah, E. & Rosen, A., Jan 1 2012, Kelley's Textbook of Rheumatology: Volume 1-2, Ninth Edition. Elsevier, Vol. 1. p. 804-817 14 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Myocardial citrullination in rheumatoid arthritis: A correlative histopathologic study

Giles, J. T., Fert-Bober, J., Park, J. K., Bingham, C. O., Andrade, F., Fox-Talbot, K., Pappas, D., Rosen, A., van Eyk, J., Bathon, J. M. & Halushka, M. K., Feb 24 2012, In: Arthritis Research and Therapy. 14, 1, R39.

Research output: Contribution to journal › Article › peer-review

Open Access

58 Scopus citations

Nets: The missing link between cell death and systemic autoimmune diseases?

Darrah, E. & Andrade, F., 2012, In: Frontiers in immunology. 3, JAN, Article 428.

Research output: Contribution to journal › Article › peer-review

Open Access

68 Scopus citations

Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: Novel insights into autoantigen selection in rheumatoid arthritis

Darrah, E., Rosen, A., Giles, J. T. & Andrade, F., Jan 2012, In: Annals of the rheumatic diseases. 71, 1, p. 92-98 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

102 Scopus citations

2011

Abnormal production of pro- and anti-inflammatory cytokines by lupus monocytes in response to apoptotic cells

Sule, S., Rosen, A., Petri, M., Akhter, E. & Andrade, F., 2011, In: PloS one. 6, 3, e17495.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

2010

Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation

Andrade, F., Darrah, E., Gucek, M., Cole, R. N., Rosen, A. & Zhu, X., Jun 2010, In: Arthritis and rheumatism. 62, 6, p. 1630-1640 11 p.

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Interferon-alpha regulates the dynamic balance between human activated regulatory and effector T cells: Implications for antiviral and autoimmune responses

Golding, A., Rosen, A., Petri, M., Akhter, E. & Andrade, F., Sep 2010, In: Immunology. 131, 1, p. 107-117 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Scopus citations

Non-cytotoxic antiviral activities of granzymes in the context of the immune antiviral state

Andrade, F., May 2010, In: Immunological reviews. 235, 1, p. 128-146 19 p.

Research output: Contribution to journal › Review article › peer-review

46 Scopus citations

Transcription of proteinase 3 and related myelopoiesis genes in peripheral blood mononuclear cells of patients with active Wegener's granulomatosis

Cheadle, C., Berger, A. E., Andrade, F., James, R., Johnson, K., Watkins, T., Park, J. K., Chen, Y. C., Ehrlich, E., Mullins, M., Chrest, F., Barnes, K. C. & Levine, S. M., Jun 2010, In: Arthritis and rheumatism. 62, 6, p. 1744-1754 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Felipe Andrade

Research output

Search results