Felipe A Andrade

Associate Professor

19942019
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Research Output 1994 2019

2019

To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps

Boeltz, S., Amini, P., Anders, H. J., Andrade, F. A., Bilyy, R., Chatfield, S., Cichon, I., Clancy, D. M., Desai, J., Dumych, T., Dwivedi, N., Gordon, R. A., Hahn, J., Hidalgo, A., Hoffmann, M. H., Kaplan, M. J., Knight, J. S., Kolaczkowska, E., Kubes, P., Leppkes, M. & 29 others, Manfredi, A. A., Martin, S. J., Maueröder, C., Maugeri, N., Mitroulis, I., Munoz, L. E., Nakazawa, D., Neeli, I., Nizet, V., Pieterse, E., Radic, M. Z., Reinwald, C., Ritis, K., Rovere-Querini, P., Santocki, M., Schauer, C., Schett, G., Shlomchik, M. J., Simon, H. U., Skendros, P., Stojkov, D., Vandenabeele, P., Berghe, T. V., van der Vlag, J., Vitkov, L., von Köckritz-Blickwede, M., Yousefi, S., Zarbock, A. & Herrmann, M., Jan 1 2019, (Accepted/In press) In : Cell Death and Differentiation.

Research output: Contribution to journalArticle

Dissent and Disputes
Research
Extracellular Traps
Cell Death
Anti-Inflammatory Agents
2018

Affinity maturation shapes the function of agonistic antibodies to peptidylarginine deiminase type 4 in rheumatoid arthritis

Shi, J., Darrah, E., Sims, G. P., Mustelin, T., Sampson, K., Konig, M. F., Bingham, C., Rosen, A. & Andrade, F. A., Jan 1 2018, In : Annals of the Rheumatic Diseases. 77, 1, p. 141-148 8 p.

Research output: Contribution to journalArticle

Rheumatoid Arthritis
Antibodies
Autoantibodies
protein-arginine deiminase
B-Lymphocytes

Autoantibodies to peptidylarginine deiminase 2 are associated with less severe disease in rheumatoid arthritis

Darrah, E., Giles, J. T., Davis, R. L., Naik, P., Wang, H., Konig, M. F., Cappelli, L., Bingham, C., Danoff, S. & Andrade, F. A., Nov 20 2018, In : Frontiers in Immunology. 9, NOV, 02696.

Research output: Contribution to journalArticle

Autoantibodies
Rheumatoid Arthritis
Anti-Idiotypic Antibodies
Antibodies
Joint Diseases
Experimental Arthritis
Adaptive Immunity
Rheumatoid Arthritis
Neutrophils
Fibroblasts

Response to comment on “Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis”

Konig, M. F., Giles, J. T., Teles, R. P., Moutsopoulos, N. M. & Andrade, F. A., Mar 21 2018, In : Science Translational Medicine. 10, 433, 3031.

Research output: Contribution to journalArticle

Aggregatibacter actinomycetemcomitans
Periodontitis
Autoimmunity
Rheumatoid Arthritis
Antibodies

Rheumatoid arthritis and citrullination

Darrah, E. & Andrade, F. A., Jan 1 2018, In : Current Opinion in Rheumatology. 30, 1, p. 72-78 7 p.

Research output: Contribution to journalReview article

Rheumatoid Arthritis
Joints
Calcium
Complement Membrane Attack Complex
Bacterial Toxins

Rheumatoid arthritis-associated autoimmunity due to Aggregatibacter actinomycetemcomitans and its resolution with antibiotic therapy

Mukherjee, A., Jantsch, V., Khan, R., Hartung, W., Fischer, R., Jantsch, J., Ehrenstein, B., Konig, M. F. & Andrade, F. A., Oct 16 2018, In : Frontiers in Immunology. 9, OCT, 02352.

Research output: Contribution to journalArticle

Aggregatibacter actinomycetemcomitans
Autoimmunity
Rheumatoid Arthritis
Anti-Bacterial Agents
Therapeutics
2017

Spontaneous secretion of the citrullination enzyme PAD2 and cell surface exposure of PAD4 by neutrophils

Zhou, Y., Chen, B., Mittereder, N., Chaerkady, R., Strain, M., An, L. L., Rahman, S., Ma, W., Low, C. P., Chan, D., Neal, F., Bingham, C., Sampson, K., Darrah, E., Siegel, R. M., Hasni, S., Andrade, F. A., Vousden, K. A., Mustelin, T. & Sims, G. P., Sep 25 2017, In : Frontiers in Immunology. 8, SEP, 1200.

Research output: Contribution to journalArticle

Rheumatoid Arthritis
Neutrophils
Enzymes
Calcium
Neutrophil Activation
2016
Mitochondrial Degradation
Biological Phenomena
Neutrophils
NADPH Oxidase
Autoantigens

Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis

Konig, M. F., Abusleme, L., Reinholdt, J., Palmer, R. J., Teles, R. P., Sampson, K., Rosen, A., Nigrovic, P. A., Sokolove, J., Giles, J. T., Moutsopoulos, N. M. & Andrade, F. A., Dec 14 2016, In : Science Translational Medicine. 8, 369, 369ra176.

Research output: Contribution to journalArticle

Aggregatibacter actinomycetemcomitans
Autoimmunity
Rheumatoid Arthritis
Infection
Periodontitis
Heterogeneous-Nuclear Ribonucleoprotein Group A-B
Rheumatoid Arthritis
Antibodies
Proteins
Autoantigens
2015

Citrullination of myofilament proteins in heart failure

Fert-Bober, J., Giles, J. T., Holewinski, R. J., Kirk, J. A., Uhrigshardt, H., Crowgey, E. L., Andrade, F. A., Bingham, C., Park, J. K., Halushka, M. K., Kass, D. A., Bathon, J. M. & Van Eyk, J. E., Jan 7 2015, In : Cardiovascular Research. 108, 2, p. 232-242 11 p.

Research output: Contribution to journalArticle

Myofibrils
pioglitazone
Heart Failure
Adenosine Triphosphatases
Proteins

Defining the role of Porphyromonas gingivalis peptidylarginine deiminase (PPAD) in rheumatoid arthritis through the study of PPAD biology

Konig, M. F., Paracha, A. S., Moni, M., Bingham, C. & Andrade, F. A., Nov 1 2015, In : Annals of the Rheumatic Diseases. 74, 11, p. 2054-2061 8 p.

Research output: Contribution to journalArticle

Porphyromonas gingivalis
Rheumatoid Arthritis
Periodontal Diseases
Antibodies
protein-arginine deiminase

Development of autoantibodies against musclespecific FHL1 in severe inflammatory myopathies

Albrecht, I., Wick, C., Hallgren, A., Tjärnlund, A., Nagaraju, K., Andrade, F. A., Thompson, K., Coley, W., Phadke, A., Diaz-Gallo, L. M., Bottai, M., Nennesmo, I., Chemin, K., Herrath, J., Johansson, K., Wikberg, A., Jimmy Ytterberg, A., Zubarev, R. A., Danielsson, O., Krystufkova, O. & 6 others, Vencovsky, J., Landegren, N., Wahren-Herlenius, M., Padyukov, L., Kämpe, O. & Lundberg, I. E., Dec 1 2015, In : Journal of Clinical Investigation. 125, 12, p. 4612-4624 13 p.

Research output: Contribution to journalArticle

Myositis
Autoantibodies
Muscular Diseases
Muscles
Autoimmunity
Acetaldehyde
Autoantigens
Malondialdehyde
Autoantibodies
Rheumatoid Arthritis
Cyclic Peptides
Citrulline
Porphyromonas gingivalis
Bacterial Proteins
Periodontitis
2014

Association of cross-reactive antibodies targeting peptidyl-arginine deiminase 3 and 4 with rheumatoid arthritis-associated interstitial lung disease

Giles, J. T., Darrah, E., Danoff, S., Johnson, C., Andrade, F. A., Rosen, A. & Bathon, J. M., Jun 5 2014, In : PLoS One. 9, 6, e98794.

Research output: Contribution to journalArticle

arginine deiminase
Pulmonary diseases
rheumatoid arthritis
Interstitial Lung Diseases
respiratory tract diseases
Experimental Arthritis
Hydrolases
Theoretical Models
Tumor Necrosis Factor-alpha
Antigens
2013

Erosive rheumatoid arthritis is associated with antibodies that activate PAD4 by increasing calcium sensitivity

Darrah, E., Giles, J. T., Ols, M. L., Bull, H. G., Andrade, F. A. & Rosen, A., May 22 2013, In : Science Translational Medicine. 5, 186, 186ra65.

Research output: Contribution to journalArticle

Autoantibodies
Rheumatoid Arthritis
Calcium
Antibodies
Autoantigens

Granzyme H

Andrade, F. A. & Jenne, D. E., 2013, Handbook of Proteolytic Enzymes. Elsevier Ltd, Vol. 3. p. 2721-2724 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Granzymes

Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis

Romero, V., Fert-Bober, J., Nigrovic, P. A., Darrah, E., Haque, U. J., Lee, D. M., Van Eyk, J., Rosen, A. & Andrade, F. A., Oct 30 2013, In : Science Translational Medicine. 5, 209, 209ra150.

Research output: Contribution to journalArticle

Autoantigens
Rheumatoid Arthritis
Perforin
Complement Membrane Attack Complex
Neutrophil Activation
2012

Myocardial citrullination in rheumatoid arthritis: A correlative histopathologic study

Giles, J. T., Fert-Bober, J., Park, J. K., Bingham, C., Andrade, F. A., Fox-Talbot, K., Pappas, D., Rosen, A., van Eyk, J., Bathon, J. M. & Halushka, M. K., Feb 24 2012, In : Arthritis Research and Therapy. 14, 1, R39.

Research output: Contribution to journalArticle

Rheumatoid Arthritis
Staining and Labeling
Citrulline
Myocarditis
Heart Failure

Nets: The missing link between cell death and systemic autoimmune diseases?

Darrah, E. & Andrade, F. A., 2012, In : Frontiers in Immunology. 3, JAN, Article 428.

Research output: Contribution to journalArticle

Autoimmune Diseases
Cell Death
Granulomatosis with Polyangiitis
Apoptosis
Autoimmunity
Autoantigens
Rheumatoid Arthritis
Neutrophils
Substrates
Actins
2011
monocytes
Monocytes
lupus erythematosus
cytokines
Anti-Inflammatory Agents
2010
arginine deiminase
peptidylarginine deiminase type IV
Cell Line
Rheumatoid Arthritis
Citrulline
Regulatory T-Lymphocytes
Autoimmunity
Interferon-alpha
Antiviral Agents
Systemic Lupus Erythematosus

Non-cytotoxic antiviral activities of granzymes in the context of the immune antiviral state

Andrade, F. A., May 2010, In : Immunological Reviews. 235, 1, p. 128-146 19 p.

Research output: Contribution to journalArticle

Granzymes
Antiviral Agents
Viral Structures
Virus Diseases
Viruses

Transcription of proteinase 3 and related myelopoiesis genes in peripheral blood mononuclear cells of patients with active Wegener's granulomatosis

Cheadle, C., Berger, A. E., Andrade, F. A., James, R., Johnson, K., Watkins, T., Park, J. K., Chen, Y. C., Ehrlich, E., Mullins, M., Chrest, F., Barnes, K. C. & Levine, S. M., Jun 2010, In : Arthritis and Rheumatism. 62, 6, p. 1744-1754 11 p.

Research output: Contribution to journalArticle

Myeloblastin
Myelopoiesis
Granulomatosis with Polyangiitis
Blood Cells
Genes
2009

Cleavage of La protein by granzyme H induces cytoplasmic translocation and interferes with La-mediated HCV-IRES translational activity

Romero, V., Fellows, E., Jenne, D. E. & Andrade, F. A., 2009, In : Cell Death and Differentiation. 16, 2, p. 340-348 9 p.

Research output: Contribution to journalArticle

Granzymes
Hepacivirus
Proteins
Phosphoproteins
Viral RNA
2008

Non-apoptotic functions of granzymes

Romero, V. & Andrade, F. A., May 2008, In : Tissue Antigens. 71, 5, p. 409-416 8 p.

Research output: Contribution to journalArticle

Granzymes
Peptide Hydrolases
Cell Death
Oncogenic Viruses
Virus Diseases
2007

Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition

Andrade, F. A., Fellows, E., Jenne, D. E., Rosen, A. & Young, C. S. H., Apr 18 2007, In : The EMBO journal. 26, 8, p. 2148-2157 10 p.

Research output: Contribution to journalArticle

Granzymes
Viral DNA
DNA Replication
Proteins
DNA-Binding Proteins
2005

Apoptosis in lupus erythematosus

Andrade, F. A., Rosen, A. & Casciola Rosen, L. A., 2005, Cutaneous Lupus Erythematosus. Springer Berlin Heidelberg, p. 239-249 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Systemic Lupus Erythematosus
Autoantibodies
Apoptosis
Phenotype
Skin Diseases
Autoantigens
Autoimmunity
RNA
Proteins
Keratinocytes
2004

Granzyme B-induced cell death

Andrade, F. A., Casciola Rosen, L. A. & Rosen, A., 2004, In : Acta Haematologica. 111, 1-2, p. 28-41 14 p.

Research output: Contribution to journalArticle

Granzymes
Cell Death
Oncogenic Viruses
Serine Proteases
Lymphocytes
2003
Granzymes
Adenoviridae
Peptide Hydrolases
Catalytic Domain
Enzyme Inhibitors

El impacto del descubrimiento de la estructura del DNA en reumatología

Translated title of the contribution: The discovery of DNA structure and its importance in rheumatologyAndrade, F. A. & Sánchez-Guerrero, J., Mar 2003, In : Revista de Investigacion Clinica. 55, 2, p. 196-199 4 p.

Research output: Contribution to journalArticle

Nucleic Acid Conformation
Animal Disease Models
Genetically Modified Animals
Rheumatology
Molecular Cloning
2002

Distribution of class I and class III MHC antigens in the Tarasco Amerindians

Loeza, F., Vargas-Alarcón, G., Andrade, F. A., Vergara, Y., Rodríguez-Pérez, J., Ruiz-Morales, J. A., Alarcón-Segovia, D. & Granados, J., 2002, In : Human Immunology. 63, 2, p. 143-148 6 p.

Research output: Contribution to journalArticle

Histocompatibility Antigens
Major Histocompatibility Complex
Haplotypes
Antigens
HLA-B27 Antigen
2001

Adenovirus L4-100K assembly protein is a Granzyme B substrate that potently inhibits Granzyme B-mediated cell death

Andrade, F. A., Bull, H. G., Thornberry, N. A., Ketner, G. W., Casciola Rosen, L. A. & Rosen, A., 2001, In : Immunity. 14, 6, p. 751-761 11 p.

Research output: Contribution to journalArticle

Granzymes
Adenoviridae
Cell Death
Proteins
Viral Proteins
2000
Systemic Lupus Erythematosus
Apoptosis
Antigens
Autoantigens
Blister
1999

Cleavage by granzyme B is strongly predictive of autoantigen status: Implications for initiation of autoimmunity

Casciola Rosen, L. A., Andrade, F. A., Ulanet, D., Wong, W. B. & Rosen, A., Sep 20 1999, In : Journal of Experimental Medicine. 190, 6, p. 815-825 11 p.

Research output: Contribution to journalArticle

Granzymes
Autoantigens
Autoimmunity
Caspase 8
Apoptosis

Immunogenetics of mixed connective tissue disease in a Mexican Mestizo population

Weckmann, A. L., Granados, J., Cardiel, M. H., Andrade, F. A., Vargas-Alarcón, G., Alcocer-Varela, J. & Alarcón-Segovia, D., 1999, In : Clinical and Experimental Rheumatology. 17, 1, p. 91-94 4 p.

Research output: Contribution to journalArticle

Mixed Connective Tissue Disease
Immunogenetics
Alleles
Population
HLA-B35 Antigen
1998

Complotype SC30 is associated with susceptibility to develop ulcerative colitis in Mexicans [1]

Yamamoto-Furusho, J. K., Cantu, C., Vargas-Alarcon, G., Andrade, F. A., Zuniga, J., Rodriguez, J., Boom, R. & Granados, J., 1998, In : Journal of Clinical Gastroenterology. 27, 2, p. 178-179 2 p.

Research output: Contribution to journalArticle

Granzyme B directly and efficiently cleaves several downstream caspases substrates: Implications for CTL-induced apoptosis

Andrade, F. A., Roy, S., Nicholson, D., Thornberry, N., Rosen, A. & Casciola Rosen, L. A., Apr 1998, In : Immunity. 8, 4, p. 451-460 10 p.

Research output: Contribution to journalArticle

Granzymes
Caspases
Apoptosis
Proteolysis
Cell Death
1997

Relationship of anticardiolipin antibodies and antiphospholipid syndrome to HLA-DR7 in Mexican patients with systemic lupus erythematosus (SLE)

Granados, J., Vargas-Alarcón, G., Drenkard, C., Andrade, F. A., Melín-Aldana, H., Alcocer-Varela, J. & Alarcón-Segovia, D., 1997, In : Lupus. 6, 1, p. 57-62 6 p.

Research output: Contribution to journalArticle

HLA-DR7 Antigen
Anticardiolipin Antibodies
Antiphospholipid Syndrome
Systemic Lupus Erythematosus
Major Histocompatibility Complex
1996

Independent associations of the HLA-B27 antigen and the complement haplotype SC21 in chronic anterior uveitis

Arellanes, L., Yamamoto-Furusho, J. K., Andrade, F. A., Vargas-Alarcón, G., Barojas, E., García-Garduño, L. M. & Granados, J., 1996, In : Ocular Immunology and Inflammation. 4, 4, p. 203-206 4 p.

Research output: Contribution to journalArticle

Anterior Uveitis
HLA-B27 Antigen
Haplotypes
Major Histocompatibility Complex
HLA-B35 Antigen

The role of HLA-DR alleles and complotypes through the ethnic barrier in systemic lupus erythematosus in Mexicans

Granados, J., Vargas-Alarcón, G., Andrade, F. A., Melin-Aldana, H., Alcocer-Varela, J. & Alarcón-Segovia, D., 1996, In : Lupus. 5, 3, p. 184-189 6 p.

Research output: Contribution to journalArticle

HLA-DR Antigens
Systemic Lupus Erythematosus
Alleles
Haplotypes
HLA-DR3 Antigen
1994

HLA-B alleles and complotypes in Mexican patients with seronegative spondyloarthropathies

Vargas-Alarcón, G., Garcia, A., Bahena, S., Melín-Aldana, H., Andrade, F. A., Ibañez-De-Kasep, G., Alcocer-Varela, J., Alarcón-Segovia, D. & Granados, J., 1994, In : Annals of the Rheumatic Diseases. 53, 11, p. 755-758 4 p.

Research output: Contribution to journalArticle

Spondylarthropathies
HLA-B Antigens
HLA-B27 Antigen
Alleles
Haplotypes

Linkage disequilibrium of HLA-DR3 and HLA-DR4 with HLA-B alleles in Mexican patients with rheumatoid arthritis

Avila-Portillo, L. M., Vargas-Alarcon, G., Andrade, F. A., Alarcon-Segovia, D. & Granados, J., 1994, In : Clinical and Experimental Rheumatology. 12, 5, p. 497-502 6 p.

Research output: Contribution to journalArticle

HLA-DR3 Antigen
HLA-DR4 Antigen
HLA-B Antigens
Linkage Disequilibrium
Haplotypes