Research Output 2002 2016

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2016

Foxp3, Regulatory T Cell, and Autoimmune Diseases

Tao, J. H., Cheng, M., Tang, J. P., Liu, Q., Pan, F. & Li, X. P. Nov 24 2016 In : Inflammation. p. 1-12 12 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Autoimmune Diseases
Immunosuppressive Agents
Immune Tolerance
Systemic Lupus Erythematosus

MicroRNA-17 Modulates Regulatory T Cell Function by Targeting Co-regulators of the Foxp3 Transcription Factor

Yang, H. Y., Barbi, J., Wu, C. Y., Zheng, Y., Vignali, P. D. A., Wu, X., Tao, J. H., Park, B. V., Bandara, S., Novack, L., Ni, X., Yang, X., Chang, K. Y., Wu, R. C., Zhang, J., Yang, C. W., Pardoll, D. M., Li, H. & Pan, F. Jul 19 2016 In : Immunity. 45, 1, p. 83-93 11 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
MicroRNAs
Transcription Factors
Interleukin-6
Cytokines

SHARPINing the knowledge of TCR signal control

Bowman, M., Pan, F. & Harhaj, E. W. Feb 1 2016 In : Nature Immunology. 17, 3, p. 221-222 2 p.

Research output: Contribution to journalArticle

TGFβ1-mediated SMAD3 enhances PD-1 expression on antigen-specific T cells in cancer

Park, B. V., Freeman, Z. T., Ghasemzadeh, A., Chattergoon, M. A., Rutebemberwa, A., Steigner, J., Winter, M. E., Huynh, T. V., Sebald, S. M., Lee, S. J., Pan, F., Pardoll, D. M. & Cox, A. L. Dec 1 2016 In : Cancer Discovery. 6, 12, p. 1366-1381 16 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Antigens
Neoplasms
Tumor Microenvironment
Up-Regulation
2015

53BP1 promotes microhomology-mediated end-joining in G1-phase cells

Xiong, X., Du, Z., Wang, Y., Feng, Z., Fan, P., Yan, C., Willers, H. & Zhang, J. 2015 In : Nucleic Acids Research. 43, 3, p. 1659-1670 12 p.

Research output: Contribution to journalArticle

G1 Phase
Double-Stranded DNA Breaks
Sequence Deletion
Genomic Instability
Homologous Recombination
Anoxia
T-Lymphocytes
Oxygen
Adaptive Immunity
Innate Immunity

Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α

Mascanfroni, I. D., Takenaka, M. C., Yeste, A., Patel, B., Wu, Y., Kenison, J. E., Siddiqui, S., Basso, A. S., Otterbein, L. E., Pardoll, D. M., Pan, F., Priel, A., Clish, C. B., Robson, S. C. & Quintana, F. J. Jun 9 2015 In : Nature Medicine. 21, 6, p. 638-646 9 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Regulatory T-Lymphocytes
Cell Differentiation
Anoxia
T-cells

Metabolic regulation of T cell differentiation and function

Park, B. V. & Pan, F. Dec 1 2015 In : Molecular Immunology. 68, 2, p. 497-506 10 p.

Research output: Contribution to journalArticle

Cell Differentiation
T-Lymphocytes
Cytokines
Transcription Factors
Food

The role of nuclear receptors in regulation of Th17/Treg biology and its implications for diseases

Park, B. V. & Pan, F. Sep 8 2015 In : Cellular and Molecular Immunology. 12, 5, p. 533-542 10 p.

Research output: Contribution to journalArticle

Cytoplasmic and Nuclear Receptors
Regulatory T-Lymphocytes
Cytokines
Th17 Cells
Myeloid Cells

Ubiquitin-dependent regulation of Foxp3 and Treg function

Barbi, J., Pardoll, D. M. & Pan, F. Jul 1 2015 In : Immunological Reviews. 266, 1, p. 27-45 19 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Ubiquitin
Transcription Factors
Transcriptome
Immune System
2014

Treg functional stability and its responsiveness to the microenvironment

Barbi, J., Pardoll, D. & Pan, F. 2014 In : Immunological Reviews. 259, 1, p. 115-139 25 p.

Research output: Contribution to journalArticle

Forkhead Transcription Factors
Regulatory T-Lymphocytes
Post Translational Protein Processing
Autoimmunity
Epigenomics

Ubiquitous points of control over regulatory T cells

Pan, F. & Barbi, J. 2014 In : Journal of Molecular Medicine. 92, 6, p. 555-569 15 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Ubiquitin
Ubiquitin-Specific Proteases
Cell Cycle Proteins
Ubiquitin-Protein Ligases
2013

An Inherently Bifunctional Subset of Foxp3+ T Helper Cells Is Controlled by the Transcription Factor Eos

Sharma, M., Huang, L., Choi, J. H., Lee, E. J., Wilson, J., Lemos, H., Pan, F., Blazar, B., Pardoll, D., Mellor, A., Shi, H. & Munn, D. May 23 2013 In : Immunity. 38, 5, p. 998-1012 15 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Helper-Inducer T-Lymphocytes
Transcription Factors
Co-Repressor Proteins
Thymus Gland

Metabolic control of the Treg/Th17 axis

Barbi, J., Pardoll, D. & Pan, F. Mar 2013 In : Immunological Reviews. 252, 1, p. 52-77 26 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Cues
Immune Tolerance
Metabolome
T-Lymphocyte Subsets

Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases treg-cell-suppressive capacity

vanLoosdregt, J., Fleskens, V., Fu, J., Brenkman, A., Bekker, C. J., Pals, C. G. M., Meerding, J., Berkers, C., Barbi, J., Gröne, A., Sijts, A. A. M., Maurice, M., Kalkhoven, E., Prakken, B., Ovaa, H., Pan, F., Zaiss, D. W. & Coffer, P. Aug 22 2013 In : Immunity. 39, 2, p. 259-271 13 p.

Research output: Contribution to journalArticle

Ubiquitin-Specific Proteases
Regulatory T-Lymphocytes
Transcription Factors
Adoptive Transfer
Proteasome Endopeptidase Complex

STAT3 regulates arginase-i in myeloid-derived suppressor cells from cancer patients

Vasquez-Dunddel, D., Pan, F., Zeng, Q., Gorbounov, M., Albesiano, E., Fu, J., Blosser, R. L., Tam, A. J., Bruno, T., Zhang, H., Pardoll, D. & Kim, Y. Apr 1 2013 In : Journal of Clinical Investigation. 123, 4, p. 1580-1589 10 p.

Research output: Contribution to journalArticle

Arginase
Neoplasms
Squamous Cell Carcinoma
Neck
Autoantigens

The ubiquitin ligase stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3

Chen, Z. , Barbi, J. , Bu, S. , Yang, H. Y. , Li, Z. , Gao, Y. , Jinasena, D. , Fu, J. , Lin, F. , Chen, C. , Zhang, J. , Yu, N. , Li, X. , Shan, Z. , Nie, J. , Gao, Z. , Tian, H. , Li, Y. , Yao, Z. , Zheng, Y. & 16 others Park, B., Pan, Z., Zhang, J., Dang, E., Li, Z., Wang, H., Luo, W., Li, L., Semenza, G., Zheng, S. G., Loser, K., Tsun, A., Greene, M., Pardoll, D., Pan, F. & Li, B. Aug 22 2013 In : Immunity. 39, 2, p. 272-285 14 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Ligases
Ubiquitin
Transcription Factors
Ubiquitin-Protein Ligases
2012
Hypoxia-Inducible Factor 1
Cell Differentiation
T-Lymphocytes
Interleukin-17
Regulatory T-Lymphocytes

Loss of Epigenetic Modification Driven by the Foxp3 Transcription Factor Leads to Regulatory T Cell Insufficiency

Bettini, M. L., Pan, F., Bettini, M., Finkelstein, D., Rehg, J. E., Floess, S., Bell, B. D., Ziegler, S. F., Huehn, J., Pardoll, D. M. & Vignali, D. A. A. May 25 2012 In : Immunity. 36, 5, p. 717-730 14 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Epigenomics
Transcription Factors
Autoimmunity
Histone Acetyltransferases

T cell signaling targets for enhancing regulatory or effector function

Pan, F., Fan, H., Liu, Z. & Jiang, S. Jul 31 2012 In : Science Signaling. 5, 235, pe32

Research output: Contribution to journalArticle

T-Lymphocytes
T-cells
Histone Deacetylases
Cape Verde
SKP Cullin F-Box Protein Ligases

The role of STAT3 activation in modulating the immune microenvironment of GBM

See, A. P., Han, J. E., Phallen, J., Binder, Z., Gallia, G., Pan, F., Jinasena, D., Jackson, C., Belcaid, Z., Jeong, S. J., Gottschalk, C., Zeng, J., Ruzevick, J., Nicholas, S., Kim, Y., Albesiano, E., Pardoll, D. M. & Lim, M. Dec 2012 In : Journal of Neuro-Oncology. 110, 3, p. 359-368 10 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Glioblastoma
Transcriptional Activation
Cell Line
Immunosuppressive Agents
2011

Control of TH17/Treg balance by hypoxia-inducible factor 1

Dang, E. V., Barbi, J., Yang, H. Y., Jinasena, D., Yu, H., Zheng, Y., Bordman, Z., Fu, J., Kim, Y., Yen, H. R., Luo, W., Zeller, K., Shimoda, L., Topalian, S. L., Semenza, G. L., Dang, C. V., Pardoll, D. M. & Pan, F. Sep 2 2011 In : Cell. 146, 5, p. 772-784 13 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
T-Lymphocytes
T-cells
Interleukin-17
Regulatory T-Lymphocytes

GATA6 activates Wnt signaling in pancreatic cancer by negatively regulating the Wnt antagonist Dickkopf-1

Zhong, Y., Wang, Z., Fu, B., Pan, F., Yachida, S., Dhara, M., Albesiano, E., Li, L., Naito, Y., Vilardell, F., Cummings, C., Martinelli, P., Li, A., Yonescu, R., Ma, Q., Griffin, C. A., Real, F. X. & Iacobuzio-Donahue, C. A. 2011 In : PLoS One. 6, 7, e22129

Research output: Contribution to journalArticle

neoplasms
Pancreatic Neoplasms
Neoplasms
adenocarcinoma
cells

The Yin and Yang of signaling in Tregs and TH17 cells

Pan, F., Fan, H., Lu, L., Liu, Z. & Jiang, S. Mar 22 2011 In : Science Signaling. 4, 165, mr4

Research output: Contribution to journalArticle

T-cells
Blood Flow Velocity
Autistic Disorder
Yin-Yang
Th17 Cells
2010

A role for the transcription factor Helios in human CD4+CD25+ regulatory T cells

Getnet, D., Grosso, J. F., Goldberg, M. V., Harris, T. J., Yen, H. R., Bruno, T. C., Durham, N. M., Hipkiss, E. L., Pyle, K. J., Wada, S., Pan, F., Pardoll, D. M. & Drake, C. G. Apr 2010 In : Molecular Immunology. 47, 7-8, p. 1595-1600 6 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Transcription Factors
Ikaros Transcription Factor
Chromatin Immunoprecipitation
Oligonucleotides
2009

Eos mediates foxp3-dependent gene silencing in CD4+ regulatory T cells

Pan, F., Yu, H., Dang, E. V., Barbi, J., Pan, X., Grosso, J. F., Jinasena, D., Sharma, S. M., McCadden, E. M., Getnet, D., Drake, C. G., Liu, J. O., Ostrowski, M. C. & Pardoll, D. M. 2009 In : Science. 325, 5944, p. 1142-1146 5 p.

Research output: Contribution to journalArticle

Gene Silencing
Regulatory T-Lymphocytes
Ikaros Transcription Factor
Self Tolerance
Zinc Fingers
2008

Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes

Ren, Y. R., Pan, F., Parvez, S., Fleig, A., Chong, C. R., Xu, J., Dang, Y., Zhang, J., Jiang, H., Penner, R. & Liu, J. O. Dec 23 2008 In : PLoS One. 3, 12, e4009

Research output: Contribution to journalArticle

Kv1.3 Potassium Channel
Clofazimine
Calcium Signaling
T-Lymphocytes
T-lymphocytes
2007

Calcineurin promotes hypoxia-inducible factor 1α expression by dephosphorylating RACK1 and blocking RACK1 dimerization

Liu, Y. V., Hubbi, M. E., Pan, F., McDonald, K. R., Mansharamani, M., Cole, R. N., Liu, J. O. & Semenza, G. L. Dec 21 2007 In : Journal of Biological Chemistry. 282, 51, p. 37064-37073 10 p.

Research output: Contribution to journalArticle

Calcineurin
Dimerization
Anoxia
4-Aminobutyrate Transaminase
Hypoxia-Inducible Factor 1

Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin

Pan, F., Sun, L., Kardian, D. B., Whartenby, K. A., Pardoll, D. M. & Liu, J. O. Jan 25 2007 In : Nature. 445, 7126, p. 433-436 4 p.

Research output: Contribution to journalArticle

Calcineurin
T-Cell Antigen Receptor
Proteins
Calcineurin Inhibitors
T-Lymphocytes
2006

Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target

Chong, C. R., Qian, D. Z., Pan, F., Wei, Y., Pili, R., Sullivan, D. J. & Liu, J. O. May 4 2006 In : Journal of Medicinal Chemistry. 49, 9, p. 2677-2680 4 p.

Research output: Contribution to journalArticle

Inosine Monophosphate
Oxidoreductases
Endothelial Cells
Endothelial cells
Cell Proliferation
2005

Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation

Pan, F., Means, A. R. & Liu, J. O. Jun 15 2005 In : The EMBO journal. 24, 12, p. 2104-2113 10 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 4
Calcium-Calmodulin-Dependent Protein Kinases
Cell Nucleus Active Transport
T-Lymphocytes
T-cells
2004
MEF2 Transcription Factors
NFATC Transcription Factors
Calcium Signaling
Interleukin-2
Calcium
2003

Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2

Han, A., Pan, F., Stroud, J. C., Youn, H. D., Liu, J. O. & Chen, L. Apr 17 2003 In : Nature. 422, 6933, p. 730-734 5 p.

Research output: Contribution to journalArticle

MEF2 Transcription Factors
Co-Repressor Proteins
DNA
Histone Deacetylases
Cardiac Myocytes
2002

Synthesis of Cyclosporin A-Derived Affinity Reagents by Olefin Metathesis

Smulik, J. A., Diver, S. T., Pan, F. & Liu, J. O. Jun 13 2002 In : Organic Letters. 4, 12, p. 2051-2054 4 p.

Research output: Contribution to journalArticle

reagents
Alkenes
Cyclosporine
metathesis
alkenes