Research Output 2002 2017

Filter
Article
2016

Foxp3, Regulatory T Cell, and Autoimmune Diseases

Tao, J. H., Cheng, M., Tang, J. P., Liu, Q., Pan, F. & Li, X. P. Nov 24 2016 (Accepted/In press) In : Inflammation. p. 1-12 12 p.

Research output: Research - peer-reviewArticle

Regulatory T-Lymphocytes
Autoimmune Diseases
Immunosuppressive Agents
Immune Tolerance
Systemic Lupus Erythematosus

MicroRNA-17 Modulates Regulatory T Cell Function by Targeting Co-regulators of the Foxp3 Transcription Factor

Yang, H. Y., Barbi, J., Wu, C. Y., Zheng, Y., Vignali, P. D. A., Wu, X., Tao, J. H., Park, B. V., Bandara, S., Novack, L., Ni, X., Yang, X., Chang, K. Y., Wu, R. C., Zhang, J., Yang, C. W., Pardoll, D. M., Li, H. & Pan, F. Jul 19 2016 In : Immunity. 45, 1, p. 83-93 11 p.

Research output: Research - peer-reviewArticle

Regulatory T-Lymphocytes
MicroRNAs
Transcription Factors
Interleukin-6
Cytokines

SHARPINing the knowledge of TCR signal control

Bowman, M., Pan, F. & Harhaj, E. W. Feb 1 2016 In : Nature Immunology. 17, 3, p. 221-222 2 p.

Research output: Research - peer-reviewArticle

TGFβ1-mediated SMAD3 enhances PD-1 expression on antigen-specific T cells in cancer

Park, B. V., Freeman, Z. T., Ghasemzadeh, A., Chattergoon, M. A., Rutebemberwa, A., Steigner, J., Winter, M. E., Huynh, T. V., Sebald, S. M., Lee, S. J., Pan, F., Pardoll, D. M. & Cox, A. L. Dec 1 2016 In : Cancer Discovery. 6, 12, p. 1366-1381 16 p.

Research output: Research - peer-reviewArticle

T-Lymphocytes
Antigens
Neoplasms
Tumor Microenvironment
Up-Regulation
2015

53BP1 promotes microhomology-mediated end-joining in G1-phase cells

Xiong, X., Du, Z., Wang, Y., Feng, Z., Fan, P., Yan, C., Willers, H. & Zhang, J. 2015 In : Nucleic Acids Research. 43, 3, p. 1659-1670 12 p.

Research output: Research - peer-reviewArticle

G1 Phase
Double-Stranded DNA Breaks
Sequence Deletion
Genomic Instability
Homologous Recombination
T-Lymphocytes
Hypoxia
Oxygen
Adaptive Immunity
Innate Immunity

Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α

Mascanfroni, I. D., Takenaka, M. C., Yeste, A., Patel, B., Wu, Y., Kenison, J. E., Siddiqui, S., Basso, A. S., Otterbein, L. E., Pardoll, D. M., Pan, F., Priel, A., Clish, C. B., Robson, S. C. & Quintana, F. J. Jun 9 2015 In : Nature Medicine. 21, 6, p. 638-646 9 p.

Research output: Research - peer-reviewArticle

Aryl Hydrocarbon Receptors
Regulatory T-Lymphocytes
Cell Differentiation
Hypoxia
T-cells

Metabolic regulation of T cell differentiation and function

Park, B. V. & Pan, F. Dec 1 2015 In : Molecular Immunology. 68, 2, p. 497-506 10 p.

Research output: Research - peer-reviewArticle

Cell Differentiation
T-Lymphocytes
Cytokines
Transcription Factors
Food

The role of nuclear receptors in regulation of Th17/Treg biology and its implications for diseases

Park, B. V. & Pan, F. Sep 8 2015 In : Cellular and Molecular Immunology. 12, 5, p. 533-542 10 p.

Research output: Research - peer-reviewArticle

Cytoplasmic and Nuclear Receptors
Th17 Cells
Regulatory T-Lymphocytes
Cytokines
Myeloid Cells

Ubiquitin-dependent regulation of Foxp3 and Treg function

Barbi, J., Pardoll, D. M. & Pan, F. Jul 1 2015 In : Immunological Reviews. 266, 1, p. 27-45 19 p.

Research output: Research - peer-reviewArticle

Regulatory T-Lymphocytes
Ubiquitin
Transcription Factors
Therapeutics
Transcriptome
2014

Treg functional stability and its responsiveness to the microenvironment

Barbi, J., Pardoll, D. & Pan, F. 2014 In : Immunological Reviews. 259, 1, p. 115-139 25 p.

Research output: Research - peer-reviewArticle

Forkhead Transcription Factors
Regulatory T-Lymphocytes
Post Translational Protein Processing
Autoimmunity
Epigenomics

Ubiquitous points of control over regulatory T cells

Pan, F. & Barbi, J. 2014 In : Journal of Molecular Medicine. 92, 6, p. 555-569 15 p.

Research output: Research - peer-reviewArticle

Regulatory T-Lymphocytes
Ubiquitin
Cell Cycle Proteins
Ubiquitin-Protein Ligases
Post Translational Protein Processing
2013

An Inherently Bifunctional Subset of Foxp3+ T Helper Cells Is Controlled by the Transcription Factor Eos

Sharma, M., Huang, L., Choi, J. H., Lee, E. J., Wilson, J., Lemos, H., Pan, F., Blazar, B., Pardoll, D., Mellor, A., Shi, H. & Munn, D. May 23 2013 In : Immunity. 38, 5, p. 998-1012 15 p.

Research output: Research - peer-reviewArticle

Regulatory T-Lymphocytes
Helper-Inducer T-Lymphocytes
Transcription Factors
Co-Repressor Proteins
Thymus Gland

Metabolic control of the Treg/Th17 axis

Barbi, J., Pardoll, D. & Pan, F. Mar 2013 In : Immunological Reviews. 252, 1, p. 52-77 26 p.

Research output: Research - peer-reviewArticle

T-Lymphocytes
Cues
Th17 Cells
Immune Tolerance
Metabolome

Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases treg-cell-suppressive capacity

vanLoosdregt, J., Fleskens, V., Fu, J., Brenkman, A., Bekker, C. J., Pals, C. G. M., Meerding, J., Berkers, C., Barbi, J., Gröne, A., Sijts, A. A. M., Maurice, M., Kalkhoven, E., Prakken, B., Ovaa, H., Pan, F., Zaiss, D. W. & Coffer, P. Aug 22 2013 In : Immunity. 39, 2, p. 259-271 13 p.

Research output: Research - peer-reviewArticle

Regulatory T-Lymphocytes
Transcription Factors
Deubiquitinating Enzymes
Adoptive Transfer
Proteasome Endopeptidase Complex

STAT3 regulates arginase-i in myeloid-derived suppressor cells from cancer patients

Vasquez-Dunddel, D., Pan, F., Zeng, Q., Gorbounov, M., Albesiano, E., Fu, J., Blosser, R. L., Tam, A. J., Bruno, T., Zhang, H., Pardoll, D. & Kim, Y. Apr 1 2013 In : Journal of Clinical Investigation. 123, 4, p. 1580-1589 10 p.

Research output: Research - peer-reviewArticle

Arginase
Neoplasms
Myeloid-Derived Suppressor Cells
Carcinoma, squamous cell of head and neck
Autoantigens

The ubiquitin ligase stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3

Chen, Z. , Barbi, J. , Bu, S. , Yang, H. Y. , Li, Z. , Gao, Y. , Jinasena, D. , Fu, J. , Lin, F. , Chen, C. , Zhang, J. , Yu, N. , Li, X. , Shan, Z. , Nie, J. , Gao, Z. , Tian, H. , Li, Y. , Yao, Z. , Zheng, Y. & 16 others Park, B., Pan, Z., Zhang, J., Dang, E., Li, Z., Wang, H., Luo, W., Li, L., Semenza, G., Zheng, S. G., Loser, K., Tsun, A., Greene, M., Pardoll, D., Pan, F. & Li, B. Aug 22 2013 In : Immunity. 39, 2, p. 272-285 14 p.

Research output: Research - peer-reviewArticle

Regulatory T-Lymphocytes
Ligases
Ubiquitin
Transcription Factors
Th1 Cells
2012
Hypoxia-Inducible Factor 1
Cell Differentiation
T-Lymphocytes
Therapeutics
Interleukin-17

Loss of Epigenetic Modification Driven by the Foxp3 Transcription Factor Leads to Regulatory T Cell Insufficiency

Bettini, M. L., Pan, F., Bettini, M., Finkelstein, D., Rehg, J. E., Floess, S., Bell, B. D., Ziegler, S. F., Huehn, J., Pardoll, D. M. & Vignali, D. A. A. May 25 2012 In : Immunity. 36, 5, p. 717-730 14 p.

Research output: Research - peer-reviewArticle

Regulatory T-Lymphocytes
Epigenomics
Transcription Factors
Autoimmunity
Histone Acetyltransferases

T cell signaling targets for enhancing regulatory or effector function

Pan, F., Fan, H., Liu, Z. & Jiang, S. Jul 31 2012 In : Science Signaling. 5, 235, pe32

Research output: Research - peer-reviewArticle

T-Lymphocytes
Cell signaling
T-cells
Histone Deacetylases
Chemical activation

The role of STAT3 activation in modulating the immune microenvironment of GBM

See, A. P., Han, J. E., Phallen, J., Binder, Z., Gallia, G., Pan, F., Jinasena, D., Jackson, C., Belcaid, Z., Jeong, S. J., Gottschalk, C., Zeng, J., Ruzevick, J., Nicholas, S., Kim, Y., Albesiano, E., Pardoll, D. M. & Lim, M. Dec 2012 In : Journal of Neuro-Oncology. 110, 3, p. 359-368 10 p.

Research output: Research - peer-reviewArticle

STAT3 Transcription Factor
Glioblastoma
Transcriptional Activation
Cell Line
Immunosuppressive Agents
2011

Control of TH17/Treg balance by hypoxia-inducible factor 1

Dang, E. V., Barbi, J., Yang, H. Y., Jinasena, D., Yu, H., Zheng, Y., Bordman, Z., Fu, J., Kim, Y., Yen, H. R., Luo, W., Zeller, K., Shimoda, L., Topalian, S. L., Semenza, G. L., Dang, C. V., Pardoll, D. M. & Pan, F. Sep 2 2011 In : Cell. 146, 5, p. 772-784 13 p.

Research output: Research - peer-reviewArticle

Hypoxia-Inducible Factor 1
T-Lymphocytes
T-cells
Interleukin-17
Regulatory T-Lymphocytes

GATA6 activates Wnt signaling in pancreatic cancer by negatively regulating the Wnt antagonist Dickkopf-1

Zhong, Y., Wang, Z., Fu, B., Pan, F., Yachida, S., Dhara, M., Albesiano, E., Li, L., Naito, Y., Vilardell, F., Cummings, C., Martinelli, P., Li, A., Yonescu, R., Ma, Q., Griffin, C. A., Real, F. X. & Iacobuzio-Donahue, C. A. 2011 In : PLoS One. 6, 7, e22129

Research output: Research - peer-reviewArticle

pancreatic neoplasms
adenocarcinoma
antagonists
neoplasm cells
Pancreatic Neoplasms

The Yin and Yang of signaling in Tregs and TH17 cells

Pan, F., Fan, H., Lu, L., Liu, Z. & Jiang, S. Mar 22 2011 In : Science Signaling. 4, 165, mr4

Research output: Research - peer-reviewArticle

Yin-Yang
Th17 Cells
T-cells
Interleukin-17
Cytokines
2010

A role for the transcription factor Helios in human CD4+CD25+ regulatory T cells

Getnet, D., Grosso, J. F., Goldberg, M. V., Harris, T. J., Yen, H. R., Bruno, T. C., Durham, N. M., Hipkiss, E. L., Pyle, K. J., Wada, S., Pan, F., Pardoll, D. M. & Drake, C. G. Apr 2010 In : Molecular Immunology. 47, 7-8, p. 1595-1600 6 p.

Research output: Research - peer-reviewArticle

Regulatory T-Lymphocytes
Transcription Factors
Ikaros Transcription Factor
Chromatin Immunoprecipitation
Oligonucleotides
2009

Eos mediates foxp3-dependent gene silencing in CD4+ regulatory T cells

Pan, F., Yu, H., Dang, E. V., Barbi, J., Pan, X., Grosso, J. F., Jinasena, D., Sharma, S. M., McCadden, E. M., Getnet, D., Drake, C. G., Liu, J. O., Ostrowski, M. C. & Pardoll, D. M. 2009 In : Science. 325, 5944, p. 1142-1146 5 p.

Research output: Research - peer-reviewArticle

Gene Silencing
Regulatory T-Lymphocytes
Ikaros Transcription Factor
Self Tolerance
Zinc Fingers
2008

Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes

Ren, Y. R., Pan, F., Parvez, S., Fleig, A., Chong, C. R., Xu, J., Dang, Y., Zhang, J., Jiang, H., Penner, R. & Liu, J. O. Dec 23 2008 In : PLoS One. 3, 12, e4009

Research output: Research - peer-reviewArticle

potassium channels
oscillation
T-lymphocytes
calcium
Kv1.3 Potassium Channel
2007

Calcineurin promotes hypoxia-inducible factor 1α expression by dephosphorylating RACK1 and blocking RACK1 dimerization

Liu, Y. V., Hubbi, M. E., Pan, F., McDonald, K. R., Mansharamani, M., Cole, R. N., Liu, J. O. & Semenza, G. L. Dec 21 2007 In : Journal of Biological Chemistry. 282, 51, p. 37064-37073 10 p.

Research output: Research - peer-reviewArticle

Calcineurin
Dimerization
Hypoxia
Degradation
elongin

Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin

Pan, F., Sun, L., Kardian, D. B., Whartenby, K. A., Pardoll, D. M. & Liu, J. O. Jan 25 2007 In : Nature. 445, 7126, p. 433-436 4 p.

Research output: Research - peer-reviewArticle

Calcineurin
T-Cell Antigen Receptor
Proteins
Calcineurin Inhibitors
T-Lymphocytes
2006

Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target

Chong, C. R., Qian, D. Z., Pan, F., Wei, Y., Pili, R., Sullivan, D. J. & Liu, J. O. May 4 2006 In : Journal of Medicinal Chemistry. 49, 9, p. 2677-2680 4 p.

Research output: Research - peer-reviewArticle

Inosine Monophosphate
Oxidoreductases
Endothelial Cells
Pharmaceutical Preparations
Endothelial cells
2005

Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation

Pan, F., Means, A. R. & Liu, J. O. Jun 15 2005 In : The EMBO journal. 24, 12, p. 2104-2113 10 p.

Research output: Research - peer-reviewArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 4
T-cells
Calmodulin
Chemical activation
Calcium-Calmodulin-Dependent Protein Kinases
2004
MEF2 Transcription Factors
NFATC Transcription Factors
Calcium Signaling
Interleukin-2
Calcium
2003

Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2

Han, A., Pan, F., Stroud, J. C., Youn, H. D., Liu, J. O. & Chen, L. Apr 17 2003 In : Nature. 422, 6933, p. 730-734 5 p.

Research output: Research - peer-reviewArticle

MEF2 Transcription Factors
Co-Repressor Proteins
DNA
Histone Deacetylases
Cardiac Myocytes
2002

Synthesis of Cyclosporin A-Derived Affinity Reagents by Olefin Metathesis

Smulik, J. A., Diver, S. T., Pan, F. & Liu, J. O. Jun 13 2002 In : Organic Letters. 4, 12, p. 2051-2054 4 p.

Research output: Research - peer-reviewArticle

metathesis
alkenes
reagents
affinity
synthesis