Fan Pan

Associate Professor

20022020

Research output per year

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Research Output

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Article
2020

YAP Attenuates CD8 T Cell-Mediated Anti-tumor Response

Lebid, A., Chung, L., Pardoll, D. M. & Pan, F., Apr 8 2020, In : Frontiers in immunology. 11, 580.

Research output: Contribution to journalArticle

Open Access
2019

A biologic scaffold-associated type 2 immune microenvironment inhibits tumor formation and synergizes with checkpoint immunotherapy

Wolf, M. T., Ganguly, S., Wang, T. L., Anderson, C. W., Sadtler, K., Narain, R., Cherry, C., Parrillo, A. J., Park, B. V., Wang, G., Pan, F., Sukumar, S., Pardoll, D. M. & Elisseeff, J. H., Jan 30 2019, In : Science Translational Medicine. 11, 477, aat7973.

Research output: Contribution to journalArticle

Mechanisms regulating PD-L1 expression on tumor and immune cells

Chen, S., Crabill, G. A., Pritchard, T. S., McMiller, T. L., Wei, P., Pardoll, D. M., Pan, F. & Topalian, S. L., Nov 15 2019, In : Journal for immunotherapy of cancer. 7, 1, 305.

Research output: Contribution to journalArticle

Open Access

Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells

Fleskens, V., Minutti, C. M., Wu, X., Wei, P., Pals, C. E. G. M., McCrae, J., Hemmers, S., Groenewold, V., Vos, H. J., Rudensky, A., Pan, F., Li, H., Zaiss, D. M. & Coffer, P. J., Mar 26 2019, In : Cell Reports. 26, 13, p. 3600-3612.e6

Research output: Contribution to journalArticle

Open Access

TRAF6 directs FOXP3 localization and facilitates regulatory T-cell function through K63-linked ubiquitination

Ni, X., Kou, W., Gu, J., Wei, P., Wu, X., Peng, H., Tao, J., Yan, W., Yang, X., Lebid, A., Park, B. V., Chen, Z., Tian, Y., Fu, J., Newman, S., Wang, X., Shen, H., Li, B., Blazar, B. R., Wang, X. & 3 others, Barbi, J., Pan, F. & Lu, L., May 2 2019, In : EMBO Journal. 38, 9, e99766.

Research output: Contribution to journalArticle

Open Access
2018

YAP is essential for treg-mediated suppression of antitumor immunity

Ni, X., Tao, J., Barbi, J., Chen, Q., Park, B. V., Li, Z., Zhang, N., Lebid, A., Ramaswamy, A., Wei, P., Zheng, Y., Zhang, X., Wu, X., Vignali, P., Yang, C. P., Li, H., Pardoll, A. M., Lu, L., Pan, D. & Pan, F., Aug 1 2018, In : Cancer Discovery. 8, 8, p. 1026-1043 18 p.

Research output: Contribution to journalArticle

2016

Foxp3, Regulatory T Cell, and Autoimmune Diseases

Tao, J. H., Cheng, M., Tang, J. P., Liu, Q., Pan, F. & Li, X. P., Nov 24 2016, (Accepted/In press) In : Inflammation. p. 1-12 12 p.

Research output: Contribution to journalArticle

MicroRNA-17 Modulates Regulatory T Cell Function by Targeting Co-regulators of the Foxp3 Transcription Factor

Yang, H. Y., Barbi, J., Wu, C. Y., Zheng, Y., Vignali, P. D. A., Wu, X., Tao, J. H., Park, B. V., Bandara, S., Novack, L., Ni, X., Yang, X., Chang, K. Y., Wu, R. C., Zhang, J., Yang, C. W., Pardoll, D. M., Li, H. & Pan, F., Jul 19 2016, In : Immunity. 45, 1, p. 83-93 11 p.

Research output: Contribution to journalArticle

SHARPINing the knowledge of TCR signal control

Bowman, M., Pan, F. & Harhaj, E. W., Feb 1 2016, In : Nature Immunology. 17, 3, p. 221-222 2 p.

Research output: Contribution to journalArticle

TGFβ1-mediated SMAD3 enhances PD-1 expression on antigen-specific T cells in cancer

Park, B. V., Freeman, Z. T., Ghasemzadeh, A., Chattergoon, M. A., Rutebemberwa, A., Steigner, J., Winter, M. E., Huynh, T. V., Sebald, S. M., Lee, S. J., Pan, F., Pardoll, A. M. & Cox, A., Dec 1 2016, In : Cancer Discovery. 6, 12, p. 1366-1381 16 p.

Research output: Contribution to journalArticle

2015

53BP1 promotes microhomology-mediated end-joining in G1-phase cells

Xiong, X., Du, Z., Wang, Y., Feng, Z., Fan, P., Yan, C., Willers, H. & Zhang, J., Jan 1 2015, In : Nucleic acids research. 43, 3, p. 1659-1670 12 p.

Research output: Contribution to journalArticle

Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α

Mascanfroni, I. D., Takenaka, M. C., Yeste, A., Patel, B., Wu, Y., Kenison, J. E., Siddiqui, S., Basso, A. S., Otterbein, L. E., Pardoll, D. M., Pan, F., Priel, A., Clish, C. B., Robson, S. C. & Quintana, F. J., Jun 9 2015, In : Nature medicine. 21, 6, p. 638-646 9 p.

Research output: Contribution to journalArticle

Metabolic regulation of T cell differentiation and function

Park, B. V. & Pan, F., Dec 1 2015, In : Molecular Immunology. 68, 2, p. 497-506 10 p.

Research output: Contribution to journalArticle

Ubiquitin-dependent regulation of Foxp3 and Treg function

Barbi, J., Pardoll, D. M. & Pan, F., Jul 1 2015, In : Immunological reviews. 266, 1, p. 27-45 19 p.

Research output: Contribution to journalArticle

2014

Treg functional stability and its responsiveness to the microenvironment

Barbi, J., Pardoll, D. & Pan, F., May 2014, In : Immunological reviews. 259, 1, p. 115-139 25 p.

Research output: Contribution to journalArticle

2013

An Inherently Bifunctional Subset of Foxp3+ T Helper Cells Is Controlled by the Transcription Factor Eos

Sharma, M. D., Huang, L., Choi, J. H., Lee, E. J., Wilson, J. M., Lemos, H., Pan, F., Blazar, B. R., Pardoll, D. M., Mellor, A. L., Shi, H. & Munn, D. H., May 23 2013, In : Immunity. 38, 5, p. 998-1012 15 p.

Research output: Contribution to journalArticle

Metabolic control of the Treg/Th17 axis

Barbi, J., Pardoll, D. & Pan, F., Mar 1 2013, In : Immunological reviews. 252, 1, p. 52-77 26 p.

Research output: Contribution to journalArticle

Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases treg-cell-suppressive capacity

vanLoosdregt, J., Fleskens, V., Fu, J., Brenkman, A. B., Bekker, C. P. J., Pals, C. E. G. M., Meerding, J., Berkers, C. R., Barbi, J., Gröne, A., Sijts, A. J. A. M., Maurice, M. M., Kalkhoven, E., Prakken, B. J., Ovaa, H., Pan, F., Zaiss, D. M. W. & Coffer, P. J., Aug 22 2013, In : Immunity. 39, 2, p. 259-271 13 p.

Research output: Contribution to journalArticle

STAT3 regulates arginase-i in myeloid-derived suppressor cells from cancer patients

Vasquez-Dunddel, D., Pan, F., Zeng, Q., Gorbounov, M., Albesiano, E., Fu, J., Blosser, R. L., Tam, A. J., Bruno, T., Zhang, H., Pardoll, D. & Kim, Y., Apr 1 2013, In : Journal of Clinical Investigation. 123, 4, p. 1580-1589 10 p.

Research output: Contribution to journalArticle

The ubiquitin ligase stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3

Chen, Z., Barbi, J., Bu, S., Yang, H. Y., Li, Z., Gao, Y., Jinasena, D., Fu, J., Lin, F., Chen, C., Zhang, J., Yu, N., Li, X., Shan, Z., Nie, J., Gao, Z., Tian, H., Li, Y., Yao, Z., Zheng, Y. & 16 others, Park, B. V., Pan, Z., Zhang, J., Dang, E., Li, Z., Wang, H., Luo, W., Li, L., Semenza, G. L., Zheng, S. G., Loser, K., Tsun, A., Greene, M. I., Pardoll, D. M., Pan, F. & Li, B., Aug 22 2013, In : Immunity. 39, 2, p. 272-285 14 p.

Research output: Contribution to journalArticle

2012

Hypoxia-inducible factor 1: A link between metabolism and T cell differentiation and a potential therapeutic target

Pan, F., Barbi, J. & Pardoll, D. M., Nov 2 2012, In : OncoImmunology. 1, 4, p. 510-515 6 p.

Research output: Contribution to journalArticle

Loss of Epigenetic Modification Driven by the Foxp3 Transcription Factor Leads to Regulatory T Cell Insufficiency

Bettini, M. L., Pan, F., Bettini, M., Finkelstein, D., Rehg, J. E., Floess, S., Bell, B. D., Ziegler, S. F., Huehn, J., Pardoll, D. M. & Vignali, D. A. A., May 25 2012, In : Immunity. 36, 5, p. 717-730 14 p.

Research output: Contribution to journalArticle

The role of STAT3 activation in modulating the immune microenvironment of GBM

See, A. P., Han, J. E., Phallen, J., Binder, Z., Gallia, G., Pan, F., Jinasena, D., Jackson, C., Belcaid, Z., Jeong, S. J., Gottschalk, C., Zeng, J., Ruzevick, J., Nicholas, S., Kim, Y., Albesiano, E., Pardoll, D. M. & Lim, M., Dec 1 2012, In : Journal of neuro-oncology. 110, 3, p. 359-368 10 p.

Research output: Contribution to journalArticle

2011

Control of TH17/Treg balance by hypoxia-inducible factor 1

Dang, E. V., Barbi, J., Yang, H. Y., Jinasena, D., Yu, H., Zheng, Y., Bordman, Z., Fu, J., Kim, Y., Yen, H. R., Luo, W., Zeller, K., Shimoda, L., Topalian, S. L., Semenza, G. L., Dang, C. V., Pardoll, D. M. & Pan, F., Sep 2 2011, In : Cell. 146, 5, p. 772-784 13 p.

Research output: Contribution to journalArticle

GATA6 activates Wnt signaling in pancreatic cancer by negatively regulating the Wnt antagonist Dickkopf-1

Zhong, Y., Wang, Z., Fu, B., Pan, F., Yachida, S., Dhara, M., Albesiano, E., Li, L., Naito, Y., Vilardell, F., Cummings, C., Martinelli, P., Li, A., Yonescu, R., Ma, Q., Griffin, C. A., Real, F. X. & Iacobuzio-Donahue, C. A., Jul 22 2011, In : PloS one. 6, 7, e22129.

Research output: Contribution to journalArticle

The Yin and Yang of signaling in Tregs and TH17 cells

Pan, F., Fan, H., Lu, L., Liu, Z. & Jiang, S., Mar 22 2011, In : Science signaling. 4, 165, mr4.

Research output: Contribution to journalArticle

2010

A role for the transcription factor Helios in human CD4+CD25+ regulatory T cells

Getnet, D., Grosso, J. F., Goldberg, M. V., Harris, T. J., Yen, H. R., Bruno, T. C., Durham, N. M., Hipkiss, E. L., Pyle, K. J., Wada, S., Pan, F., Pardoll, D. M. & Drake, C. G., Apr 1 2010, In : Molecular Immunology. 47, 7-8, p. 1595-1600 6 p.

Research output: Contribution to journalArticle

2009

Eos mediates foxp3-dependent gene silencing in CD4+ regulatory T cells

Pan, F., Yu, H., Dang, E. V., Barbi, J., Pan, X., Grosso, J. F., Jinasena, D., Sharma, S. M., McCadden, E. M., Getnet, D., Drake, C. G., Liu, J. O., Ostrowski, M. C. & Pardoll, D. M., Sep 7 2009, In : Science. 325, 5944, p. 1142-1146 5 p.

Research output: Contribution to journalArticle

2008

Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes

Ren, Y. R., Pan, F., Parvez, S., Fleig, A., Chong, C. R., Xu, J., Dang, Y., Zhang, J., Jiang, H., Penner, R. & Liu, J. O., Dec 23 2008, In : PloS one. 3, 12, e4009.

Research output: Contribution to journalArticle

2007

Calcineurin promotes hypoxia-inducible factor 1α expression by dephosphorylating RACK1 and blocking RACK1 dimerization

Liu, Y. V., Hubbi, M. E., Pan, F., McDonald, K. R., Mansharamani, M., Cole, R. N., Liu, J. O. & Semenza, G. L., Dec 21 2007, In : Journal of Biological Chemistry. 282, 51, p. 37064-37073 10 p.

Research output: Contribution to journalArticle

Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin

Pan, F., Sun, L., Kardian, D. B., Whartenby, K. A., Pardoll, D. M. & Liu, J. O., Jan 25 2007, In : Nature. 445, 7126, p. 433-436 4 p.

Research output: Contribution to journalArticle

2006

Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target

Chong, C. R., Qian, D. Z., Pan, F., Wei, Y., Pili, R., Sullivan, D. J. & Liu, J. O., May 4 2006, In : Journal of medicinal chemistry. 49, 9, p. 2677-2680 4 p.

Research output: Contribution to journalArticle

2005

Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation

Pan, F., Means, A. R. & Liu, J. O., Jun 15 2005, In : EMBO Journal. 24, 12, p. 2104-2113 10 p.

Research output: Contribution to journalArticle

2004
2003

Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2

Han, A., Pan, F., Stroud, J. C., Youn, H. D., Liu, J. O. & Chen, L., Apr 17 2003, In : Nature. 422, 6933, p. 730-734 5 p.

Research output: Contribution to journalArticle

2002

Synthesis of Cyclosporin A-Derived Affinity Reagents by Olefin Metathesis

Smulik, J. A., Diver, S. T., Pan, F. & Liu, J. O., Jun 13 2002, In : Organic Letters. 4, 12, p. 2051-2054 4 p.

Research output: Contribution to journalArticle