Fan Pan

Associate Professor

20022019
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Research Output 2002 2019

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Article
2019

A biologic scaffold-associated type 2 immune microenvironment inhibits tumor formation and synergizes with checkpoint immunotherapy

Wolf, M. T., Ganguly, S., Wang, T. L., Anderson, C. W., Sadtler, K., Narain, R., Cherry, C., Parrillo, A. J., Park, B. V., Wang, G., Pan, F., Sukumar, S., Pardoll, A. M. & Elisseeff, J. H., Jan 30 2019, In : Science Translational Medicine. 11, 477, aat7973.

Research output: Contribution to journalArticle

Tumor Microenvironment
Immunotherapy
Wound Healing
Neoplasms
Urinary Bladder

Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells

Fleskens, V., Minutti, C. M., Wu, X., Wei, P., Pals, C. E. G. M., McCrae, J., Hemmers, S., Groenewold, V., Vos, H. J., Rudensky, A., Pan, F., Li, H., Zaiss, D. M. & Coffer, P. J., Mar 26 2019, In : Cell Reports. 26, 13, p. 3600-3612.e6

Research output: Contribution to journalArticle

Open Access
Immune Tolerance
T-cells
Regulatory T-Lymphocytes
Phosphotransferases
Maintenance

TRAF6 directs FOXP3 localization and facilitates regulatory T-cell function through K63-linked ubiquitination

Ni, X., Kou, W., Gu, J., Wei, P., Wu, X., Peng, H., Tao, J., Yan, W., Yang, X., Lebid, A., Park, B. V., Chen, Z., Tian, Y., Fu, J., Newman, S., Wang, X., Shen, H., Li, B., Blazar, B. R., Wang, X. & 3 others, Barbi, J., Pan, F. & Lu, L., May 2 2019, In : EMBO Journal. 38, 9, e99766.

Research output: Contribution to journalArticle

Open Access
TNF Receptor-Associated Factor 6
T-cells
Ubiquitination
Regulatory T-Lymphocytes
Tumors
2018
Triple Negative Breast Neoplasms
Drug Therapy
gemcitabine
Breast Neoplasms
Carboplatin

YAP is essential for treg-mediated suppression of antitumor immunity

Ni, X., Tao, J., Barbi, J., Chen, Q., Park, B. V., Li, Z., Zhang, N., Lebid, A., Ramaswamy, A., Wei, P., Zheng, Y., Zhang, X., Wu, X., Vignali, P., Yang, C. P., Li, H., Pardoll, A. M., Lu, L., Pan, D. & Pan, F., Aug 1 2018, In : Cancer Discovery. 8, 8, p. 1026-1043 18 p.

Research output: Contribution to journalArticle

Immunity
Activins
Activin Receptors
Self Tolerance
Regulatory T-Lymphocytes
2016

Foxp3, Regulatory T Cell, and Autoimmune Diseases

Tao, J. H., Cheng, M., Tang, J. P., Liu, Q., Pan, F. & Li, X. P., Nov 24 2016, (Accepted/In press) In : Inflammation. p. 1-12 12 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Autoimmune Diseases
Immunosuppressive Agents
Immune Tolerance
Systemic Lupus Erythematosus

MicroRNA-17 Modulates Regulatory T Cell Function by Targeting Co-regulators of the Foxp3 Transcription Factor

Yang, H. Y., Barbi, J., Wu, C. Y., Zheng, Y., Vignali, P. D. A., Wu, X., Tao, J. H., Park, B. V., Bandara, S., Novack, L., Ni, X., Yang, X., Chang, K. Y., Wu, R. C., Zhang, J., Yang, C. W., Pardoll, A. M., Li, H. & Pan, F., Jul 19 2016, In : Immunity. 45, 1, p. 83-93 11 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
MicroRNAs
Transcription Factors
Interleukin-6
Cytokines

SHARPINing the knowledge of TCR signal control

Bowman, M., Pan, F. & Harhaj, E. W., Feb 1 2016, In : Nature Immunology. 17, 3, p. 221-222 2 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
T-Cell Antigen Receptor
Carrier Proteins

TGFβ1-mediated SMAD3 enhances PD-1 expression on antigen-specific T cells in cancer

Park, B. V., Freeman, Z. T., Ghasemzadeh, A., Chattergoon, M. A., Rutebemberwa, A., Steigner, J., Winter, M. E., Huynh, T. V., Sebald, S. M., Lee, S. J., Pan, F., Pardoll, A. M. & Cox, A., Dec 1 2016, In : Cancer Discovery. 6, 12, p. 1366-1381 16 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Antigens
Neoplasms
Tumor Microenvironment
Up-Regulation
2015

53BP1 promotes microhomology-mediated end-joining in G1-phase cells

Xiong, X., Du, Z., Wang, Y., Feng, Z., Pan, F., Yan, C., Willers, H. & Zhang, J., 2015, In : Nucleic Acids Research. 43, 3, p. 1659-1670 12 p.

Research output: Contribution to journalArticle

G1 Phase
Double-Stranded DNA Breaks
Sequence Deletion
Genomic Instability
Homologous Recombination
T-Lymphocytes
Oxygen
Adaptive Immunity
Hypoxia
Innate Immunity

Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α

Mascanfroni, I. D., Takenaka, M. C., Yeste, A., Patel, B., Wu, Y., Kenison, J. E., Siddiqui, S., Basso, A. S., Otterbein, L. E., Pardoll, A. M., Pan, F., Priel, A., Clish, C. B., Robson, S. C. & Quintana, F. J., Jun 9 2015, In : Nature Medicine. 21, 6, p. 638-646 9 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
T-cells
Regulatory T-Lymphocytes
Cell Differentiation
Metabolism

Metabolic regulation of T cell differentiation and function

Park, B. V. & Pan, F., Dec 1 2015, In : Molecular Immunology. 68, 2, p. 497-506 10 p.

Research output: Contribution to journalArticle

Cell Differentiation
T-Lymphocytes
Cytokines
Transcription Factors
Food

The role of nuclear receptors in regulation of Th17/Treg biology and its implications for diseases

Park, B. V. & Pan, F., Sep 8 2015, In : Cellular and Molecular Immunology. 12, 5, p. 533-542 10 p.

Research output: Contribution to journalArticle

Cytoplasmic and Nuclear Receptors
Th17 Cells
Regulatory T-Lymphocytes
Cytokines
Myeloid Cells

Ubiquitin-dependent regulation of Foxp3 and Treg function

Barbi, J., Pardoll, A. M. & Pan, F., Jul 1 2015, In : Immunological Reviews. 266, 1, p. 27-45 19 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Ubiquitin
Transcription Factors
Transcriptome
Immune System
2014

Treg functional stability and its responsiveness to the microenvironment

Barbi, J., Pardoll, A. M. & Pan, F., 2014, In : Immunological Reviews. 259, 1, p. 115-139 25 p.

Research output: Contribution to journalArticle

Forkhead Transcription Factors
Regulatory T-Lymphocytes
Post Translational Protein Processing
Autoimmunity
Epigenomics

Ubiquitous points of control over regulatory T cells

Pan, F. & Barbi, J., 2014, In : Journal of Molecular Medicine. 92, 6, p. 555-569 15 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Ubiquitin
Cell Cycle Proteins
Ubiquitin-Protein Ligases
Post Translational Protein Processing
2013

An Inherently Bifunctional Subset of Foxp3+ T Helper Cells Is Controlled by the Transcription Factor Eos

Sharma, M., Huang, L., Choi, J. H., Lee, E. J., Wilson, J., Lemos, H., Pan, F., Blazar, B., Pardoll, A. M., Mellor, A., Shi, H. & Munn, D., May 23 2013, In : Immunity. 38, 5, p. 998-1012 15 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Helper-Inducer T-Lymphocytes
Transcription Factors
Co-Repressor Proteins
Thymus Gland

Metabolic control of the Treg/Th17 axis

Barbi, J., Pardoll, A. M. & Pan, F., Mar 2013, In : Immunological Reviews. 252, 1, p. 52-77 26 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Cues
Th17 Cells
Immune Tolerance
Metabolome

Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases treg-cell-suppressive capacity

vanLoosdregt, J., Fleskens, V., Fu, J., Brenkman, A., Bekker, C. J., Pals, C. G. M., Meerding, J., Berkers, C., Barbi, J., Gröne, A., Sijts, A. A. M., Maurice, M., Kalkhoven, E., Prakken, B., Ovaa, H., Pan, F., Zaiss, D. W. & Coffer, P., Aug 22 2013, In : Immunity. 39, 2, p. 259-271 13 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Transcription Factors
Adoptive Transfer
Proteasome Endopeptidase Complex
Colitis

STAT3 regulates arginase-i in myeloid-derived suppressor cells from cancer patients

Vasquez-Dunddel, D., Pan, F., Zeng, Q., Gorbounov, M., Albesiano, E., Fu, J., Blosser, R. L., Tam, A. J., Bruno, T., Zhang, H., Pardoll, A. M. & Kim, Y., Apr 1 2013, In : Journal of Clinical Investigation. 123, 4, p. 1580-1589 10 p.

Research output: Contribution to journalArticle

Arginase
Neoplasms
Autoantigens
HLA-DR Antigens
Immunosuppressive Agents

The ubiquitin ligase stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3

Chen, Z., Barbi, J., Bu, S., Yang, H. Y., Li, Z., Gao, Y., Jinasena, D., Fu, J., Lin, F., Chen, C., Zhang, J., Yu, N., Li, X., Shan, Z., Nie, J., Gao, Z., Tian, H., Li, Y., Yao, Z., Zheng, Y. & 16 others, Park, B., Pan, Z., Zhang, J., Dang, E., Li, Z., Wang, H., Luo, W., Li, L., Semenza, G. L., Zheng, S. G., Loser, K., Tsun, A., Greene, M., Pardoll, A. M., Pan, F. & Li, B., Aug 22 2013, In : Immunity. 39, 2, p. 272-285 14 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Ligases
Ubiquitin
Transcription Factors
Th1 Cells
2012

Hypoxia-inducible factor 1: A link between metabolism and T cell differentiation and a potential therapeutic target

Pan, F., Barbi, J. & Pardoll, A. M., 2012, In : OncoImmunology. 1, 4, p. 510-515 6 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Interleukin-17
Regulatory T-Lymphocytes
Cell Differentiation
Interleukin-23

Loss of Epigenetic Modification Driven by the Foxp3 Transcription Factor Leads to Regulatory T Cell Insufficiency

Bettini, M. L., Pan, F., Bettini, M., Finkelstein, D., Rehg, J. E., Floess, S., Bell, B. D., Ziegler, S. F., Huehn, J., Pardoll, A. M. & Vignali, D. A. A., May 25 2012, In : Immunity. 36, 5, p. 717-730 14 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Epigenomics
Transcription Factors
Autoimmunity
Histone Acetyltransferases

T cell signaling targets for enhancing regulatory or effector function

Pan, F., Fan, H., Liu, Z. & Jiang, S., Jul 31 2012, In : Science Signaling. 5, 235, pe32.

Research output: Contribution to journalArticle

Cell signaling
T-cells
Histone Deacetylases
T-Lymphocytes
Sirtuin 1

The role of STAT3 activation in modulating the immune microenvironment of GBM

See, A. P., Han, J. E., Phallen, J., Binder, Z., Gallia, G. L., Pan, F., Jinasena, D., Jackson, C., Belcaid, Z., Jeong, S. J., Gottschalk, C., Zeng, J., Ruzevick, J., Nicholas, S., Kim, Y., Albesiano, E., Pardoll, A. M. & Lim, M., Dec 2012, In : Journal of Neuro-Oncology. 110, 3, p. 359-368 10 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Glioblastoma
Transcriptional Activation
Cell Line
Immunosuppressive Agents
2011

Control of TH17/Treg balance by hypoxia-inducible factor 1

Dang, E. V., Barbi, J., Yang, H. Y., Jinasena, D., Yu, H., Zheng, Y., Bordman, Z., Fu, J., Kim, Y., Yen, H. R., Luo, W., Zeller, K., Shimoda, L., Topalian, S., Semenza, G. L., Dang, C. V., Pardoll, A. M. & Pan, F., Sep 2 2011, In : Cell. 146, 5, p. 772-784 13 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
T-cells
T-Lymphocytes
Regulatory T-Lymphocytes
Interleukin-17

GATA6 activates Wnt signaling in pancreatic cancer by negatively regulating the Wnt antagonist Dickkopf-1

Zhong, Y., Wang, Z., Fu, B., Pan, F., Yachida, S., Dhara, M., Albesiano, E., Li, L., Naito, Y., Vilardell, F., Cummings, C., Martinelli, P., Li, A., Yonescu, R., Ma, Q., Griffin, C. A., Real, F. X. & Iacobuzio-Donahue, C. A., 2011, In : PLoS One. 6, 7, e22129.

Research output: Contribution to journalArticle

pancreatic neoplasms
adenocarcinoma
Pancreatic Neoplasms
antagonists
carcinogenesis

The Yin and Yang of signaling in Tregs and TH17 cells

Pan, F., Fan, H., Lu, L., Liu, Z. & Jiang, S., Mar 22 2011, In : Science Signaling. 4, 165, mr4.

Research output: Contribution to journalArticle

Yin-Yang
Th17 Cells
T-cells
Interleukin-17
Cytokines
2010

A role for the transcription factor Helios in human CD4+CD25+ regulatory T cells

Getnet, D., Grosso, J. F., Goldberg, M. V., Harris, T. J., Yen, H. R., Bruno, T. C., Durham, N. M., Hipkiss, E. L., Pyle, K. J., Wada, S., Pan, F., Pardoll, A. M. & Drake, C. G., Apr 2010, In : Molecular Immunology. 47, 7-8, p. 1595-1600 6 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Transcription Factors
Ikaros Transcription Factor
Chromatin Immunoprecipitation
Oligonucleotides
2009

Eos mediates foxp3-dependent gene silencing in CD4+ regulatory T cells

Pan, F., Yu, H., Dang, E. V., Barbi, J., Pan, X., Grosso, J. F., Jinasena, D., Sharma, S. M., McCadden, E. M., Getnet, D., Drake, C. G., Liu, J., Ostrowski, M. C. & Pardoll, A. M., 2009, In : Science. 325, 5944, p. 1142-1146 5 p.

Research output: Contribution to journalArticle

Gene Silencing
Regulatory T-Lymphocytes
Ikaros Transcription Factor
Self Tolerance
Zinc Fingers
2008

Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes

Ren, Y. R., Pan, F., Parvez, S., Fleig, A., Chong, C. R., Xu, J., Dang, Y., Zhang, J., Jiang, H., Penner, R. & Liu, J., Dec 23 2008, In : PLoS One. 3, 12, e4009.

Research output: Contribution to journalArticle

Kv1.3 Potassium Channel
Clofazimine
Calcium Signaling
T-cells
potassium channels
2007

Calcineurin promotes hypoxia-inducible factor 1α expression by dephosphorylating RACK1 and blocking RACK1 dimerization

Liu, Y. V., Hubbi, M. E., Pan, F., McDonald, K. R., Mansharamani, M., Cole, R. N., Liu, J. & Semenza, G. L., Dec 21 2007, In : Journal of Biological Chemistry. 282, 51, p. 37064-37073 10 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Dimerization
Calcineurin
Degradation
Ubiquitin-Protein Ligases

Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin

Pan, F., Sun, L., Kardian, D. B., Whartenby, K., Pardoll, A. M. & Liu, J., Jan 25 2007, In : Nature. 445, 7126, p. 433-436 4 p.

Research output: Contribution to journalArticle

Calcineurin
T-Cell Antigen Receptor
Proteins
ras GTPase-Activating Proteins
T-Lymphocytes
2006

Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target

Chong, C. R., Qian, D. Z., Pan, F., Wei, Y., Pili, R., Sullivan, D. J. & Liu, J., May 4 2006, In : Journal of Medicinal Chemistry. 49, 9, p. 2677-2680 4 p.

Research output: Contribution to journalArticle

Inosine Monophosphate
Endothelial cells
Oxidoreductases
Endothelial Cells
Cell proliferation
2005

Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation

Pan, F., Means, A. R. & Liu, J., Jun 15 2005, In : The EMBO journal. 24, 12, p. 2104-2113 10 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 4
Calcium-Calmodulin-Dependent Protein Kinases
T-cells
Cell Nucleus Active Transport
Calmodulin
2004
MEF2 Transcription Factors
NFATC Transcription Factors
Calcium Signaling
T-cells
Transcription
2003

Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2

Han, A., Pan, F., Stroud, J. C., Youn, H. D., Liu, J. & Chen, L., Apr 17 2003, In : Nature. 422, 6933, p. 730-734 5 p.

Research output: Contribution to journalArticle

MEF2 Transcription Factors
Co-Repressor Proteins
Histone Deacetylases
DNA
Muscle Cells
2002

Synthesis of Cyclosporin A-Derived Affinity Reagents by Olefin Metathesis

Smulik, J. A., Diver, S. T., Pan, F. & Liu, J., Jun 13 2002, In : Organic Letters. 4, 12, p. 2051-2054 4 p.

Research output: Contribution to journalArticle

metathesis
Alkenes
Cyclosporine
alkenes
reagents