Ernst W Spannhake

Professor Emeritus

1976 …2019
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Research Output 1976 2019

2019
Civil Defense
Emergencies
Disasters
Public Health
Emotions
2018

The Acute Effects of Age and Particulate Matter Exposure on Heart Rate and Heart Rate Variability in Mice

Bennett, B. A., Spannhake, E. W., Rule, A. M., Breysse, P. N. & Tankersley, C. G., May 17 2018, (Accepted/In press) In : Cardiovascular Toxicology. p. 1-13 13 p.

Research output: Contribution to journalArticle

Particulate Matter
Heart Rate
Homeostasis
Inbred DBA Mouse
Ventilation
2017

Perioperative participation of orthopedic patients and surgical staff in a nasal decolonization intervention to reduce Staphylococcus spp surgical site infections

Mullen, A., Wieland, H. J., Wieser, E. S., Spannhake, E. W. & Marinos, R. S., May 1 2017, In : American Journal of Infection Control. 45, 5, p. 554-556 3 p.

Research output: Contribution to journalArticle

Patient Participation
Surgical Wound Infection
Staphylococcus
Nose
Orthopedics
2014

Reduction of nasal Staphylococcus aureus carriage in health care professionals by treatment with a nonantibiotic, alcohol-based nasal antiseptic

Steed, L. L., Costello, J., Lohia, S., Jones, T., Spannhake, E. W. & Nguyen, S., 2014, In : American Journal of Infection Control. 42, 8, p. 841-846 6 p.

Research output: Contribution to journalArticle

Local Anti-Infective Agents
Nose
Staphylococcus aureus
Alcohols
Delivery of Health Care
2013

Characterization of a portable method for the collection of exhaled breath condensate and subsequent analysis of metal content

Fox, J. R., Spannhake, E. W., Macri, K. K., Torrey, C. M., Mihalic, J. N., Eftim, S. E., Lees, P. S. & Geyh, A. S., Apr 2013, In : Environmental Sciences: Processes and Impacts. 15, 4, p. 721-729 9 p.

Research output: Contribution to journalArticle

condensate
Metals
metal
Limit of Detection
detection method
Tyrosine
Lipopolysaccharides
Phosphorylation
Lung
Protein Kinase C
2012

Lysophosphatidic acid increases soluble ST2 expression in mouse lung and human bronchial epithelial cells

Zhao, J., Chen, Q., Li, H., Myerburg, M., Spannhake, E. W., Natarajan, V. & Zhao, Y., Jan 2012, In : Cellular Signalling. 24, 1, p. 77-85 9 p.

Research output: Contribution to journalArticle

Epithelial Cells
Lung
Acetylation
Genetic Promoter Regions
Endotoxins
2011
Respiratory System
Oils
Anti-Inflammatory Agents
Antioxidants
Epithelial Cells
2009

Lysophosphatidic acid enhances pulmonary epithelial barrier integrity and protects endotoxin-induced epithelial barrierdisruption and lung injury

He, D., Su, Y., Usatyuk, P. V., Spannhake, E. W., Kogut, P., Solway, J., Natarajan, V. & Zhao, Y., Sep 4 2009, In : Journal of Biological Chemistry. 284, 36, p. 24123-24132 10 p.

Research output: Contribution to journalArticle

Lung Injury
Endotoxins
Cadherins
Lung
Acoustic impedance

Regulation of COX-2 expression and IL-6 release by particulate matter in airway epithelial cells

Zhao, Y., Usatyuk, P. V., Gorshkova, I. A., He, D., Wang, T., Moreno-Vinasco, L., Geyh, A. S., Breysse, P. N., Samet, J. M., Spannhake, E. W., Garcia, J. G. N. & Natarajan, V., Jan 1 2009, In : American Journal of Respiratory Cell and Molecular Biology. 40, 1, p. 19-30 12 p.

Research output: Contribution to journalArticle

Particulate Matter
Cyclooxygenase 2
Interleukin-6
Epithelial Cells
Reactive Oxygen Species
acylglycerol kinase
Interleukin-8
Epidermal Growth Factor Receptor
Transcriptional Activation
Epithelial Cells
2008

Interactions of Pollutants with the Epithelium

Spannhake, E. W., May 14 2008, The Pulmonary Epithelium in Health and Disease. John Wiley and Sons, p. 275-299 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Granulocyte Colony-Stimulating Factor
Epithelium

Lysophosphatidic acid-induced transactivation of epidermal growth factor receptor regulates cyclo-oxygenase-2 expression and prostaglandin E2 release via C/EBPβ in human bronchial epithelial cells

He, D., Natarajan, V., Stern, R., Gorshkova, I. A., Solway, J., Spannhake, E. W. & Zhao, Y., May 15 2008, In : Biochemical Journal. 412, 1, p. 153-162 10 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Prostaglandin-Endoperoxide Synthases
Epidermal Growth Factor Receptor
Dinoprostone
Transcriptional Activation
Nasal Polyps
Polyps
Down-Regulation
Epithelial Cells
Cytokines
2007
Nasal Polyps
Nose
Epithelial Cells
Flow Cytometry
Mucous Membrane

Lysophosphatidic acid induces interleukin-13 (IL-13) receptor α2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cells

Zhao, Y., He, D., Zhao, J., Wang, L., Leff, A. R., Spannhake, E. W., Georas, S. & Natarajan, V., Apr 6 2007, In : Journal of Biological Chemistry. 282, 14, p. 10172-10179 8 p.

Research output: Contribution to journalArticle

Interleukin-13 Receptors
Interleukin-13
Epithelial Cells
Gene expression
Phosphorylation

Lysophosphatidic acid modulates c-Met redistribution and hepatocyte growth factor/c-Met signaling in human bronchial epithelial cells through PKC δ and E-cadherin

Zhao, Y., He, D., Stern, R., Usatyuk, P. V., Spannhake, E. W., Salgia, R. & Natarajan, V., Nov 2007, In : Cellular Signalling. 19, 11, p. 2329-2338 10 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Cadherins
Epithelial Cells
Phosphorylation
Cell Membrane
Toll-Like Receptor 9
Polyps
Epithelial Cells
Nasal Polyps
Messenger RNA
Acrolein
Interleukin-8
Smoke
Tobacco Products
Epithelial Cells
2006
Hyaluronic Acid
Interleukin-8
Epithelial Cells
Chemokines
Inflammation
Matrix Metalloproteinases
Interleukin-8
Epidermal Growth Factor Receptor
Protein Kinase C
Transcriptional Activation

Transcriptional regulation of lysophosphatidic acid-induced interleukin-8 expression and secretion by p38 MAPK and JNK in human bronchial epithelial cells

Saatian, B., Zhao, Y., He, D., Georas, S. N., Watkins, T., Spannhake, E. W. & Natarajan, V., Feb 1 2006, In : Biochemical Journal. 393, 3, p. 657-668 12 p.

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
p38 Mitogen-Activated Protein Kinases
Interleukin-8
Epithelial Cells
Transcription

Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-κB activation and interleukin-8 secretion in human bronchial epithelial cells

Zhao, Y., Usatyuk, P. V., Cummings, R., Saatian, B., He, D., Watkins, T., Morris, A., Spannhake, E. W., Brindley, D. N. & Natarajan, V., Jan 15 2005, In : Biochemical Journal. 385, 2, p. 493-502 10 p.

Research output: Contribution to journalArticle

Interleukin-8
Epithelial Cells
Chemical activation
Calcium
Phosphorylation

Signal transduction of phorbol 12-myristate 13-acetate (PMA)-induced growth inhibition of human monocytic leukemia THP-1 cells is reactive oxygen dependent

Traore, K., Trush, M. A., George, M., Spannhake, E. W., Anderson, W. & Asseffa, A., Aug 2005, In : Leukemia Research. 29, 8, p. 863-879 17 p.

Research output: Contribution to journalArticle

Signal Transduction
Leukemia
Acetates
Oxygen
Growth
2004
HLA Antigens
Nose
Cell Differentiation
Epithelial Cells
Ligands

mRNA for genes associated with antigen presentation are expressed by human middle meatal epithelial cells in culture

Lane, A. P., Saatian, B., Yu, X. Y. & Spannhake, E. W., Oct 2004, In : Laryngoscope. 114, 10 I, p. 1827-1832 6 p.

Research output: Contribution to journalArticle

Antigen Presentation
HLA Antigens
Cell Culture Techniques
Epithelial Cells
Air

Protein kinase Cδ mediates lysophosphatidic acid-induced NF-κB activation and interleukin-8 secretion in human bronchial epithelial cells

Cummings, R., Zhao, Y., Jacoby, D., Spannhake, E. W., Ohba, M., Garcia, J. G. N., Watkins, T., He, D., Saatian, B. & Natarajan, V., Sep 24 2004, In : Journal of Biological Chemistry. 279, 39, p. 41085-41094 10 p.

Research output: Contribution to journalArticle

Interleukin-8
Protein Kinase C
Epithelial Cells
Chemical activation
G12-G13 GTP-Binding Protein alpha Subunits
2001

Repetitive ozone exposure of young adults: Evidence of persistent small airway dysfunction

Frank, R., Liu, M. C. H., Spannhake, E. W., Mlynarek, S., Macri, K. & Weinmann, G. G., Oct 1 2001, In : American Journal of Respiratory and Critical Care Medicine. 164, 7, p. 1253-1260 8 p.

Research output: Contribution to journalArticle

Ozone
Therapeutic Irrigation
Young Adult
Exercise
Tachypnea
2000

Tissue prostanoids as biomarkers for chemoprevention of colorectal neoplasia: Correlation between prostanoid synthesis and clinical response in familial adenomatous polyposis

Yang, V. W., Geiman, D. E., Hubbard, W. C., Spannhake, E. W., Hylind, L. M., Hamilton, S. R. & Giardiello, F. M., Jan 2000, In : Prostaglandins and Other Lipid Mediators. 60, 1-3, p. 83-96 14 p.

Research output: Contribution to journalArticle

Sulindac
Adenomatous Polyposis Coli
Chemoprevention
Biomarkers
Prostaglandins
1998

Correlates of infection control practices in dentistry

Gershon, R. R. M., Karkashian, C., Vlahov, D., Grimes, M. & Spannhake, E. W., 1998, In : American Journal of Infection Control. 26, 1, p. 29-34 6 p.

Research output: Contribution to journalArticle

Infection Control
Dentistry
Dentists
Blood-Borne Pathogens
Safety Management

Prostaglandin levels in human colorectal mucosa: Effects of sulindac in patients with familial adenomatous polyposis

Giardiello, F. M., Spannhake, E. W., Dubois, R. N., Hylind, L. M., Robinson, C. R., Hubbard, W. C., Hamilton, S. R. & Yang, V. W., 1998, In : Digestive Diseases and Sciences. 43, 2, p. 311-316 6 p.

Research output: Contribution to journalArticle

Sulindac
Adenomatous Polyposis Coli
Prostaglandins
Mucous Membrane
Prostaglandin D2

Size-dependent increase in prostanoid levels in adenomas of patients with familial adenomatous polyposis

Yang, V. W., Shields, J. M., Hamilton, S. R., Spannhake, E. W., Hubbard, W. C., Hylind, L. M., Robinson, C. R. & Giardiello, F. M., Apr 15 1998, In : Cancer Research. 58, 8, p. 1750-1753 4 p.

Research output: Contribution to journalArticle

Adenomatous Polyposis Coli
Adenoma
Prostaglandins
Prostaglandin-Endoperoxide Synthases
Mucous Membrane
1996

Down-regulation of canine airway mast cell function following exposure to ozone in vivo

Spannhake, E. W., 1996, In : Experimental Lung Research. 22, 2, p. 163-178 16 p.

Research output: Contribution to journalArticle

Ozone
Mast Cells
Canidae
Prostaglandin D2
Down-Regulation
Substance P
Permeability
Cell Culture Techniques
Epithelial Cells
Ozone
1995

Expression of ICAM-1 in airway epithelium after acute ozone exposure in the mouse

Takahashi, N., Yu, X. Y., Schofield, B. H., Kleeberger, S. R., Scott, A. L., Hasegawa, S. & Spannhake, E. W., 1995, In : Journal of Applied Physiology. 79, 5, p. 1753-1761 9 p.

Research output: Contribution to journalArticle

Ozone
Intercellular Adhesion Molecule-1
Epithelium
Neutrophils
Bronchioles

Specific binding of endothelin-1 to canine tracheal epithelial cells in culture

Ninomiya, H., Yu, X. Y., Uchida, Y., Hasegawa, S. & Spannhake, E. W., 1995, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 268, 3 12-3

Research output: Contribution to journalArticle

endothelins
Endothelin-1
Canidae
cell culture
epithelial cells

The 5-lipoxygenase pathway in cultured human intestinal epithelial cells

Cortese, J. F., Spannhake, E. W., Eisinger, W., Potter, J. J. & Yang, V. W., 1995, In : Prostaglandins. 49, 3, p. 155-166 12 p.

Research output: Contribution to journalArticle

Arachidonate 5-Lipoxygenase
Leukotrienes
Epithelial Cells
RNA
Poly A

The effects of ozone on immune function

Jakab, G. J., Spannhake, E. W., Canning, B. J., Kleeberger, S. R. & Gilmour, M. I., 1995, In : Environmental Health Perspectives. 103, SUPPL. 2, p. 77-89 13 p.

Research output: Contribution to journalArticle

Immunization
Ozone
ozone
Antigens
Design of experiments
1994
Poisons
Ozone
hydrogen peroxide
Hydrogen Peroxide
Epithelial Cells

Modulation of bronchial epithelial cell barrier function by in vitro ozone exposure

Yu, X. Y., Takahashi, N., Croxton, T. L. & Spannhake, E. W., 1994, In : Environmental Health Perspectives. 102, 12, p. 1068-1072 5 p.

Research output: Contribution to journalArticle

Ozone
Epithelial Cells
ozone
Modulation
Canidae

Physiologic modulation of bronchial epithelial cell barrier function by polycationic exposure.

Yu, X. Y., Schofield, B. H., Croxton, T., Takahashi, N., Gabrielson, E. & Spannhake, E. W., Aug 1994, In : American Journal of Respiratory Cell and Molecular Biology. 11, 2, p. 188-198 11 p.

Research output: Contribution to journalArticle

Epithelial Cells
Modulation
Fluxes
Lysine
Canidae

Soluble intracellular adhesion molecule 1 in bronchoalveolar lavage fluid of allergic subjects following segmental antigen challenge

Takahashi, N., Liu, M. C., Proud, D., Yu, X. Y., Hasegawa, S. & Spannhake, E. W., Sep 1994, In : American Journal of Respiratory and Critical Care Medicine. 150, 3, p. 704-709 6 p.

Research output: Contribution to journalArticle

Bronchoalveolar Lavage Fluid
Intercellular Adhesion Molecule-1
Antigens
Bronchoalveolar Lavage
Bronchoscopy
1992

Endothelin-1 induces stimulation of prostaglandin synthesis in cells obtained from canine airways by bronchoalveolar lavage

Ninomiya, H., Hasegawa, S., Yu, X. Y. & Spannhake, E. W., 1992, In : Prostaglandins. 43, 5, p. 401-411 11 p.

Research output: Contribution to journalArticle

Bronchoalveolar Lavage
Endothelin-1
Prostaglandins
Canidae
Arachidonic Acid
Smooth Muscle
Canidae
Buffers
Epithelial Cells
Dinoprostone
1991

Contractile responses of guinea pig trachea to oxybarbiturates and thiobarbiturates

Curry, C., Lenox, W. C., Spannhake, E. W. & Hirshman, C. A., 1991, In : Anesthesiology. 75, 4, p. 679-683 5 p.

Research output: Contribution to journalArticle

Thiobarbiturates
Thiamylal
Trachea
Constriction
Guinea Pigs

Mediators, initiating the inflammatory response, released in organ culture by full-thickness human skin explants exposed to the irritant, sulfur mustard

Rikimaru, T., Nakamura, M., Yano, T., Beck, G., Habicht, G. S., Rennie, L. L., Widra, M., Hirshman, C. A., Boulay, M. G., Spannhake, E. W., Lazarus, G. S., Pula, P. J. & Dannenberg, A. M., Jun 1991, In : Journal of Investigative Dermatology. 96, 6, p. 888-897 10 p.

Research output: Contribution to journalArticle

Mustard Gas
Irritants
Organ Culture Techniques
Skin
Fluids
Ozone
Alveolar Macrophages
Peritoneal Macrophages
Phagocytosis
Prostaglandins
1990
Topical Administration
Mast Cells
Canidae
Steroids
Antigens
Alveolar Macrophages
Arachidonic Acid
Metabolism
Phospholipids
Metabolites