Research Output 2005 2018

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2018

Affinity maturation shapes the function of agonistic antibodies to peptidylarginine deiminase type 4 in rheumatoid arthritis

Shi, J., Darrah, E., Sims, G. P., Mustelin, T., Sampson, K., Konig, M. F., Bingham, C. O., Rosen, A. & Andrade, F. Jan 1 2018 In : Annals of the rheumatic diseases. 77, 1, p. 141-148 8 p.

Research output: Contribution to journalArticle

Delta wing aircraft
Antibody Affinity
Cross Reactions
Autoantibodies
Disease Progression
Autoantibodies
Rheumatoid Arthritis
Smoking
Antibodies
Epitopes
2017
Antigen Presentation
Epitopes
Immunodominant Epitopes
Antigens
Proteins

Proteolysis by Granzyme B Enhances Presentation of Autoantigenic Peptidylarginine Deiminase 4 Epitopes in Rheumatoid Arthritis

Darrah, E., Kim, A., Zhang, X., Boronina, T., Cole, R. N., Fava, A., Giles, J. T., Bingham, C. O., Chalmers, M. J., Griffin, P. R., Sadegh-Nasseri, S. & Rosen, A. Jan 6 2017 In : Journal of Proteome Research. 16, 1, p. 355-365 11 p.

Research output: Contribution to journalArticle

Proteolysis
Granzymes
Epitopes
Rheumatoid Arthritis
T-cells

Spontaneous secretion of the citrullination enzyme PAD2 and cell surface exposure of PAD4 by neutrophils

Zhou, Y., Chen, B., Mittereder, N., Chaerkady, R., Strain, M., An, L. L., Rahman, S., Ma, W., Low, C. P., Chan, D., Neal, F., Bingham, C. O., Sampson, K., Darrah, E., Siegel, R. M., Hasni, S., Andrade, F., Vousden, K. A., Mustelin, T. & Sims, G. P. Sep 25 2017 In : Frontiers in Immunology. 8, SEP, 1200

Research output: Contribution to journalArticle

Rheumatoid Arthritis
Neutrophils
Enzymes
Calcium
Neutrophil Activation
2016

Anti-peptidyl-arginine deaminase 3 (PAD3) antibodies as a promising marker to measure joint damage in patients with rheumatoid arthritis

Seaman, A., Darrah, E., Infantino, M., Meacci, F., Manfredi, M., Benucci, M. & Mahler, M. Mar 7 2016 (Accepted/In press) In : Autoimmunity Reviews.

Research output: Contribution to journalArticle

Arginine
Rheumatoid Arthritis
Joints
Antibodies
Immunoassay

Association of anti-peptidyl arginine deiminase antibodies with radiographic severity of rheumatoid arthritis in African Americans

Navarro-Millán, I., Darrah, E., Westfall, A. O., Mikuls, T. R., Reynolds, R. J., Danila, M. I., Curtis, J. R., Rosen, A., Bridges, S. L. & CLEAR Investigators Oct 22 2016 In : Arthritis Research and Therapy. 18, 1, 241

Research output: Contribution to journalArticle

African Americans
Rheumatoid Arthritis
Antibodies
arginine deiminase
Autoantibodies
2015
Acetaldehyde
Autoantigens
Malondialdehyde
Autoantibodies
Rheumatoid Arthritis
2014
arginine deiminase
Pulmonary diseases
rheumatoid arthritis
Interstitial Lung Diseases
respiratory tract diseases

Association of the autoimmune disease scleroderma with an immunologic response to cancer

Joseph, C. G., Darrah, E., Shah, A. A., Skora, A. D., Casciola-Rosen, L. A., Wigley, F. M., Boin, F., Fava, A., Thoburn, C., Kinde, I., Jiao, Y., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Rosen, A. 2014 In : Science. 343, 6167, p. 152-157 6 p.

Research output: Contribution to journalArticle

Autoimmune Diseases
Neoplasms
Antibodies
Antigens
Connective Tissue Diseases
Experimental Arthritis
Hydrolases
Theoretical Models
Tumor Necrosis Factor-alpha
Antigens
2013

Erosive rheumatoid arthritis is associated with antibodies that activate PAD4 by increasing calcium sensitivity

Darrah, E., Giles, J. T., Ols, M. L., Bull, H. G., Andrade, F. & Rosen, A. May 22 2013 In : Science Translational Medicine. 5, 186, 186ra65

Research output: Contribution to journalArticle

Autoantibodies
Rheumatoid Arthritis
Calcium
Antibodies
Autoantigens

Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis

Romero, V., Fert-Bober, J., Nigrovic, P. A., Darrah, E., Haque, U. J., Lee, D. M., Van Eyk, J., Rosen, A. & Andrade, F. Oct 30 2013 In : Science Translational Medicine. 5, 209, 209ra150

Research output: Contribution to journalArticle

Autoantigens
Rheumatoid Arthritis
Perforin
Complement Membrane Attack Complex
Neutrophil Activation

Prevalence of anti-peptidylarginine deiminase type 4 antibodies in rheumatoid arthritis and unaffected first-degree relatives in indigenous North American populations

Ferucci, E. D., Darrah, E., Smolik, I., Choromanski, T. L., Robinson, D. B., Newkirk, M. M., Fritzler, M. J., Rosen, A. & El-Gabalawy, H. S. Sep 2013 In : Journal of Rheumatology. 40, 9, p. 1523-1528 6 p.

Research output: Contribution to journalArticle

Rheumatoid Arthritis
Antibodies
Population
Peptides
Epitopes
2012

Nets: The missing link between cell death and systemic autoimmune diseases?

Darrah, E. & Andrade, F. 2012 In : Frontiers in Immunology. 3, JAN, Article 428

Research output: Contribution to journalArticle

Autoimmune Diseases
Cell Death
Granulomatosis with Polyangiitis
Apoptosis
Autoimmunity
Autoantigens
Actins
Rheumatoid Arthritis
Neutrophils
Substrates
2010
arginine deiminase
peptidylarginine deiminase type IV
Cell Line
Rheumatoid Arthritis
Citrulline

Autoimmunity to peptidyl arginine deiminase type 4 precedes clinical onset of rheumatoid arthritis

Kolfenbach, J. R., Deane, K. D., Derber, L. A., O'Donnell, C. I., Gilliland, W. R., Edison, J. D., Rosen, A., Darrah, E., Norris, J. M. & Holers, V. M. 2010 In : Arthritis and Rheumatism. 62, 9, p. 2633-2639 7 p.

Research output: Contribution to journalArticle

Autoimmunity
Rheumatoid Arthritis
Autoantibodies
Antibodies
Anti-Idiotypic Antibodies

Granzyme B cleavage of autoantigens in autoimmunity

Darrah, E. & Rosen, A. Apr 2010 In : Cell Death and Differentiation. 17, 4, p. 624-632 9 p.

Research output: Contribution to journalArticle

Granzymes
Autoantigens
Autoimmunity
Autoimmune Diseases
Epitopes
2008

Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis

Harris, M. L., Darrah, E., Lam, G. K., Bartlett, S. J., Giles, J. T., Grant, A. V., Gao, P., Scott, W. W., El-Gabalawy, H., Casciola-Rosen, L., Barnes, K. C., Bathon, J. M. & Rosen, A. Jul 2008 In : Arthritis and Rheumatism. 58, 7, p. 1958-1967 10 p.

Research output: Contribution to journalArticle

Autoimmunity
Rheumatoid Arthritis
Genotype
Autoantibodies
arginine deiminase
2005

The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain

Rus, H., Pardo, C. A., Hu, L., Darrah, E., Cudrici, C., Niculescu, T., Niculescu, F., Mullen, K. M., Allie, R., Guo, L., Wulff, H., Beeton, C., Judge, S. I. V., Kerr, D. A., Knaus, H. G., Chandy, K. G. & Calabresi, P. A. Aug 2 2005 In : Proceedings of the National Academy of Sciences of the United States of America. 102, 31, p. 11094-11099 6 p.

Research output: Contribution to journalArticle

Voltage-Gated Potassium Channels
Multiple Sclerosis
Brain
T-Lymphocytes
Cerebrospinal Fluid